| Name |
Ptpn11
|
| Type |
gene
|
| Species |
Mus musculus
|
| Tissue |
Lymphocyte
|
| Experiment Method |
Surface Staining;Flow Cytometry;Western Blot;Histology
|
| Up/Down |
NA
|
| Pro/Anti |
NA
|
| Funtion Description |
Ptpn11gene deletion driven by CD4 Cre recombinase leads to cartilage tumors in wrist bones in a T cell-independent manner. These tumors resemble miniature cartilaginous growth plates and contain CD4-lineage positive chondrocyte-like cells. Altogether thes
|
| Regulation Gene |
NA
|
| Year |
2017
|
| Pubmed ID |
29085371
|
| Title |
Ptpn11 Deletion in CD4+ Cells Does Not Affect T Cell Development and Functions but Causes Cartilage Tumors in a T Cell-Independent Manner
|
| Drug |
NA
|
| Disease |
Cartilage Tumors
|
| Environment Factors |
NA
|
| Circulating |
NA
|
| Variant |
Deletion mutation
|
| High-throughput |
NA
|