Details
| Name | SIRT6 |
| Type | gene |
| Species | Mus musculus |
| Tissue | NA |
| Experiment Method | qRT-PCR |
| Up/Down | Up |
| Pro/Anti | Anti |
| Funtion Description | ATM-centered DNA damage response (DDR) progressively declines with senescence and age, while low dose of chloroquine (CQ) activates ATM, promotes DNA damage clearance, rescues age-related metabolic shift, and prolongs replicative lifespan. Molecularly, A |
| Regulation Gene | NA |
| Year | 2018 |
| Pubmed ID | 29717979 |
| Title | Boosting ATM activity alleviates aging and extends lifespan in a mouse model of progeria |
| Drug | NA |
| Disease | NA |
| Environment Factors | NA |
| Circulating | NA |
| Variant | CNV |
| High-throughput | GSE109280 |