| Name |
AP4
|
| Type |
gene
|
| Species |
Homo sapiens
|
| Tissue |
Confluent retinal pigment epithelial cell
|
| Experiment Method |
qRT-PCR
|
| Up/Down |
Up
|
| Pro/Anti |
Pro
|
| Funtion Description |
We demonstrated that the induced cellular senescence was mediated by enhanced p53 expression and that AP4 regulates the p53 gene by binding directly to two of the three E-boxes present on the promoter of the p53 gene.
|
| Regulation Gene |
NA
|
| Year |
2015
|
| Pubmed ID |
26439195
|
| Title |
Ectopic AP4 expression induces cellular senescence via activation of p53 in long-term confluent retinal pigment epithelial cells
|
| Drug |
NA
|
| Disease |
NA
|
| Environment Factors |
NA
|
| Circulating |
NA
|
| Variant |
NA
|
| High-throughput |
NA
|