| Name |
PARP1
|
| Type |
gene
|
| Species |
Homo sapiens
|
| Tissue |
HCA2
|
| Experiment Method |
RT-PCR,immunofluorescence
|
| Up/Down |
NA
|
| Pro/Anti |
NA
|
| Funtion Description |
Researchers used normal human fibroblasts with a chromosomally integrated HR reporter cassette to examine the changes in HR efficiency as cells progress to replicative senescence. We show that HR declines sharply with increasing replicative age, with an u
|
| Regulation Gene |
NA
|
| Year |
2012
|
| Pubmed ID |
22753495
|
| Title |
Sirtuin 6 (SIRT6) rescues the decline of homologous recombination repair during replicative senescence.
|
| Drug |
NA
|
| Disease |
NA
|
| Environment Factors |
NA
|
| Circulating |
NA
|
| Variant |
NA
|
| High-throughput |
NA
|