Details
| Name | SIRT1 |
| Type | gene |
| Species | Homo sapiens |
| Tissue | U-2 OS |
| Experiment Method | PCR,Western Blot,other |
| Up/Down | Up |
| Pro/Anti | Anti |
| Funtion Description | Mutations in genes for WRN and BLM RecQ family helicases cause cancer prone syndromes. Werner syndrome, resulting from WRN mutation, is a segmental progeria. Endogenous WRN and BLM proteins localize in nucleoli and in nuclear PML bodies defined by isoform |
| Regulation Gene | NA |
| Year | 2007 |
| Pubmed ID | 17996922 |
| Title | Expression and localization of Werner syndrome protein is modulated by SIRT1 and PML. |
| Drug | NA |
| Disease | NA |
| Environment Factors | NA |
| Circulating | NA |
| Variant | NA |
| High-throughput | NA |