6-Mercaptopurine rep1	FDA approved	Purine metabolism	path:00230_1	15	7.151555	0.007760532	POLR3F ADCY1 ADCY8 ADCY9 AK8 AK1 AK5 ZNRD1 NME1 PDE1C PDE1B POLR2A POLR3B POLR3E POLR1B	10621 107 114 115 158067 203 26289 30834 4830 5137 5153 5430 55703 55718 84172
6-Mercaptopurine rep1	FDA approved	Calcium signaling pathway	path:04020_1	9	6.10298	0.044345898	ADCY1 ATP2A3 PDE1C PDE1B CALML5 PHKG1 ITPKC CALM3 CALML3	107 489 5137 5153 51806 5260 80271 808 810
6-Mercaptopurine rep1	FDA approved	Focal adhesion	path:04510_1	3	6.69849	0.014412417	ITGAV VASP TLN2	3685 7408 83660
6-Mercaptopurine rep2	FDA approved	Purine metabolism	path:00230_2	14	7.066286	0.002173913	POLR3F ADCY1 POLR3A ADCY8 ADCY9 GUCY2D ZNRD1 NME3 PDE1C POLR2G POLR2I POLR2J POLR2K POLR3E	10621 107 11128 114 115 3000 30834 4832 5137 5436 5438 5439 5440 55718
6-Mercaptopurine rep2	FDA approved	Pyrimidine metabolism	path:00240_1	10	6.233842	0.015217391	POLR3F POLR3C POLR3A ZNRD1 NME3 POLR3K POLR2G POLR2I POLR2L POLR1C	10621 10623 11128 30834 4832 51728 5436 5438 5441 9533
6-Mercaptopurine rep2	FDA approved	Glycerophospholipid metabolism	path:00564_1	7	5.446644	0.044565217	LPCAT3 CEPT1 PLA2G16 LYPLA2 PTDSS2 PLA2G12A PLA2G4C	10162 10390 11145 11313 81490 81579 8605
6-Mercaptopurine rep2	FDA approved	Calcium signaling pathway	path:04020_2	9	7.110611	0.002173913	ADCY1 ADCY8 GNAL MYLK ATP2A1 PDE1C PHKG1 PHKG2 CALM3	107 114 2774 4638 487 5137 5260 5261 808
6-Mercaptopurine rep2	FDA approved	HIF-1 signaling pathway	path:04066_1	8	6.324093	0.013043478	CREBBP EDN1 EGF HIF1A HMOX1 PFKL VEGFA HKDC1	1387 1906 1950 3091 3162 5211 7422 80201
6-Mercaptopurine rep2	FDA approved	Adrenergic signaling in cardiomyocytes	path:04261_1	8	5.471185	0.044565217	CALML5 PPP2R1A PPP2R2C PRKX CACNB1 CACNB4 CALM3 CAMK2G	51806 5518 5522 5613 782 785 808 818
6-Mercaptopurine rep2	FDA approved	Focal adhesion	path:04510_2	6	5.654452	0.033695652	EGFR ITGB5 PDGFRB PGF PTK2 BCAR1	1956 3693 5159 5228 5747 9564
6-Mercaptopurine rep2	FDA approved	Leukocyte transendothelial migration	path:04670_1	6	6.186403	0.015217391	MYL9 RHOA PXN ACTB ROCK1 BCAR1	10398 387 5829 60 6093 9564
6-Mercaptopurine rep2	FDA approved	Regulation of actin cytoskeleton	path:04810_1	5	6.041424	0.020652174	MYL9 MYLK PFN2 ACTB ROCK1	10398 4638 5217 60 6093
6-Mercaptopurine rep2	FDA approved	Insulin signaling pathway	path:04910_1	5	7.402206	0.001086957	GYS1 PHKG1 PHKG2 PYGL CALM3	2997 5260 5261 5836 808
6-Mercaptopurine rep2	FDA approved	Estrogen signaling pathway	path:04915_1	6	5.365564	0.048913043	CREB3 ADCY1 ADCY9 GNAS PRKX CREB5	10488 107 115 2778 5613 9586
6-Mercaptopurine rep2	FDA approved	Glucagon signaling pathway	path:04922_1	7	6.565601	0.008695652	PHKG1 PHKG2 PRKACA PYGL PYGM CALM3 CALML3	5260 5261 5566 5836 5837 808 810
6-Mercaptopurine rep2	FDA approved	Glioma	path:05214_1	7	5.546837	0.039130435	EGF EGFR AKT1 PIK3R5 KRAS PIK3CG SHC1	1950 1956 207 23533 3845 5294 6464
6-Mercaptopurine rep3	FDA approved	Purine metabolism	path:00230_3	8	5.674195	0.047884187	ADCY3 NT5C3B AK1 HPRT1 PDE3B PDE4A GMPS ENTPD6	109 115024 203 3251 5140 5141 8833 955
6-Mercaptopurine rep3	FDA approved	Pyrimidine metabolism	path:00240_2	9	6.045049	0.028953229	POLR3F POLR3C ZNRD1 NUDT2 NME3 POLR2D POLR2L POLR3E POLR3GL	10621 10623 30834 318 4832 5433 5441 55718 84265
6-Mercaptopurine rep3	FDA approved	Lysine degradation	path:00310_1	5	6.772171	0.008908686	EHMT2 KMT2A KMT2C SUV39H2 SETD1A	10919 4297 58508 79723 9739
6-Mercaptopurine rep3	FDA approved	Calcium signaling pathway	path:04020_3	9	6.561797	0.012249443	ADCY3 GNAL ATP2B1 P2RX5 CALML5 PRKACA ITPKC CALM3 CAMK2G	109 2774 490 5026 51806 5566 80271 808 818
6-Mercaptopurine rep3	FDA approved	cGMP-PKG signaling pathway	path:04022_1	16	6.965105	0.0077951	CREB1 ATF6B ATP1B4 GTF2I PPP1R12A ATP1B1 FXYD2 ATP2B1 PDE3B PLCB3 PPP1CB PRKG2 BAD ROCK1 VASP CREB5	1385 1388 23439 2969 4659 481 486 490 5140 5331 5500 5593 572 6093 7408 9586
6-Mercaptopurine rep3	FDA approved	cAMP signaling pathway	path:04024_1	9	6.279831	0.021158129	CREB1 GRIN2C ATP2B1 PDE3B PPP1CA PPP1CB PRKACB RELA CACNA1S	1385 2905 490 5140 5499 5500 5567 5970 779
6-Mercaptopurine rep3	FDA approved	Adrenergic signaling in cardiomyocytes	path:04261_2	6	5.950422	0.033407572	CREB1 ATF6B ATP1B4 PRKACA CACNB1 CREB5	1385 1388 23439 5566 782 9586
6-Mercaptopurine rep3	FDA approved	TNF signaling pathway	path:04668_1	9	6.209566	0.021158129	CREB1 ATF6B MAPK14 BIRC2 MAPK11 MAP2K3 RIPK1 RPS6KA4 CREB5	1385 1388 1432 329 5600 5606 8737 8986 9586
6-Mercaptopurine rep3	FDA approved	Tuberculosis	path:05152_1	5	6.139332	0.024498886	MALT1 MAPK14 IL18 MAPK11 RELA	10892 1432 3606 5600 5970
6-Mercaptopurine rep3	FDA approved	Influenza A	path:05164_1	10	6.66897	0.011135857	EIF2S1 DNAJB1 NFKB1 NFKBIA NFKBIB MAP2K3 MAP2K7 EIF2AK2 DNAJC3 RELA	1965 3337 4790 4792 4793 5606 5609 5610 5611 5970
6-Mercaptopurine rep4	FDA approved	Purine metabolism	path:00230_4	8	6.720186	0.016722408	ADCY5 ADK AK8 ITPA PDE3B POLR2C POLR2G POLR2I	111 132 158067 3704 5140 5432 5436 5438
6-Mercaptopurine rep4	FDA approved	Ras signaling pathway	path:04014_1	11	5.887419	0.043478261	RALBP1 PIK3R5 RASGRP3 KRAS PIK3R2 RALA RALGDS SOS2 TIAM1 PIK3R3 SYNGAP1	10928 23533 25780 3845 5296 5898 5900 6655 7074 8503 8831
6-Mercaptopurine rep4	FDA approved	NF-kappa B signaling pathway	path:04064_1	10	5.757072	0.049052397	CHUK BIRC2 ICAM1 NFKB1 NFKB2 PTGS2 RELA RELB TRAF1 TRAF2	1147 329 3383 4790 4791 5743 5970 5971 7185 7186
6-Mercaptopurine rep4	FDA approved	FoxO signaling pathway	path:04068_1	18	6.237309	0.026755853	BCL2L11 PLK4 GADD45G CHUK FBXO32 PLK3 MAPK14 GADD45A FOXO1 IL7R NLK PRKAA1 MAPK3 MAPK8 MAPK11 CCND1 SETD7 S1PR4	10018 10733 10912 1147 114907 1263 1432 1647 2308 3575 51701 5562 5595 5599 5600 595 80854 8698
6-Mercaptopurine rep4	FDA approved	Focal adhesion	path:04510_3	4	5.942942	0.041248606	FLNB ITGAV TLN1 CAPN2	2317 3685 7094 824
6-Mercaptopurine rep4	FDA approved	Tuberculosis	path:05152_2	5	5.870979	0.043478261	IL18 NFKB1 MAPK8 MAPK11 RELA	3606 4790 5599 5600 5970
ABT-199	FDA approved	Valine, leucine and isoleucine degradation	path:00280_1	7	6.511088	0.019758507	ACAA2 EHHADH HADHB HMGCS1 ACAT2 PCCB MCEE	10449 1962 3032 3157 39 5096 84693
ABT-199	FDA approved	Calcium signaling pathway	path:04020_4	8	6.400398	0.024149286	ITPR1 P2RX7 VDAC1 VDAC3 ORAI2 CALML3 SLC25A31 ORAI3	3708 5027 7416 7419 80228 810 83447 93129
ABT-199	FDA approved	cGMP-PKG signaling pathway	path:04022_2	10	6.105741	0.045005488	KCNMB2 CREB1 KCNU1 PLCB3 PPP1CA PRKCE PRKG2 BAD RAF1 TRPC6	10242 1385 157855 5331 5499 5581 5593 572 5894 7225
ABT-199	FDA approved	Hippo signaling pathway	path:04390_1	5	6.236275	0.03402854	PPP1CA PPP2CA PPP2CB PPP2R1B YWHAE	5499 5515 5516 5519 7531
Actinomycin D rep1	FDA approved	Fructose and mannose metabolism	path:00051_1	10	6.282369	0.022826087	ALDOC HK2 KHK PFKFB4 PFKM PFKP AKR1B10 SORD TPI1 HKDC1	230 3099 3795 5210 5213 5214 57016 6652 7167 80201
Actinomycin D rep1	FDA approved	Purine metabolism	path:00230_5	25	9.03689	0	POLR3G ADCY1 ADCY3 POLR3A ADCY9 NT5C3B AK5 PDE7B GUCY2C GUCY2D POLR1D PDE4A PDE4B PDE4D PDE6D PDE6G POLR2A POLR2C POLR2D POLR2F POLR2G POLR3B POLR1B PNPT1 ENTPD2	10622 107 109 11128 115 115024 26289 27115 2984 3000 51082 5141 5142 5144 5147 5148 5430 5432 5433 5435 5436 55703 84172 87178 954
Actinomycin D rep1	FDA approved	Pyrimidine metabolism	path:00240_3	11	9.398283	0	POLR3G NME1 POLR1D CMPK1 POLR2A POLR2C POLR2D POLR2F POLR3B RRM2 PNPT1	10622 4830 51082 51727 5430 5432 5433 5435 55703 6241 87178
Actinomycin D rep1	FDA approved	Calcium signaling pathway	path:04020_5	9	6.412973	0.018478261	ADRA1B GNAQ GRIN1 SLC25A5 PLCB3 PRKCG TNNC1 CALML3 CACNA1G	147 2776 2902 292 5331 5582 7134 810 8913
Actinomycin D rep1	FDA approved	ECM-receptor interaction	path:04512_1	3	6.000968	0.033695652	ITGAV ITGB1 THBS1	3685 3688 7057
Actinomycin D rep2	FDA approved	Pyrimidine metabolism	path:00240_4	6	6.821394	0.01880531	NME1 NT5E POLA1 RRM2 DCTPP1 ENTPD4	4830 4907 5422 6241 79077 9583
Actinomycin D rep2	FDA approved	Chemokine signaling pathway	path:04062_1	7	6.246198	0.042035398	CCR1 GNAI1 GNB1 GNG11 PIK3CG PLCB4 GNG12	1230 2770 2782 2791 5294 5332 55970
Actinomycin D rep2	FDA approved	PI3K-Akt signaling pathway	path:04151_1	4	7.209768	0.009955752	ITGAV ITGB1 PTK2 THBS1	3685 3688 5747 7057
Actinomycin D rep2	FDA approved	Focal adhesion	path:04510_4	5	8.167937	0.001106195	FLNA ITGAV ITGB1 TLN1 TLN2	2316 3685 3688 7094 83660
Actinomycin D rep2	FDA approved	ECM-receptor interaction	path:04512_2	3	6.909011	0.015486726	ITGAV ITGB1 THBS1	3685 3688 7057
Actinomycin D rep2	FDA approved	Small cell lung cancer	path:05222_1	3	6.772681	0.021017699	ITGAV ITGB1 PTK2	3685 3688 5747
Afatinib	FDA approved	Purine metabolism	path:00230_6	9	6.812022	0.007692308	ADCY9 POLR3H ZNRD1 POLR2F POLR2G POLR2I POLR3B POLR1C ENTPD3	115 171568 30834 5435 5436 5438 55703 9533 956
Afatinib	FDA approved	Pyrimidine metabolism	path:00240_5	8	6.535981	0.014285714	POLR3H ZNRD1 NME1 POLR2F POLR2I POLR3B POLR1E POLR1C	171568 30834 4830 5435 5438 55703 64425 9533
Afatinib	FDA approved	Inositol phosphate metabolism	path:00562_1	9	6.541826	0.014285714	INPP5A INPPL1 PLCE1 PIK3CG PLCB2 PLCB3 PLCG2 PTEN PIP4K2C	3632 3636 51196 5294 5330 5331 5336 5728 79837
Afatinib	FDA approved	MAPK signaling pathway	path:04010_1	10	6.526476	0.014285714	DUSP1 DUSP5 DUSP7 DUSP8 MAPK8IP3 HSPA1L MAPK1 MAPK8 PTPN7 DUSP16	1843 1847 1849 1850 23162 3305 5594 5599 5778 80824
Afatinib	FDA approved	Rap1 signaling pathway	path:04015_1	24	6.417611	0.017582418	CRKL CSF1R EFNA1 EFNA2 EFNA4 FGF9 FGFR3 FGFR2 FGFR4 FGF21 GNAQ ANGPT1 ANGPT2 RAPGEF1 IGF1 NGF PDGFA PDGFB PDGFRB PLCB2 PLCB3 PDGFC VEGFA BCAR1	1399 1436 1942 1943 1945 2254 2261 2263 2264 26291 2776 284 285 2889 3479 4803 5154 5155 5159 5330 5331 56034 7422 9564
Afatinib	FDA approved	cGMP-PKG signaling pathway	path:04022_3	15	5.987602	0.040659341	CNGA1 ATF6B KCNMB3 ITPR1 ITPR3 ATP1A1 ATP2B2 ATP2B4 PLCB2 PLCB3 PPP1CA PRKG1 RAF1 SLC8A2 CACNA1D	1259 1388 27094 3708 3710 476 491 493 5330 5331 5499 5592 5894 6543 776
Afatinib	FDA approved	Chemokine signaling pathway	path:04062_2	8	6.730669	0.008791209	CXCR6 CCR1 CCR7 CCR8 GNAI2 GRK5 GRK6 CXCR1	10663 1230 1236 1237 2771 2869 2870 3577
Afatinib	FDA approved	Phosphatidylinositol signaling system	path:04070_1	14	7.444739	0.002197802	DGKH INPP5A INPPL1 ITPR1 ITPR3 PLCE1 PIK3C2A PIK3CG PI4KA PLCB2 PLCB3 PLCG2 PTEN DGKZ	160851 3632 3636 3708 3710 51196 5286 5294 5297 5330 5331 5336 5728 8525
Afatinib	FDA approved	Sphingolipid signaling pathway	path:04071_1	8	6.241165	0.024175824	FYN GNAI2 PDPK1 PIK3CG PLD2 SPHK2 RAC3 GAB2	2534 2771 5170 5294 5338 56848 5881 9846
Afatinib	FDA approved	Vascular smooth muscle contraction	path:04270_1	9	5.916586	0.045054945	PLA2G4E ADRA1B GNAQ ITPR1 ITPR3 PLCB2 PLCB3 PRKACA PRKCG	123745 147 2776 3708 3710 5330 5331 5566 5582
Afatinib	FDA approved	Hippo signaling pathway	path:04390_2	4	6.129712	0.030769231	PPP1CA PPP2R2C PPP2R2D BTRC	5499 5522 55844 8945
Afatinib	FDA approved	Serotonergic synapse	path:04726_1	10	5.964397	0.040659341	PLA2G4E GNAI2 GNAQ GNB2 GNGT2 HTR1D ITPR1 ITPR3 PLCB2 PLCB3	123745 2771 2776 2783 2793 3352 3708 3710 5330 5331
Afatinib	FDA approved	Long-term depression	path:04730_1	8	6.02443	0.038461538	PLA2G4E GNAI2 PLCB2 PLCB3 PPP2CA PRKCG MAP2K2 RAF1	123745 2771 5330 5331 5515 5582 5605 5894
Afatinib	FDA approved	Oxytocin signaling pathway	path:04921_1	6	5.821471	0.048351648	GNAI2 OXTR CACNA2D3 CACNA1C CACNA1D CACNG1	2771 5021 55799 775 776 786
Alectinib	FDA approved	Purine metabolism	path:00230_7	6	7.136214	0.004429679	POLR3F NME3 NPR2 POLR2E POLR2G POLR3D	10621 4832 4882 5434 5436 661
Alectinib	FDA approved	Pyrimidine metabolism	path:00240_6	10	5.903174	0.035437431	POLR3F POLR3G NUDT2 NME3 POLR2E POLR2G RRM2 POLR3D PNPT1 ENTPD4	10621 10622 318 4832 5434 5436 6241 661 87178 9583
antineoplastic-117281	-	Purine metabolism	path:00230_8	6	6.633834	0.012048193	PDE10A AK5 NT5E PDE8A PKM ENTPD6	10846 26289 4907 5151 5315 955
antineoplastic-117281	-	MAPK signaling pathway	path:04010_2	6	5.975043	0.030668127	AKT3 CRK FLNA FLNC MAPK10 MAP2K4	10000 1398 2316 2318 5602 6416
antineoplastic-117281	-	ErbB signaling pathway	path:04012_1	10	5.904975	0.031763417	CRK HBEGF EGF EGFR ERBB2 ABL2 SHC4 SHC1 STAT5A TGFA	1398 1839 1950 1956 2064 27 399694 6464 6776 7039
antineoplastic-117281	-	Rap1 signaling pathway	path:04015_2	10	6.528389	0.013143483	CRK EGFR EPHA2 PLCB1 RASGRP3 IGF1R MET PLCB4 PDGFC VEGFC	1398 1956 1969 23236 25780 3480 4233 5332 56034 7424
antineoplastic-117281	-	Chemokine signaling pathway	path:04062_3	8	7.288273	0.004381161	AKT3 PLCB1 GNAI1 GNG11 PIK3CB PIK3R1 PLCB4 GNG12	10000 23236 2770 2791 5291 5295 5332 55970
antineoplastic-117281	-	Phosphatidylinositol signaling system	path:04070_2	16	5.749213	0.037239869	DGKH PLCB1 PIK3R5 INPP1 INPP5D OCRL PIK3C2A PIK3CB PIK3CG PIK3R1 PLCB4 PI4K2A PIP4K2C ITPKC DGKZ DGKE	160851 23236 23533 3628 3635 4952 5286 5291 5294 5295 5332 55361 79837 80271 8525 8526
antineoplastic-117281	-	PI3K-Akt signaling pathway	path:04151_2	8	7.416103	0.004381161	AKT3 CREB3 PIK3R5 PIK3CB PIK3R1 PPP2R2A PPP2R3A CREB5	10000 10488 23533 5291 5295 5520 5523 9586
antineoplastic-117281	-	Wnt signaling pathway	path:04310_1	3	5.668118	0.038335159	PLCB1 PLCB4 PPP3R1	23236 5332 5534
antineoplastic-117281	-	Hippo signaling pathway	path:04390_3	3	8.097671	0.00109529	ITGB2 SMAD7 YWHAZ	3689 4092 7534
antineoplastic-117281	-	Focal adhesion	path:04510_5	10	7.385437	0.004381161	ILK ITGA2 ITGA5 ITGAV ITGB3 PRKCB PXN SRC THBS1 TLN1	3611 3673 3678 3685 3690 5579 5829 6714 7057 7094
antineoplastic-117281	-	Jak-STAT signaling pathway	path:04630_1	7	6.625115	0.012048193	CSF2 IFNGR2 IL2RG IL6ST IL10RA IL13RA1 OSMR	1437 3460 3561 3572 3587 3597 9180
antineoplastic-117281	-	Circadian entrainment	path:04713_1	5	5.903629	0.031763417	PLCB1 GNAI1 GNG11 PLCB4 GNG12	23236 2770 2791 5332 55970
antineoplastic-117281	-	Cholinergic synapse	path:04725_1	6	6.499472	0.015334064	AKT3 GNAI1 GNG11 PIK3CB PIK3R1 GNG12	10000 2770 2791 5291 5295 55970
antineoplastic-117281	-	Serotonergic synapse	path:04726_2	6	6.13682	0.024096386	PLCB1 GNAI1 GNG11 HTR1D PLCB4 GNG12	23236 2770 2791 3352 5332 55970
antineoplastic-117281	-	GABAergic synapse	path:04727_1	6	6.004392	0.029572837	GABARAPL1 GABBR1 GABRA2 GNAI1 GNG11 GNG12	23710 2550 2555 2770 2791 55970
antineoplastic-117281	-	Dopaminergic synapse	path:04728_1	5	5.916837	0.030668127	PLCB1 GNAI1 GNG11 PLCB4 GNG12	23236 2770 2791 5332 55970
antineoplastic-117281	-	Regulation of actin cytoskeleton	path:04810_2	6	6.334539	0.021905805	MYL9 PFN4 MYLK PFN2 ACTB WAS	10398 375189 4638 5217 60 7454
antineoplastic-117281	-	Insulin signaling pathway	path:04910_2	4	5.503099	0.049288061	AKT3 MTOR PHKA1 PYGL	10000 2475 5255 5836
antineoplastic-117281	-	GnRH signaling pathway	path:04912_1	9	5.510955	0.047097481	PTK2B PLCB1 GNA11 MAP3K4 PLCB4 PLD2 PRKCA MAPK7 SRC	2185 23236 2767 4216 5332 5338 5578 5598 6714
antineoplastic-117281	-	Thyroid hormone signaling pathway	path:04919_1	7	7.082919	0.005476451	AKT3 HIF1A ATP1B1 PFKFB2 PFKP PIK3CB PIK3R1	10000 3091 481 5208 5214 5291 5295
antineoplastic-117281	-	Oxytocin signaling pathway	path:04921_2	7	5.986688	0.030668127	EGFR PLCB1 GNAI1 PIK3CB PIK3CG PIK3R1 PLCB4	1956 23236 2770 5291 5294 5295 5332
antineoplastic-117281	-	Salmonella infection	path:05132_1	5	5.652454	0.038335159	FLNA PFN4 PFN2 ACTB WAS	2316 375189 5217 60 7454
antineoplastic-117281	-	Pathways in cancer	path:05200_1	6	6.761638	0.008762322	EGLN3 EGFR HIF1A EGLN1 TGFA TGFB2	112399 1956 3091 54583 7039 7042
antineoplastic-117281	-	Pancreatic cancer	path:05212_1	7	6.570827	0.013143483	AKT3 EGFR PIK3CB PIK3CG PIK3R1 BCL2L1 TGFA	10000 1956 5291 5294 5295 598 7039
antineoplastic-117281	-	Glioma	path:05214_2	8	5.716602	0.038335159	AKT3 EGFR IGF1R PIK3CB PIK3CG PIK3R1 SHC1 TGFA	10000 1956 3480 5291 5294 5295 6464 7039
antineoplastic-117281	-	Prostate cancer	path:05215_1	8	6.29891	0.021905805	AKT3 EGFR IGF1R PIK3CB PIK3CG PIK3R1 PDGFC TGFA	10000 1956 3480 5291 5294 5295 56034 7039
antineoplastic-131513	-	Citrate cycle (TCA cycle)	path:00020_1	8	5.827482	0.041758242	DLAT DLD IDH1 IDH3B IDH3G OGDH ACO2 PDHA1	1737 1738 3417 3420 3421 4967 50 5160
antineoplastic-131513	-	Purine metabolism	path:00230_9	8	5.661207	0.047252747	ADCY7 PKLR POLR2D POLR2F POLR2H POLR2J POLR1E POLR1B	113 5313 5433 5435 5437 5439 64425 84172
antineoplastic-131513	-	Pyrimidine metabolism	path:00240_7	13	6.336433	0.018681319	POLR3G NME7 ZNRD1 POLR1D POLR2D POLR2F POLR2H POLR2J POLR3B POLR1E POLR1B PNPT1 POLR1C	10622 29922 30834 51082 5433 5435 5437 5439 55703 64425 84172 87178 9533
antineoplastic-131513	-	MAPK signaling pathway	path:04010_3	8	7.687032	0.002197802	DUSP1 DUSP4 DUSP6 ELK1 FOS MAPK10 MAP2K7 MAP2K4	1843 1846 1848 2002 2353 5602 5609 6416
antineoplastic-131513	-	Rap1 signaling pathway	path:04015_3	8	5.660953	0.047252747	EGFR FGF7 RASGRP3 HGF PDGFA PDGFB PLCB4 PDGFC	1956 2252 25780 3082 5154 5155 5332 56034
antineoplastic-131513	-	Focal adhesion	path:04510_6	5	6.540189	0.012087912	FLNA FLNC ITGAV ITGB1 TLN2	2316 2318 3685 3688 83660
antineoplastic-187675	-	Pyrimidine metabolism	path:00240_8	7	6.19146	0.032547699	NME4 POLR2C POLR2G POLR2J CTPS2 POLR3GL POLR1C	4833 5432 5436 5439 56474 84265 9533
antineoplastic-187675	-	Glycosphingolipid biosynthesis - lacto and neolacto series	path:00601_1	8	6.338866	0.023569024	B3GALT5 FUT1 FUT2 FUT6 GCNT2 ST3GAL4 B4GALT4 B3GALT2	10317 2523 2524 2528 2651 6484 8702 8707
