A Manually Curated Knowledgebase of Aging across a variety of Species

Details


Name PromL
Type gene
Species Saccharomyces cerevisiae
Tissue brain
Experiment Method RNA-seq, PCR, RNAi, Western blot
Up/Down Down
Pro/Anti Anti
Funtion Description Importantly, the PromL protein is predominantly expressed in the pars intercerebralis region with insulin producing cells (IPCs) of the adult brain. When we inhibited promL in IPCs, these flies showed an extended lifespan, metabolic defects, and reduced i
Regulation Gene NA
Year 2018
Pubmed ID 30590420
Title Prominin-like regulates longevity and glucose metabolism via insulin signaling in Drosophila.
Drug RU486, ActinGS
Disease NA
Environment Factors NA
Circulating NA
Variant NA
High-throughput NA