| Name |
PRMT6
|
| Type |
gene
|
| Species |
Homo sapiens
|
| Tissue |
Human breast cancer cell line MCF7, MDA-MB-231, SK-BR-3, MDA-MB-468, MCF10A and BT474
|
| Experiment Method |
qRT-PCR;Western blotting;Chromatin immunoprecipitation;Senescence-associated acidic B-galactosidase staining
|
| Up/Down |
Down
|
| Pro/Anti |
Pro
|
| Funtion Description |
Here, we report that protein arginine methyltransferase 6 (PRMT6), a type I PRMT known to act as a transcriptional cofactor, directly represses the p21 promoter. PRMT6 knock-down (KD) results in a p21 derepression in breast cancer cells, which is p53-inde
|
| Regulation Gene |
NA
|
| Year |
2012
|
| Pubmed ID |
22987071
|
| Title |
p53-Independent regulation of p21Waf1/Cip1 expression and senescence by PRMT6.
|
| Drug |
NA
|
| Disease |
breast cancer
|
| Environment Factors |
NA
|
| Circulating |
NA
|
| Variant |
NA
|
| High-throughput |
NA
|