Details
| Name | SP1 |
| Type | gene |
| Species | Homo sapiens |
| Tissue | 2BS |
| Experiment Method | ChIP,RNAi |
| Up/Down | NA |
| Pro/Anti | Anti |
| Funtion Description | GC- II is the key site for Sp1 binding and increase of Sp1 binding activity rather than protein levels contributes to the induction of p16(INK4a) expression during cell aging. |
| Regulation Gene | NA |
| Year | 2007 |
| Pubmed ID | 17225865 |
| Title | Sp1 is essential for p16 expression in human diploid fibroblasts during senescence. |
| Drug | NA |
| Disease | NA |
| Environment Factors | NA |
| Circulating | NA |
| Variant | NA |
| High-throughput | NA |