| Name |
SIRT1
|
| Type |
gene
|
| Species |
Mus musculus
|
| Tissue |
neurons
|
| Experiment Method |
Western blotting,immunoprecipitation,other
|
| Up/Down |
NA
|
| Pro/Anti |
NA
|
| Funtion Description |
Sirtuins are known to protect cells and extend life span, but our previous studies indicated that S. cerevisiae Sir2 can also increase stress sensitivity and limit life-span extension. Here we provide evidence for a role of the mammalian Sir2 ortholog Sir
|
| Regulation Gene |
NA
|
| Year |
2008
|
| Pubmed ID |
18590691
|
| Title |
SirT1 inhibition reduces IGF-I/IRS-2/Ras/ERK1/2 signaling and protects neurons.
|
| Drug |
NA
|
| Disease |
NA
|
| Environment Factors |
NA
|
| Circulating |
NA
|
| Variant |
NA
|
| High-throughput |
NA
|