Details
| Name | SIRT1 |
| Type | gene |
| Species | Homo sapiens |
| Tissue | embryos,MEFs |
| Experiment Method | RT-PCR,Western blot,other |
| Up/Down | Down |
| Pro/Anti | NA |
| Funtion Description | In lower eukaryotes, Sir2 serves as a histone deacetylase and is implicated in chromatin silencing, longevity, and genome stability. Here we mutated the Sirt1 gene, a homolog of yeast Sir2, in mice to study its function. We show that a majority of SIRT1 n |
| Regulation Gene | NA |
| Year | 2008 |
| Pubmed ID | 18835033 |
| Title | Impaired DNA damage response, genome instability, and tumorigenesis in SIRT1 mutant mice. |
| Drug | NA |
| Disease | NA |
| Environment Factors | NA |
| Circulating | NA |
| Variant | NA |
| High-throughput | NA |