| Name |
Ras
|
| Type |
gene
|
| Species |
Homo sapiens
|
| Tissue |
human primary fibroblasts (IMR90, WI38) and an amphotrophic retrovirus packaging line (BING)
|
| Experiment Method |
other
|
| Up/Down |
Up
|
| Pro/Anti |
Pro
|
| Funtion Description |
Here we show that expression of oncogenic ras in primary human or rodent cells results in a permanent G1 arrest. The arrest induced by ras is accompanied by accumulation of p53 and p16, and is phenotypically indistinguishable from cellular senescence.
|
| Regulation Gene |
NA
|
| Year |
1997
|
| Pubmed ID |
9054499
|
| Title |
Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a.
|
| Drug |
NA
|
| Disease |
NA
|
| Environment Factors |
NA
|
| Circulating |
NA
|
| Variant |
NA
|
| High-throughput |
NA
|