Details
| Name | AEG-1 |
| Type | gene |
| Species | Homo sapiens |
| Tissue | LNCaP;C42B |
| Experiment Method | Cell proliferation assay |
| Up/Down | Down |
| Pro/Anti | Anti |
| Funtion Description | Downregulation of AEG-1 induced senescence in cells treated with overtly cytotoxic concentrations of DIM or ring-DIMs and inhibited the onset of apoptosis in response to these compounds. In summary, we have identified a novel mechanism for DIM- and ring-D |
| Regulation Gene | NA |
| Year | 2017 |
| Pubmed ID | 28923415 |
| Title | Diindolylmethane and its halogenated derivatives induce protective autophagy in human prostate cancer cells via induction of the oncogenic protein AEG-1 and activation of AMP-activated protein kinase (AMPK). |
| Drug | DIM;ring-DIMs |
| Disease | prostate cancer |
| Environment Factors | NA |
| Circulating | NA |
| Variant | NA |
| High-throughput | NA |