| Name |
SIRT1
|
| Type |
gene
|
| Species |
Mus musculus
|
| Tissue |
Sirt1TG mice;The Bmi1 heterozygous(Bmi1+/) mouse line;Sirt1TGBmi1+/ double-mutant mice;Mouse bone marrow mesenchymal stem cells
|
| Experiment Method |
immunohistochemistry;Immunoprecipitation and Western blot;quantitative Real Time RT-PCR
|
| Up/Down |
Up
|
| Pro/Anti |
Anti
|
| Funtion Description |
The Sirt1 activator resveratrol inhibited human MSC senescence and promoted their differentiation into osteoblasts, which were associated with upregulating the expression levels of Sirt1 and nuclear translocation of Bmi1.The present results suggested that
|
| Regulation Gene |
NA
|
| Year |
2019
|
| Pubmed ID |
30690778
|
| Title |
Sirt1 Promotes Osteogenic Differentiation and Increases Alveolar Bone Mass via Bmi1 Activation in Mice.
|
| Drug |
0
|
| Disease |
NA
|
| Environment Factors |
NA
|
| Circulating |
NA
|
| Variant |
NA
|
| High-throughput |
NA
|