Details
| Name | SIRT1 |
| Type | gene |
| Species | Homo sapiens |
| Tissue | LNCaP,DU145 |
| Experiment Method | RT-PCR,knockdown,other |
| Up/Down | NA |
| Pro/Anti | Anti |
| Funtion Description | Sirtuin 1 (SIRT1), a nicotinamide adenosine dinucleotide-dependent histone deacetylase (HDAC) linked to the regulation of longevity, is required for androgen antagonist-mediated transcriptional repression and growth suppression. |
| Regulation Gene | NA |
| Year | 2007 |
| Pubmed ID | 17505061 |
| Title | Sirtuin 1 is required for antagonist-induced transcriptional repression of androgen-responsive genes by the androgen receptor. |
| Drug | NA |
| Disease | NA |
| Environment Factors | NA |
| Circulating | NA |
| Variant | NA |
| High-throughput | NA |