antineoplastic-187675	-	HIF-1 signaling pathway	path:04066_2	9	5.998349	0.042648709	CREBBP ENO1 EP300 ALDOA GAPDH ARNT LTBR PFKL VEGFA	1387 2023 2033 226 2597 405 4055 5211 7422
antineoplastic-187675	-	Insulin signaling pathway	path:04910_3	8	5.980215	0.044893378	AKT3 GSK3B PDPK1 PPP1CA BAD RPS6KB2 TSC2 CALM3	10000 2932 5170 5499 572 6199 7249 808
antineoplastic-301477	-	Purine metabolism	path:00230_10	7	7.029895	0.006666667	NUDT16 AK1 NME1 NT5E PDE6C ENTPD6 ENTPD5	131870 203 4830 4907 5146 955 957
antineoplastic-301477	-	Pyrimidine metabolism	path:00240_9	6	6.041533	0.032222222	DHODH NME1 NT5E UMPS ENTPD6 ENTPD5	1723 4830 4907 7372 955 957
antineoplastic-301477	-	PPAR signaling pathway	path:03320_1	12	6.405262	0.017777778	SORBS1 CYP27A1 DBI EHHADH ACADL ILK ME1 PCK1 PPARG RXRA UBC FADS2	10580 1593 1622 1962 33 3611 4199 5105 5468 6256 7316 9415
antineoplastic-301477	-	Endocytosis	path:04144_1	6	6.606591	0.012222222	WWP1 ERBB3 SH3GLB1 SMURF2 ITCH CBLB	11059 2065 51100 64750 83737 868
antineoplastic-301477	-	Hippo signaling pathway	path:04390_4	6	6.723076	0.01	PPP1CB PPP1CC PPP2CB YWHAB YWHAG YWHAZ	5500 5501 5516 7529 7532 7534
antineoplastic-301477	-	Focal adhesion	path:04510_7	3	6.639273	0.011111111	ITGA2B ITGA5 PXN	3674 3678 5829
antineoplastic-301477	-	ECM-receptor interaction	path:04512_3	3	5.824143	0.044444444	ITGAV ITGB1 THBS1	3685 3688 7057
antineoplastic-301477	-	Adherens junction	path:04520_1	6	6.668267	0.011111111	CSNK2A2 CTNNB1 CTNND1 ERBB2 RAC3 CDH1	1459 1499 1500 2064 5881 999
antineoplastic-301477	-	Glutamatergic synapse	path:04724_1	10	5.804775	0.045555556	ADCY6 ADCY9 GNAO1 GNG3 GNG5 GNGT2 GRM4 PRKACB GNG12 GNB4	112 115 2775 2785 2787 2793 2914 5567 55970 59345
antineoplastic-301477	-	Cholinergic synapse	path:04725_2	10	6.042264	0.032222222	ADCY6 ADCY9 GNAO1 GNG3 GNG5 GNGT2 PIK3CG PRKACB GNG12 GNB4	112 115 2775 2785 2787 2793 5294 5567 55970 59345
antineoplastic-301477	-	Melanogenesis	path:04916_1	4	6.47141	0.017777778	GNAO1 PLCB4 PRKACB PRKCB	2775 5332 5567 5579
antineoplastic-301477	-	Morphine addiction	path:05032_1	11	5.929215	0.036666667	ADCY6 ADCY9 GNAO1 GNG3 GNG5 GNGT2 OPRM1 PRKACB PRKCB GNG12 GNB4	112 115 2775 2785 2787 2793 4988 5567 5579 55970 59345
antineoplastic-301477	-	Proteoglycans in cancer	path:05205_1	5	7.162945	0.006666667	CTNNB1 ERBB2 ERBB3 MYC CBLB	1499 2064 2065 4609 868
antineoplastic-301477	-	Basal cell carcinoma	path:05217_1	3	5.968637	0.034444444	CTNNB1 GLI1 GSK3B	1499 2735 2932
antineoplastic-328785	-	cGMP-PKG signaling pathway	path:04022_4	13	6.59161	0.018930958	MRVI1 CREB3 KCNMA1 ATP1B2 ATP1B3 NPR2 PLCB2 PLCB4 PPP1CA PPP1CC PRKG2 BAD CREB5	10335 10488 3778 482 483 4882 5330 5332 5499 5501 5593 572 9586
antineoplastic-328785	-	Phosphatidylinositol signaling system	path:04070_3	14	6.481731	0.018930958	CDS1 DGKG DGKQ ITPKA PIK3C3 PIK3CG PIP4K2A PLCB2 PLCB4 PI4K2A PIP4K2C DGKZ DGKE DGKI	1040 1608 1609 3706 5289 5294 5305 5330 5332 55361 79837 8525 8526 9162
antineoplastic-328785	-	Hippo signaling pathway	path:04390_5	7	6.022271	0.04454343	FGF1 SERPINE1 PPP1CA PPP1CC PPP2CB PPP2R1B YWHAZ	2246 5054 5499 5501 5516 5519 7534
antineoplastic-328785	-	Focal adhesion	path:04510_8	9	8.818974	0	FLNA ITGB3 ITGB5 PXN THBS1 TLN1 CAV1 CAV2 CAV3	2316 3690 3693 5829 7057 7094 857 858 859
antineoplastic-328785	-	Circadian entrainment	path:04713_2	12	6.792686	0.014476615	ADCY6 ADCY8 ADCY9 ADCY4 GNG3 GNG7 GNG11 GNGT1 PLCB2 PLCB4 GNG12 GNB4	112 114 115 196883 2785 2788 2791 2792 5330 5332 55970 59345
antineoplastic-328785	-	Retrograde endocannabinoid signaling	path:04723_1	10	6.071444	0.042316258	ADCY6 ADCY8 ADCY9 ADCY4 GNG3 GNG7 GNG11 GNGT1 GNG12 GNB4	112 114 115 196883 2785 2788 2791 2792 55970 59345
antineoplastic-328785	-	Cholinergic synapse	path:04725_3	11	6.703818	0.0155902	ADCY6 ADCY8 ADCY9 ADCY4 GNG3 GNG7 GNG11 GNGT1 PIK3CG GNG12 GNB4	112 114 115 196883 2785 2788 2791 2792 5294 55970 59345
antineoplastic-328785	-	Serotonergic synapse	path:04726_3	4	6.464288	0.020044543	GNG11 PLCB4 GNG12 GNB4	2791 5332 55970 59345
antineoplastic-328785	-	GABAergic synapse	path:04727_2	8	6.806603	0.014476615	ADCY8 ADCY4 GABBR1 GNG3 GNG11 GNGT1 GNG12 GNB4	114 196883 2550 2785 2791 2792 55970 59345
antineoplastic-328785	-	Dopaminergic synapse	path:04728_2	4	6.464288	0.020044543	GNG11 PLCB4 GNG12 GNB4	2791 5332 55970 59345
antineoplastic-328785	-	Morphine addiction	path:05032_2	10	6.071444	0.042316258	ADCY6 ADCY8 ADCY9 ADCY4 GNG3 GNG7 GNG11 GNGT1 GNG12 GNB4	112 114 115 196883 2785 2788 2791 2792 55970 59345
antineoplastic-353527	-	Rap1 signaling pathway	path:04015_4	16	7.292582	0.002232143	CRK CSF1 EGF EGFR EPHA2 FGF1 FGF2 FGF5 FGF8 FGF12 FGF13 PLCB1 MET PDGFC VEGFB VEGFC	1398 1435 1950 1956 1969 2246 2247 2250 2253 2257 2258 23236 4233 56034 7423 7424
antineoplastic-353527	-	Chemokine signaling pathway	path:04062_4	5	6.283937	0.015625	AKT3 PIK3R5 GNG11 GNG12 GNB4	10000 23533 2791 55970 59345
antineoplastic-353527	-	HIF-1 signaling pathway	path:04066_3	8	5.656377	0.037946429	EGF HIF1A NPPA SERPINE1 EGLN1 STAT3 TEK TFRC	1950 3091 4878 5054 54583 6774 7010 7037
antineoplastic-353527	-	mTOR signaling pathway	path:04150_1	7	6.778149	0.008928571	AKT3 EIF4B MTOR HIF1A PRKAA2 RPS6KB2 ULK2	10000 1975 2475 3091 5563 6199 9706
antineoplastic-353527	-	PI3K-Akt signaling pathway	path:04151_3	4	6.248161	0.016741071	ITGAV ITGB1 ITGB3 THBS1	3685 3688 3690 7057
antineoplastic-353527	-	Hippo signaling pathway	path:04390_6	5	7.355539	0.002232143	SMAD3 SMAD4 MYC SERPINE1 BMPR2	4088 4089 4609 5054 659
antineoplastic-353527	-	Focal adhesion	path:04510_9	14	5.650239	0.037946429	FLNA FLNC ITGA5 ITGAV ITGB3 ITGB5 PRKCA PTK2 SRC THBS1 TLN1 VASP CAV2 CAV3	2316 2318 3678 3685 3690 3693 5578 5747 6714 7057 7094 7408 858 859
antineoplastic-353527	-	Jak-STAT signaling pathway	path:04630_2	9	6.46806	0.013392857	CBLC IFNG IL4 IL6ST LIF IL20RA STAT3 SOCS3 OSMR	23624 3458 3565 3572 3976 53832 6774 9021 9180
antineoplastic-353527	-	Circadian entrainment	path:04713_3	5	5.605877	0.0390625	ADCY8 ADCY9 GNG11 GNG12 GNB4	114 115 2791 55970 59345
antineoplastic-353527	-	Retrograde endocannabinoid signaling	path:04723_2	11	5.882924	0.025669643	ADCY1 ADCY8 ADCY9 GNAO1 GNG5 GNG11 GNG13 GNG12 MAPK13 PRKX GNB4	107 114 115 2775 2787 2791 51764 55970 5603 5613 59345
antineoplastic-353527	-	Glutamatergic synapse	path:04724_2	11	5.736168	0.035714286	ADCY1 ADCY8 ADCY9 GNAO1 GNAS GNG5 GNG11 GNG13 GNG12 PRKX GNB4	107 114 115 2775 2778 2787 2791 51764 55970 5613 59345
antineoplastic-353527	-	Cholinergic synapse	path:04725_4	10	6.626289	0.010044643	ADCY8 ADCY9 PIK3R5 GNAO1 GNG11 GNG13 GNG12 PRKX GNB4 CAMK4	114 115 23533 2775 2791 51764 55970 5613 59345 814
antineoplastic-353527	-	GABAergic synapse	path:04727_3	8	5.669939	0.037946429	ADCY8 ADCY9 GNAO1 GNG11 GNG13 GNG12 PRKX GNB4	114 115 2775 2791 51764 55970 5613 59345
antineoplastic-353527	-	Dopaminergic synapse	path:04728_3	8	5.566606	0.040178571	CREB3 PLCB1 GRIA3 GRIA4 ATF4 PRKCB PRKX CALM1	10488 23236 2892 2893 468 5579 5613 801
antineoplastic-353527	-	Insulin signaling pathway	path:04910_4	7	6.191587	0.016741071	AKT3 PIK3R5 MTOR INPPL1 PRKCZ SLC2A4 IRS4	10000 23533 2475 3636 5590 6517 8471
antineoplastic-353527	-	Morphine addiction	path:05032_3	12	5.768046	0.034598214	ADCY1 ADCY8 ADCY9 GNAO1 GNAS GNG5 GNG11 GNG13 PRKCB GNG12 PRKX GNB4	107 114 115 2775 2778 2787 2791 51764 5579 55970 5613 59345
antineoplastic-353527	-	Salmonella infection	path:05132_2	3	5.555318	0.041294643	FLNA PFN2 ACTB	2316 5217 60
antineoplastic-353527	-	Pathways in cancer	path:05200_2	6	5.525825	0.042410714	AKT3 CRK EGFR PIK3R5 PIK3CD STAT3	10000 1398 1956 23533 5293 6774
antineoplastic-353527	-	Melanoma	path:05218_1	14	5.855952	0.027901786	EGF EGFR FGF1 FGF2 FGF3 FGF5 FGF6 FGF8 FGF9 FGF12 FGF13 MET PDGFC PDGFD	1950 1956 2246 2247 2248 2250 2251 2253 2254 2257 2258 4233 56034 80310
antineoplastic-376265	-	Nicotinate and nicotinamide metabolism	path:00760_1	5	6.187506	0.03622393	NAMPT AOX1 NNMT NT5E ENPP1	10135 316 4837 4907 5167
antineoplastic-376265	-	FoxO signaling pathway	path:04068_2	10	7.012057	0.006586169	AKT3 PLK2 GADD45A FOXO4 GADD45B PRKAB1 BCL6 BNIP3 STAT3 CCNB2	10000 10769 1647 4303 4616 5564 604 664 6774 9133
antineoplastic-376265	-	p53 signaling pathway	path:04115_1	9	6.344898	0.024149286	GADD45A IGFBP3 GADD45B SERPINE1 SHISA5 THBS1 TP53 TSC2 CCNB2	1647 3486 4616 5054 51246 7057 7157 7249 9133
antineoplastic-376265	-	mTOR signaling pathway	path:04150_2	5	6.76602	0.009879254	AKT3 MTOR PRKAA2 RPS6KA1 TSC2	10000 2475 5563 6195 7249
antineoplastic-376265	-	PI3K-Akt signaling pathway	path:04151_4	13	7.357165	0.001097695	CSF1 EFNA5 EGFR EPHA2 FGF2 FGF5 FGF13 HGF MET NGF PDGFC VEGFA VEGFC	1435 1946 1956 1969 2247 2250 2258 3082 4233 4803 56034 7422 7424
antineoplastic-376265	-	AMPK signaling pathway	path:04152_1	7	6.35713	0.024149286	AKT3 PDPK1 PFKFB3 PRKAB1 TSC2 SCD5 CD36	10000 5170 5209 5564 7249 79966 948
antineoplastic-376265	-	Adrenergic signaling in cardiomyocytes	path:04261_3	6	6.022147	0.046103183	CREB3 ATP1B1 PRKACA PRKX CACNA2D1 CREB5	10488 481 5566 5613 781 9586
antineoplastic-376265	-	Focal adhesion	path:04510_10	10	7.962991	0	FLNA FLNB FLNC ITGAV ITGB3 ITGB5 PTK2 THBS1 CAV2 CAV3	2316 2317 2318 3685 3690 3693 5747 7057 858 859
antineoplastic-376265	-	ECM-receptor interaction	path:04512_4	4	7.847683	0	ITGAV ITGB1 ITGB3 THBS1	3685 3688 3690 7057
antineoplastic-376265	-	Insulin signaling pathway	path:04910_5	7	7.136638	0.005488474	AKT3 PDPK1 PHKG1 PPP1CC PYGL RPS6KB1 TSC2	10000 5170 5260 5501 5836 6198 7249
antineoplastic-376265	-	Pathways in cancer	path:05200_3	8	6.821255	0.006586169	HIF1A JUN EGLN1 STAT1 TGFB2 VEGFA VEGFC VHL	3091 3725 54583 6772 7042 7422 7424 7428
antineoplastic-382459	-	Purine metabolism	path:00230_11	10	6.260983	0.015695067	ADCY6 AK1 POLR2J2 GUCY2F GUCY2D NT5C PDE6B PKM POLR2L ADCY10	112 203 246721 2986 3000 30833 5158 5315 5441 55811
antineoplastic-382459	-	beta-Alanine metabolism	path:00410_1	6	5.688444	0.040358744	ALDH3B1 ALDH9A1 ALDH3A2 GAD2 ALDH7A1 UPB1	221 223 224 2572 501 51733
antineoplastic-382459	-	MAPK signaling pathway	path:04010_4	10	5.744088	0.036995516	CRK CRKL JUND MAPK1 MAPK8 MAP2K7 PTPN7 RPS6KA2 TP53 MAP3K13	1398 1399 3727 5594 5599 5609 5778 6196 7157 9175
antineoplastic-382459	-	Rap1 signaling pathway	path:04015_5	7	5.975044	0.020179372	CRK EFNA5 EGF EPHA2 FGF9 FLT4 PLCB3	1398 1946 1950 1969 2254 2324 5331
antineoplastic-382459	-	Calcium signaling pathway	path:04020_6	10	6.160827	0.016816143	PTK2B GRIN2A SLC25A4 ATP2A3 ATP2B4 P2RX1 P2RX3 P2RX5 PRKCB CALM3	2185 2903 291 489 493 5023 5024 5026 5579 808
antineoplastic-382459	-	AMPK signaling pathway	path:04152_2	8	5.615271	0.045964126	ADRA1A MTOR HMGCR PFKFB3 PRKAG3 PRKAA1 PRKAB2 STK11	148 2475 3156 5209 53632 5562 5565 6794
antineoplastic-382459	-	Wnt signaling pathway	path:04310_2	4	6.09746	0.01793722	NFATC1 PLCB3 PPP3CB CAMK2D	4772 5331 5532 817
antineoplastic-382459	-	Signaling pathways regulating pluripotency of stem cells	path:04550_1	4	6.489938	0.010089686	SMAD4 MAPK1 BMPR2 ACVR1	4089 5594 659 90
antineoplastic-382459	-	Circadian entrainment	path:04713_4	6	5.697365	0.039237668	GNB5 GNAQ PLCB3 PRKCA PRKCB PRKCG	10681 2776 5331 5578 5579 5582
antineoplastic-382459	-	Regulation of actin cytoskeleton	path:04810_3	4	6.567097	0.007847534	CRK ITGAM RAC1 BCAR1	1398 3684 5879 9564
antineoplastic-382459	-	Melanogenesis	path:04916_2	7	5.689708	0.040358744	GNAO1 PLCB3 PRKCB PRKX CALM3 CAMK2D CREB3L3	2775 5331 5579 5613 808 817 84699
antineoplastic-382459	-	Thyroid hormone signaling pathway	path:04919_2	6	6.3032	0.015695067	PIK3R5 ATP1B1 ATP1B2 MAPK1 SRC THRA	23533 481 482 5594 6714 7067
antineoplastic-382459	-	Adipocytokine signaling pathway	path:04920_1	6	5.663789	0.043721973	PRKAG3 PRKAB2 G6PC2 SLC2A1 STK11 G6PC3	53632 5565 57818 6513 6794 92579
antineoplastic-382459	-	Oxytocin signaling pathway	path:04921_3	7	6.455805	0.013452915	GNAQ PLCB3 PPP3CB PRKCB CALM3 CAMK4 CAMK2D	2776 5331 5532 5579 808 814 817
antineoplastic-382459	-	Bacterial invasion of epithelial cells	path:05100_1	7	5.767696	0.036995516	CRK CRKL PIK3R5 GAB1 MET PIK3CD PIK3CG	1398 1399 23533 2549 4233 5293 5294
antineoplastic-382459	-	Pathways in cancer	path:05200_4	5	5.735086	0.036995516	CRK CRKL PIK3R5 ABL1 STAT5A	1398 1399 23533 25 6776
antineoplastic-382459	-	Chronic myeloid leukemia	path:05220_1	6	6.225296	0.015695067	CRK CRKL PIK3R5 ABL1 SHC1 STAT5A	1398 1399 23533 25 6464 6776
antineoplastic-400008	-	Purine metabolism	path:00230_12	8	6.359807	0.016538037	ZNRD1 NUDT2 NPR2 PKM POLR2H POLR2J POLR3GL POLR1C	30834 318 4882 5315 5437 5439 84265 9533
antineoplastic-400008	-	Pyrimidine metabolism	path:00240_10	10	5.712712	0.038588754	POLR2J2 ZNRD1 NUDT2 NME3 POLR1D POLR2C POLR2H POLR2J POLR3GL POLR1C	246721 30834 318 4832 51082 5432 5437 5439 84265 9533
antineoplastic-400008	-	Rap1 signaling pathway	path:04015_6	9	6.835764	0.006615215	CRK EGFR EPHA2 RASGRP3 GNAQ PLCB2 PLCB3 VEGFA VEGFC	1398 1956 1969 25780 2776 5330 5331 7422 7424
antineoplastic-400008	-	Calcium signaling pathway	path:04020_7	7	5.703822	0.038588754	ADRA1B AGTR1 GNA15 GNAQ PLCE1 PLCB2 PRKCA	147 185 2769 2776 51196 5330 5578
antineoplastic-400008	-	FoxO signaling pathway	path:04068_3	17	5.76739	0.036383682	AKT3 CDKN1A CDKN2D PLK2 GABARAPL2 MAPK14 GADD45A FOXO1 GABARAPL1 FASLG FOXO4 NLK PRKAG1 MAPK10 STAT3 SETD7 TNFSF10	10000 1026 1032 10769 11345 1432 1647 2308 23710 356 4303 51701 5571 5602 6774 80854 8743
antineoplastic-400008	-	Phosphatidylinositol signaling system	path:04070_4	10	6.362557	0.016538037	INPP4A INPP5D PLCE1 PIK3C2A PIK3CG PIP4K2A PLCB2 PLCB3 PIK3R3 DGKZ	3631 3635 51196 5286 5294 5305 5330 5331 8503 8525
antineoplastic-400008	-	Focal adhesion	path:04510_11	6	6.193629	0.018743109	FYN SHC3 PRKCA PTK2 CAV2 CAV3	2534 53358 5578 5747 858 859
antineoplastic-400008	-	Jak-STAT signaling pathway	path:04630_3	7	6.200937	0.018743109	CNTFR IL2RA IL2RB IL10 LIFR IL23A OSMR	1271 3559 3560 3586 3977 51561 9180
antineoplastic-400008	-	Natural killer cell mediated cytotoxicity	path:04650_1	6	5.91415	0.027563396	LAT GRB2 LCP2 SHC3 SHC1 SOS1	27040 2885 3937 53358 6464 6654
antineoplastic-400008	-	Circadian entrainment	path:04713_5	16	6.538143	0.012127894	GNB5 ADCY3 ADCY5 ADCY6 ADCY9 GNAI1 GNAQ GNB3 GNG3 GNGT1 PLCB2 PLCB3 PRKACA PRKCA GNG12 PRKX	10681 109 111 112 115 2770 2776 2784 2785 2792 5330 5331 5566 5578 55970 5613
antineoplastic-400008	-	Retrograde endocannabinoid signaling	path:04723_3	14	5.925392	0.027563396	GNB5 ADCY3 ADCY5 ADCY6 ADCY9 MAPK14 GNAI1 GNB3 GNG3 GNGT1 PRKACA GNG12 MAPK10 PRKX	10681 109 111 112 115 1432 2770 2784 2785 2792 5566 55970 5602 5613
antineoplastic-400008	-	Cholinergic synapse	path:04725_5	11	6.298257	0.017640573	AKT3 GNB5 ADCY3 ADCY6 GNAI1 GNB3 GNG3 PIK3CG GNG12 PRKX PIK3R3	10000 10681 109 112 2770 2784 2785 5294 55970 5613 8503
antineoplastic-400008	-	Dopaminergic synapse	path:04728_4	7	6.220025	0.017640573	GNB5 GNAQ GNB3 PLCB2 PLCB3 PRKCA GNG12	10681 2776 2784 5330 5331 5578 55970
antineoplastic-400008	-	Regulation of actin cytoskeleton	path:04810_4	8	6.432619	0.015435502	PIK3CG RAC2 RRAS SOS1 BRAF VAV1 VAV2 PIK3R3	5294 5880 6237 6654 673 7409 7410 8503
antineoplastic-400008	-	Oxytocin signaling pathway	path:04921_4	8	5.726145	0.038588754	EGFR GNAI1 ITPR1 PIK3CG PLCB3 PLCB4 PRKCA PIK3R3	1956 2770 3708 5294 5331 5332 5578 8503
antineoplastic-400008	-	Morphine addiction	path:05032_4	10	5.927178	0.027563396	GNB5 ADCY3 ADCY6 ADCY9 GNAI1 GNB3 OPRM1 PRKCA GNG12 PRKX	10681 109 112 115 2770 2784 4988 5578 55970 5613
antineoplastic-400008	-	Alcoholism	path:05034_1	6	5.660104	0.038588754	GNB5 ADCY5 GNAI1 GNG3 PRKACA GNG12	10681 111 2770 2785 5566 55970
antineoplastic-400008	-	Pathways in cancer	path:05200_5	5	5.907298	0.027563396	CRK EGFR PIK3CG PTK2 STAT1	1398 1956 5294 5747 6772
antineoplastic-400008	-	Glioma	path:05214_3	6	5.548865	0.048511577	AKT3 EGFR HRAS PIK3CG SHC3 PIK3R3	10000 1956 3265 5294 53358 8503
antineoplastic-400008	-	Choline metabolism in cancer	path:05231_1	7	6.026614	0.023153252	EGFR GRB2 PIK3CG PLD2 RALGDS SOS1 PIK3R3	1956 2885 5294 5338 5900 6654 8503
antineoplastic-402867	-	Steroid hormone biosynthesis	path:00140_1	13	6.476794	0.024891775	AKR1C4 CYP1A1 CYP1B1 CYP3A4 CYP3A5 AKR1C1 HSD17B1 UGT1A10 SRD5A2 AKR1D1 UGT2B4 UGT2B7 SRD5A3	1109 1543 1545 1576 1577 1645 3292 54575 6716 6718 7363 7364 79644
antineoplastic-402867	-	MAPK signaling pathway	path:04010_5	6	6.041604	0.048701299	MAPK14 DUSP5 HSPA2 MAPK9 MAPK10 PTPN7	1432 1847 3306 5601 5602 5778
antineoplastic-402867	-	ErbB signaling pathway	path:04012_2	7	6.452689	0.024891775	EGFR ERBB4 EREG NRG1 PIK3CG BTC PIK3R3	1956 2066 2069 3084 5294 685 8503
antineoplastic-402867	-	Ras signaling pathway	path:04014_2	16	6.55393	0.022727273	EFNA5 EGF EGFR EPHA2 FGF2 FGF5 FGF14 FGFR3 FGFR4 FLT4 HGF KDR MET KITLG PDGFRA PDGFD	1946 1950 1956 1969 2247 2250 2259 2261 2264 2324 3082 3791 4233 4254 5156 80310
antineoplastic-402867	-	Rap1 signaling pathway	path:04015_7	16	6.55393	0.022727273	EFNA5 EGF EGFR EPHA2 FGF2 FGF5 FGF14 FGFR3 FGFR4 FLT4 HGF KDR MET KITLG PDGFRA PDGFD	1946 1950 1956 1969 2247 2250 2259 2261 2264 2324 3082 3791 4233 4254 5156 80310
antineoplastic-402867	-	Calcium signaling pathway	path:04020_8	10	6.486308	0.023809524	ITPKB ITPR1 ATP2A1 ATP2B4 CALML5 SLC8A1 VDAC3 CACNA1S ORAI2 SLC25A31	3707 3708 487 493 51806 6546 7419 779 80228 83447
