Details
| Name | SIRT1 |
| Type | gene |
| Species | Yeast |
| Tissue | Mouse ES cell, |
| Experiment Method | ChIP,PCR,Microarray |
| Up/Down | Up |
| Pro/Anti | Anti |
| Funtion Description | Using embryonic stem cells, we show that mammalian Sir2, SIRT1, represses repetitive DNA and a functionally diverse set of genes across the mouse genome. In response to DNA damage, SIRT1 dissociates from these loci and relocalizes to DNA breaks to promote |
| Regulation Gene | NA |
| Year | 2008 |
| Pubmed ID | 19041753 |
| Title | SIRT1 redistribution on chromatin promotes genomic stability but alters gene expression during aging. |
| Drug | NA |
| Disease | NA |
| Environment Factors | NA |
| Circulating | NA |
| Variant | NA |
| High-throughput | NA |