| Name |
PARP1
|
| Type |
gene
|
| Species |
Homo sapiens
|
| Tissue |
human primary melanocytes
|
| Experiment Method |
qPCR;mass spectrometry;ChIP;Luciferase assays;Immunofluorescence staining
|
| Up/Down |
NA
|
| Pro/Anti |
Anti
|
| Funtion Description |
In human primary melanocytes, PARP1 promoted cell proliferation and rescued BRAFV600E-induced senescence phenotypes in a PARylation-independent manner. PARP1 also transformed TERT-immortalized melanocytes expressing BRAFV600E. PARP1-mediated senescence re
|
| Regulation Gene |
NA
|
| Year |
2017
|
| Pubmed ID |
28759004
|
| Title |
A common intronic variant of PARP1 confers melanoma risk and mediates melanocyte growth via regulation of MITF.
|
| Drug |
NA
|
| Disease |
melanoma
|
| Environment Factors |
NA
|
| Circulating |
NA
|
| Variant |
NA
|
| High-throughput |
NA
|