antineoplastic-402867	-	cGMP-PKG signaling pathway	path:04022_5	10	6.153647	0.041125541	CNGA1 GTF2I ATP1B1 ATP2B4 PLCB2 PPP1CB PRKCE PRKG2 RGS2 SLC8A1	1259 2969 481 493 5330 5500 5581 5593 5997 6546
antineoplastic-402867	-	Chemokine signaling pathway	path:04062_5	16	8.378351	0	CCR3 GNAI1 GRK6 CXCL1 CXCL2 CXCL3 CXCL8 CXCL10 PF4 PF4V1 PPBP CCL13 CCL14 CCL15 CXCL6 CX3CL1	1232 2770 2870 2919 2920 2921 3576 3627 5196 5197 5473 6357 6358 6359 6372 6376
antineoplastic-402867	-	PI3K-Akt signaling pathway	path:04151_5	8	7.005508	0.008658009	CHRM2 LPAR1 GNB2 GNG4 GNGT1 PIK3CG PTK2 PIK3R3	1129 1902 2783 2786 2792 5294 5747 8503
antineoplastic-402867	-	Jak-STAT signaling pathway	path:04630_4	17	9.053106	0	IL24 CSF3R EPOR IL19 IFNAR1 IL2 IL10 IL10RB IL11RA IL15 LEP LIF LIFR MPL IL20 IL21 STAT5A	11009 1441 2057 29949 3454 3558 3586 3588 3590 3600 3952 3976 3977 4352 50604 59067 6776
antineoplastic-402867	-	Leukocyte transendothelial migration	path:04670_2	9	6.965374	0.012987013	ICAM1 ITGB1 ITGB2 PLCG1 PRKCA PRKCG PTK2 VAV2 RASSF5	3383 3688 3689 5335 5578 5582 5747 7410 83593
antineoplastic-402867	-	Retrograde endocannabinoid signaling	path:04723_4	11	6.937835	0.012987013	ADCY5 CNR1 MAPK14 ADCY4 GNAI1 GNB2 GNG3 GNGT1 MAPK11 MAPK9 MAPK10	111 1268 1432 196883 2770 2783 2785 2792 5600 5601 5602
antineoplastic-402867	-	Glutamatergic synapse	path:04724_3	8	6.342247	0.03030303	ADCY5 ADCY4 GNAI1 GNB2 GNG3 GNGT1 GRM8 PRKACA	111 196883 2770 2783 2785 2792 2918 5566
antineoplastic-402867	-	Cholinergic synapse	path:04725_6	9	7.386768	0.006493506	CHRM2 ADCY4 GNAI1 GNB2 GNG3 GNGT1 PIK3CG PIK3R3 CHRNA6	1129 196883 2770 2783 2785 2792 5294 8503 8973
antineoplastic-402867	-	Serotonergic synapse	path:04726_4	7	6.964005	0.012987013	ADCY5 GNAI1 GNAO1 GNB2 GNG3 GNGT1 HTR1D	111 2770 2775 2783 2785 2792 3352
antineoplastic-402867	-	GABAergic synapse	path:04727_4	7	6.295876	0.032467532	ADCY5 ADCY4 GABBR1 GNAI1 GNB2 GNG3 GNGT1	111 196883 2550 2770 2783 2785 2792
antineoplastic-402867	-	Dopaminergic synapse	path:04728_5	6	6.693843	0.017316017	ADCY5 GNAI1 GNB2 GNG3 GNGT1 PRKACA	111 2770 2783 2785 2792 5566
antineoplastic-402867	-	Legionellosis	path:05134_1	3	6.431891	0.024891775	IL1B IL18 MYD88	3553 3606 4615
antineoplastic-402867	-	Pathways in cancer	path:05200_6	9	6.29436	0.032467532	EGFR NRAS PIK3CG PTK2 RALB RALGDS SOS1 BRAF PIK3R3	1956 4893 5294 5747 5899 5900 6654 673 8503
antineoplastic-402867	-	Choline metabolism in cancer	path:05231_2	9	6.093014	0.045454545	EGFR KRAS PIK3R2 PLCG1 PLD2 RALGDS SOS1 PDGFD PIK3R3	1956 3845 5296 5335 5338 5900 6654 80310 8503
antineoplastic-41390	-	Hippo signaling pathway	path:04390_7	3	7.083904	0.00554939	PPP1CC PPP2R1B YWHAZ	5501 5519 7534
antineoplastic-48300	-	Pyrimidine metabolism	path:00240_11	8	5.999308	0.047619048	POLD3 POLA2 NME7 POLE3 POLD1 PRIM1 PRIM2 POLD4	10714 23649 29922 54107 5424 5557 5558 57804
antineoplastic-48300	-	Ras signaling pathway	path:04014_3	10	6.44713	0.022148394	RASSF1 RRAS2 PIK3CG RALGDS RRAS SOS1 RASSF5 SYNGAP1 RASAL2 RIN1	11186 22800 5294 5900 6237 6654 83593 8831 9462 9610
antineoplastic-48300	-	Regulation of actin cytoskeleton	path:04810_5	5	6.347809	0.029900332	FGFR4 RRAS2 PIK3CG RRAS SOS1	2264 22800 5294 6237 6654
antineoplastic-615538	-	Purine metabolism	path:00230_13	12	7.977981	0	POLR3G ADCY7 NME7 ZNRD1 HDDC3 POLR1D POLR2C POLR2F POLR2J POLR1B PNPT1 POLR1C	10622 113 29922 30834 374659 51082 5432 5435 5439 84172 87178 9533
antineoplastic-615538	-	Pyrimidine metabolism	path:00240_12	10	6.456413	0.013172338	ZNRD1 POLR1D POLR2A POLR2F RRM2 POLR3D POLR1B PNPT1 POLR1C ENTPD3	30834 51082 5430 5435 6241 661 84172 87178 9533 956
antineoplastic-615538	-	FoxO signaling pathway	path:04068_4	10	6.190957	0.025246981	AKT3 CDKN2D PLK2 GABARAPL1 IL7R FOXO4 GADD45B PCK2 PRKAA2 G6PC3	10000 1032 10769 23710 3575 4303 4616 5106 5563 92579
antineoplastic-615538	-	p53 signaling pathway	path:04115_2	10	5.74226	0.048298573	CHEK2 BBC3 SFN MDM4 GADD45B SERPINE1 SIAH1 THBS1 TP53 TP73	11200 27113 2810 4194 4616 5054 6477 7057 7157 7161
antineoplastic-615538	-	Jak-STAT signaling pathway	path:04630_5	9	6.71923	0.008781559	IL24 IL6ST IL7R IL12B IL15 JAK2 LIF LIFR IL20	11009 3572 3575 3593 3600 3717 3976 3977 50604
antineoplastic-615538	-	Colorectal cancer	path:05210_1	8	5.782195	0.045005488	AKT3 KRAS PIK3R1 MAP2K1 RAF1 RALGDS CASP9 PIK3R3	10000 3845 5295 5604 5894 5900 842 8503
antineoplastic-615538	-	Pancreatic cancer	path:05212_2	9	6.154539	0.027442371	AKT3 EGFR KRAS PIK3R1 MAPK8 MAP2K1 RAF1 RALGDS TGFA	10000 1956 3845 5295 5599 5604 5894 5900 7039
antineoplastic-615804	-	Purine metabolism	path:00230_14	9	8.36136	0	POLR3F POLR3A ITPA PDE6A PDE6C POLE3 POLD1 POLR2C NME5	10621 11128 3704 5145 5146 54107 5424 5432 8382
antineoplastic-615804	-	Pyrimidine metabolism	path:00240_13	7	7.521844	0.001122334	POLR3F POLR3C POLR3A POLR2A POLR2C POLR1E NME5	10621 10623 11128 5430 5432 64425 8382
antineoplastic-615804	-	Sphingolipid metabolism	path:00600_1	9	6.123657	0.033670034	CERS1 KDSR ASAH1 SMPD3 ASAH2 SMPD1 UGCG B4GALT6 SPTLC2	10715 2531 427 55512 56624 6609 7357 9331 9517
antineoplastic-615804	-	Retinol metabolism	path:00830_1	8	5.911677	0.042648709	CYP2C8 CYP26A1 AOX1 CYP26C1 RDH11 UGT2B7 PNPLA4 DHRS3	1558 1592 316 340665 51109 7364 8228 9249
antineoplastic-615804	-	Chemokine signaling pathway	path:04062_6	9	6.859681	0.006734007	ADCY7 PLCB1 GNAI3 GNGT1 PIK3CD PLCB4 GNG12 PTK2 CXCR5	113 23236 2773 2792 5293 5332 55970 5747 643
antineoplastic-615804	-	Phosphatidylinositol signaling system	path:04070_5	8	5.884949	0.043771044	PIKFYVE OCRL PIK3C2A PIK3C3 PLCB4 PI4K2B PTEN PIK3R3	200576 4952 5286 5289 5332 55300 5728 8503
antineoplastic-615804	-	Hippo signaling pathway	path:04390_8	4	6.629406	0.013468013	SMAD2 SMAD4 SMAD7 BMPR2	4087 4089 4092 659
antineoplastic-615804	-	Pathways in cancer	path:05200_7	6	5.90771	0.042648709	HIF1A CXCL8 MYC PGF CCND1 STAT1	3091 3576 4609 5228 595 6772
antineoplastic-616241	-	Purine metabolism	path:00230_15	17	6.195562	0.03402854	ADCY2 POLR3A ADSSL1 CANT1 NUDT16 POLR3H GUCY2D APRT ENTPD8 NME1 POLR1D POLR2A POLR2D POLR2F RRM1 ENTPD2 ENTPD6	108 11128 122622 124583 131870 171568 3000 353 377841 4830 51082 5430 5433 5435 6240 954 955
antineoplastic-616241	-	ErbB signaling pathway	path:04012_3	6	6.990261	0.007683864	EGFR ERBB2 ERBB3 PIK3R5 GRB2 SHC1	1956 2064 2065 23533 2885 6464
antineoplastic-616241	-	Calcium signaling pathway	path:04020_9	9	6.157879	0.03622393	SLC25A4 ITPKA ATP2B1 PRKCA TNNC1 VDAC3 CACNA1C CACNA1D ITPKC	291 3706 490 5578 7134 7419 775 776 80271
antineoplastic-616241	-	Chemokine signaling pathway	path:04062_7	9	6.555531	0.020856202	AKT3 GNB5 PIK3R5 GNAI2 GNB3 PIK3R1 PRKCZ MAPK1 PIK3R3	10000 10681 23533 2771 2784 5295 5590 5594 8503
antineoplastic-616241	-	HIF-1 signaling pathway	path:04066_4	6	5.891993	0.048298573	AKT3 EGFR ERBB2 MTOR PIK3R1 PIK3R3	10000 1956 2064 2475 5295 8503
antineoplastic-616241	-	FoxO signaling pathway	path:04068_5	20	6.373658	0.026344676	AKT3 BCL2L11 CDK2 GADD45G SGK3 IL7R FOXO4 GADD45B PCK1 NLK PLK1 MAPK1 MAPK11 MAPK10 MAPK13 RBL2 BNIP3 SOD2 STAT3 CCNG2	10000 10018 1017 10912 23678 3575 4303 4616 5105 51701 5347 5594 5600 5602 5603 5934 664 6648 6774 901
antineoplastic-616241	-	Endocytosis	path:04144_2	5	7.423943	0.004390779	ERBB3 CBLC EPN3 SH3GLB2 ITCH	2065 23624 55040 56904 83737
antineoplastic-616241	-	Gap junction	path:04540_1	7	6.298196	0.030735456	TUBA1B ADCY2 GNAI2 PRKACB PRKCA MAPK1 PRKX	10376 108 2771 5567 5578 5594 5613
antineoplastic-616241	-	Platelet activation	path:04611_1	6	5.943051	0.047200878	AKT3 RASGRP2 GNAI2 PIK3R1 PRKCZ PLA2G4C	10000 10235 2771 5295 5590 8605
antineoplastic-616241	-	Jak-STAT signaling pathway	path:04630_6	17	8.516523	0.001097695	IFNLR1 EP300 CBLC IFNGR1 IL6 IL7R IL9 IL10RB LEPR LIFR MPL IL20RA STAT3 STAT5A CBL SOCS3 OSMR	163702 2033 23624 3459 3569 3575 3578 3588 3953 3977 4352 53832 6774 6776 867 9021 9180
antineoplastic-616241	-	Cholinergic synapse	path:04725_7	9	6.064346	0.043907794	AKT3 GNB5 ADCY2 AKT1 GNAI2 GNB3 HRAS PIK3R1 PIK3R3	10000 10681 108 207 2771 2784 3265 5295 8503
antineoplastic-616241	-	Dopaminergic synapse	path:04728_6	7	6.347137	0.027442371	FOS PRKACB PRKCA MAPK11 MAPK10 MAPK13 CREB3L3	2353 5567 5578 5600 5602 5603 84699
antineoplastic-616241	-	Regulation of actin cytoskeleton	path:04810_6	3	6.462204	0.023051592	HRAS PIK3R1 PAK6	3265 5295 56924
antineoplastic-616241	-	Insulin signaling pathway	path:04910_6	7	6.020138	0.045005488	MTOR GRB2 PIK3R1 PRKCI PRKCZ MAPK10 IRS2	2475 2885 5295 5584 5590 5602 8660
antineoplastic-616241	-	Chronic myeloid leukemia	path:05220_2	9	6.073799	0.042810099	AKT3 PIK3R5 CBLC GRB2 PIK3CB PIK3R1 PIK3R3 CBL GAB2	10000 23533 23624 2885 5291 5295 8503 867 9846
antineoplastic-624657	-	Purine metabolism	path:00230_16	7	6.156841	0.039106145	PDE10A ADSSL1 ADSL AK1 AK2 AK9 RRM2B	10846 122622 158 203 204 221264 50484
antineoplastic-624657	-	Ras signaling pathway	path:04014_4	9	5.945859	0.049162011	RASGRP2 RASSF1 ABL1 AFDN NRAS PLCE1 PIK3R2 RALGDS RIN1	10235 11186 25 4301 4893 51196 5296 5900 9610
antineoplastic-624657	-	Chemokine signaling pathway	path:04062_8	10	6.626726	0.023463687	CCR6 FGR PLCB1 GNAI1 GNAI3 GNB1 GNG11 GNGT1 GNG13 PIK3R2	1235 2268 23236 2770 2773 2782 2791 2792 51764 5296
antineoplastic-624657	-	Sphingolipid signaling pathway	path:04071_2	10	6.167789	0.039106145	PLCB1 GNAI1 GNAI3 NRAS PIK3R2 PLCB4 PLD1 SPHK2 RAC1 PIK3R3	23236 2770 2773 4893 5296 5332 5337 56848 5879 8503
antineoplastic-624657	-	Hippo signaling pathway	path:04390_9	6	6.794342	0.017877095	ITGB2 MYC PPP2R1B STK3 YWHAG YWHAZ	3689 4609 5519 6788 7532 7534
antineoplastic-624657	-	Focal adhesion	path:04510_12	7	6.314437	0.034636872	EGFR PIK3CB PIK3R2 RAC1 VAV1 VAV2 PIK3R3	1956 5291 5296 5879 7409 7410 8503
antineoplastic-624657	-	Tight junction	path:04530_1	4	6.20287	0.037988827	AFDN NRAS ACTB RRAS	4301 4893 60 6237
antineoplastic-624657	-	Fc gamma R-mediated phagocytosis	path:04666_1	6	6.658991	0.02122905	ARF6 ASAP1 PLD1 ASAP3 RAC1 ASAP2	382 50807 5337 55616 5879 8853
antineoplastic-624657	-	Leukocyte transendothelial migration	path:04670_3	7	6.600696	0.024581006	GNAI1 GNAI3 PIK3R2 RAC1 VAV1 PIK3R3 CDC42	2770 2773 5296 5879 7409 8503 998
antineoplastic-624657	-	Regulation of actin cytoskeleton	path:04810_7	7	5.934868	0.049162011	EGFR NRAS PIK3R2 RAC1 SOS2 VAV1 PIK3R3	1956 4893 5296 5879 6655 7409 8503
antineoplastic-624657	-	Bacterial invasion of epithelial cells	path:05100_2	3	6.407332	0.029050279	RAC1 ACTB WAS	5879 60 7454
antineoplastic-624657	-	Salmonella infection	path:05132_3	4	6.246123	0.037988827	MAPK14 RAC1 ACTB CDC42	1432 5879 60 998
antineoplastic-624658	-	Pyrimidine metabolism	path:00240_14	6	6.828795	0.012290503	NME7 POLE3 POLA1 POLD2 PRIM1 PRIM2	29922 54107 5422 5425 5557 5558
antineoplastic-624658	-	Ras signaling pathway	path:04014_5	8	6.4168	0.017877095	PIK3CG RALGDS RASA2 RRAS RASSF5 SYNGAP1 RASAL2 RIN1	5294 5900 5922 6237 83593 8831 9462 9610
antineoplastic-624658	-	Cell cycle	path:04110_1	7	6.013181	0.031284916	CDKN1A E2F1 E2F3 SKP2 CUL1 CCNA2 CCNE2	1026 1869 1871 6502 8454 890 9134
antineoplastic-624658	-	PI3K-Akt signaling pathway	path:04151_6	6	7.295613	0.002234637	ITGA2 ITGB1 ITGB3 ITGB5 PTK2 THBS1	3673 3688 3690 3693 5747 7057
antineoplastic-624658	-	Hippo signaling pathway	path:04390_10	4	7.269578	0.002234637	RASSF1 PPP2R1B ACTB STK3	11186 5519 60 6788
antineoplastic-624658	-	Focal adhesion	path:04510_13	8	6.838868	0.012290503	ITGB3 ITGB5 PRKCA PTK2 THBS1 TLN2 CAV1 CAV2	3690 3693 5578 5747 7057 83660 857 858
antineoplastic-624658	-	ECM-receptor interaction	path:04512_5	4	6.08496	0.030167598	ITGA2 ITGB3 THBS1 CD36	3673 3690 7057 948
antineoplastic-624658	-	Jak-STAT signaling pathway	path:04630_7	13	6.687859	0.01452514	EPOR IL19 IL2RA IL2RG IL4 IL6ST IL10RA IL13RA1 IL15 LIF OSM CBLB OSMR	2057 29949 3559 3561 3565 3572 3587 3597 3600 3976 5008 868 9180
antineoplastic-624658	-	Regulation of actin cytoskeleton	path:04810_8	6	5.91367	0.03575419	ARAF PIK3CG PIK3R1 RRAS VAV1 VAV2	369 5294 5295 6237 7409 7410
antineoplastic-624658	-	Choline metabolism in cancer	path:05231_3	9	6.283326	0.02122905	EGFR PCYT1A PIK3CG PIK3R1 PLD1 PLD2 MAPK8 MAPK10 RALGDS	1956 5130 5294 5295 5337 5338 5599 5602 5900
antineoplastic-624659	-	Purine metabolism	path:00230_17	9	5.860695	0.039647577	PDE10A ADCY3 AK2 ZNRD1 IMPDH1 PKLR POLR2H POLR3GL ENTPD6	10846 109 204 30834 3614 5313 5437 84265 955
antineoplastic-624659	-	Pyrimidine metabolism	path:00240_15	8	6.435611	0.018722467	POLR3H ZNRD1 NME4 POLR2E POLR2G POLR3B POLR3GL POLR1C	171568 30834 4833 5434 5436 55703 84265 9533
antineoplastic-624659	-	Ras signaling pathway	path:04014_6	9	5.983613	0.033039648	EFNA3 EFNA4 EFNA5 EGFR EPHA2 FGF21 NGF VEGFC PDGFD	1944 1945 1946 1956 1969 26291 4803 7424 80310
antineoplastic-624659	-	Rap1 signaling pathway	path:04015_8	10	6.44365	0.018722467	EFNA3 EFNA4 EFNA5 EGFR EPHA2 FGF21 NGF PLCB3 VEGFC PDGFD	1944 1945 1946 1956 1969 26291 4803 5331 7424 80310
antineoplastic-624659	-	FoxO signaling pathway	path:04068_6	16	6.805043	0.013215859	AKT3 CDKN2D PLK2 GABARAPL2 MAPK14 GADD45A GABARAPL1 PRMT1 IL7R FOXO4 GADD45B NLK PRKAA2 PRKAG1 MAPK8 S1PR4	10000 1032 10769 11345 1432 1647 23710 3276 3575 4303 4616 51701 5563 5571 5599 8698
antineoplastic-624659	-	PI3K-Akt signaling pathway	path:04151_7	9	5.983613	0.033039648	EFNA3 EFNA4 EFNA5 EGFR EPHA2 FGF21 NGF VEGFC PDGFD	1944 1945 1946 1956 1969 26291 4803 7424 80310
antineoplastic-624659	-	Focal adhesion	path:04510_14	9	8.307203	0	FLNA FLNB ITGAV ITGB1 PTK2 THBS1 TLN1 VASP CAPN2	2316 2317 3685 3688 5747 7057 7094 7408 824
antineoplastic-624659	-	ECM-receptor interaction	path:04512_6	3	6.667639	0.014317181	ITGAV ITGB1 THBS1	3685 3688 7057
antineoplastic-624659	-	Jak-STAT signaling pathway	path:04630_8	15	7.002188	0.008810573	EPOR IL19 IFNGR2 IL4 IL6ST IL7 IL7R IL10 IL12B IL15 LIF LIFR STAT1 CBL OSMR	2057 29949 3460 3565 3572 3574 3575 3586 3593 3600 3976 3977 6772 867 9180
antineoplastic-625543	-	Glycerophospholipid metabolism	path:00564_2	5	5.734767	0.045707915	PLD2 LPCAT2 DGKZ DGKE DGKI	5338 54947 8525 8526 9162
antineoplastic-625543	-	ErbB signaling pathway	path:04012_4	7	5.708408	0.046822742	CRK EGFR ERBB4 ABL1 ABL2 SHC1 STAT5A	1398 1956 2066 25 27 6464 6776
antineoplastic-625543	-	Rap1 signaling pathway	path:04015_9	10	6.880306	0.008918618	CRK EFNA5 EPHA2 FGF2 MET PLCB4 TEK VEGFA VEGFC PDGFD	1398 1946 1969 2247 4233 5332 7010 7422 7424 80310
antineoplastic-625543	-	cGMP-PKG signaling pathway	path:04022_6	9	6.125885	0.026755853	CREB3 ATP1B2 NPR2 PLCB4 PPP1CA PPP1CC PRKG2 CACNA1D CREB5	10488 482 4882 5332 5499 5501 5593 776 9586
antineoplastic-625543	-	FoxO signaling pathway	path:04068_7	13	6.059303	0.030100334	AKT3 CDKN2D PLK2 GADD45G GABARAP CSNK1E GADD45A FOXO4 PRKAB1 PRKAB2 RAG1 RBL2 BNIP3	10000 1032 10769 10912 11337 1454 1647 4303 5564 5565 5896 5934 664
antineoplastic-625543	-	mTOR signaling pathway	path:04150_3	9	6.947794	0.00780379	AKT3 EIF4B EIF4EBP1 MTOR HIF1A PRKCB RPS6KB1 RPS6KB2 VEGFA	10000 1975 1978 2475 3091 5579 6198 6199 7422
antineoplastic-625543	-	PI3K-Akt signaling pathway	path:04151_8	8	7.192623	0.006688963	AKT3 CREB3 PIK3R5 PPP2CB PPP2R1B PPP2R5A GNG12 CREB5	10000 10488 23533 5516 5519 5525 55970 9586
antineoplastic-625543	-	Hippo signaling pathway	path:04390_11	5	6.484966	0.016722408	SMAD2 SMAD4 TGFB2 TGFBR1 TGFBR2	4087 4089 7042 7046 7048
antineoplastic-625543	-	Focal adhesion	path:04510_15	14	9.304926	0	FLNB FLNC FYN ITGA5 ITGB3 ITGB5 PRKCB PTK2 THBS1 TLN1 TLN2 CAV1 CAV2 CAV3	2317 2318 2534 3678 3690 3693 5579 5747 7057 7094 83660 857 858 859
antineoplastic-625543	-	ECM-receptor interaction	path:04512_7	4	6.685514	0.013377926	ITGAV ITGB1 ITGB3 THBS1	3685 3688 3690 7057
antineoplastic-625543	-	Fc gamma R-mediated phagocytosis	path:04666_2	5	6.690343	0.013377926	AKT3 PLD2 RPS6KB1 RPS6KB2 SYK	10000 5338 6198 6199 6850
antineoplastic-625543	-	Dopaminergic synapse	path:04728_7	7	5.98185	0.034559643	CREB3 PPP3CB PPP3CC PRKCB CALM1 CAMK2D CREB5	10488 5532 5533 5579 801 817 9586
antineoplastic-625543	-	GnRH signaling pathway	path:04912_2	5	5.939006	0.03567447	PTK2B GNAQ PLCB4 PLD2 PRKCB	2185 2776 5332 5338 5579
antineoplastic-630680	-	Purine metabolism	path:00230_18	7	7.348907	0.005555556	ADCY5 ADCY4 GUCY1A2 NT5E POLR1D PDE8A PDE8B	111 196883 2977 4907 51082 5151 8622
antineoplastic-630680	-	Pyrimidine metabolism	path:00240_16	9	6.884563	0.014444444	CTPS1 AK9 POLR2D POLR2E POLR2H POLD4 RRM2 POLR3D ENTPD4	1503 221264 5433 5434 5437 57804 6241 661 9583
antineoplastic-630680	-	Rap1 signaling pathway	path:04015_10	15	6.159929	0.036666667	CRK EFNA1 EFNA2 FGF2 FGF11 FGFR1 FLT4 FGF20 FGF21 ANGPT2 IGF1R ANGPT4 PLCB2 VEGFA FGF23	1398 1942 1943 2247 2256 2260 2324 26281 26291 285 3480 51378 5330 7422 8074
antineoplastic-630680	-	Calcium signaling pathway	path:04020_10	10	6.045203	0.042222222	ATP2B3 CALML5 PLCB2 PRKCG RYR1 RYR2 TNNC1 VDAC1 CALML3 SLC25A31	492 51806 5330 5582 6261 6262 7134 7416 810 83447
antineoplastic-630680	-	cGMP-PKG signaling pathway	path:04022_7	11	6.774746	0.02	MYL9 CREB1 ATF2 KCNU1 ATP1B4 GUCY1A2 ATP1B3 PDE3A PLCB2 PPP1CB PRKG2	10398 1385 1386 157855 23439 2977 483 5139 5330 5500 5593
antineoplastic-630680	-	PI3K-Akt signaling pathway	path:04151_9	8	5.896005	0.047777778	AKT3 CREB1 ATF2 NR4A1 PIK3CA PPP2R2A PPP2R5A PPP2R5D	10000 1385 1386 3164 5290 5520 5525 5528
antineoplastic-630680	-	Jak-STAT signaling pathway	path:04630_9	8	5.958962	0.043333333	IFNGR1 IL2 IL9 IL11RA JAK3 IL22 IL21 SOCS1	3459 3558 3578 3590 3718 50616 59067 8651
