Details
| Name | SIRT1 |
| Type | gene |
| Species | Homo sapiens |
| Tissue | HEK293,U3OS |
| Experiment Method | SIRT1 knock-out,other |
| Up/Down | Down |
| Pro/Anti | Anti |
| Funtion Description | Sir2, an NAD-dependent histone deacetylase, has been proven to extend life span in yeast and Caenorhabditis elegans. Mammalian Sir2 (SIRT1) has also been found to regulate premature cellular senescence induced by the tumor suppressors PML and p53. SIRT1 p |
| Regulation Gene | NA |
| Year | 2008 |
| Pubmed ID | 18203716 |
| Title | Regulation of WRN protein cellular localization and enzymatic activities by SIRT1-mediated deacetylation. |
| Drug | NA |
| Disease | NA |
| Environment Factors | NA |
| Circulating | NA |
| Variant | NA |
| High-throughput | NA |