A Manually Curated Knowledgebase of Aging across a variety of Species

Details


Name PRNP
Type gene
Species Homo sapiens
Tissue MSCs
Experiment Method Western blot
Up/Down Down
Pro/Anti Anti
Funtion Description The IS-induced senescence of MSCs was significantly reduced by co-treatment with melatonin and pioglitazone compared to treatment with melatonin or pioglitazone alone. In the presence of IS, the reduced MSC proliferation was rescued by co-treatment with m
Regulation Gene NA
Year 2018
Pubmed ID 29734669
Title Co-Administration of Melatonin Effectively Enhances the Therapeutic Effects of Pioglitazone on Mesenchymal Stem Cells Undergoing Indoxyl Sulfate-Induced Senescence through Modulation of Cellular Prion Protein Expression
Drug NA
Disease NA
Environment Factors NA
Circulating NA
Variant NA
High-throughput NA