| Name |
SIRT1
|
| Type |
gene
|
| Species |
Mus musculus
|
| Tissue |
liver, white adipose, muscles, kidney, heart, brain and spleen tissues
|
| Experiment Method |
qRT-PCR,knockdown,western blot,other
|
| Up/Down |
NA
|
| Pro/Anti |
Anti
|
| Funtion Description |
The fasting-activated longevity protein sirtuin 1 (SirT1, ref. 1) promotes gluconeogenesis in part, by increasing transcription of the key gluconeogenic genes pepck1 and g6pase, through deacetylating PGC-1alpha and FOXO1.
|
| Regulation Gene |
NA
|
| Year |
2009
|
| Pubmed ID |
19295512
|
| Title |
STAT3 inhibition of gluconeogenesis is downregulated by SirT1.
|
| Drug |
NA
|
| Disease |
NA
|
| Environment Factors |
NA
|
| Circulating |
NA
|
| Variant |
NA
|
| High-throughput |
NA
|