antineoplastic-630680	-	Circadian entrainment	path:04713_6	9	7.022608	0.008888889	ADCY5 ADCY7 CREB1 ADCY4 GNB2 GNGT2 MTNR1B PRKX RPS6KA5	111 113 1385 196883 2783 2793 4544 5613 9252
antineoplastic-630680	-	Retrograde endocannabinoid signaling	path:04723_5	8	6.35917	0.03	ADCY5 CNR1 MAPK14 ADCY4 GNG4 GNGT2 MAPK9 MAPK10	111 1268 1432 196883 2786 2793 5601 5602
antineoplastic-630680	-	Serotonergic synapse	path:04726_5	8	6.424421	0.028888889	ADCY5 GNG4 GNGT2 HTR1B HTR1E HTR2A PLCB2 PTGS2	111 2786 2793 3351 3354 3356 5330 5743
antineoplastic-630680	-	Dopaminergic synapse	path:04728_8	7	6.505005	0.028888889	CREB1 ATF2 ATF6B CALML5 PLCB2 PRKCG CALML3	1385 1386 1388 51806 5330 5582 810
antineoplastic-630680	-	Oxytocin signaling pathway	path:04921_5	6	6.091781	0.041111111	ADCY5 ADCY4 GNAO1 OXTR PIK3CA PLCB2	111 196883 2775 5021 5290 5330
antineoplastic-633273	-	Purine metabolism	path:00230_19	12	5.931943	0.042128603	AK5 ZNRD1 ITPA ENTPD8 NPR2 NT5E POLR1D PDE6B POLR2A POLR2G POLR2I POLR3E	26289 30834 3704 377841 4882 4907 51082 5158 5430 5436 5438 55718
antineoplastic-633273	-	Ras signaling pathway	path:04014_7	8	6.238255	0.027716186	AKT3 ABL2 PIK3CG RALGDS RRAS RASSF5 SYNGAP1 RIN1	10000 27 5294 5900 6237 83593 8831 9610
antineoplastic-633273	-	Rap1 signaling pathway	path:04015_11	10	7.823514	0.002217295	CRK EGFR EPHA2 FGF2 FGF5 IGF1 MET PLCB4 PDGFC VEGFC	1398 1956 1969 2247 2250 3479 4233 5332 56034 7424
antineoplastic-633273	-	Chemokine signaling pathway	path:04062_9	7	6.582758	0.012195122	AKT3 GNB3 GNG11 PIK3CG PLCB4 PRKCB GNG12	10000 2784 2791 5294 5332 5579 55970
antineoplastic-633273	-	FoxO signaling pathway	path:04068_8	12	6.558703	0.012195122	AKT3 CDKN2B CDKN2D PLK2 FBXO32 CSNK1E GADD45A IL7R FOXO4 PRKAB1 PRKAB2 BNIP3	10000 1030 1032 10769 114907 1454 1647 3575 4303 5564 5565 664
antineoplastic-633273	-	PI3K-Akt signaling pathway	path:04151_10	8	6.991633	0.00886918	AKT3 CREB3 HSP90AA1 PIK3CG PPP2R1B PPP2R5B PPP2R5C CREB5	10000 10488 3320 5294 5519 5526 5527 9586
antineoplastic-633273	-	Focal adhesion	path:04510_16	10	9.937254	0	FLNB ITGA5 ITGB1 PRKCB PXN THBS1 TLN1 CAV1 CAV2 CAV3	2317 3678 3688 5579 5829 7057 7094 857 858 859
antineoplastic-633273	-	Platelet activation	path:04611_2	4	5.939913	0.042128603	AKT3 GNAI2 ITGB1 PIK3CG	10000 2771 3688 5294
antineoplastic-633273	-	Fc gamma R-mediated phagocytosis	path:04666_3	7	6.276823	0.026607539	AKT3 PIK3CG PLD2 RPS6KB1 RPS6KB2 SYK SPHK1	10000 5294 5338 6198 6199 6850 8877
antineoplastic-633273	-	Dopaminergic synapse	path:04728_9	10	6.159422	0.035476718	CREB3 GNAQ GNB3 GNG11 PLCB4 PRKCA PRKCB GNG12 PRKX CREB5	10488 2776 2784 2791 5332 5578 5579 55970 5613 9586
antineoplastic-633273	-	GnRH signaling pathway	path:04912_3	3	6.143421	0.036585366	PLCB4 PLD2 PRKCB	5332 5338 5579
antineoplastic-633273	-	Small cell lung cancer	path:05222_2	3	5.933883	0.042128603	ITGAV ITGB1 PTK2	3685 3688 5747
antineoplastic-637578	-	Rap1 signaling pathway	path:04015_12	12	6.022948	0.023153252	CRK EGF EGFR FGF2 FGF3 FGF5 IGF1 MET PDGFB PDGFC VEGFA VEGFC	1398 1950 1956 2247 2248 2250 3479 4233 5155 56034 7422 7424
antineoplastic-637578	-	Calcium signaling pathway	path:04020_11	11	6.655905	0.01323043	PPIF PTK2B ITPKA ATP2A2 ATP2A3 P2RX5 P2RX7 CALML5 PRKCB RYR1 P2RX6	10105 2185 3706 488 489 5026 5027 51806 5579 6261 9127
antineoplastic-637578	-	HIF-1 signaling pathway	path:04066_5	10	5.554473	0.049614112	EGF EGFR ENO3 HIF1A HMOX1 NFKB1 PFKFB3 EGLN1 VEGFA VHL	1950 1956 2027 3091 3162 4790 5209 54583 7422 7428
antineoplastic-637578	-	PI3K-Akt signaling pathway	path:04151_11	4	7.630613	0.002205072	ITGA5 ITGAV ITGB3 ITGB5	3678 3685 3690 3693
antineoplastic-637578	-	Adrenergic signaling in cardiomyocytes	path:04261_4	10	5.672315	0.040793826	CACNG2 CACNG5 CALML5 PPP1CA PPP1CC PPP2R1B PPP2R2C CACNB3 CAMK2D CAMK2G	10369 27091 51806 5499 5501 5519 5522 784 817 818
antineoplastic-637578	-	Focal adhesion	path:04510_17	8	8.193115	0	ITGAV ITGB1 ITGB3 ITGB5 PTK2 PXN CAV1 CAV2	3685 3688 3690 3693 5747 5829 857 858
antineoplastic-637578	-	ECM-receptor interaction	path:04512_8	3	5.854419	0.034178611	ITGAV ITGB1 ITGB3	3685 3688 3690
antineoplastic-637578	-	Adherens junction	path:04520_2	3	5.55814	0.048511577	RAC1 RAC2 ACTB	5879 5880 60
antineoplastic-637578	-	Regulation of actin cytoskeleton	path:04810_9	6	7.058273	0.009922822	CRK ITGA5 ITGAV ITGB3 ITGB5 BCAR1	1398 3678 3685 3690 3693 9564
antineoplastic-638479	-	Purine metabolism	path:00230_20	21	7.596348	0.001117318	POLR3G ADCY3 ADCY7 ADCY9 POLR3H GUCY2F ZNRD1 NUDT2 ITPA POLR1D PDE2A PDE6B POLR2C POLR2F POLR2I POLR3B ADCY10 POLR1E POLR3D POLR1B POLR1C	10622 109 113 115 171568 2986 30834 318 3704 51082 5138 5158 5432 5435 5438 55703 55811 64425 661 84172 9533
antineoplastic-638479	-	Pyrimidine metabolism	path:00240_17	14	7.039064	0.001117318	POLR3G ZNRD1 NUDT2 POLR1D POLR2C POLR2D POLR2F POLR2I POLR3E POLR1E POLR3D POLR1B PNPT1 POLR1C	10622 30834 318 51082 5432 5433 5435 5438 55718 64425 661 84172 87178 9533
antineoplastic-638479	-	MAPK signaling pathway	path:04010_6	9	5.687364	0.046927374	MAPK14 DUSP1 DUSP4 DUSP6 DUSP9 ELK1 MAPK1 MAPK10 PTPN5	1432 1843 1846 1848 1852 2002 5594 5602 84867
antineoplastic-638479	-	HIF-1 signaling pathway	path:04066_6	12	6.068167	0.026815642	EGLN2 ANGPT2 HIF1A HK2 HK3 PDK1 PFKL PGK1 RELA TFRC TIMP1 VHL	112398 285 3091 3099 3101 5163 5211 5230 5970 7037 7076 7428
antineoplastic-638479	-	FoxO signaling pathway	path:04068_9	9	6.360885	0.01452514	AKT3 AKT1 AKT2 FOXO4 PDPK1 PIK3R1 PIK3R2 IRS4 HOMER1	10000 207 208 4303 5170 5295 5296 8471 9456
antineoplastic-638479	-	Phosphatidylinositol signaling system	path:04070_6	15	6.01504	0.029050279	DGKA INPP5A INPP5B INPP5D ITPR3 MTM1 PLCE1 PIK3R1 PIK3R2 PIP4K2A PLCB3 PLCB4 PIP4K2B DGKZ PLCZ1	1606 3632 3633 3635 3710 4534 51196 5295 5296 5305 5331 5332 8396 8525 89869
antineoplastic-638479	-	Wnt signaling pathway	path:04310_3	5	7.189248	0.001117318	PLCB3 PLCB4 PPP3R1 PRKCA CAMK2A	5331 5332 5534 5578 815
antineoplastic-638479	-	Focal adhesion	path:04510_18	4	6.36151	0.01452514	FLNA FLNB ITGB1 THBS1	2316 2317 3688 7057
antineoplastic-638479	-	Thyroid hormone signaling pathway	path:04919_3	8	5.845683	0.039106145	AKT3 HIF1A ATP1A4 PDPK1 PIK3R1 PIK3R2 BAD THRA	10000 3091 480 5170 5295 5296 572 7067
antineoplastic-638479	-	Oxytocin signaling pathway	path:04921_6	7	5.891745	0.03575419	MYL9 MYLK PPP3R1 PRKCA CALM1 CALML3 CAMK2A	10398 4638 5534 5578 801 810 815
antineoplastic-638479	-	Glucagon signaling pathway	path:04922_2	6	5.855989	0.039106145	CALML5 PHKA2 PHKB PRKX PYGM CALML3	51806 5256 5257 5613 5837 810
antineoplastic-639828	-	Pyrimidine metabolism	path:00240_18	20	7.601579	0.009163803	POLR3F POLR3C DUT NME1 NME4 POLR1D POLR3K POLE3 POLA1 POLR2A POLR2D POLR2G PRIM1 RRM1 RRM2 POLR1E TK2 DCTPP1 POLR1C ENTPD3	10621 10623 1854 4830 4833 51082 51728 54107 5422 5430 5433 5436 5557 6240 6241 64425 7084 79077 9533 956
antineoplastic-639828	-	Fanconi anemia pathway	path:03460_1	8	6.351074	0.041237113	FANCD2 FANCE FANCF FAN1 MLH1 FANCM BRCA2 BRIP1	2177 2178 2188 22909 4292 57697 675 83990
antineoplastic-639828	-	Chemokine signaling pathway	path:04062_10	6	6.518965	0.035509737	CXCR6 GRK2 GRK3 GNAI1 CXCL1 ARRB2	10663 156 157 2770 2919 409
antineoplastic-639828	-	Focal adhesion	path:04510_19	7	7.384685	0.011454754	ITGAV ITGB1 ITGB3 THBS1 CAV1 CAV2 CAV3	3685 3688 3690 7057 857 858 859
antineoplastic-639828	-	Thyroid hormone signaling pathway	path:04919_4	6	6.395082	0.040091638	CTNNB1 HDAC1 PIK3CG RXRA THRA THRB	1499 3065 5294 6256 7067 7068
antineoplastic-641296	-	Glycerophospholipid metabolism	path:00564_3	10	6.899337	0.00780379	CDS1 DGKA DGKG DGKQ LPIN1 PLD2 CRLS1 DGKZ DGKE DGKI	1040 1606 1608 1609 23175 5338 54675 8525 8526 9162
antineoplastic-641296	-	Ras signaling pathway	path:04014_8	9	5.890426	0.044593088	CSF1 EFNA5 EGF FGF2 FGF5 FGFR3 IGF1 MET SHC1	1435 1946 1950 2247 2250 2261 3479 4233 6464
antineoplastic-641296	-	Calcium signaling pathway	path:04020_12	9	5.90824	0.043478261	PPIF ITPKA ATP2A2 ATP2A3 P2RX4 PRKCB TNNC1 VDAC1 CALM1	10105 3706 488 489 5025 5579 7134 7416 801
antineoplastic-641296	-	cGMP-PKG signaling pathway	path:04022_8	9	6.021326	0.040133779	MRVI1 ATP1A1 ATP1B3 PLCB2 PLCB4 PPP1CC PRKG2 BAD CREB5	10335 476 483 5330 5332 5501 5593 572 9586
antineoplastic-641296	-	Chemokine signaling pathway	path:04062_11	9	7.053398	0.005574136	RASGRP2 GNB3 GNG3 GNG4 GNG11 GNG13 PIK3CG PLCB4 GNG12	10235 2784 2785 2786 2791 51764 5294 5332 55970
antineoplastic-641296	-	FoxO signaling pathway	path:04068_10	7	6.013774	0.041248606	AKT3 AGAP2 PDPK1 PIK3CG SGK1 HOMER3 HOMER1	10000 116986 5170 5294 6446 9454 9456
antineoplastic-641296	-	Phosphatidylinositol signaling system	path:04070_7	14	7.470162	0.004459309	CDS1 DGKA DGKG DGKQ ITPKA PIK3CG PIP4K2A PLCB2 PLCB4 IMPAD1 PI4K2B DGKZ DGKE DGKI	1040 1606 1608 1609 3706 5294 5305 5330 5332 54928 55300 8525 8526 9162
antineoplastic-641296	-	Sphingolipid signaling pathway	path:04071_3	7	6.501658	0.02006689	AKT3 PDPK1 PIK3CG PLD1 PLD2 RAC1 SPHK1	10000 5170 5294 5337 5338 5879 8877
antineoplastic-641296	-	PI3K-Akt signaling pathway	path:04151_12	5	7.332108	0.004459309	ITGA2 ITGAV ITGB1 ITGB3 PTK2	3673 3685 3688 3690 5747
antineoplastic-641296	-	AMPK signaling pathway	path:04152_3	6	5.999206	0.041248606	AKT3 LIPE PFKFB4 PRKAB1 RPS6KB2 TSC2	10000 3991 5210 5564 6199 7249
antineoplastic-641296	-	Platelet activation	path:04611_3	7	5.976015	0.043478261	AKT3 RASGRP2 ITGB1 PIK3CG PLCB3 PLCB4 RAP1B	10000 10235 3688 5294 5331 5332 5908
antineoplastic-641296	-	Cholinergic synapse	path:04725_8	9	6.65296	0.015607581	GNB5 ADCY9 GNB3 GNG11 GNG13 PIK3CG GNG12 PRKX CAMK4	10681 115 2784 2791 51764 5294 55970 5613 814
antineoplastic-641296	-	GABAergic synapse	path:04727_5	6	6.162114	0.034559643	ADCY9 GABBR1 GNB3 GNG11 GNG13 GNG12	115 2550 2784 2791 51764 55970
antineoplastic-641296	-	Insulin signaling pathway	path:04910_7	7	6.522422	0.02006689	AKT3 PDPK1 PPP1CA PPP1CC BAD TSC2 CALM1	10000 5170 5499 5501 572 7249 801
antineoplastic-641296	-	Pathways in cancer	path:05200_8	7	5.925115	0.043478261	NRAS PIK3CG PRKCB MAPK9 MAPK10 RAC1 RALGDS	4893 5294 5579 5601 5602 5879 5900
antineoplastic-641296	-	Choline metabolism in cancer	path:05231_4	6	6.071016	0.037904125	NRAS PLD2 MAPK9 RAF1 RALGDS PLA2G4C	4893 5338 5601 5894 5900 8605
antineoplastic-641297	-	Glycerolipid metabolism	path:00561_1	9	6.029685	0.036666667	DGKA DGKG DGKQ AGK PNPLA3 DGKZ DGKE DGAT1 DGKI	1606 1608 1609 55750 80339 8525 8526 8694 9162
antineoplastic-641297	-	Glycerophospholipid metabolism	path:00564_4	10	6.782245	0.012222222	CDS1 PLD4 DGKA DGKG DGKQ PLD2 PLA2G12A DGKZ DGKE DGKI	1040 122618 1606 1608 1609 5338 81579 8525 8526 9162
antineoplastic-641297	-	Ras signaling pathway	path:04014_9	8	6.721026	0.013333333	RASGRP2 MRAS ABL2 NRAS PIK3CG RAB5C RASAL2 RIN1	10235 22808 27 4893 5294 5878 9462 9610
antineoplastic-641297	-	Rap1 signaling pathway	path:04015_13	10	6.619928	0.013333333	CRK CSF1 EFNA5 FGF2 FGF5 FGFR3 IGF1 MET PLCB4 PDGFD	1398 1435 1946 2247 2250 2261 3479 4233 5332 80310
antineoplastic-641297	-	Chemokine signaling pathway	path:04062_12	9	6.819353	0.01	AKT3 RASGRP2 GNG3 GNG11 NRAS PIK3CG PLCB2 PLCB4 GNG12	10000 10235 2785 2791 4893 5294 5330 5332 55970
antineoplastic-641297	-	FoxO signaling pathway	path:04068_11	21	6.063567	0.035555556	AKT3 PLK4 PLK2 GABARAP FBXO32 CSNK1E GADD45A FOXO1 GABARAPL1 PRMT1 ATM PCK1 PRKAB1 PRKAB2 MAPK10 MAPK13 RAG2 CCND1 SGK1 BNIP3 CCNG2	10000 10733 10769 11337 114907 1454 1647 2308 23710 3276 472 5105 5564 5565 5602 5603 5897 595 6446 664 901
antineoplastic-641297	-	Phosphatidylinositol signaling system	path:04070_8	7	6.755001	0.013333333	CDS1 DGKG DGKQ PLCB4 DGKZ DGKE DGKI	1040 1608 1609 5332 8525 8526 9162
antineoplastic-641297	-	Adrenergic signaling in cardiomyocytes	path:04261_5	7	5.84279	0.044444444	PPP1CC PPP2R1B PPP2R3A PPP2R5C PRKX CACNA1F CAMK2D	5501 5519 5523 5527 5613 778 817
antineoplastic-641297	-	Focal adhesion	path:04510_20	3	8.200597	0	FLNA ITGB5 TLN1	2316 3693 7094
antineoplastic-641297	-	Fc gamma R-mediated phagocytosis	path:04666_4	7	5.799223	0.045555556	AKT3 PIK3CG PLD2 RPS6KB2 SYK VAV2 PIP5K1B	10000 5294 5338 6199 6850 7410 8395
antineoplastic-641297	-	Cholinergic synapse	path:04725_9	7	6.102018	0.033333333	AKT3 ADCY9 GNG3 GNG11 NRAS PIK3CG GNG12	10000 115 2785 2791 4893 5294 55970
antineoplastic-641318	-	Purine metabolism	path:00230_21	3	5.740548	0.033370412	PDE9A PDE1B ENTPD6	5152 5153 955
antineoplastic-641318	-	MAPK signaling pathway	path:04010_7	6	5.995616	0.025583982	DDIT3 DUSP2 DUSP5 ELK1 MAPK11 PTPRR	1649 1844 1847 2002 5600 5801
antineoplastic-641318	-	p53 signaling pathway	path:04115_3	8	6.489105	0.014460512	CDKN1A CHEK1 SERPINB5 TP53 TSC2 SESN2 PPM1D EI24	1026 1111 5268 7157 7249 83667 8493 9538
antineoplastic-641318	-	PI3K-Akt signaling pathway	path:04151_13	3	6.664435	0.011123471	ITGA5 ITGAV ITGB1	3678 3685 3688
antineoplastic-641318	-	Adrenergic signaling in cardiomyocytes	path:04261_6	8	5.69341	0.033370412	PPP1CA PPP1CB PPP2CA PPP2R1B PPP2R2C PPP2R5E CACNB4 CAMK2D	5499 5500 5515 5519 5522 5529 785 817
antineoplastic-641318	-	Focal adhesion	path:04510_21	6	5.6018	0.040044494	ITGA2B ITGA5 ITGAV ITGB1 VASP TLN2	3674 3678 3685 3688 7408 83660
antineoplastic-641318	-	Jak-STAT signaling pathway	path:04630_10	8	7.219038	0.006674082	IL6ST IL7 IL10RA IL11RA IL15 IL22 IL26 IL21	3572 3574 3587 3590 3600 50616 55801 59067
antineoplastic-641318	-	Thyroid hormone signaling pathway	path:04919_5	7	6.199269	0.0189099	PIK3R5 HIF1A FXYD2 PIK3CG SRC THRA THRB	23533 3091 486 5294 6714 7067 7068
antineoplastic-641318	-	Pathways in cancer	path:05200_9	8	5.908383	0.027808676	CDK4 ETS1 FOS CXCL8 MMP1 NFKB1 CCND1 VEGFA	1019 2113 2353 3576 4312 4790 595 7422
antineoplastic-641319	-	Purine metabolism	path:00230_22	8	7.644552	0.003311258	ADCY6 ADCY9 POLR3H AK1 ZNRD1 NME4 PDE9A PDE1B	112 115 171568 203 30834 4833 5152 5153
antineoplastic-641319	-	Pyrimidine metabolism	path:00240_19	8	6.176685	0.026490066	POLR3H ZNRD1 NME4 NT5E CMPK1 POLR2K POLR1E PNPT1	171568 30834 4833 4907 51727 5440 64425 87178
antineoplastic-641319	-	Inositol phosphate metabolism	path:00562_2	9	5.972658	0.036423841	INPP5J INPP5A ITPKA PLCE1 PIK3CG PLCB2 PLCB4 PIP4K2C ITPKC	27124 3632 3706 51196 5294 5330 5332 79837 80271
antineoplastic-641319	-	Rap1 signaling pathway	path:04015_14	15	6.182725	0.026490066	EFNA5 EGFR EPHA2 FGF6 FGFR2 FGFR4 ANGPT1 KITLG NGF PDGFA PDGFB PLCB2 PLCB4 PDGFC TEK	1946 1956 1969 2251 2263 2264 284 4254 4803 5154 5155 5330 5332 56034 7010
antineoplastic-641319	-	cAMP signaling pathway	path:04024_2	6	5.894193	0.041942605	RAPGEF3 PLCE1 RAP1B RRAS ARAP3 VAV1	10411 51196 5908 6237 64411 7409
antineoplastic-641319	-	Phosphatidylinositol signaling system	path:04070_9	11	6.25661	0.023178808	DGKA INPP5J INPP5A ITPKA ITPR3 PLCE1 PIK3CG PLCB2 PLCB4 PIP4K2C ITPKC	1606 27124 3632 3706 3710 51196 5294 5330 5332 79837 80271
antineoplastic-641319	-	PI3K-Akt signaling pathway	path:04151_14	6	6.478037	0.015452539	ITGA5 ITGAV ITGB1 ITGB3 PTK2 THBS1	3678 3685 3688 3690 5747 7057
antineoplastic-641319	-	Hippo signaling pathway	path:04390_12	4	6.80516	0.008830022	RASSF1 PPP2R1A PPP2R1B STK3	11186 5518 5519 6788
antineoplastic-641319	-	Focal adhesion	path:04510_22	10	7.781502	0.003311258	FLNA FLNB ITGA5 ITGB1 ITGB5 PTK2 THBS1 TLN2 CAV2 CAV3	2316 2317 3678 3688 3693 5747 7057 83660 858 859
antineoplastic-641319	-	Jak-STAT signaling pathway	path:04630_11	8	6.020991	0.035320088	CSF2 IL2RA IL2RG IL10RA LIF MPL OSM CBL	1437 3559 3561 3587 3976 4352 5008 867
antineoplastic-641319	-	Circadian entrainment	path:04713_7	10	6.181235	0.026490066	ADCY6 ADCY9 GNAI1 GNB3 GNG11 GNGT1 PLCB2 PLCB4 GNG12 GNB4	112 115 2770 2784 2791 2792 5330 5332 55970 59345
antineoplastic-641319	-	Dopaminergic synapse	path:04728_10	8	6.080842	0.034216336	GNG11 GNGT2 ITPR3 PLCB2 PLCB4 PRKCB GNG12 GNB4	2791 2793 3710 5330 5332 5579 55970 59345
antineoplastic-641319	-	Insulin secretion	path:04911_1	8	5.695328	0.049668874	CREB3 ADCY6 ADCY9 ITPR3 ATF4 PRKACA CACNA1S CREB5	10488 112 115 3710 468 5566 779 9586
antineoplastic-641454	-	Pyrimidine metabolism	path:00240_20	13	6.890386	0.0110011	POLR3F POLD3 CANT1 POLR3H NME7 NME4 POLD2 POLR2D POLR2G POLD4 POLR1B ENTPD6 ENTPD5	10621 10714 124583 171568 29922 4833 5425 5433 5436 57804 84172 955 957
antineoplastic-641454	-	cAMP signaling pathway	path:04024_3	9	6.426662	0.02530253	CHRM1 CHRM2 HCAR1 GNAI2 HTR1D HTR6 SUCNR1 TSHR VIPR2	1128 1129 27198 2771 3352 3362 56670 7253 7434
antineoplastic-641454	-	Jak-STAT signaling pathway	path:04630_12	6	7.077603	0.00660066	IFNLR1 EPOR IFNGR1 IFNGR2 LIF IL22RA1	163702 2057 3459 3460 3976 58985
antineoplastic-642198	-	cAMP signaling pathway	path:04024_4	9	6.804247	0.014689266	ADCY6 DRD1 HCAR1 GNAI2 HTR1D HTR6 PDE4A CALML5 CAMK4	112 1812 27198 2771 3352 3362 5141 51806 814
antineoplastic-642198	-	Chemokine signaling pathway	path:04062_13	8	7.733102	0.004519774	ADCY6 PIK3R5 GNAI2 GNB1 GNG7 CXCL2 SRC CXCR4	112 23533 2771 2782 2788 2920 6714 7852
antineoplastic-642198	-	Phosphatidylinositol signaling system	path:04070_10	9	5.96401	0.046327684	PIKFYVE PIK3R5 INPP4A PLCE1 PIK3C2A PIK3C2B PTEN PIP4K2C PIP5K1A	200576 23533 3631 51196 5286 5287 5728 79837 8394
antineoplastic-642198	-	Cell cycle	path:04110_2	10	5.914261	0.047457627	MAD2L2 ANAPC13 SFN PLK1 YWHAG YWHAZ CDC14A CCNB2 CDC25B CDC25C	10459 25847 2810 5347 7532 7534 8556 9133 994 995
antineoplastic-642198	-	Retrograde endocannabinoid signaling	path:04723_6	7	6.087855	0.038418079	ADCY6 GNAI2 GNB1 GNG7 MAPK11 MAPK9 MAPK13	112 2771 2782 2788 5600 5601 5603
