A Manually Curated Knowledgebase of Aging across a variety of Species

Details


Name SIRT1
Type gene
Species Mus musculus
Tissue IMR90,MEFs
Experiment Method PCR,other
Up/Down Up
Pro/Anti Anti
Funtion Description Sir2 is an NAD+-dependent deacetylase that regulates lifespan in yeast, worms and flies. The mammalian orthologs of Sir2 include SIRT1 in humans and mice. In this study, we analyzed the level of SIRT1 in human lung fibroblasts (IMR90) and mouse embryonic
Regulation Gene NA
Year 2006
Pubmed ID 16939484
Title Progressive loss of SIRT1 with cell cycle withdrawal.
Drug NA
Disease NA
Environment Factors NA
Circulating NA
Variant NA
High-throughput NA