| Name |
SRSF1
|
| Type |
gene
|
| Species |
Homo sapiens
|
| Tissue |
BJ, HeLa, U2OS, and NCI-H1299 cells;Tet-on Advanced HeLa, BJ, and U2OS cells (Clontech)
|
| Experiment Method |
Immunoblotting;Immunoprecipitations;RNA Interference;RT-PCR;Senescence-associated B-galactosidase
|
| Up/Down |
Up
|
| Pro/Anti |
Pro
|
| Funtion Description |
We report that the oncogenic splicing factor SRSF1, which is overexpressed in many cancers, stabilizes the tumor suppressor protein p53 by abrogating its MDM2-dependent proteasomal degradation. We show that SRSF1 is a necessary component of an MDM2/riboso
|
| Regulation Gene |
NA
|
| Year |
2013
|
| Pubmed ID |
23478443
|
| Title |
Splicing-factor oncoprotein SRSF1 stabilizes p53 via RPL5 and induces cellular senescence.
|
| Drug |
NA
|
| Disease |
NA
|
| Environment Factors |
NA
|
| Circulating |
NA
|
| Variant |
NA
|
| High-throughput |
NA
|