Details
| Name | RKIP |
| Type | gene |
| Species | Homo sapiens |
| Tissue | NA |
| Experiment Method | RT-qPCR |
| Up/Down | Up |
| Pro/Anti | Pro |
| Funtion Description | Through several molecular biologic analyses, we found that RKIP, an inhibitor of Raf kinase, is responsible for p53-mediated ERK suppression and senescence.Overexpression of RKIP can induce cellular senescence in several types of cell lines |
| Regulation Gene | NA |
| Year | 2013 |
| Pubmed ID | 23814485 |
| Title | A new p53 target gene, RKIP, is essential for DNA damage-induced cellular senescence and suppression of ERK activation. |
| Drug | NA |
| Disease | NA |
| Environment Factors | NA |
| Circulating | NA |
| Variant | NA |
| High-throughput | NA |