| Name |
SIRT1
|
| Type |
gene
|
| Species |
Mus musculus
|
| Tissue |
liver
|
| Experiment Method |
qRT-PCR,ChIP-Seq,microarry
|
| Up/Down |
Down
|
| Pro/Anti |
Anti
|
| Funtion Description |
Using Sirt1-deficient mice, we found that Sirt1 and Period 2 (Per2) constitute a reciprocal negative regulation loop that plays important roles in modulating hepatic circadian rhythmicity and aging. Sirt1-deficient mice exhibited profound premature aging
|
| Regulation Gene |
NA
|
| Year |
2016
|
| Pubmed ID |
27346580
|
| Title |
Negative reciprocal regulation between Sirt1 and Per2 modulates the circadian clock and aging.
|
| Drug |
NA
|
| Disease |
NA
|
| Environment Factors |
NA
|
| Circulating |
NA
|
| Variant |
NA
|
| High-throughput |
NA
|