Details
| Name | SIRT1 |
| Type | gene |
| Species | Homo sapiens |
| Tissue | fibroblasts |
| Experiment Method | RT-PCR, western blot |
| Up/Down | Up |
| Pro/Anti | Anti |
| Funtion Description | Here, we show that the expression patterns of HDAC4 and SIRT1 (Sirtuin 1, the mammalian homolog of Sir2) are positively correlated during cellular senescence. Moreover, the overexpression of HDAC4 delays senescence, whereas the knockdown of HDAC4 leads to |
| Regulation Gene | NA |
| Year | 2016 |
| Pubmed ID | 26414199 |
| Title | HDAC4 stabilizes SIRT1 via Sumoylation SIRT1 to delay cellular senescence |
| Drug | NA |
| Disease | NA |
| Environment Factors | NA |
| Circulating | NA |
| Variant | NA |
| High-throughput | NA |