antineoplastic-642198	-	Serotonergic synapse	path:04726_6	6	6.758026	0.014689266	GNAI2 GNB1 GNG7 HTR1D HTR6 HTR7	2771 2782 2788 3352 3362 3363
antineoplastic-642294	-	Purine metabolism	path:00230_23	7	5.553888	0.045353982	ADCY7 NPR2 PDE6B POLR2G POLR2L POLR3E POLR1B	113 4882 5158 5436 5441 55718 84172
antineoplastic-642294	-	Calcium signaling pathway	path:04020_13	8	8.502748	0	GRIN2A ATP2A1 P2RX7 TNNC2 CALM1 CACNA1H P2RX6 ORAI3	2903 487 5027 7125 801 8912 9127 93129
antineoplastic-642294	-	Chemokine signaling pathway	path:04062_14	9	6.567971	0.008849558	AKT1 GNAI3 GNB3 GNG3 GNG5 NRAS PIK3CA PIK3R2 PREX1	207 2773 2784 2785 2787 4893 5290 5296 57580
antineoplastic-642294	-	p53 signaling pathway	path:04115_4	9	5.709753	0.039823009	CHEK1 BBC3 SFN RPRM SIAH1 TP53 SESN2 PPM1D EI24	1111 27113 2810 56475 6477 7157 83667 8493 9538
antineoplastic-642294	-	PI3K-Akt signaling pathway	path:04151_15	6	6.243718	0.014380531	AKT1 NRAS PIK3CA PIK3CB PIK3R1 PIK3R2	207 4893 5290 5291 5295 5296
antineoplastic-642294	-	Fc gamma R-mediated phagocytosis	path:04666_5	5	5.528914	0.047566372	AKT1 LAT PIK3R2 RPS6KB2 GAB2	207 27040 5296 6199 9846
antineoplastic-642294	-	Neurotrophin signaling pathway	path:04722_1	14	6.14332	0.01659292	AKT1 KRAS MAP3K3 NGFR NRAS PIK3CA PIK3CB PIK3R1 MAPK1 MAPK3 MAPK13 MAP2K2 MAPK12 BRAF	207 3845 4215 4804 4893 5290 5291 5295 5594 5595 5603 5605 6300 673
antineoplastic-642313	-	Rap1 signaling pathway	path:04015_15	21	5.736665	0.040044494	CSF1R EFNA5 FGF1 FGF2 FGFR1 FGFR3 FGFR4 FLT4 FGF20 FGF21 KDR KIT KITLG PDGFB PDGFRB PGF TEK VEGFC PDGFD FGF18 FGF17	1436 1946 2246 2247 2260 2261 2264 2324 26281 26291 3791 3815 4254 5155 5159 5228 7010 7424 80310 8817 8822
antineoplastic-642313	-	cGMP-PKG signaling pathway	path:04022_9	14	6.847684	0.005561735	CNGB1 ATF2 GTF2I KCNMB1 PPP1R12A ATP2B1 ATP2B2 PDE3B PPP1CC PRKG2 SLC8A3 VASP CACNA1F GTF2IRD1	1258 1386 2969 3779 4659 490 491 5140 5501 5593 6547 7408 778 9569
antineoplastic-642313	-	PI3K-Akt signaling pathway	path:04151_16	22	6.111961	0.023359288	CSF1R EFNA5 FGF1 FGF2 FGFR1 FGFR3 FGFR4 FLT4 FGF20 FGF21 GRB2 KDR KIT KITLG PDGFB PDGFRB PGF TEK VEGFC PDGFD FGF18 FGF17	1436 1946 2246 2247 2260 2261 2264 2324 26281 26291 2885 3791 3815 4254 5155 5159 5228 7010 7424 80310 8817 8822
antineoplastic-642313	-	AMPK signaling pathway	path:04152_4	4	6.251232	0.015572859	GYS1 GYS2 PRKAA1 ULK1	2997 2998 5562 8408
antineoplastic-642313	-	Hippo signaling pathway	path:04390_13	9	5.749947	0.040044494	FGF1 BBC3 PPP1CC PPP2CB PPP2R1A PPP2R2A PPP2R2B YWHAG BTRC	2246 27113 5501 5516 5518 5520 5521 7532 8945
antineoplastic-642314	-	Purine metabolism	path:00230_24	10	7.09889	0.006564551	NUDT2 POLR1D POLR2A POLR2C POLR2H POLR3B POLR3E POLR1E POLR3D PNPT1	318 51082 5430 5432 5437 55703 55718 64425 661 87178
antineoplastic-642314	-	Pyrimidine metabolism	path:00240_21	8	6.757084	0.009846827	NUDT2 POLR1D POLR2A POLR2C POLR3E POLR1E POLR3D PNPT1	318 51082 5430 5432 55718 64425 661 87178
antineoplastic-642314	-	p53 signaling pathway	path:04115_5	10	5.624112	0.042669584	GADD45A SERPINE1 ATR RRM2 ZMAT3 TP53 CASP3 CASP8 TNFRSF10B CCNG1	1647 5054 545 6241 64393 7157 836 841 8795 900
antineoplastic-642314	-	PI3K-Akt signaling pathway	path:04151_17	4	5.918581	0.02297593	ITGA2B ITGAV ITGB3 ITGB5	3674 3685 3690 3693
antineoplastic-642314	-	AMPK signaling pathway	path:04152_5	8	6.504695	0.013129103	ADRA1A GYS1 LIPE PFKFB1 PRKAG3 PRKAA1 PRKAA2 STK11	148 2997 3991 5207 53632 5562 5563 6794
antineoplastic-642314	-	Wnt signaling pathway	path:04310_4	6	6.091481	0.020787746	NFATC3 PLCB4 PPP3CC PRKCB PRKCG CAMK2A	4775 5332 5533 5579 5582 815
antineoplastic-642314	-	Focal adhesion	path:04510_23	5	6.857189	0.008752735	ILK ITGAV ITGB3 KDR PIK3CA	3611 3685 3690 3791 5290
antineoplastic-642314	-	ECM-receptor interaction	path:04512_9	3	5.843273	0.027352298	ITGA2B ITGAV ITGB3	3674 3685 3690
antineoplastic-642314	-	Dopaminergic synapse	path:04728_11	8	5.637397	0.0404814	CREB3 ATF2 PLCB4 PRKACA PRKCB PRKCG CALM1 CAMK2A	10488 1386 5332 5566 5579 5582 801 815
antineoplastic-642314	-	Oxytocin signaling pathway	path:04921_7	7	5.55423	0.049234136	MYLK PPP3CC PRKAA1 PRKAA2 PRKCG CALM3 CAMK2A	4638 5533 5562 5563 5582 808 815
antineoplastic-642315	-	Purine metabolism	path:00230_25	10	7.374451	0.002214839	ADCY7 NUDT2 NME3 POLR1D PKM POLA1 PRIM2 POLR3B POLR3E POLR1E	113 318 4832 51082 5315 5422 5558 55703 55718 64425
antineoplastic-642315	-	Pyrimidine metabolism	path:00240_22	9	6.953109	0.004429679	NUDT2 NME1 POLR1D POLR2C POLR2J POLR2L POLR3B POLR3E POLR1E	318 4830 51082 5432 5439 5441 55703 55718 64425
antineoplastic-642315	-	Inositol phosphate metabolism	path:00562_3	8	5.973716	0.021040975	INPP5K PIK3CA PIP4K2A PLCB3 PLCB4 PLCG2 PIP5K1B PIP4K2B	51763 5290 5305 5331 5332 5336 8395 8396
antineoplastic-642315	-	PPAR signaling pathway	path:03320_2	7	5.645325	0.028792913	ACSL3 PDPK1 PPARD RXRB UBC ACSBG2 ACOX3	2181 5170 5467 6257 7316 81616 8310
antineoplastic-642315	-	Chemokine signaling pathway	path:04062_15	9	7.285012	0.002214839	AKT1 GNAI3 GNG3 GNG5 PIK3CA PIK3R2 PLCB3 PLCB4 PRKCB	207 2773 2785 2787 5290 5296 5331 5332 5579
antineoplastic-642315	-	Phosphatidylinositol signaling system	path:04070_11	17	7.400292	0.002214839	CDIPT ITPR3 MTM1 INPP5K PIK3CA PIK3R1 PIK3R2 PI4KA PI4KB PIP4K2A PLCB3 PLCB4 PLCG2 PIP4K2B DGKZ DGKE CDS2	10423 3710 4534 51763 5290 5295 5296 5297 5298 5305 5331 5332 5336 8396 8525 8526 8760
antineoplastic-642315	-	Sphingolipid signaling pathway	path:04071_4	7	5.893554	0.024363234	MAPK14 CTSD AKT1 PDPK1 PPP2CA PPP2R2A PPP2R5C	1432 1509 207 5170 5515 5520 5527
antineoplastic-642315	-	AMPK signaling pathway	path:04152_6	8	5.532942	0.03654485	ADRA1A GYS2 ACACA LIPE PFKFB4 PRKAA1 PRKAA2 PRKAG1	148 2998 31 3991 5210 5562 5563 5571
antineoplastic-642315	-	Focal adhesion	path:04510_24	5	6.286069	0.014396456	PAK4 MYLK RAC1 MYLK3 CDC42	10298 4638 5879 91807 998
antineoplastic-642315	-	Platelet activation	path:04611_4	8	6.263177	0.014396456	RASGRP1 ADCY7 GNAI3 PIK3CA PLCB3 PLCG2 PRKCZ RAP1A	10125 113 2773 5290 5331 5336 5590 5906
antineoplastic-642315	-	B cell receptor signaling pathway	path:04662_1	6	5.563922	0.034330011	BLNK PLCG2 PRKCB RAC1 VAV1 CARD11	29760 5336 5579 5879 7409 84433
antineoplastic-642315	-	Fc epsilon RI signaling pathway	path:04664_1	8	6.160848	0.015503876	AKT1 PDPK1 PIK3CA PIK3R1 PIK3R2 PLCG2 PRKCB RAC1	207 5170 5290 5295 5296 5336 5579 5879
antineoplastic-642315	-	Circadian entrainment	path:04713_8	13	6.782462	0.005537099	ADCY7 ADCYAP1R1 GNAI3 GNB1 GNG3 GNG5 PLCB3 PLCB4 PRKCB PRKCG MAPK1 MAPK3 CAMK2A	113 117 2773 2782 2785 2787 5331 5332 5579 5582 5594 5595 815
antineoplastic-642315	-	Cholinergic synapse	path:04725_10	10	6.044961	0.018826135	ADCY7 AKT1 GNAI3 GNB1 GNG3 GNG5 HRAS KRAS PIK3R1 PIK3R2	113 207 2773 2782 2785 2787 3265 3845 5295 5296
antineoplastic-642315	-	Serotonergic synapse	path:04726_7	8	5.548292	0.035437431	GNAI3 GNB1 GNG3 GNG5 HTR5A ITPR3 PLCB3 PLCB4	2773 2782 2785 2787 3361 3710 5331 5332
antineoplastic-642315	-	Dopaminergic synapse	path:04728_12	11	5.900638	0.024363234	FOS GNAI3 GNB1 GNG3 GNG5 ITPR3 ATF4 PLCB3 PLCB4 PRKCB PRKCG	2353 2773 2782 2785 2787 3710 468 5331 5332 5579 5582
antineoplastic-642315	-	Insulin signaling pathway	path:04910_8	7	5.454533	0.043189369	AKT1 MTOR PDPK1 INPP5K PIK3CA PIK3CD PRKCZ	207 2475 5170 51763 5290 5293 5590
antineoplastic-642315	-	Thyroid hormone signaling pathway	path:04919_6	6	7.034527	0.004429679	ATP1A1 PIK3CA PRKCB MAPK1 MAP2K2 THRA	476 5290 5579 5594 5605 7067
antineoplastic-642315	-	Oxytocin signaling pathway	path:04921_8	4	6.259809	0.014396456	GNAI3 PLCB3 PRKCB PRKCG	2773 5331 5579 5582
antineoplastic-642315	-	Pathways in cancer	path:05200_10	6	6.083089	0.017718715	AKT1 MTOR HRAS PIK3CA PIK3CB PIK3R2	207 2475 3265 5290 5291 5296
antineoplastic-642315	-	Pancreatic cancer	path:05212_3	9	5.90092	0.024363234	AKT1 KRAS PIK3CA PIK3CB RAC1 RAF1 RALGDS RELA VEGFA	207 3845 5290 5291 5879 5894 5900 5970 7422
antineoplastic-642316	-	Purine metabolism	path:00230_26	9	8.399792	0.001113586	ADCY7 NUDT2 POLR2C POLR2E POLR3B POLR3E POLR1E POLR3D NTPCR	113 318 5432 5434 55703 55718 64425 661 84284
antineoplastic-642316	-	Pyrimidine metabolism	path:00240_23	9	8.066485	0.001113586	NUDT2 NME3 POLR2C POLR2E POLR3B POLR3E CTPS2 POLR1E POLR3D	318 4832 5432 5434 55703 55718 56474 64425 661
antineoplastic-642316	-	Calcium signaling pathway	path:04020_14	15	6.433421	0.020044543	PTK2B GRIN2D SLC25A5 ITPKA ATP2B1 ATP2B4 PRKCG RYR2 SLC8A2 VDAC3 CACNA1D ORAI2 ITPKC CACNA1H ORAI3	2185 2906 292 3706 490 493 5582 6262 6543 7419 776 80228 80271 8912 93129
antineoplastic-642316	-	Chemokine signaling pathway	path:04062_16	7	5.905953	0.042316258	AKT3 DOCK2 GNAI3 GNG11 PIK3R1 PIK3R2 SRC	10000 1794 2773 2791 5295 5296 6714
antineoplastic-642316	-	NF-kappa B signaling pathway	path:04064_2	10	5.945721	0.042316258	TNFRSF13C CSNK2A1 CSNK2B DDX58 IKBKB LTBR NFKBIA RELA MAP3K7 TRAF2	115650 1457 1460 23586 3551 4055 4792 5970 6885 7186
antineoplastic-642316	-	Sphingolipid signaling pathway	path:04071_5	6	6.417632	0.021158129	AKT2 MAP3K5 PPP2CB PPP2R2A PPP2R5D MAPK13	208 4217 5516 5520 5528 5603
antineoplastic-642316	-	PI3K-Akt signaling pathway	path:04151_18	8	6.559093	0.017817372	AKT2 FOXO3 IKBKB ATF4 PIK3R1 PIK3R2 PPP2CB PPP2R2A	208 2309 3551 468 5295 5296 5516 5520
antineoplastic-642316	-	AMPK signaling pathway	path:04152_7	7	5.820496	0.048997773	ADRA1A ACACA PFKFB1 PFKFB2 PRKAG1 STK11 MAP3K7	148 31 5207 5208 5571 6794 6885
antineoplastic-642316	-	Apoptosis	path:04210_1	7	6.095705	0.034521158	BIRC3 XIAP IKBKB NFKBIA BCL2 RELA BCL2L1	330 331 3551 4792 596 5970 598
antineoplastic-642316	-	Toll-like receptor signaling pathway	path:04620_1	7	6.007872	0.040089087	AKT3 AKT1 IKBKB IL12B NFKBIA PIK3R1 RELA	10000 207 3551 3593 4792 5295 5970
antineoplastic-642316	-	RIG-I-like receptor signaling pathway	path:04622_1	5	6.872111	0.010022272	IKBKB NFKBIA NFKBIB RELA CASP8	3551 4792 4793 5970 841
antineoplastic-642316	-	TNF signaling pathway	path:04668_2	9	7.455197	0.004454343	BIRC3 IKBKB PIK3R1 PIK3R2 MAPK13 MAP2K3 MAP2K7 MAP3K7 TRAF2	330 3551 5295 5296 5603 5606 5609 6885 7186
antineoplastic-642316	-	Chagas disease (American trypanosomiasis)	path:05142_1	6	6.579378	0.017817372	IKBKB NFKBIA TRAF6 CASP8 IKBKG CFLAR	3551 4792 7189 841 8517 8837
antineoplastic-642316	-	Small cell lung cancer	path:05222_3	6	6.176405	0.028953229	AKT3 IKBKB NFKBIA PIK3R1 PIK3R2 RELA	10000 3551 4792 5295 5296 5970
antineoplastic-642319	-	Purine metabolism	path:00230_27	11	8.055719	0	ADCY7 NME7 NUDT2 NPR2 POLR1D PDE6B POLR2C POLR2G POLR3E POLR1E POLR3D	113 29922 318 4882 51082 5158 5432 5436 55718 64425 661
antineoplastic-642319	-	Pyrimidine metabolism	path:00240_24	7	6.507335	0.011123471	NME7 ITPA UCK2 UCK1 ENTPD6 ENTPD5 ENTPD4	29922 3704 7371 83549 955 957 9583
antineoplastic-642319	-	Rap1 signaling pathway	path:04015_16	7	5.667411	0.038932147	CSF1R FGF9 FGF20 FGF22 ANGPT2 PLCB3 FGF23	1436 2254 26281 27006 285 5331 8074
antineoplastic-642319	-	Chemokine signaling pathway	path:04062_17	10	6.52838	0.011123471	GNB1 GNG5 GNG7 KRAS GNG13 PIK3CB PIK3R2 PLCB3 PRKCZ RAF1	2782 2787 2788 3845 51764 5291 5296 5331 5590 5894
antineoplastic-642319	-	AMPK signaling pathway	path:04152_8	8	5.71477	0.036707453	CFTR ADRA1A MTOR GYS2 ACACA PFKFB1 PRKAA1 PRKAG1	1080 148 2475 2998 31 5207 5562 5571
antineoplastic-642319	-	Wnt signaling pathway	path:04310_5	3	6.170815	0.0189099	CSNK2A1 CSNK2A2 PLCB3	1457 1459 5331
antineoplastic-642319	-	Adherens junction	path:04520_3	5	5.591623	0.043381535	CTNND1 RAC2 WAS FARP2 CDC42	1500 5880 7454 9855 998
antineoplastic-642319	-	Circadian entrainment	path:04713_9	10	6.681621	0.007786429	ADCY7 GNAI3 GNB1 GNG3 GNG5 GNG7 MTNR1B PLCB3 PRKCG MAPK1	113 2773 2782 2785 2787 2788 4544 5331 5582 5594
antineoplastic-642319	-	Retrograde endocannabinoid signaling	path:04723_7	7	6.414755	0.011123471	ADCY7 GNAI3 GNB1 GNG3 GNG5 GNG7 MAPK1	113 2773 2782 2785 2787 2788 5594
antineoplastic-642319	-	Glutamatergic synapse	path:04724_4	4	6.156865	0.021134594	ADCY7 GNAI3 GNB1 GNG5	113 2773 2782 2787
antineoplastic-642319	-	Cholinergic synapse	path:04725_11	4	6.156865	0.021134594	ADCY7 GNAI3 GNB1 GNG5	113 2773 2782 2787
antineoplastic-642319	-	GABAergic synapse	path:04727_6	4	6.156865	0.021134594	ADCY7 GNAI3 GNB1 GNG5	113 2773 2782 2787
antineoplastic-642319	-	Dopaminergic synapse	path:04728_13	7	5.892206	0.03003337	GNAI3 GNB1 GNG3 GNG5 GNG7 PLCB3 PRKCG	2773 2782 2785 2787 2788 5331 5582
antineoplastic-642319	-	Thyroid hormone signaling pathway	path:04919_7	5	6.48782	0.011123471	AKT1 ATP1A1 FXYD2 PIK3CB THRA	207 476 486 5291 7067
antineoplastic-642319	-	Morphine addiction	path:05032_5	4	6.156865	0.021134594	ADCY7 GNAI3 GNB1 GNG5	113 2773 2782 2787
antineoplastic-642319	-	Alcoholism	path:05034_2	8	5.505336	0.04894327	ADCY5 GNAI3 GNB1 GNB3 GNG3 GNG5 GNG7 PRKACA	111 2773 2782 2784 2785 2787 2788 5566
antineoplastic-643001	-	Purine metabolism	path:00230_28	8	5.95106	0.04454343	CANT1 POLR3H NME7 NME3 PKM POLA1 POLD2 POLD4	124583 171568 29922 4832 5315 5422 5425 57804
antineoplastic-643001	-	MAPK signaling pathway	path:04010_8	7	8.175607	0.002227171	DUSP1 DUSP3 DUSP7 ELK1 MAPK3 MAPK9 PTPN7	1843 1845 1849 2002 5595 5601 5778
antineoplastic-643001	-	ErbB signaling pathway	path:04012_5	8	6.530082	0.014476615	EGFR ERBB2 EREG PLCG1 PRKCB SHC1 SRC STAT5A	1956 2064 2069 5335 5579 6464 6714 6776
antineoplastic-643001	-	Calcium signaling pathway	path:04020_15	9	7.125466	0.006681514	ITPR3 CALML5 PHKA2 PHKB PLCG1 PRKCB TNNC1 CACNA1D ITPKC	3710 51806 5256 5257 5335 5579 7134 776 80271
antineoplastic-643001	-	Chemokine signaling pathway	path:04062_18	9	6.153906	0.030066815	CCR7 GRK3 PIK3R5 GNAI2 GNB1 CXCL2 CCL28 SRC ELMO1	1236 157 23533 2771 2782 2920 56477 6714 9844
antineoplastic-643001	-	HIF-1 signaling pathway	path:04066_7	9	6.575019	0.013363029	CREBBP EDN1 ALDOA HIF1A HMOX1 LTBR PFKFB3 SLC2A1 HKDC1	1387 1906 226 3091 3162 4055 5209 6513 80201
antineoplastic-643001	-	FoxO signaling pathway	path:04068_12	16	7.233428	0.005567929	SGK2 CDKN2D PLK2 GADD45G FASLG FOXO4 GADD45B MAPK3 MAPK9 MAPK13 RBL2 CCND1 STAT3 STK4 CCNB3 G6PC3	10110 1032 10769 10912 356 4303 4616 5595 5601 5603 5934 595 6774 6789 85417 92579
antineoplastic-643001	-	Phosphatidylinositol signaling system	path:04070_12	15	5.992695	0.040089087	PIKFYVE INPP5J IMPA2 INPP4A INPP5B ITPR3 PLCE1 PIK3C2B PLCB4 PLCG1 PI4K2A PTEN PIP4K2C ITPKC PIP5K1A	200576 27124 3613 3631 3633 3710 51196 5287 5332 5335 55361 5728 79837 80271 8394
antineoplastic-643001	-	Focal adhesion	path:04510_25	4	7.559649	0.004454343	FLNB ITGA5 PTK2 SRC	2317 3678 5747 6714
antineoplastic-643001	-	Jak-STAT signaling pathway	path:04630_13	7	6.905177	0.010022272	IFNGR1 IL2RG IL4R IL15RA MPL TSLP SOCS1	3459 3561 3566 3601 4352 85480 8651
antineoplastic-643001	-	Thyroid hormone signaling pathway	path:04919_8	9	5.943441	0.045657016	ATP1B1 PLCE1 PLCB4 PLCG1 PRKACA PRKACB PRKCB MAPK3 MAP2K2	481 51196 5332 5335 5566 5567 5579 5595 5605
antineoplastic-643001	-	Pathways in cancer	path:05200_11	10	6.36339	0.022271715	EGFR ERBB2 HRAS IGF1R PIK3CA PLCG1 PRKCB RET BRAF TGFA	1956 2064 3265 3480 5290 5335 5579 5979 673 7039
antineoplastic-643812	-	Purine metabolism	path:00230_29	9	7.23302	0.00554939	POLR3G ADCY6 POLR3H NME4 NPR2 PDE4D PDE9A POLR2L POLR3D	10622 112 171568 4833 4882 5144 5152 5441 661
antineoplastic-643812	-	Ras signaling pathway	path:04014_10	14	5.953302	0.046614872	RASSF1 AKT2 RRAS2 HRAS AFDN PLCE1 PIK3CA PIK3CB PIK3R1 RASA1 SOS1 TIAM1 SYNGAP1 RASAL2	11186 208 22800 3265 4301 51196 5290 5291 5295 5921 6654 7074 8831 9462
antineoplastic-643812	-	Rap1 signaling pathway	path:04015_17	17	7.049154	0.011098779	CRK EGFR EPHA2 FGF3 FGF5 FGFR1 FGFR3 FGFR2 FGFR4 PLCB1 FGF20 ANGPT1 ANGPT2 KDR MET PDGFA PDGFB	1398 1956 1969 2248 2250 2260 2261 2263 2264 23236 26281 284 285 3791 4233 5154 5155
antineoplastic-643812	-	Calcium signaling pathway	path:04020_16	8	6.393949	0.028856826	EGFR PLCB1 ITPR1 ATP2A1 P2RX7 PLCE1 PLCG2 CALM3	1956 23236 3708 487 5027 51196 5336 808
antineoplastic-643812	-	cAMP signaling pathway	path:04024_5	5	5.977151	0.046614872	ADCY6 GABBR1 GNAI2 HTR1D CALM3	112 2550 2771 3352 808
antineoplastic-643812	-	HIF-1 signaling pathway	path:04066_8	11	6.121215	0.036625971	CREBBP EGF ALDOA FLT1 ANGPT1 ANGPT2 HK3 PFKL PGK1 SLC2A1 HKDC1	1387 1950 226 2321 284 285 3101 5211 5230 6513 80201
antineoplastic-643812	-	FoxO signaling pathway	path:04068_13	15	7.715395	0.002219756	BCL2L11 SGK2 PLK2 CSNK1E PRMT1 IKBKB FOXO4 PRKAB2 MAPK3 MAPK8 MAPK11 MAPK9 MAPK10 BCL6 BNIP3	10018 10110 10769 1454 3276 3551 4303 5565 5595 5599 5600 5601 5602 604 664
antineoplastic-643812	-	Phosphatidylinositol signaling system	path:04070_13	14	6.790277	0.014428413	CDIPT PLCB1 INPP5A ITPR1 PLCE1 INPP5K PIK3C2A PIK3CA PI4KB PLCG1 PLCG2 PIP4K2C ITPKC PLCZ1	10423 23236 3632 3708 51196 51763 5286 5290 5298 5335 5336 79837 80271 89869
antineoplastic-643812	-	PI3K-Akt signaling pathway	path:04151_19	15	6.746627	0.017758047	EGFR EPHA2 FGF3 FGF5 FGFR1 FGFR3 FGFR2 FGFR4 FGF20 ANGPT1 ANGPT2 KDR MET PDGFA PDGFB	1956 1969 2248 2250 2260 2261 2263 2264 26281 284 285 3791 4233 5154 5155
antineoplastic-643812	-	Adrenergic signaling in cardiomyocytes	path:04261_7	5	6.219998	0.033296337	ATF4 ATP1B1 ATP1B3 PRKACB CACNA2D3	468 481 483 5567 55799
antineoplastic-643812	-	Focal adhesion	path:04510_26	5	8.273208	0	FLNB FLNC ITGA5 VASP TLN2	2317 2318 3678 7408 83660
