| Name |
SIRT1
|
| Type |
gene
|
| Species |
Mus musculus
|
| Tissue |
NA
|
| Experiment Method |
PCR,Western Blot,knockdown,other
|
| Up/Down |
Down
|
| Pro/Anti |
Anti
|
| Funtion Description |
SIRT1, the mammalian homolog of SIR2 in Saccharomyces cerevisiae, is an NAD-dependent deacetylase implicated in regulation of lifespan. By designing effective short hairpin RNAs and a silent shRNA-resistant mutant SIRT1 in a genetically defined system, we
|
| Regulation Gene |
NA
|
| Year |
2008
|
| Pubmed ID |
18184747
|
| Title |
SIRT1 acts as a nutrient-sensitive growth suppressor and its loss is associated with increased AMPK and telomerase activity.
|
| Drug |
NA
|
| Disease |
NA
|
| Environment Factors |
NA
|
| Circulating |
NA
|
| Variant |
NA
|
| High-throughput |
NA
|