A Manually Curated Knowledgebase of Aging across a variety of Species

Details


Name SIRT1
Type gene
Species Caenorhabditis elegans
Tissue NA
Experiment Method other
Up/Down Up
Pro/Anti Anti
Funtion Description The activation of Sirtuin-1 (by the pharmacological agent resveratrol and/or genetic means) per se ignites autophagy, and that Sirtuin-1 is required for the autophagic response to nutrient deprivation, in both human and nematode cells, but not for autopha
Regulation Gene NA
Year 2010
Pubmed ID 20023410
Title The life span-prolonging effect of sirtuin-1 is mediated by autophagy.
Drug NA
Disease NA
Environment Factors NA
Circulating NA
Variant NA
High-throughput NA