A Manually Curated Knowledgebase of Aging across a variety of Species

Details


Name a-Klotho
Type gene
Species Mus musculus
Tissue brain
Experiment Method Western Blotting,Immunofluorescence
Up/Down down
Pro/Anti Anti
Funtion Description We detected a-Klotho in mouse brain regions and determined that the expression of Klotho in the hippocampus of mice decreased significantly during aging. Overexpression of human secreted Klotho in neurons of the CA1 area enhanced object recognition, objec
Regulation Gene NA
Year 2019
Pubmed ID 31001090
Title Enhanced Expression of Secreted a-Klotho in the Hippocampus Alters Nesting Behavior and Memory Formation in Mice
Drug NA
Disease NA
Environment Factors NA
Circulating NA
Variant NA
High-throughput NA