| Name |
SETD8
|
| Type |
gene
|
| Species |
Homo sapiens
|
| Tissue |
lung fibroblast IMR90
|
| Experiment Method |
SA-B-Gal staining;RT-qPCR;Flow cytometry-based analysis;Western blot analysis;ChIP assay
|
| Up/Down |
Down
|
| Pro/Anti |
Pro
|
| Funtion Description |
Knockdown of SETD8 triggered senescence induction in proliferative culture, irrespectively of the p53 status of the cells;
|
| Regulation Gene |
NA
|
| Year |
2017
|
| Pubmed ID |
28514051
|
| Title |
The PPARr-SETD8 axis constitutes an epigenetic, p53-independent checkpoint on p21-mediated cellular senescence
|
| Drug |
NA
|
| Disease |
NA
|
| Environment Factors |
NA
|
| Circulating |
NA
|
| Variant |
NA
|
| High-throughput |
NA
|