| Name |
SIX1
|
| Type |
gene
|
| Species |
Mus musculus
|
| Tissue |
brain
|
| Experiment Method |
PCR, ChiP, Flow cytometry assay, Cell proliferation assay, Western blot
|
| Up/Down |
Up
|
| Pro/Anti |
Anti
|
| Funtion Description |
we show that SIX1 has a strong pro-tumorigenic action in this model, linked to the repression of a senescence-related gene signature and the induction of an undiferentiated phenotype mediated, at least in part, by the regulation of the stemness factor
|
| Regulation Gene |
NA
|
| Year |
2019
|
| Pubmed ID |
30723235
|
| Title |
SIX1 represses senescence and promotes SOX2-mediated cellular plasticity during tumorigenesis.
|
| Drug |
0
|
| Disease |
glioma
|
| Environment Factors |
NA
|
| Circulating |
NA
|
| Variant |
NA
|
| High-throughput |
GSE113385
|