A Manually Curated Knowledgebase of Aging across a variety of Species

Details


Name SATB2
Type gene
Species Rat Rattus
Tissue BMSCs
Experiment Method RT-PCR
Up/Down Up
Pro/Anti Pro
Funtion Description Estrogen mediated pluripotency and senescence of BMSCs, primarily through estrogen receptor beta (ERB). BMSCs from the OVX rats displayed increased senescence and weaker SATB2 expression, stemness, and osteogenic differentiation, while estrogen could resc
Regulation Gene NA
Year 2018
Pubmed ID 29030963
Title Estrogen regulates stemness and senescence of bone marrow stromal cells to prevent osteoporosis via ERB-SATB2 pathway.
Drug NA
Disease NA
Environment Factors NA
Circulating NA
Variant NA
High-throughput NA