antineoplastic-643812	-	Tight junction	path:04530_2	3	6.555564	0.023307436	AFDN PRKCD ACTG1	4301 5580 71
antineoplastic-643812	-	Jak-STAT signaling pathway	path:04630_14	8	7.831919	0.002219756	CBLC IFNAR1 IFNAR2 IFNGR2 IL10RB IL11RA IL15 MPL	23624 3454 3455 3460 3588 3590 3600 4352
antineoplastic-643812	-	Serotonergic synapse	path:04726_8	4	6.29899	0.031076582	PLCB1 GNAI2 HTR1D ITPR1	23236 2771 3352 3708
antineoplastic-643812	-	Dopaminergic synapse	path:04728_14	6	7.046319	0.011098779	PLCB1 GNAI2 ITPR1 ATF4 PRKCA CALM3	23236 2771 3708 468 5578 808
antineoplastic-643812	-	Oxytocin signaling pathway	path:04921_9	13	6.171938	0.036625971	ADCY6 EGFR PLCB1 GNAI1 GNAI2 ITPR1 PIK3CA PIK3CB PIK3CG PIK3R1 PIK3R2 PLCB4 PRKCA	112 1956 23236 2770 2771 3708 5290 5291 5294 5295 5296 5332 5578
antineoplastic-643812	-	Glucagon signaling pathway	path:04922_3	8	6.02032	0.043285239	PLCB1 ACACA ITPR1 ATF4 PHKB PRKAB2 PRKACB CALM3	23236 31 3708 468 5257 5565 5567 808
antineoplastic-643812	-	Gastric acid secretion	path:04971_1	3	6.269003	0.032186459	ADCY6 GNAI2 PRKACB	112 2771 5567
antineoplastic-643812	-	Prostate cancer	path:05215_2	11	5.910479	0.04772475	EGFR ERBB2 AKT2 FGFR1 FGFR2 PDGFA PDGFB PIK3CA PIK3CB PIK3R1 TGFA	1956 2064 208 2260 2263 5154 5155 5290 5291 5295 7039
antineoplastic-644916	-	Purine metabolism	path:00230_30	8	7.552968	0.00550055	ZNRD1 NME1 PKM POLE PRIM1 POLR3B POLR1C ENTPD6	30834 4830 5315 5426 5557 55703 9533 955
antineoplastic-644916	-	Pyrimidine metabolism	path:00240_25	6	7.367394	0.00770077	ZNRD1 NME1 POLR3K POLR2F POLR3B POLR1C	30834 4830 51728 5435 55703 9533
antineoplastic-644916	-	Focal adhesion	path:04510_27	4	6.948483	0.00990099	FLNA ITGA2 VASP TLN2	2316 3673 7408 83660
antineoplastic-644916	-	ECM-receptor interaction	path:04512_10	3	6.174256	0.02750275	ITGA2 ITGAV ITGB1	3673 3685 3688
antineoplastic-644916	-	Regulation of actin cytoskeleton	path:04810_10	9	5.875775	0.04070407	PAK4 RRAS2 PIK3CG RAC2 RAF1 RRAS SOS1 VAV1 VAV2	10298 22800 5294 5880 5894 6237 6654 7409 7410
antineoplastic-645645	-	Galactose metabolism	path:00052_1	4	6.49055	0.018660812	B4GALT1 HK1 LCT HKDC1	2683 3098 3938 80201
antineoplastic-645645	-	Retinol metabolism	path:00830_2	3	6.372163	0.024149286	CYP2B6 CYP3A4 CYP2S1	1555 1576 29785
antineoplastic-645645	-	Metabolism of xenobiotics by cytochrome P450	path:00980_1	4	6.461254	0.020856202	CYP2B6 CYP3A4 CYP2S1 CBR1	1555 1576 29785 873
antineoplastic-645645	-	Ras signaling pathway	path:04014_11	9	6.548837	0.018660812	RASSF1 HRAS PIK3CA RGL2 RASA1 RASGRF1 TIAM1 SYNGAP1 RASAL2	11186 3265 5290 5863 5921 5923 7074 8831 9462
antineoplastic-645645	-	Calcium signaling pathway	path:04020_17	9	5.962791	0.041712404	SLC25A4 ITPR3 ATP2A1 PHKA2 VDAC2 CACNA1D ITPKC CALM3 ORAI3	291 3710 487 5256 7417 776 80271 808 93129
antineoplastic-645645	-	cAMP signaling pathway	path:04024_6	9	6.668936	0.015367728	ADCY6 DRD1 GABBR1 GIPR HCAR1 GNAI2 HTR1D VIPR2 CALM3	112 1812 2550 2696 27198 2771 3352 7434 808
antineoplastic-645645	-	FoxO signaling pathway	path:04068_14	12	6.475826	0.019758507	BCL2L11 SGK2 CSNK1E IKBKB FOXO4 PRKAB2 MAPK3 MAPK11 RBL2 CCND1 BNIP3 STAT3	10018 10110 1454 3551 4303 5565 5595 5600 5934 595 664 6774
antineoplastic-645645	-	Focal adhesion	path:04510_28	3	6.126715	0.035126235	FLNB ITGA5 VASP	2317 3678 7408
antineoplastic-645646	-	Purine metabolism	path:00230_31	10	7.115175	0.017241379	POLR3F NUDT16 POLR3H ZNRD1 IMPDH1 NME4 AK3 POLR2F POLR2H POLD4	10621 131870 171568 30834 3614 4833 50808 5435 5437 57804
antineoplastic-645646	-	MAPK signaling pathway	path:04010_9	6	6.542844	0.034482759	MAPK14 DUSP7 MAPK9 MAPK13 DUSP16 MAPKAPK5	1432 1849 5601 5603 80824 8550
antineoplastic-645646	-	Rap1 signaling pathway	path:04015_18	12	7.662906	0.00862069	EFNA2 EGFR EPHA2 FGFR1 FGFR3 FGFR2 FGFR4 PLCB1 FLT4 PDGFA PDGFB PLCB4	1943 1956 1969 2260 2261 2263 2264 23236 2324 5154 5155 5332
antineoplastic-645646	-	Chemokine signaling pathway	path:04062_19	6	6.478846	0.037715517	PLCB1 GNAI2 GNGT2 PLCB4 PRKCD GNB4	23236 2771 2793 5332 5580 59345
antineoplastic-645646	-	FoxO signaling pathway	path:04068_15	12	6.684957	0.028017241	CDKN1A CDKN2D PLK2 MAPK14 CSNK1E IKBKB FASLG FOXO4 MAPK9 MAPK13 CCND1 STK11	1026 1032 10769 1432 1454 3551 356 4303 5601 5603 595 6794
antineoplastic-645646	-	PI3K-Akt signaling pathway	path:04151_20	9	7.606174	0.00862069	EFNA2 EGFR EPHA2 FGFR1 FGFR3 FGFR2 FGFR4 PDGFA PDGFB	1943 1956 1969 2260 2261 2263 2264 5154 5155
antineoplastic-645646	-	Jak-STAT signaling pathway	path:04630_15	15	7.073729	0.017241379	EPOR CBLC IFNAR2 IFNGR1 IL4 IL6R IL10 IL11RA IL12RB2 IL15 LIF IL20RB IL22RA1 STAT5A SOCS1	2057 23624 3455 3459 3565 3570 3586 3590 3595 3600 3976 53833 58985 6776 8651
antineoplastic-645804	-	Starch and sucrose metabolism	path:00500_1	10	6.258007	0.031763417	GPI PGM2L1 GYS1 HK1 HK2 HK3 ENPP1 ENPP3 PGM1 HKDC1	2821 283209 2997 3098 3099 3101 5167 5169 5236 80201
antineoplastic-645804	-	FoxO signaling pathway	path:04068_16	16	6.415328	0.026286966	AKT3 SGK2 GADD45G FBXO32 AKT2 FOXO3 IL7R ATM PCK2 PRKAG2 MAPK3 MAP2K2 BCL6 STK4 TNFSF10 CCNG2	10000 10110 10912 114907 208 2309 3575 472 5106 51422 5595 5605 604 6789 8743 901
antineoplastic-645804	-	Glutamatergic synapse	path:04724_5	9	5.802903	0.049288061	ADCY3 GNAI1 GNB1 GNG7 GNGT1 GRIK2 GRM4 GNG13 GNB4	109 2770 2782 2788 2792 2898 2914 51764 59345
antineoplastic-645805	-	Purine metabolism	path:00230_32	6	6.114959	0.03956044	AK7 CANT1 PDE3B PDE4D RRM2 NME5	122481 124583 5140 5144 6241 8382
antineoplastic-645805	-	Pyrimidine metabolism	path:00240_26	9	6.311454	0.030769231	POLR3A CTPS1 POLR2J2 POLR1D POLR2D POLR2E POLR2J POLR3D NME5	11128 1503 246721 51082 5433 5434 5439 661 8382
antineoplastic-645805	-	Chemokine signaling pathway	path:04062_20	8	6.706577	0.023076923	GNAI1 GNB2 GNG7 GNG11 GNGT1 PLCB4 GNB4 PIK3R3	2770 2783 2788 2791 2792 5332 59345 8503
antineoplastic-645805	-	FoxO signaling pathway	path:04068_17	12	7.614715	0.00989011	CHUK PLK3 GADD45A FOXO3 GADD45B PRKAA2 MAPK9 G6PC2 RAG1 STK11 S1PR4 ATG12	1147 1263 1647 2309 4616 5563 5601 57818 5896 6794 8698 9140
antineoplastic-645805	-	Hedgehog signaling pathway	path:04340_1	4	7.310142	0.014285714	GLI1 PRKX PTCH1 BTRC	2735 5613 5727 8945
antineoplastic-645805	-	Glutamatergic synapse	path:04724_6	12	6.358091	0.030769231	ADCY8 GNAI1 GNAI2 GNAO1 GNB2 GNG3 GNG4 GNG7 GNG11 GNGT1 GRM8 GNB4	114 2770 2771 2775 2783 2785 2786 2788 2791 2792 2918 59345
antineoplastic-645805	-	Cholinergic synapse	path:04725_12	10	6.128049	0.03956044	ADCY8 GNAI1 GNAO1 GNB2 GNG4 GNG7 GNG11 GNGT1 GNB4 PIK3R3	114 2770 2775 2783 2786 2788 2791 2792 59345 8503
antineoplastic-645806	-	Glycolysis / Gluconeogenesis	path:00010_1	8	5.608432	0.049944506	ENO2 ALDOC GAPDHS GPI PFKM PGM1 BPGM MINPP1	2026 230 26330 2821 5213 5236 669 9562
antineoplastic-645806	-	Pyrimidine metabolism	path:00240_27	10	5.747751	0.045504994	POLR3F POLR3G POLR3A CTPS1 CMPK1 POLR2D POLR2H NME5 POLR1B PNPT1	10621 10622 11128 1503 51727 5433 5437 8382 84172 87178
antineoplastic-645806	-	Ras signaling pathway	path:04014_12	6	5.970943	0.033296337	GNG11 HTR7 NRAS GNG12 RASGRF2 GNB4	2791 3363 4893 55970 5924 59345
antineoplastic-645806	-	Calcium signaling pathway	path:04020_18	7	7.712473	0.001109878	PPIF GRIN2D SLC25A5 PLCE1 PLCB4 PRKCB VDAC2	10105 2906 292 51196 5332 5579 7417
antineoplastic-645806	-	cGMP-PKG signaling pathway	path:04022_10	6	6.321724	0.023307436	CREB3 PLCB1 GNAQ KCNMA1 PLCB4 PRKG1	10488 23236 2776 3778 5332 5592
antineoplastic-645806	-	cAMP signaling pathway	path:04024_7	10	6.327028	0.023307436	CREB3 CFTR FOS GRIN2D RHOA FXYD1 PRKACA PRKX ROCK1 SLC9A1	10488 1080 2353 2906 387 5348 5566 5613 6093 6548
antineoplastic-645806	-	Chemokine signaling pathway	path:04062_21	8	7.236212	0.004439512	PLCB1 GNAI3 GNG11 GNGT1 PLCB4 GNG12 CXCR5 PIK3R3	23236 2773 2791 2792 5332 55970 643 8503
antineoplastic-645806	-	FoxO signaling pathway	path:04068_18	11	6.272959	0.025527192	AKT3 CDKN1B PLK2 GADD45G CHUK GADD45A FOXO3 PRMT1 GADD45B PRKAA2 STK11	10000 1027 10769 10912 1147 1647 2309 3276 4616 5563 6794
antineoplastic-645806	-	Phosphatidylinositol signaling system	path:04070_14	10	5.765443	0.044395117	PLCB1 INPP5A PLCE1 PIK3CD PLCB4 PI4K2A PTEN PIK3R3 CDS2 DGKI	23236 3632 51196 5293 5332 55361 5728 8503 8760 9162
antineoplastic-645806	-	Sphingolipid signaling pathway	path:04071_6	11	6.219448	0.02663707	ADORA3 PLCB1 GNAI2 GNAI3 GNAQ NRAS OPRD1 PIK3CD PLCB4 PRKCB PIK3R3	140 23236 2771 2773 2776 4893 4985 5293 5332 5579 8503
antineoplastic-645806	-	PI3K-Akt signaling pathway	path:04151_21	8	6.806645	0.008879023	AKT3 CDKN1B CREB3 CHUK FOXO3 PPP2R1A PPP2R2D PIK3R3	10000 1027 10488 1147 2309 5518 55844 8503
antineoplastic-645806	-	Adrenergic signaling in cardiomyocytes	path:04261_8	8	5.950388	0.033296337	CREB3 ATP1A1 PPP2CA PPP2R1A PRKACA PRKX SLC9A1 CACNB4	10488 476 5515 5518 5566 5613 6548 785
antineoplastic-645806	-	Wnt signaling pathway	path:04310_6	6	5.658026	0.046614872	PLCB1 NFATC4 PLCB4 PPP3CA PPP3CB PRKCB	23236 4776 5332 5530 5532 5579
antineoplastic-645806	-	Hedgehog signaling pathway	path:04340_2	6	6.667232	0.012208657	GLI3 PRKACA PRKACB PRKX BMP2 BTRC	2737 5566 5567 5613 650 8945
antineoplastic-645806	-	Focal adhesion	path:04510_29	11	7.173428	0.004439512	FLNA ITGA5 ITGB1 ITGB3 ITGB5 PRKCB THBS1 TLN1 TLN2 CAV1 CAV3	2316 3678 3688 3690 3693 5579 7057 7094 83660 857 859
antineoplastic-645806	-	Circadian entrainment	path:04713_10	11	6.563302	0.014428413	ADCY9 PLCB1 GNAI2 GNAI3 GNAQ GNB2 GNG11 GNGT1 PLCB4 GNG12 GNB4	115 23236 2771 2773 2776 2783 2791 2792 5332 55970 59345
antineoplastic-645806	-	Long-term potentiation	path:04720_1	10	6.56151	0.014428413	ADCY8 GRIN1 GRIN2D GRM5 NRAS PPP3CA PPP3CB PRKX RAP1A CALM3	114 2902 2906 2915 4893 5530 5532 5613 5906 808
antineoplastic-645806	-	Serotonergic synapse	path:04726_9	10	6.410671	0.02108768	PLCB1 GNAI2 GNAI3 GNAQ GNG11 GNGT1 HTR5A PLCB4 GNG12 GNB4	23236 2771 2773 2776 2791 2792 3361 5332 55970 59345
antineoplastic-645806	-	Dopaminergic synapse	path:04728_15	9	7.173443	0.004439512	PLCB1 GNAI2 GNAQ GNG11 GNGT1 PLCB4 PRKCB GNG12 GNB4	23236 2771 2776 2791 2792 5332 5579 55970 59345
antineoplastic-645806	-	Regulation of actin cytoskeleton	path:04810_11	4	5.79259	0.041065483	PAK4 GNG12 ROCK1 CDC42	10298 55970 6093 998
antineoplastic-645806	-	Estrogen signaling pathway	path:04915_2	8	6.342715	0.023307436	CREB3 ATF6B GNAI2 GNAI3 NOS3 NRAS PRKX RAF1	10488 1388 2771 2773 4846 4893 5613 5894
antineoplastic-645806	-	Thyroid hormone synthesis	path:04918_1	6	6.446475	0.018867925	CREB3 ADCY3 PRKACA PRKACB PRKCB PRKX	10488 109 5566 5567 5579 5613
antineoplastic-645806	-	Oxytocin signaling pathway	path:04921_10	9	6.782127	0.009988901	PLCB1 GNAI3 GNAQ NRAS OXTR PLCB4 PRKCB RAF1 CALM3	23236 2773 2776 4893 5021 5332 5579 5894 808
antineoplastic-645806	-	Prostate cancer	path:05215_3	7	5.604775	0.049944506	AKT3 FGFR2 PIK3CD PDGFC PTEN TGFA PIK3R3	10000 2263 5293 56034 5728 7039 8503
antineoplastic-645807	-	Purine metabolism	path:00230_33	10	6.515795	0.00877193	ADCY1 ADCY2 POLR3A POLR2J2 GUCY1A2 POLR2A POLR2E POLR2J POLR1B PDE8B	107 108 11128 246721 2977 5430 5434 5439 84172 8622
antineoplastic-645807	-	Pyrimidine metabolism	path:00240_28	9	5.532996	0.040570175	POLR3F POLR3A POLR2A POLR2D POLR2E POLR2H POLR2J CTPS2 ENTPD1	10621 11128 5430 5433 5434 5437 5439 56474 953
antineoplastic-645807	-	Glutathione metabolism	path:00480_1	12	6.9238	0.003289474	GSTO2 GPX6 GGT7 GPX2 GPX3 GPX7 GSTM1 GSTM2 GSTM4 GSTM5 GSTK1 MGST2	119391 257202 2686 2877 2878 2882 2944 2946 2948 2949 373156 4258
antineoplastic-645807	-	Arachidonic acid metabolism	path:00590_1	20	5.440763	0.046052632	CYP2C19 CYP2C8 CYP2E1 CYP2J2 EPHX2 ALOX12 ALOX5 ALOX12B ALOX15 ALOX15B GPX6 GPX1 GPX2 GPX3 GPX5 GPX7 PLA2G2A PLA2G5 PLA2G12A CYP4F2	1557 1558 1571 1573 2053 239 240 242 246 247 257202 2876 2877 2878 2880 2882 5320 5322 81579 8529
antineoplastic-645807	-	Nicotinate and nicotinamide metabolism	path:00760_2	9	5.428599	0.046052632	NAMPT NT5C2 NMNAT2 NMRK2 NT5C NNMT NT5E BST1 CD38	10135 22978 23057 27231 30833 4837 4907 683 952
antineoplastic-645807	-	Metabolism of xenobiotics by cytochrome P450	path:00980_2	9	6.366009	0.012061404	GSTO2 CYP2E1 CYP3A4 CYP3A5 GSTM1 GSTM2 GSTM4 GSTM5 GSTK1	119391 1571 1576 1577 2944 2946 2948 2949 373156
antineoplastic-645807	-	Drug metabolism - cytochrome P450	path:00982_1	7	5.666028	0.033991228	GSTO2 ADH6 GSTM1 GSTM2 GSTM4 GSTM5 GSTK1	119391 130 2944 2946 2948 2949 373156
antineoplastic-645807	-	Ras signaling pathway	path:04014_13	23	6.986239	0.003289474	EFNA2 EFNA4 FGF1 FGF3 FGF5 FGF6 FGF8 FGF11 FGF13 FGF14 FGFR1 FGFR2 FLT1 INSR SHC4 MET NGFR ANGPT4 PDGFRB PDGFC VEGFB VEGFC FGF19	1943 1945 2246 2248 2250 2251 2253 2256 2258 2259 2260 2263 2321 3643 399694 4233 4804 51378 5159 56034 7423 7424 9965
antineoplastic-645807	-	Rap1 signaling pathway	path:04015_19	22	6.284858	0.013157895	EFNA2 EFNA4 EFNA5 FGF1 FGF2 FGF5 FGF6 FGF8 FGF11 FGFR2 FLT1 INSR KIT MET ANGPT4 PDGFA PLCB4 PDGFC VEGFB VEGFC PDGFD FGF19	1943 1945 1946 2246 2247 2250 2251 2253 2256 2263 2321 3643 3815 4233 51378 5154 5332 56034 7423 7424 80310 9965
antineoplastic-645807	-	cGMP-PKG signaling pathway	path:04022_11	6	6.048827	0.016447368	GNAI1 PIK3CB PIK3CD IRS4 PIK3R3 IRS2	2770 5291 5293 8471 8503 8660
antineoplastic-645807	-	cAMP signaling pathway	path:04024_8	11	5.439962	0.046052632	ADCY5 ADORA1 GPR119 FSHR GLP1R GNAI1 GNAS HTR1E HTR6 OXTR VIPR2	111 134 139760 2492 2740 2770 2778 3354 3362 5021 7434
antineoplastic-645807	-	Chemokine signaling pathway	path:04062_22	7	7.445967	0.003289474	GNAI2 GNB2 GNG11 GNGT1 PIK3CD GNB4 PIK3R3	2771 2783 2791 2792 5293 59345 8503
antineoplastic-645807	-	Sphingolipid signaling pathway	path:04071_7	5	5.993871	0.016447368	GNAI2 OPRD1 PIK3CD PIK3CG PIK3R3	2771 4985 5293 5294 8503
antineoplastic-645807	-	PI3K-Akt signaling pathway	path:04151_22	8	6.169735	0.013157895	AKT3 NOS3 PIK3CD PIK3CG PPP2R2A PTEN RAF1 PIK3R3	10000 4846 5293 5294 5520 5728 5894 8503
antineoplastic-645807	-	Hippo signaling pathway	path:04390_14	7	5.7665	0.029605263	YWHAQ FGF1 SERPINE1 PPP2CA PPP2R2D TGFBR1 BTRC	10971 2246 5054 5515 55844 7046 8945
antineoplastic-645807	-	Focal adhesion	path:04510_30	11	6.223505	0.013157895	FLT1 SHC4 MET PDGFRB PIK3CD PIK3CG PDGFC VAV2 VEGFB VEGFC PIK3R3	2321 399694 4233 5159 5293 5294 56034 7410 7423 7424 8503
antineoplastic-645807	-	Leukocyte transendothelial migration	path:04670_4	7	5.527004	0.040570175	GNAI2 PIK3CD PIK3CG PIK3R1 VCAM1 CXCR4 PIK3R3	2771 5293 5294 5295 7412 7852 8503
antineoplastic-645807	-	Circadian entrainment	path:04713_11	9	5.795614	0.027412281	ADCY1 ADCY5 GNAI1 GNAI2 GNB2 GNG11 GNGT1 PLCB4 GNB4	107 111 2770 2771 2783 2791 2792 5332 59345
antineoplastic-645807	-	Retrograde endocannabinoid signaling	path:04723_8	9	6.141083	0.015350877	ADCY1 ADCY5 CNR1 GNAI1 GNAI2 GNB2 GNG11 GNGT1 GNB4	107 111 1268 2770 2771 2783 2791 2792 59345
antineoplastic-645807	-	Glutamatergic synapse	path:04724_7	6	7.310936	0.003289474	GRIA2 GRIK3 GRIN1 GRIN2D GRM1 GRM7	2891 2899 2902 2906 2911 2917
antineoplastic-645807	-	Cholinergic synapse	path:04725_13	11	7.104177	0.003289474	ADCY1 ADCY5 GNAI1 GNAI2 GNB2 GNG11 GNGT1 PIK3CG PRKX GNB4 PIK3R3	107 111 2770 2771 2783 2791 2792 5294 5613 59345 8503
antineoplastic-645807	-	Serotonergic synapse	path:04726_10	11	7.072302	0.003289474	ADCY5 GNAI1 GNAI2 GNB2 GNG11 GNGT1 HTR1E HTR5A HTR6 PLCB4 GNB4	111 2770 2771 2783 2791 2792 3354 3361 3362 5332 59345
antineoplastic-645807	-	GABAergic synapse	path:04727_7	9	6.695843	0.006578947	ADCY1 ADCY5 GABBR1 GNAI1 GNAI2 GNB2 GNG11 GNGT1 GNB4	107 111 2550 2770 2771 2783 2791 2792 59345
antineoplastic-645807	-	Dopaminergic synapse	path:04728_16	9	6.011783	0.016447368	ADCY5 DRD2 GNAI1 GNAI2 GNB2 GNG11 GNGT1 PLCB4 GNB4	111 1813 2770 2771 2783 2791 2792 5332 59345
antineoplastic-645807	-	Oxytocin signaling pathway	path:04921_11	8	6.315026	0.012061404	ADCY1 ADCY5 GNAI1 GNAI2 OXTR PIK3CD PIK3CG PIK3R3	107 111 2770 2771 5021 5293 5294 8503
antineoplastic-645807	-	Type II diabetes mellitus	path:04930_1	4	5.532969	0.040570175	PIK3CD PIK3CG SLC2A4 PIK3R3	5293 5294 6517 8503
antineoplastic-645807	-	Morphine addiction	path:05032_6	11	6.576262	0.00877193	ADCY1 ADCY5 ADCY8 GABBR1 GNAI2 GNAS GNB2 GNG11 GNGT1 OPRM1 GNB4	107 111 114 2550 2771 2778 2783 2791 2792 4988 59345
antineoplastic-645807	-	Alcoholism	path:05034_3	8	5.711655	0.032894737	ADCY5 DRD2 GNAI1 GNAI2 GNB2 GNG11 GNGT1 GNB4	111 1813 2770 2771 2783 2791 2792 59345
antineoplastic-645807	-	Chemical carcinogenesis	path:05204_1	9	6.673154	0.007675439	GSTO2 CYP2C8 CYP2E1 CYP3A4 GSTM1 GSTM2 GSTM4 GSTM5 GSTK1	119391 1558 1571 1576 2944 2946 2948 2949 373156
antineoplastic-645807	-	Melanoma	path:05218_2	12	5.565297	0.036184211	FGF1 FGF3 FGF5 FGF6 FGF8 FGF11 FGF13 FGFR1 MET PDGFRB PDGFC FGF19	2246 2248 2250 2251 2253 2256 2258 2260 4233 5159 56034 9965
antineoplastic-645807	-	Acute myeloid leukemia	path:05221_1	7	5.395217	0.047149123	AKT3 CHUK FLT3 NFKB1 PIK3CD PIK3CG PIK3R3	10000 1147 2322 4790 5293 5294 8503
antineoplastic-646699	-	Purine metabolism	path:00230_34	16	8.371457	0	NME6 POLR3G ADCY2 ADSL NT5C2 HPRT1 IMPDH2 ENTPD8 NME4 PDE6D POLE3 POLR3E ADCY10 RRM2 ENTPD2 ENTPD5	10201 10622 108 158 22978 3251 3615 377841 4833 5147 54107 55718 55811 6241 954 957
antineoplastic-646699	-	Glutathione metabolism	path:00480_2	6	6.023799	0.042951542	GGT6 GCLC GPX1 GPX4 GSTM1 GSTO1	124975 2729 2876 2879 2944 9446
