A Manually Curated Knowledgebase of Aging across a variety of Species

Details


Name STAT3
Type gene
Species Mus musculus
Tissue blood samples;liver tissues
Experiment Method Western Blotting;qPCR
Up/Down Down
Pro/Anti Pro
Funtion Description We conclude that growth hormone-induced activation of Stat-3 is specifically decreased with age and contributes to the age-related decline in GHR signal transduction and IGF-I gene expression. These effects are reversed by moderate caloric restriction, re
Regulation Gene NA
Year 1996
Pubmed ID 8944679
Title Growth hormone-induced nuclear translocation of Stat-3 decreases with age: modulation by caloric restriction.
Drug NA
Disease NA
Environment Factors NA
Circulating 1
Variant NA
High-throughput NA