Details
| Name | TNFa |
| Type | gene |
| Species | Homo sapiens |
| Tissue | HUVECs |
| Experiment Method | RT-PCR;Western blots |
| Up/Down | Up |
| Pro/Anti | Pro |
| Funtion Description | y gene expression profiling, we identified the crucial involvement of inflammatory and JAK/STAT pathways in TNFa-mediated senescence. We found that TNFa activates a STAT-dependent autocrine loop that sustains cytokine secretion and an interferon signature |
| Regulation Gene | NA |
| Year | 2017 |
| Pubmed ID | 29176033 |
| Title | TNFa-senescence initiates a STAT-dependent positive feedback loop, leading to a sustained interferon signature, DNA damage, and cytokine secretion. |
| Drug | NA |
| Disease | NA |
| Environment Factors | NA |
| Circulating | NA |
| Variant | NA |
| High-throughput | GSE98081 |