Details
| Name | PIM-1 |
| Type | gene |
| Species | Homo sapiens |
| Tissue | NA |
| Experiment Method | RT-PCR,RNAi |
| Up/Down | Up |
| Pro/Anti | Pro |
| Funtion Description | Unexpectedly, we found that the expression of proto-oncogene PIM-1, which can promote tumorigenesis, is induced at transcriptional level during senescence. Inhibition of PIM-1 alleviated both replicative and oncogene-induced senescence. |
| Regulation Gene | NA |
| Year | 2014 |
| Pubmed ID | 25040935 |
| Title | PIM-1 modulates cellular senescence and links IL-6 signaling to heterochromatin formation. |
| Drug | NA |
| Disease | NA |
| Environment Factors | NA |
| Circulating | NA |
| Variant | NA |
| High-throughput | NA |