A Manually Curated Knowledgebase of Aging across a variety of Species

Details


Name PKCeta
Type gene
Species Homo sapiens
Tissue Human cells
Experiment Method Immunoblot;Immunoprecipitations;quantitative real-time PCR
Up/Down NA
Pro/Anti Pro
Funtion Description Here we show that PKCeta, an epithelial specific and anti-apoptotic kinase, promotes senescence induced by oxidative stress and DNA damage.PKCeta promotes senescence through its ability to upregulate the expression of the cell cycle inhibitors p21(Cip1) a
Regulation Gene p21,p27
Year 2014
Pubmed ID 25412309
Title PKCeta promotes senescence induced by oxidative stress and chemotherapy.
Drug NA
Disease NA
Environment Factors NA
Circulating NA
Variant NA
High-throughput NA