| Name |
SIRT3
|
| Type |
gene
|
| Species |
Mus musculus
|
| Tissue |
Eight-week old female C57BL/6 mice;Human A375 melanoma, mouse NIH3T3 fibroblast cells, HeLa cells and NHEKs from adult abdominal skin
|
| Experiment Method |
siRNA transfection;HPLC-ECD;HPLC;SA B-galactosidase staining;Western blotting and immunoprecipitation
|
| Up/Down |
Up
|
| Pro/Anti |
Pro
|
| Funtion Description |
Mechanistically, caffeine facilitated the elimination of ROS by activating autophagy. Using a combination of RNAi and chemical treatment, we demonstrate that caffeine activates autophagy through a series of sequential events, starting from the inhibition
|
| Regulation Gene |
NA
|
| Year |
2018
|
| Pubmed ID |
30555576
|
| Title |
Caffeine Protects Skin from Oxidative Stress-Induced Senescence through the Activation of Autophagy
|
| Drug |
NA
|
| Disease |
NA
|
| Environment Factors |
NA
|
| Circulating |
NA
|
| Variant |
NA
|
| High-throughput |
NA
|