Details
| Name | SIX1 |
| Type | gene |
| Species | Homo sapiens |
| Tissue | NA |
| Experiment Method | RT-PCR |
| Up/Down | Down |
| Pro/Anti | Anti |
| Funtion Description | Our data show that SIX1 is specifically downregulated in fibroblasts upon oncogenic stress and other pro-senescence stimuli, as well as in senescent skin premalignant lesions. Silencing of SIX1 in human fibroblasts suffices to trigger senescence |
| Regulation Gene | NA |
| Year | 2016 |
| Pubmed ID | 26500063 |
| Title | The homeoprotein SIX1 controls cellular senescence through the regulation of p16INK4A and differentiation-related genes. |
| Drug | NA |
| Disease | NA |
| Environment Factors | NA |
| Circulating | NA |
| Variant | NA |
| High-throughput | GSE15641,GSE6290 |