Details
| Name | Ras |
| Type | gene |
| Species | Homo sapiens |
| Tissue | TIG-3 cells;REF52 cells |
| Experiment Method | Senescence-associated b-galactosidase;Immunoblotting;RT-PCR |
| Up/Down | NA |
| Pro/Anti | Pro |
| Funtion Description | Here, we show that through the Ras/MEK pathway, Ras oncogene up-regulated the expression of superoxide-generating oxidases, Nox1 in rat REF52 cells and Nox4 in primary human lung TIG-3 cells, leading to an increase in intracellular level of ROS.Furthermor |
| Regulation Gene | NA |
| Year | 2013 |
| Pubmed ID | 23216904 |
| Title | ROS-generating oxidases Nox1 and Nox4 contribute to oncogenic Ras-induced premature senescence. |
| Drug | NA |
| Disease | NA |
| Environment Factors | NA |
| Circulating | NA |
| Variant | NA |
| High-throughput | NA |