Details
| Name | PAI-1 |
| Type | gene |
| Species | Mus musculus |
| Tissue | embryo |
| Experiment Method | RT-PCR |
| Up/Down | Down |
| Pro/Anti | NA |
| Funtion Description | suppression of the p53 target gene encoding plasminogen activator inhibitor-1 (PAI-1) by RNA interference (RNAi) leads to escape from replicative senescence both in primary mouse embryo fibroblasts and primary human BJ fibroblasts. |
| Regulation Gene | NA |
| Year | 2006 |
| Pubmed ID | 16862142 |
| Title | Plasminogen activator inhibitor-1 is a critical downstream target of p53 in the induction of replicative senescence. |
| Drug | NA |
| Disease | NA |
| Environment Factors | NA |
| Circulating | NA |
| Variant | NA |
| High-throughput | NA |