| Name |
Sin3B
|
| Type |
gene
|
| Species |
Homo sapiens
|
| Tissue |
fibroblasts
|
| Experiment Method |
PCR, ChiP, Western blot, Immunofluorescence
|
| Up/Down |
Up
|
| Pro/Anti |
Pro
|
| Funtion Description |
We show that fibroblasts genetically inactivated for the chromatin-associated Sin3B protein are refractory to replicative and oncogene-induced senescence. Conversely, overexpression of Sin3B triggers senescence and the formation of senescence-associated h
|
| Regulation Gene |
NA
|
| Year |
2009
|
| Pubmed ID |
19654306
|
| Title |
Sin3B expression is required for cellular senescence and is up-regulated upon oncogenic stress.
|
| Drug |
0
|
| Disease |
NA
|
| Environment Factors |
NA
|
| Circulating |
NA
|
| Variant |
NA
|
| High-throughput |
NA
|