A Manually Curated Knowledgebase of Aging across a variety of Species

Details


Name SOS1
Type gene
Species Mus musculus
Tissue Eight-week-old and two-year-old male C57BL/6 mice
Experiment Method UPLC/Q-TOF MS;Western Blot
Up/Down Down
Pro/Anti Pro
Funtion Description Treatment with fucoidan and fucoxanthin reduced the expression levels of SOS1 and GRB2 while increasing GSK3B, CREB and IRS1 proteins expression in the aging process. Three main metabolic pathways, namely the TCA cycle, glycolysis, and steroid hormone bio
Regulation Gene NA
Year 2019
Pubmed ID 30669571
Title FucoidanFucoxanthin Ameliorated Cardiac Function via IRS1/GRB2/ SOS1, GSK3B/CREB Pathways and Metabolic Pathways in Senescent Mice.
Drug fucoidan,fucoxanthin
Disease NA
Environment Factors NA
Circulating NA
Variant NA
High-throughput NA