Details
| Name | SIRT1 |
| Type | gene |
| Species | Mus musculus |
| Tissue | primary mouse embryo fibroblasts |
| Experiment Method | qPCR |
| Up/Down | Up |
| Pro/Anti | Pro |
| Funtion Description | When overexpressed in primary mouse embryo fibroblasts (MEFs), SIRT1 antagonizes PML-induced acetylation of p53 and rescues PML-mediated premature cellular senescence. Taken together, our data establish the SIRT1 deacetylase as a novel negative regulator |
| Regulation Gene | NA |
| Year | 2002 |
| Pubmed ID | 12006491 |
| Title | Human SIR2 deacetylates p53 and antagonizes PML/p53-induced cellular senescence. |
| Drug | NA |
| Disease | NA |
| Environment Factors | NA |
| Circulating | NA |
| Variant | NA |
| High-throughput | NA |