Details
| Name | SIRT1 |
| Type | gene |
| Species | Mus musculus |
| Tissue | heart |
| Experiment Method | Western blot |
| Up/Down | Down |
| Pro/Anti | Anti |
| Funtion Description | AMPK upstream LKB1 is hyper-acetylated in both aged WT and icSIRT1 KO hearts; this could blunt activation of LKB1, leading to an impaired AMPK activation. The working heart perfusion results demonstrated that SIRT1 deficiency significantly impaired substr |
| Regulation Gene | NA |
| Year | 2018 |
| Pubmed ID | 29409011 |
| Title | Cardiomyocyte-specific deletion of Sirt1 gene sensitizes myocardium to ischaemia and reperfusion injury |
| Drug | NA |
| Disease | NA |
| Environment Factors | NA |
| Circulating | NA |
| Variant | NA |
| High-throughput | GSE98749 |