antineoplastic-646699	-	Glycerophospholipid metabolism	path:00564_5	8	5.873123	0.049559471	CDS1 DGKG DGKQ LPIN1 PLD2 DGKE DGKD DGKI	1040 1608 1609 23175 5338 8526 8527 9162
antineoplastic-646699	-	Arachidonic acid metabolism	path:00590_2	8	6.088937	0.042951542	PLA2G16 CYP2J2 ALOX12 ALOX15 GPX1 GPX2 PTGS2 PLA2G12A	11145 1573 239 246 2876 2877 5743 81579
antineoplastic-646699	-	Rap1 signaling pathway	path:04015_20	15	6.07725	0.042951542	CRKL EFNA1 EFNA4 EFNA5 FGF1 FGF6 FGF7 FGF11 FGFR3 FGFR2 FGFR4 FLT1 PDGFB VEGFB FGF18	1399 1942 1945 1946 2246 2251 2252 2256 2261 2263 2264 2321 5155 7423 8817
antineoplastic-646699	-	Calcium signaling pathway	path:04020_19	7	6.037847	0.042951542	ERBB2 ITPR1 P2RX5 PLCG1 TNNC1 CACNA1D ITPKC	2064 3708 5026 5335 7134 776 80271
antineoplastic-646699	-	cAMP signaling pathway	path:04024_9	6	6.187798	0.039647577	RAPGEF3 ADCY2 GABBR1 HCAR1 GNAI2 ADCY10	10411 108 2550 27198 2771 55811
antineoplastic-646699	-	Chemokine signaling pathway	path:04062_23	6	7.783257	0.003303965	GNB5 CCR3 GNAI2 GNB1 GNG7 LYN	10681 1232 2771 2782 2788 4067
antineoplastic-646699	-	FoxO signaling pathway	path:04068_19	17	6.108198	0.042951542	AKT3 SGK2 GADD45G GABARAP CHUK CSNK1E FOXO3 FASLG ATM PLK1 PRKAB1 MAPK3 MAPK9 MAPK13 STK11 CCNG2 ATG12	10000 10110 10912 11337 1147 1454 2309 356 472 5347 5564 5595 5601 5603 6794 901 9140
antineoplastic-646699	-	Endocytosis	path:04144_3	6	6.480633	0.025330396	FGFR3 FGFR2 FGFR4 CBLC EPN3 SH3GLB2	2261 2263 2264 23624 55040 56904
antineoplastic-646699	-	PI3K-Akt signaling pathway	path:04151_23	11	6.169639	0.04185022	EFNA1 EFNA5 FGF7 FGF11 FGFR3 FGFR2 FGFR4 FLT1 IRS1 PDGFB FGF18	1942 1946 2252 2256 2261 2263 2264 2321 3667 5155 8817
antineoplastic-646699	-	Axon guidance	path:04360_1	6	6.666562	0.02092511	EFNA1 FYN HRAS RHOA MAPK3 RASA1	1942 2534 3265 387 5595 5921
antineoplastic-646699	-	Focal adhesion	path:04510_31	3	7.670216	0.004405286	FLNB ITGA2 ITGA5	2317 3673 3678
antineoplastic-646699	-	Jak-STAT signaling pathway	path:04630_16	14	6.282149	0.034140969	IL24 CSF2 CBLC IFNG IFNGR1 IL4 IL4R IL15RA IL20 IL22 IL20RA IL20RB IL26 IL22RA1	11009 1437 23624 3458 3459 3565 3566 3601 50604 50616 53832 53833 55801 58985
antineoplastic-646699	-	Circadian entrainment	path:04713_12	9	6.433103	0.02753304	GNB5 ADCY2 ADCY6 GNAI2 GNB1 GNG7 PRKACB ADCY10 MAPK3	10681 108 112 2771 2782 2788 5567 55811 5595
antineoplastic-646699	-	Retrograde endocannabinoid signaling	path:04723_9	9	6.294342	0.033039648	GNB5 ADCY2 ADCY6 GNAI2 GNB1 GNG7 PRKACB MAPK3 MAPK13	10681 108 112 2771 2782 2788 5567 5595 5603
antineoplastic-646699	-	Cholinergic synapse	path:04725_14	13	6.785569	0.015418502	AKT3 GNB5 ADCY2 ADCY6 PIK3R5 FYN GNAI2 GNB1 GNG7 PIK3R1 PRKACB MAPK3 CAMK4	10000 10681 108 112 23533 2534 2771 2782 2788 5295 5567 5595 814
antineoplastic-646699	-	GABAergic synapse	path:04727_8	9	6.726877	0.018722467	GNB5 ADCY2 ADCY3 ADCY6 GABBR1 GNAI2 GNG7 PRKACB CACNA1D	10681 108 109 112 2550 2771 2788 5567 776
antineoplastic-646699	-	Morphine addiction	path:05032_7	7	6.625978	0.022026432	GNB5 ADCY2 GABBR1 GNAI2 GNG7 PRKACB GNB4	10681 108 2550 2771 2788 5567 59345
antineoplastic-647246	-	Purine metabolism	path:00230_35	9	7.797391	0.004415011	ADCY6 POLR3H NME7 ZNRD1 NME4 POLD2 POLR2D POLR2E RRM2	112 171568 29922 30834 4833 5425 5433 5434 6241
antineoplastic-647246	-	Pyrimidine metabolism	path:00240_29	17	7.133264	0.008830022	POLR3G POLD3 CANT1 POLR3H DUT NME7 ZNRD1 NME4 POLD2 POLR2D POLR2E POLR2F POLD4 RRM2 POLR1E POLR1B ENTPD5	10622 10714 124583 171568 1854 29922 30834 4833 5425 5433 5434 5435 57804 6241 64425 84172 957
antineoplastic-647246	-	Ras signaling pathway	path:04014_14	10	7.039966	0.009933775	EFNA1 EFNA3 EFNA4 EFNA5 EGFR EPHA2 FGFR2 FGFR4 ANGPT1 PDGFB	1942 1944 1945 1946 1956 1969 2263 2264 284 5155
antineoplastic-647246	-	Rap1 signaling pathway	path:04015_21	9	7.015859	0.011037528	EFNA1 EFNA4 EFNA5 EGFR EPHA2 FGFR2 FGFR4 ANGPT1 PDGFB	1942 1945 1946 1956 1969 2263 2264 284 5155
antineoplastic-647246	-	cGMP-PKG signaling pathway	path:04022_12	10	6.079903	0.035320088	KCNMB4 GTF2I ATF4 ATP1B1 PDE3B PPP1CB PRKG1 RGS2 CACNA1D CACNA1S	27345 2969 468 481 5140 5500 5592 5997 776 779
antineoplastic-647246	-	p53 signaling pathway	path:04115_6	16	5.836738	0.048565121	CDKN1A GADD45G SFN FAS MDM2 MDM4 SHISA5 GTSE1 PTEN BAX RRM2 PERP THBS1 TP53 TP73 CCNG2	1026 10912 2810 355 4193 4194 51246 51512 5728 581 6241 64065 7057 7157 7161 901
antineoplastic-647246	-	PI3K-Akt signaling pathway	path:04151_24	3	6.040236	0.039735099	ITGA5 ITGAV THBS1	3678 3685 7057
antineoplastic-647246	-	Adrenergic signaling in cardiomyocytes	path:04261_9	8	7.044104	0.009933775	ATF4 ATP1B1 PPP1CB PPP2R2C PRKACB CACNA2D3 CACNA1D CACNA1S	468 481 5500 5522 5567 55799 776 779
antineoplastic-647246	-	Wnt signaling pathway	path:04310_7	4	5.781348	0.049668874	CSNK2A2 CSNK2B MAPK9 RAC1	1459 1460 5601 5879
antineoplastic-647246	-	Axon guidance	path:04360_2	5	6.957723	0.011037528	PAK4 EPHA2 PAK6 RAC1 CDC42	10298 1969 56924 5879 998
antineoplastic-647246	-	Jak-STAT signaling pathway	path:04630_17	17	6.318774	0.028697572	CREBBP CSF2 IFNLR1 EP300 EPOR CBLC IFNAR1 IFNAR2 IFNG IFNGR1 IL10RB IL15 IL15RA LIF IL26 IL22RA1 TSLP	1387 1437 163702 2033 2057 23624 3454 3455 3458 3459 3588 3600 3601 3976 55801 58985 85480
antineoplastic-647246	-	Pathways in cancer	path:05200_12	7	6.049631	0.039735099	EGLN3 EP300 HIF1A ARNT PDGFB TGFA RBX1	112399 2033 3091 405 5155 7039 9978
antineoplastic-648770	-	Purine metabolism	path:00230_36	10	6.97061	0.008820287	POLR3F POLR3A AK5 NUDT2 NME1 POLR1D POLR3B POLR1E PNPT1 POLR1C	10621 11128 26289 318 4830 51082 55703 64425 87178 9533
antineoplastic-648770	-	Pyrimidine metabolism	path:00240_30	9	7.150725	0.005512679	POLR3A CTPS1 NME1 POLR1D POLR2H POLR3B PNPT1 POLR1C ENTPD6	11128 1503 4830 51082 5437 55703 87178 9533 955
antineoplastic-648770	-	Nicotinate and nicotinamide metabolism	path:00760_3	4	5.801735	0.036383682	NT5C2 PNP NMRK1 NMNAT1	22978 4860 54981 64802
antineoplastic-648770	-	cAMP signaling pathway	path:04024_10	7	5.745277	0.044101433	EDNRA FSHR GNAI3 NPY1R SUCNR1 PTGER3 GABBR2	1909 2492 2773 4886 56670 5733 9568
antineoplastic-648770	-	FoxO signaling pathway	path:04068_20	15	5.945549	0.029768467	KLF2 PLK2 GADD45G PLK3 MAPK14 GADD45A FOXO1 FOXO4 PRKAG3 PRKAA2 MAPK10 RAG2 BCL6 TNFSF10 CCNB2	10365 10769 10912 1263 1432 1647 2308 4303 53632 5563 5602 5897 604 8743 9133
antineoplastic-648770	-	Phosphatidylinositol signaling system	path:04070_15	7	5.796128	0.037486218	INPP5B MTM1 PIK3C2A PIK3C3 PIK3CA PIK3CD PLCB4	3633 4534 5286 5289 5290 5293 5332
antineoplastic-648770	-	Cell cycle	path:04110_3	8	5.929079	0.030871003	CDK4 CDKN1C GADD45G PCNA ANAPC11 SKP2 CCNB2 RBX1	1019 1028 10912 5111 51529 6502 9133 9978
antineoplastic-648770	-	Wnt signaling pathway	path:04310_8	3	6.628353	0.016538037	PLCB4 PPP3R1 CAMK2G	5332 5534 818
antineoplastic-648770	-	Focal adhesion	path:04510_32	10	7.312859	0.005512679	FLNA FLNB ILK ITGAV ITGB5 PIK3CD THBS1 TLN1 TLN2 CAV3	2316 2317 3611 3685 3693 5293 7057 7094 83660 859
antineoplastic-648770	-	Serotonergic synapse	path:04726_11	7	6.571557	0.016538037	GNB5 GNAI3 GNAQ GNG3 PLCB4 GNG12 GNB4	10681 2773 2776 2785 5332 55970 59345
antineoplastic-648771	-	Purine metabolism	path:00230_37	8	5.885018	0.03190319	ADCY9 NUDT16 DCK PDE7B IMPDH1 PDE2A PDE5A ENTPD6	115 131870 1633 27115 3614 5138 8654 955
antineoplastic-648771	-	Pyrimidine metabolism	path:00240_31	9	5.72578	0.03410341	POLR3C NME7 ZNRD1 POLR2B POLR2D POLR2F POLR2J POLR3B POLR1C	10623 29922 30834 5431 5433 5435 5439 55703 9533
antineoplastic-648771	-	Starch and sucrose metabolism	path:00500_2	8	5.784009	0.0330033	AGL GAA GANC GBE1 ENPP1 ENPP3 PGM1 HKDC1	178 2548 2595 2632 5167 5169 5236 80201
antineoplastic-648771	-	Rap1 signaling pathway	path:04015_22	15	5.473359	0.04730473	CRK CRKL CSF1R EFNA3 FGF7 FGFR3 FGF21 HGF INSR KIT MET PDGFB PLCB3 PLCB4 PDGFD	1398 1399 1436 1944 2252 2261 26291 3082 3643 3815 4233 5155 5331 5332 80310
antineoplastic-648771	-	Chemokine signaling pathway	path:04062_24	7	7.423632	0	GNAI1 GNB2 GNG7 GNG11 GNGT1 PLCB3 PLCB4	2770 2783 2788 2791 2792 5331 5332
antineoplastic-648771	-	FoxO signaling pathway	path:04068_21	6	7.380698	0	AKT3 FOXO1 IKBKB PIK3CG PTEN HOMER1	10000 2308 3551 5294 5728 9456
antineoplastic-648771	-	Phosphatidylinositol signaling system	path:04070_16	10	6.050028	0.02750275	CDIPT ITPKA PIK3C3 PIK3CG PIK3R1 PLCB4 IMPAD1 PTEN DGKZ DGKE	10423 3706 5289 5294 5295 5332 54928 5728 8525 8526
antineoplastic-648771	-	Sphingolipid signaling pathway	path:04071_8	8	5.484982	0.04510451	AKT3 PPP2CA PPP2R1B PPP2R2B PPP2R5C PPP2R5D PPP2R2D PRKCZ	10000 5515 5519 5521 5527 5528 55844 5590
antineoplastic-648771	-	Cell cycle	path:04110_4	5	6.035883	0.02750275	ANAPC10 BUB1B CDC14A CCNB2 BUB3	10393 701 8556 9133 9184
antineoplastic-648771	-	Wnt signaling pathway	path:04310_9	3	6.947767	0.00220022	PLCB4 RAC3 CAMK2A	5332 5881 815
antineoplastic-648771	-	Hippo signaling pathway	path:04390_15	5	5.857775	0.03190319	SERPINE1 PPP2CA PPP2R1B PPP2R2B PPP2R2D	5054 5515 5519 5521 55844
antineoplastic-648771	-	Focal adhesion	path:04510_33	7	5.472792	0.04730473	FLNA ITGA2 ITGA2B ITGAV ITGB3 PXN THBS1	2316 3673 3674 3685 3690 5829 7057
antineoplastic-648771	-	Platelet activation	path:04611_5	8	6.020635	0.02860286	AKT3 RASGRP1 ADCY8 ADCY9 GNAI1 PIK3CG PIK3R1 PRKX	10000 10125 114 115 2770 5294 5295 5613
antineoplastic-648771	-	Circadian entrainment	path:04713_13	10	7.188612	0.00110011	ADCY8 ADCY9 GNAI1 GNAI3 GNB2 GNG7 GNG11 GNGT1 PLCB4 MAPK3	114 115 2770 2773 2783 2788 2791 2792 5332 5595
antineoplastic-648771	-	Retrograde endocannabinoid signaling	path:04723_10	16	6.932548	0.00220022	ADCY8 ADCY9 MAPK14 GNAI1 GNAI3 GNAO1 GNB2 GNG4 GNG7 GNG11 GNGT1 MAPK3 GNG12 MAPK8 MAPK10 PRKX	114 115 1432 2770 2773 2775 2783 2786 2788 2791 2792 5595 55970 5599 5602 5613
antineoplastic-648771	-	Glutamatergic synapse	path:04724_8	12	6.502466	0.0110011	ADCY8 ADCY9 GNAI1 GNAI3 GNAO1 GNB2 GNG4 GNG7 GNG11 GNGT1 GNG12 PRKX	114 115 2770 2773 2775 2783 2786 2788 2791 2792 55970 5613
antineoplastic-648771	-	Cholinergic synapse	path:04725_15	14	7.608109	0	AKT3 ADCY8 ADCY9 GNAI1 GNAO1 GNB2 GNG4 GNG7 GNG11 GNGT1 PIK3CG PIK3R1 GNG12 PRKX	10000 114 115 2770 2775 2783 2786 2788 2791 2792 5294 5295 55970 5613
antineoplastic-648771	-	Serotonergic synapse	path:04726_12	11	6.50858	0.0110011	GNAI1 GNAI3 GNAO1 GNB2 GNG4 GNG7 GNG11 GNGT1 HTR1F PLCB4 GNG12	2770 2773 2775 2783 2786 2788 2791 2792 3355 5332 55970
antineoplastic-648771	-	GABAergic synapse	path:04727_9	9	6.353066	0.01760176	ADCY8 GABBR1 GNAI1 GNAO1 GNB2 GNG7 GNG11 GNGT1 CACNA1D	114 2550 2770 2775 2783 2788 2791 2792 776
antineoplastic-648771	-	Dopaminergic synapse	path:04728_17	9	6.335812	0.01760176	GNAI1 GNAI3 GNAO1 GNB2 GNG7 GNG11 GNGT1 PLCB4 GNG12	2770 2773 2775 2783 2788 2791 2792 5332 55970
antineoplastic-648771	-	Morphine addiction	path:05032_8	9	5.738102	0.03410341	GABBR1 GNAI3 GNAO1 GNB2 GNG7 GNG11 GNGT1 PRKCG GNG12	2550 2773 2775 2783 2788 2791 2792 5582 55970
antineoplastic-648773	-	Pyrimidine metabolism	path:00240_32	7	6.287897	0.029572837	POLR3A NME7 ZNRD1 POLR1D POLR2A POLR3B POLR1C	11128 29922 30834 51082 5430 55703 9533
antineoplastic-648773	-	FoxO signaling pathway	path:04068_22	13	6.93825	0.013143483	CDK2 CDKN1B CDKN2B CHUK GADD45A FOXO1 GABARAPL1 NLK PRKAG1 STAT3 STK4 CCND2 CCNB2	1017 1027 1030 1147 1647 2308 23710 51701 5571 6774 6789 894 9133
antineoplastic-648773	-	Cell cycle	path:04110_5	9	9.152	0.00109529	CDK4 CDKN1B CDKN2B CDKN2C GADD45A SMAD4 PCNA CCND2 CDC25A	1019 1027 1030 1031 1647 4089 5111 894 993
antineoplastic-648773	-	Endocytosis	path:04144_4	4	6.375341	0.025191676	RNF41 ERBB4 EPN2 MDM2	10193 2066 22905 4193
antineoplastic-648773	-	PI3K-Akt signaling pathway	path:04151_25	4	7.963021	0.004381161	ITGA5 ITGAV ITGB3 PTK2	3678 3685 3690 5747
antineoplastic-648773	-	Focal adhesion	path:04510_34	5	7.525577	0.005476451	FLNA ITGA5 ITGAV ITGB1 TLN2	2316 3678 3685 3688 83660
antineoplastic-648773	-	Jak-STAT signaling pathway	path:04630_18	4	6.574888	0.019715225	SOS2 STAT2 STAT5B CCND2	6655 6773 6777 894
antineoplastic-648773	-	Pathways in cancer	path:05200_13	8	8.201559	0.003285871	CDK2 CDK4 CDKN1B CDKN2A CDKN2B MDM2 RB1 TP53	1017 1019 1027 1029 1030 4193 5925 7157
antineoplastic-648773	-	Chronic myeloid leukemia	path:05220_3	8	7.100932	0.009857612	CDK4 CDKN1B CDKN2A CHUK AKT2 MDM2 RB1 TP53	1019 1027 1029 1147 208 4193 5925 7157
antineoplastic-648773	-	Small cell lung cancer	path:05222_4	5	6.326662	0.028477547	CDK2 CDK4 CDKN1B CDKN2B RB1	1017 1019 1027 1030 5925
antineoplastic-648776	-	Purine metabolism	path:00230_38	18	8.090982	0.001112347	POLR3F ADCY6 ADSSL1 AK2 PDE7B NUDT2 HPRT1 IMPDH2 NME1 POLR1D PDE9A PDE6B POLR2C ADCY10 RRM2 POLR1E POLR1C ENTPD6	10621 112 122622 204 27115 318 3251 3615 4830 51082 5152 5158 5432 55811 6241 64425 9533 955
antineoplastic-648776	-	Rap1 signaling pathway	path:04015_23	8	5.64982	0.045606229	FGF6 FGFR1 FGFR2 PLCB1 ANGPT1 PLCB4 VEGFA PDGFD	2251 2260 2263 23236 284 5332 7422 80310
antineoplastic-648776	-	Calcium signaling pathway	path:04020_20	11	5.837973	0.038932147	ADRA1D PLCB1 GNAQ HTR2A NTSR1 OXTR PLCB4 PLCG1 PTAFR TBXA2R TRHR	146 23236 2776 3356 4923 5021 5332 5335 5724 6915 7201
antineoplastic-648776	-	Chemokine signaling pathway	path:04062_25	6	6.852313	0.004449388	PIK3R5 GNB1 GNB3 GNG11 GNGT1 PLCB4	23533 2782 2784 2791 2792 5332
antineoplastic-648776	-	HIF-1 signaling pathway	path:04066_9	6	5.610705	0.04894327	ANGPT1 HIF1A SERPINE1 PGK1 TIMP1 VEGFA	284 3091 5054 5230 7076 7422
antineoplastic-648776	-	Phosphatidylinositol signaling system	path:04070_17	14	5.784118	0.038932147	DGKA PLCB1 INPP5B ITPKA MTM1 PIK3C2B PIK3CG PLCB4 PLCG1 PTEN PIP5K1A DGKZ CDS2 SYNJ2	1606 23236 3633 3706 4534 5287 5294 5332 5335 5728 8394 8525 8760 8871
antineoplastic-648776	-	Serotonergic synapse	path:04726_13	10	5.96778	0.035595106	PLCB1 GNAI3 GNB3 GNG11 GNGT1 HTR1B HTR1D HTR2A HTR6 PLCB4	23236 2773 2784 2791 2792 3351 3352 3356 3362 5332
antineoplastic-648776	-	Inflammatory mediator regulation of TRP channels	path:04750_1	7	5.704448	0.042269188	ADCY6 GNAS PRKACA PTGER4 MAPK12 TRPV1 CALM1	112 2778 5566 5734 6300 7442 801
antineoplastic-648776	-	Oxytocin signaling pathway	path:04921_12	8	6.488247	0.010011123	ADCY2 ADCY6 PLCB1 GNAI3 GNAS OXTR PLCB4 SRC	108 112 23236 2773 2778 5021 5332 6714
antineoplastic-648778	-	Purine metabolism	path:00230_39	8	6.470191	0.02062975	NME6 AK8 AK1 NME7 ITPA NPR2 POLR1E POLR3D	10201 158067 203 29922 3704 4882 64425 661
antineoplastic-648778	-	HIF-1 signaling pathway	path:04066_10	14	7.019742	0.009771987	ENO2 GAPDH ANGPT1 ANGPT2 HIF1A ARNT LTBR NOS2 NPPA PDK1 PFKL TFRC TIMP1 VEGFA	2026 2597 284 285 3091 405 4055 4843 4878 5163 5211 7037 7076 7422
antineoplastic-648778	-	FoxO signaling pathway	path:04068_23	11	6.198836	0.027144408	CDKN1A PLK2 PLK3 FOXO4 PRKAB2 MAPK3 RAG2 CCND1 CAT CCNB3 CCNB1	1026 10769 1263 4303 5565 5595 5897 595 847 85417 891
antineoplastic-648778	-	Jak-STAT signaling pathway	path:04630_19	8	5.659396	0.049945711	IFNLR1 IL19 IFNAR2 IL2RG IL10RB IL11RA IL15RA IL20RA	163702 29949 3455 3561 3588 3590 3601 53832
antineoplastic-648778	-	Regulation of actin cytoskeleton	path:04810_12	5	6.426333	0.021715527	PAK3 RAC2 WAS MYLK3 CDC42	5063 5880 7454 91807 998
antineoplastic-648780	-	Purine metabolism	path:00230_40	6	6.697918	0.01650165	AK8 AK1 RRM1 PNPT1 ENTPD6 ENTPD5	158067 203 6240 87178 955 957
antineoplastic-648780	-	Pyrimidine metabolism	path:00240_33	6	7.41272	0.00440044	POLR2J2 ENTPD8 POLR2A POLR2D RRM1 PNPT1	246721 377841 5430 5433 6240 87178
antineoplastic-648780	-	Calcium signaling pathway	path:04020_21	8	5.923748	0.04620462	GRIN2A GRIN2D ATP2A3 ATP2B4 P2RX4 RYR2 SLC8A2 CACNA1S	2903 2906 489 493 5025 6262 6543 779
antineoplastic-648780	-	cGMP-PKG signaling pathway	path:04022_13	10	5.936443	0.04510451	ATF4 ATP1A4 ATP1B1 ATP2B4 PLCB4 PPP1CB PRKG2 SLC8A2 CACNA1S CREB5	468 480 481 493 5332 5500 5593 6543 779 9586
antineoplastic-648780	-	FoxO signaling pathway	path:04068_24	16	6.926722	0.01320132	AKT3 SGK2 CDK2 CDKN1A PLK4 PLK2 PLK3 FOXO1 IKBKB FASLG PRKAA2 PRKAB2 RAG2 CCND1 SETD7 CCNB1	10000 10110 1017 1026 10733 10769 1263 2308 3551 356 5563 5565 5897 595 80854 891
antineoplastic-648784	-	Purine metabolism	path:00230_41	8	6.148978	0.042081949	NUDT16 HPRT1 ITPA PNP PDE6D GMPS ENTPD6 ENTPD4	131870 3251 3704 4860 5147 8833 955 9583
antineoplastic-648784	-	Glycerophospholipid metabolism	path:00564_6	12	6.111061	0.042081949	DGKH DGKQ PLD1 PLD2 CRLS1 LPCAT2 PLA2G12A DGKZ DGKE CDS2 DGKI LPIN2	160851 1609 5337 5338 54675 54947 81579 8525 8526 8760 9162 9663
antineoplastic-648784	-	Chemokine signaling pathway	path:04062_26	7	7.058533	0.009966777	GNAI1 GNB1 GNB2 GNG11 GNGT1 CXCR3 PLCB4	2770 2782 2783 2791 2792 2833 5332
antineoplastic-648784	-	Phosphatidylinositol signaling system	path:04070_18	3	6.154234	0.042081949	PLCB4 DGKZ CDS2	5332 8525 8760
antineoplastic-648784	-	Hippo signaling pathway	path:04390_16	6	5.915483	0.049833887	SMAD2 SMAD3 SERPINE1 BMP2 BMPR1B GDF5	4087 4088 5054 650 658 8200
antineoplastic-648784	-	Focal adhesion	path:04510_35	5	6.780537	0.018826135	FLNA FLNC ITGA2 ITGB1 THBS1	2316 2318 3673 3688 7057
antineoplastic-648784	-	Circadian entrainment	path:04713_14	3	6.045769	0.045404208	GNG11 GNGT1 PLCB4	2791 2792 5332
antineoplastic-648784	-	Cholinergic synapse	path:04725_16	8	6.225931	0.035437431	AKT3 ADCY2 GNAI1 GNAO1 GNB1 GNG11 GNGT1 PIK3R1	10000 108 2770 2775 2782 2791 2792 5295
