Details
| Name | TACC3 |
| Type | gene |
| Species | Homo sapiens |
| Tissue | MCF-7 and MCF-7/caspase-3 cells |
| Experiment Method | Western blot;RNA interference; |
| Up/Down | Down |
| Pro/Anti | Pro |
| Funtion Description | Unlike PTX, knockdown of TACC3 did not trigger a cell death response, but instead resulted in a progressive loss of the pro-apoptotic Bcl-2 protein Bim that links microtubule integrity to spindle poison-induced cell death. nterestingly, TACC3-depleted cel |
| Regulation Gene | NA |
| Year | 2010 |
| Pubmed ID | 20729911 |
| Title | The centrosomal protein TACC3 controls paclitaxel sensitivity by modulating a premature senescence program. |
| Drug | paclitaxel,doxycycline |
| Disease | breast cancer |
| Environment Factors | NA |
| Circulating | NA |
| Variant | NA |
| High-throughput | NA |