Details
| Name | Ras |
| Type | gene |
| Species | Homo sapiens |
| Tissue | normal diploid human IMR90 fibroblasts |
| Experiment Method | other |
| Up/Down | NA |
| Pro/Anti | Pro |
| Funtion Description | In summary, our data demonstrate that oncogenic Ras promotes premature senescence through activation of the MAPK cascade. Ras is initially mitogenic but eventually induces premature senescence involving the p53 and p16INK4a tumor suppressors. Constitutive |
| Regulation Gene | NA |
| Year | 1998 |
| Pubmed ID | 9765203 |
| Title | Premature senescence involving p53 and p16 is activated in response to constitutive MEK/MAPK mitogenic signaling |
| Drug | NA |
| Disease | NA |
| Environment Factors | NA |
| Circulating | NA |
| Variant | somatic mutation |
| High-throughput | NA |