| Name |
PPARa
|
| Type |
gene
|
| Species |
Homo sapiens
|
| Tissue |
NA
|
| Experiment Method |
Senescence-associated B-galactosidase staining,IHC,IF,Western blotting and RT-qPCR
|
| Up/Down |
up
|
| Pro/Anti |
Anti
|
| Funtion Description |
The stable KD of PPARa in GSC completely abolished intracranial tumour formation. This was associated with the induction of cellular senescence in vitro, driven by the reduced expression of mitogenic and stemness factors. These data provide evidence of th
|
| Regulation Gene |
NA
|
| Year |
2018
|
| Pubmed ID |
30565681
|
| Title |
shRNA-mediated PPARa knockdown in human glioma stem cells reduces in vitro proliferation and inhibits orthotopic xenograft tumour growth
|
| Drug |
NA
|
| Disease |
glioma
|
| Environment Factors |
NA
|
| Circulating |
NA
|
| Variant |
NA
|
| High-throughput |
GSE15209
|