Details
| Name | SIRT6 |
| Type | gene |
| Species | Homo sapiens |
| Tissue | Cartilage tissues |
| Experiment Method | qRT-PCR, western blot |
| Up/Down | Down |
| Pro/Anti | Anti |
| Funtion Description | Depletion of SIRT6 in human chondrocytes caused increased DNA damage and telomere dysfunction, and subsequent premature senescence. These findings suggest that SIRT6 plays an important role in the regulation of senescence of human chondrocytes |
| Regulation Gene | NA |
| Year | 2015 |
| Pubmed ID | 25819580 |
| Title | Depletion of SIRT6 causes cellular senescence, DNA damage, and telomere dysfunction in human chondrocytes |
| Drug | NA |
| Disease | NA |
| Environment Factors | NA |
| Circulating | NA |
| Variant | NA |
| High-throughput | NA |