Details
| Name | SKN-1 |
| Type | gene |
| Species | Caenorhabditis elegans |
| Tissue | C. elegans |
| Experiment Method | Lifespan and stress assays;Protein oxidation measurements;RT qPCR and chromatin immunoprecipitation;Epifluorescence microscopy |
| Up/Down | NA |
| Pro/Anti | Anti |
| Funtion Description | Here, we report that effects ofSKN-1 on Oxr and longevity can be dissociated. We also establish thatskn-1expression can be activated by theDAF-16/FoxO transcription factor, another central regulator of growth, metabolism, and aging. Notably,skn-1is requir |
| Regulation Gene | NA |
| Year | 2017 |
| Pubmed ID | 28612944 |
| Title | The SKN-1/Nrf2 transcription factor can protect against oxidative stress and increase lifespan in C. elegans by distinct mechanisms |
| Drug | NA |
| Disease | NA |
| Environment Factors | NA |
| Circulating | NA |
| Variant | NA |
| High-throughput | NA |