| Name |
TAp63
|
| Type |
gene
|
| Species |
Mus musculus
|
| Tissue |
NA
|
| Experiment Method |
PCR, ChiP, Western blot, Immunofluorescence
|
| Up/Down |
Up
|
| Pro/Anti |
Pro
|
| Funtion Description |
Here we show that TAp63 isoforms are robust mediators of senescence that inhibit tumorigenesis in vivo. Whereas gain of TAp63 induces senescence, loss of p63 enhances sarcoma development in mice lacking p53. Using a new TAp63-specific conditional mouse mo
|
| Regulation Gene |
NA
|
| Year |
2009
|
| Pubmed ID |
19898465
|
| Title |
TAp63 induces senescence and suppresses tumorigenesis in vivo.
|
| Drug |
Dox
|
| Disease |
NA
|
| Environment Factors |
NA
|
| Circulating |
NA
|
| Variant |
NA
|
| High-throughput |
NA
|