antineoplastic-648784	-	Serotonergic synapse	path:04726_14	3	6.045769	0.045404208	GNG11 GNGT1 PLCB4	2791 2792 5332
antineoplastic-648784	-	Dopaminergic synapse	path:04728_18	3	6.045769	0.045404208	GNG11 GNGT1 PLCB4	2791 2792 5332
antineoplastic-648784	-	Proteoglycans in cancer	path:05205_2	4	6.123293	0.042081949	CTNNB1 ITGA2 ITGB1 VEGFA	1499 3673 3688 7422
antineoplastic-648785	-	Purine metabolism	path:00230_42	21	6.21046	0.019079686	ADA ADCY9 ADCY4 NT5C2 AMPD3 GUCY1A2 NME7 NT5C ZNRD1 HPRT1 NPR2 GMPR2 PDE2A PDE3A PDE3B PDE6G POLR2C POLR3B POLR3E ENTPD1 POLR1C	100 115 196883 22978 272 2977 29922 30833 30834 3251 4882 51292 5138 5139 5140 5148 5432 55703 55718 953 9533
antineoplastic-648785	-	Glycerophospholipid metabolism	path:00564_7	10	5.70303	0.04040404	PEMT PLA2G16 DGKA PLD1 LPCAT2 AGPAT3 CHPT1 PLA2G2F PLA2G12A CDS2	10400 11145 1606 5337 54947 56894 56994 64600 81579 8760
antineoplastic-648785	-	MAPK signaling pathway	path:04010_10	8	6.056646	0.028058361	FGF12 FGFR2 GRB2 KRAS NTRK2 PRKCB RASGRF2 SOS2	2257 2263 2885 3845 4915 5579 5924 6655
antineoplastic-648785	-	FoxO signaling pathway	path:04068_25	20	6.290894	0.015712682	BCL2L11 GADD45G CHUK AKT1 FASLG FOXO4 PCK2 PLK1 PRKAG1 MAPK3 MAPK8 MAPK11 G6PC2 RAG2 BCL6 MAPK12 CCNB3 TNFSF10 CCNB2 G6PC3	10018 10912 1147 207 356 4303 5106 5347 5571 5595 5599 5600 57818 5897 604 6300 85417 8743 9133 92579
antineoplastic-648785	-	Adherens junction	path:04520_4	3	6.017737	0.028058361	CTNND1 RAC1 RAC2	1500 5879 5880
antineoplastic-648785	-	Jak-STAT signaling pathway	path:04630_20	14	7.038023	0.007856341	CSF2RB IL2RB IL4 IL4R IL5 IL7 IL9 IL10 IL13RA1 JAK2 TSLP SOCS1 CBLB SOCS3	1439 3560 3565 3566 3567 3574 3578 3586 3597 3717 85480 8651 868 9021
antineoplastic-648785	-	Regulation of actin cytoskeleton	path:04810_13	5	5.698168	0.04040404	KRAS PAK3 RAC1 RAC2 MYLK3	3845 5063 5879 5880 91807
antineoplastic-648785	-	Insulin signaling pathway	path:04910_9	8	6.078263	0.026936027	FASN GRB2 PIK3CA PIK3CB PRKCI MAPK8 IRS4 IRS2	2194 2885 5290 5291 5584 5599 8471 8660
antineoplastic-648785	-	Pathways in cancer	path:05200_14	6	5.811592	0.035914703	GRB2 KIT KRAS PIK3CA SOS2 CBLB	2885 3815 3845 5290 6655 868
antineoplastic-651079	-	Glycerophospholipid metabolism	path:00564_8	12	6.753289	0.012074643	CDS1 PLA2G16 PLD4 DGKA DGKG LPIN1 PLA2G15 PLD2 PLA2G2F DGKE DGKD PLA2G4C	1040 11145 122618 1606 1608 23175 23659 5338 64600 8526 8527 8605
antineoplastic-651079	-	Ether lipid metabolism	path:00565_1	8	6.919145	0.009879254	PLA2G16 PLD4 ENPP6 PAFAH1B1 PAFAH1B2 PLD2 PLA2G2F PLA2G4C	11145 122618 133121 5048 5049 5338 64600 8605
antineoplastic-651079	-	Glycosphingolipid biosynthesis - lacto and neolacto series	path:00601_2	5	6.504225	0.020856202	FUT1 FUT2 FUT3 FUT4 FUT6	2523 2524 2525 2526 2528
antineoplastic-651079	-	Ras signaling pathway	path:04014_15	18	6.09574	0.03622393	CSF1R FGF2 FGF6 FGF8 FGF11 FGF20 FGF21 IGF1R INSR ANGPT4 PDGFA PDGFB SHC1 TEK VEGFB PDGFD FGF23 FGF18	1436 2247 2251 2253 2256 26281 26291 3480 3643 51378 5154 5155 6464 7010 7423 80310 8074 8817
antineoplastic-651079	-	Calcium signaling pathway	path:04020_22	10	7.947152	0	PTK2B ATP2A3 ATP2B3 P2RX1 P2RX3 P2RX5 SLC8A2 TNNC2 CACNA1C CALM3	2185 489 492 5023 5024 5026 6543 7125 775 808
antineoplastic-651079	-	Chemokine signaling pathway	path:04062_27	19	5.97582	0.037321625	CCR1 CCR6 CCR7 GNAI2 ARRB2 PF4V1 CCL28 CXCL16 CCL2 CCL8 CCL11 CCL13 CCL18 CCL23 CCL25 CXCL11 CXCL5 CXCR5 CXCL14	1230 1235 1236 2771 409 5197 56477 58191 6347 6355 6356 6357 6362 6368 6370 6373 6374 643 9547
antineoplastic-651079	-	TGF-beta signaling pathway	path:04350_1	3	5.806073	0.047200878	SMAD2 ACVR1 ZFYVE16	4087 90 9765
antineoplastic-651079	-	Fc gamma R-mediated phagocytosis	path:04666_6	9	5.82532	0.047200878	AKT3 PIK3R5 PIK3CG PLD2 SPHK2 RAC1 VAV1 WAS PIP5K1A	10000 23533 5294 5338 56848 5879 7409 7454 8394
antineoplastic-651079	-	Circadian entrainment	path:04713_15	12	6.444327	0.023051592	GNB5 ADCY1 ADCY3 ADCY9 ADCY4 GNAQ GNB3 GNG3 MTNR1A MTNR1B PLCB2 PRKX	10681 107 109 115 196883 2776 2784 2785 4543 4544 5330 5613
antineoplastic-651079	-	Retrograde endocannabinoid signaling	path:04723_11	12	5.858008	0.046103183	GNB5 ADCY1 ADCY3 ADCY9 ADCY4 GNB1 GNB3 GNG3 MAPK11 MAPK10 PRKX MAPK12	10681 107 109 115 196883 2782 2784 2785 5600 5602 5613 6300
antineoplastic-651079	-	Glutamatergic synapse	path:04724_9	6	6.556469	0.019758507	GNAQ GRIA4 GRIK4 GRIN2D GRM5 HOMER2	2776 2893 2900 2906 2915 9455
antineoplastic-651079	-	Cholinergic synapse	path:04725_17	11	5.931501	0.039517014	AKT3 GNB5 ADCY1 ADCY3 ADCY4 PIK3R5 GNB1 GNB3 GNG3 PIK3CG PRKX	10000 10681 107 109 196883 23533 2782 2784 2785 5294 5613
antineoplastic-651079	-	GABAergic synapse	path:04727_10	8	6.23844	0.027442371	GNB5 ADCY1 ADCY3 ADCY4 GABBR1 GNB3 GNG3 CACNA1C	10681 107 109 196883 2550 2784 2785 775
antineoplastic-651079	-	Dopaminergic synapse	path:04728_19	7	6.281973	0.027442371	GNB5 DRD2 GNB1 GNB3 GNG3 GNGT2 PLCB2	10681 1813 2782 2784 2785 2793 5330
antineoplastic-651079	-	Regulation of actin cytoskeleton	path:04810_14	3	6.493824	0.021953897	CRK ITGAV RAC1	1398 3685 5879
antineoplastic-651079	-	Morphine addiction	path:05032_9	10	5.759011	0.048298573	GNB5 ADCY1 ADCY3 ADCY9 ADCY4 GABBR1 GNB1 GNB3 GNG3 PRKX	10681 107 109 115 196883 2550 2782 2784 2785 5613
antineoplastic-651079	-	Glioma	path:05214_4	9	5.799213	0.047200878	AKT3 PIK3R5 IGF1R ARAF NRAS PIK3CG SHC1 CALM3 CAMK2G	10000 23533 3480 369 4893 5294 6464 808 818
antineoplastic-651080	-	Purine metabolism	path:00230_43	10	7.173819	0.004474273	POLR3G GUCY2D ZNRD1 POLR2B POLR2G POLR2I POLR2L POLR1E POLR3D ENTPD2	10622 3000 30834 5431 5436 5438 5441 64425 661 954
antineoplastic-651080	-	Pyrimidine metabolism	path:00240_34	12	6.937662	0.010067114	NME6 POLR3G ZNRD1 ENTPD8 RRM2B POLR2A POLR2B POLR2G POLR2I POLR2L POLR1E POLR3D	10201 10622 30834 377841 50484 5430 5431 5436 5438 5441 64425 661
antineoplastic-651080	-	Inositol phosphate metabolism	path:00562_4	11	6.998551	0.010067114	PLCB1 OCRL INPP5K PIK3CA PIK3CG PLCB2 PLCB3 PLCB4 PLCG2 PTEN MINPP1	23236 4952 51763 5290 5294 5330 5331 5332 5336 5728 9562
antineoplastic-651080	-	Glycerophospholipid metabolism	path:00564_9	7	6.51906	0.020134228	CEPT1 PLA2G16 DGKA PLD2 CHPT1 DGKE PLA2G4C	10390 11145 1606 5338 56994 8526 8605
antineoplastic-651080	-	Ether lipid metabolism	path:00565_2	7	6.31013	0.027964206	CEPT1 PLA2G16 PAFAH1B1 PAFAH1B2 PLD2 CHPT1 PLA2G4C	10390 11145 5048 5049 5338 56994 8605
antineoplastic-651080	-	MAPK signaling pathway	path:04010_11	7	6.298193	0.029082774	CRK MAPK10 MAPK13 MAP2K7 PTPN7 TP53 MAPK8IP1	1398 5602 5603 5609 5778 7157 9479
antineoplastic-651080	-	Rap1 signaling pathway	path:04015_24	7	8.217174	0	CRK FGF2 FGF5 FGF13 KDR PLCB2 PLCB4	1398 2247 2250 2258 3791 5330 5332
antineoplastic-651080	-	Calcium signaling pathway	path:04020_23	9	7.163512	0.004474273	PTK2B SLC25A5 ITPR1 ATP2A3 ATP2B4 P2RX1 TNNC2 TNNC1 CALM3	2185 292 3708 489 493 5023 7125 7134 808
antineoplastic-651080	-	Chemokine signaling pathway	path:04062_28	14	7.576626	0.001118568	CCL26 CCR1 CCR3 CCR7 GRK2 GRK3 GNAI1 CXCR3 GRK6 CXCL8 ARRB2 PF4V1 CXCL16 CXCR4	10344 1230 1232 1236 156 157 2770 2833 2870 3576 409 5197 58191 7852
antineoplastic-651080	-	Phosphatidylinositol signaling system	path:04070_19	19	8.544581	0	DGKA PLCB1 PIK3R5 INPP4A INPP5D ITPKA OCRL INPP5K PIK3CA PIK3CG PIK3R1 PI4KB PLCB2 PLCB3 PLCB4 PLCG2 PI4K2B PTEN DGKE	1606 23236 23533 3631 3635 3706 4952 51763 5290 5294 5295 5298 5330 5331 5332 5336 55300 5728 8526
antineoplastic-651080	-	PI3K-Akt signaling pathway	path:04151_26	4	7.527659	0.001118568	ITGA5 ITGAV ITGB1 PTK2	3678 3685 3688 5747
antineoplastic-651080	-	Apoptosis	path:04210_2	7	6.044757	0.045861298	XIAP NFKB1 BCL2 BCL2L1 TP53 BIRC7 CASP3	331 4790 596 598 7157 79444 836
antineoplastic-651080	-	Wnt signaling pathway	path:04310_10	4	6.162484	0.041387025	NFATC3 PLCB2 PPP3CC PRKCG	4775 5330 5533 5582
antineoplastic-651080	-	Jak-STAT signaling pathway	path:04630_21	5	6.993703	0.010067114	IL2RG IL6ST IL9 IL15RA OSM	3561 3572 3578 3601 5008
antineoplastic-651080	-	Fc epsilon RI signaling pathway	path:04664_2	12	6.337065	0.027964206	VAV3 PIK3R5 LCP2 PIK3CA PIK3CG PIK3R1 PLCG2 MAP2K7 RAC1 RAC2 SYK VAV1	10451 23533 3937 5290 5294 5295 5336 5609 5879 5880 6850 7409
antineoplastic-651080	-	Fc gamma R-mediated phagocytosis	path:04666_7	8	6.585139	0.01901566	AKT2 PIK3R5 PIK3CA PIK3CG PLCG2 PLD2 SYK SPHK1	208 23533 5290 5294 5336 5338 6850 8877
antineoplastic-651080	-	Leukocyte transendothelial migration	path:04670_5	6	6.096041	0.044742729	PTK2B ITGAL RAC1 RAC2 VAV1 RASSF5	2185 3683 5879 5880 7409 83593
antineoplastic-651080	-	Regulation of actin cytoskeleton	path:04810_15	4	6.527707	0.01901566	CRK PAK6 RAC1 RAC2	1398 56924 5879 5880
antineoplastic-651080	-	Pathways in cancer	path:05200_15	8	7.803857	0.001118568	CRK PIK3R5 ABL1 PIK3CA PIK3CG BAD BCL2L1 STAT5A	1398 23533 25 5290 5294 572 598 6776
antineoplastic-651080	-	Chronic myeloid leukemia	path:05220_4	9	8.664803	0	CRK PIK3R5 ABL1 PIK3CA PIK3CG BAD BCL2L1 SHC1 STAT5A	1398 23533 25 5290 5294 572 598 6464 6776
antineoplastic-651195	-	Purine metabolism	path:00230_44	12	6.80888	0.007683864	ADCY6 ADCY7 ADCY9 NME7 ZNRD1 NUDT2 POLR1D PDE6G POLR2C POLR2H POLR1E ENTPD2	112 113 115 29922 30834 318 51082 5148 5432 5437 64425 954
antineoplastic-651195	-	Pyrimidine metabolism	path:00240_35	9	6.337803	0.021953897	CANT1 DUT NME7 NUDT2 POLR1D POLR2D POLR2H PRIM1 POLR1E	124583 1854 29922 318 51082 5433 5437 5557 64425
antineoplastic-651195	-	Ras signaling pathway	path:04014_16	14	5.712859	0.03622393	CSF1 CSF1R EFNA2 EGFR EPHA2 FGF2 FGF7 IGF1 SHC4 MET PDGFA PDGFB PDGFC VEGFC	1435 1436 1943 1956 1969 2247 2252 3479 399694 4233 5154 5155 56034 7424
antineoplastic-651195	-	Rap1 signaling pathway	path:04015_25	8	6.765161	0.008781559	AKT3 PIK3R5 RAPGEF1 PIK3R1 RAC3 RALGDS RAP1B RAP1GAP	10000 23533 2889 5295 5881 5900 5908 5909
antineoplastic-651195	-	Sphingolipid signaling pathway	path:04071_9	6	6.317783	0.021953897	AKT3 PDPK1 PIK3R1 PLD2 RAC3 SPHK1	10000 5170 5295 5338 5881 8877
antineoplastic-651195	-	Focal adhesion	path:04510_36	5	6.988131	0.007683864	FLNB ITGA2 ITGB1 THBS1 TLN2	2317 3673 3688 7057 83660
antineoplastic-651195	-	Jak-STAT signaling pathway	path:04630_22	6	6.861171	0.007683864	IL6ST IL7R IL12A LIF LIFR OSMR	3572 3575 3592 3976 3977 9180
antineoplastic-651195	-	Neurotrophin signaling pathway	path:04722_2	8	5.746806	0.035126235	AKT3 PIK3R5 HRAS PDPK1 PIK3R1 MAPK11 RPS6KA1 MAPKAPK2	10000 23533 3265 5170 5295 5600 6195 9261
antineoplastic-651195	-	Cholinergic synapse	path:04725_18	9	5.933977	0.030735456	ADCY6 ADCY9 GNB3 GNG11 GNGT1 GNG13 PIK3R1 PRKX CAMK2A	112 115 2784 2791 2792 51764 5295 5613 815
antineoplastic-651195	-	Insulin signaling pathway	path:04910_10	5	5.61807	0.047200878	AKT3 GYS2 PDPK1 PHKB PPP1CA	10000 2998 5170 5257 5499
antineoplastic-651195	-	Thyroid hormone signaling pathway	path:04919_9	3	6.198944	0.023051592	MYC PIK3R1 THRB	4609 5295 7068
antineoplastic-651195	-	Pathways in cancer	path:05200_16	9	7.105675	0.006586169	AKT3 RASSF1 EGFR PIK3R5 HRAS PIK3CB PIK3R1 RAC3 RALGDS	10000 11186 1956 23533 3265 5291 5295 5881 5900
antineoplastic-651195	-	Endometrial cancer	path:05213_1	7	6.00545	0.027442371	AKT3 EGFR PIK3R5 ILK PDPK1 PIK3R1 CASP9	10000 1956 23533 3611 5170 5295 842
antineoplastic-651195	-	Prostate cancer	path:05215_4	8	6.812784	0.007683864	AKT3 EGFR PIK3R5 PDGFA PDGFB PDPK1 PIK3R1 PDGFC	10000 1956 23533 5154 5155 5170 5295 56034
antineoplastic-651195	-	Small cell lung cancer	path:05222_5	3	5.606723	0.047200878	ITGA2 ITGB1 PTK2	3673 3688 5747
antineoplastic-651195	-	Choline metabolism in cancer	path:05231_5	8	6.721682	0.009879254	AKT3 EGFR PIK3R5 HRAS PDPK1 PIK3R1 PLD2 RALGDS	10000 1956 23533 3265 5170 5295 5338 5900
antineoplastic-651590	-	Purine metabolism	path:00230_45	24	7.092037	0.007821229	NME6 ADCY1 ADCY8 ADCY9 ADSL AK2 PDE7B AMPD3 ZNRD1 POLR1D PDE1C PDE4A PDE8A PDE1B POLR3K PKLR PKM POLD1 POLR2L PRIM1 PRIM2 POLR3GL GMPS POLR1C	10201 107 114 115 158 204 27115 272 30834 51082 5137 5141 5151 5153 51728 5313 5315 5424 5441 5557 5558 84265 8833 9533
antineoplastic-651590	-	Rap1 signaling pathway	path:04015_26	6	6.618128	0.013407821	RGS14 ITGB1 ITGB2 PRKD1 RAP1B RASSF5	10636 3688 3689 5587 5908 83593
antineoplastic-651590	-	Calcium signaling pathway	path:04020_24	11	6.030761	0.031284916	ADCY8 PTK2B MYLK ATP2A1 PDE1C PDE1B PHKA2 PRKCB CALM1 ITPKC CALML3	114 2185 4638 487 5137 5153 5256 5579 801 80271 810
antineoplastic-651590	-	Chemokine signaling pathway	path:04062_29	6	6.703031	0.013407821	GRK2 GNAI1 CXCR3 GRK6 CCL1 CXCR5	156 2770 2833 2870 6346 643
antineoplastic-651590	-	FoxO signaling pathway	path:04068_26	13	6.331477	0.02122905	AKT3 PLK2 MAPK14 GABARAPL1 FOXO4 PRKAA2 PRKAB2 MAPK8 MAPK9 CCND1 SGK1 BNIP3 CCNG2	10000 10769 1432 23710 4303 5563 5565 5599 5601 595 6446 664 901
antineoplastic-651590	-	Phosphatidylinositol signaling system	path:04070_20	12	5.622861	0.043575419	DGKH INPP5B OCRL PLCE1 PIK3CG PLCB4 PI4K2A ITPKC PIP5K1A DGKZ DGKE DGKD	160851 3633 4952 51196 5294 5332 55361 80271 8394 8525 8526 8527
antineoplastic-651590	-	Sphingolipid signaling pathway	path:04071_10	7	5.568928	0.044692737	GNAI1 PIK3CB PIK3CG PLD2 RAC1 RAC2 RAC3	2770 5291 5294 5338 5879 5880 5881
antineoplastic-651590	-	mTOR signaling pathway	path:04150_4	6	6.257848	0.022346369	AKT3 MTOR HIF1A PRKAA2 PRKCB ULK2	10000 2475 3091 5563 5579 9706
antineoplastic-651590	-	PI3K-Akt signaling pathway	path:04151_27	3	6.189165	0.023463687	ITGB5 PTK2 THBS1	3693 5747 7057
antineoplastic-651590	-	Adherens junction	path:04520_5	4	5.95906	0.034636872	RAC1 RAC2 ACTB CDC42	5879 5880 60 998
antineoplastic-651590	-	Natural killer cell mediated cytotoxicity	path:04650_2	6	5.950771	0.034636872	LAT GRB2 LCP2 SHC1 SYK VAV2	27040 2885 3937 6464 6850 7410
antineoplastic-651590	-	Fc epsilon RI signaling pathway	path:04664_3	8	6.404745	0.018994413	MAPK14 MAPK9 MAP2K3 RAC1 RAC2 RAC3 MAP2K4 VAV1	1432 5601 5606 5879 5880 5881 6416 7409
antineoplastic-651590	-	Leukocyte transendothelial migration	path:04670_6	8	6.389937	0.018994413	PTK2B ITGB2 RAC1 RAC2 VAV1 VAV2 RASSF5 CDC42	2185 3689 5879 5880 7409 7410 83593 998
antineoplastic-651590	-	Circadian entrainment	path:04713_16	9	6.611339	0.013407821	ADCY8 ADCY9 ADCYAP1R1 GNAI1 GNG11 GNG13 PLCB4 PRKCB GNG12	114 115 117 2770 2791 51764 5332 5579 55970
antineoplastic-651590	-	Retrograde endocannabinoid signaling	path:04723_12	9	6.460953	0.016759777	ADCY8 ADCY9 MAPK14 GNAI1 GNG11 GNG13 GNG12 MAPK8 MAPK9	114 115 1432 2770 2791 51764 55970 5599 5601
antineoplastic-651590	-	Glutamatergic synapse	path:04724_10	6	5.763671	0.039106145	ADCY8 ADCY9 GNAI1 GNG11 GNG13 GNG12	114 115 2770 2791 51764 55970
antineoplastic-651590	-	Cholinergic synapse	path:04725_19	6	5.763671	0.039106145	ADCY8 ADCY9 GNAI1 GNG11 GNG13 GNG12	114 115 2770 2791 51764 55970
antineoplastic-651590	-	Serotonergic synapse	path:04726_15	8	5.771805	0.036871508	GNB5 GNAI1 GNG11 HTR1D GNG13 PLCB2 PLCB4 GNG12	10681 2770 2791 3352 51764 5330 5332 55970
antineoplastic-651590	-	GABAergic synapse	path:04727_11	7	5.600352	0.044692737	GABARAPL1 GABRA1 GABRA3 GABRA6 GABRE GABRG2 GABBR2	23710 2554 2556 2559 2564 2566 9568
antineoplastic-651590	-	Dopaminergic synapse	path:04728_20	7	6.785279	0.011173184	GNAI1 GNAO1 GNG11 PLCB2 PLCB4 PRKCB GNG12	2770 2775 2791 5330 5332 5579 55970
antineoplastic-651590	-	Regulation of actin cytoskeleton	path:04810_16	6	6.495651	0.015642458	CRK ITGAV ITGB2 PTK2 RAC1 RAC2	1398 3685 3689 5747 5879 5880
antineoplastic-651590	-	Oxytocin signaling pathway	path:04921_13	5	5.682356	0.041340782	ADCY8 ADCY9 GNAI1 PLCB2 PRKX	114 115 2770 5330 5613
antineoplastic-651590	-	Morphine addiction	path:05032_10	6	6.243792	0.022346369	ADCY1 ADCY8 GABBR1 GNAI1 GNG11 GNG12	107 114 2550 2770 2791 55970
antineoplastic-651590	-	Proteoglycans in cancer	path:05205_3	4	5.669889	0.043575419	RAC1 ACTB VAV2 CDC42	5879 60 7410 998
antineoplastic-651744	-	Purine metabolism	path:00230_46	11	6.394564	0.0110011	POLD3 ADCY2 POLR3H POLA2 GUCY2D PDE6C PKLR POLR2F POLD4 POLR3D NME5	10714 108 171568 23649 3000 5146 5313 5435 57804 661 8382
antineoplastic-651744	-	Pyrimidine metabolism	path:00240_36	7	5.661467	0.04950495	POLR3H POLR3K POLR2F POLR2G POLR3D NME5 POLR1C	171568 51728 5435 5436 661 8382 9533
antineoplastic-651744	-	Glutathione metabolism	path:00480_3	9	7.205692	0.00440044	GGT6 ANPEP GSTA3 GSTM1 GSTM2 GSTM3 GSTM4 GSTM5 GSTP1	124975 290 2940 2944 2946 2947 2948 2949 2950
antineoplastic-651744	-	Sphingolipid metabolism	path:00600_2	8	5.972027	0.03080308	DEGS2 KDSR CERS6 GALC ENPP7 ASAH1 SMPD4 SPTLC2	123099 2531 253782 2581 339221 427 55627 9517
antineoplastic-651744	-	Metabolism of xenobiotics by cytochrome P450	path:00980_3	10	7.44078	0.00330033	CYP2B6 CYP2F1 CYP3A4 GSTA3 GSTM1 GSTM2 GSTM3 GSTM4 GSTM5 GSTP1	1555 1572 1576 2940 2944 2946 2947 2948 2949 2950
antineoplastic-651744	-	Drug metabolism - cytochrome P450	path:00982_2	8	6.585253	0.00770077	ALDH3B1 GSTA3 GSTM1 GSTM2 GSTM3 GSTM4 GSTM5 GSTP1	221 2940 2944 2946 2947 2948 2949 2950
antineoplastic-651744	-	MAPK signaling pathway	path:04010_12	7	6.148259	0.02090209	MAPK8IP2 HSPA2 MAP3K11 NFATC1 MAPK10 PTPN5 MAPK8IP1	23542 3306 4296 4772 5602 84867 9479
antineoplastic-651744	-	Ras signaling pathway	path:04014_17	12	6.261772	0.01540154	EGFR FGF3 FLT1 FLT4 FGF21 ANGPT1 NGF NGFR ANGPT4 PDGFA VEGFB FGF19	1956 2248 2321 2324 26291 284 4803 4804 51378 5154 7423 9965
antineoplastic-651744	-	Calcium signaling pathway	path:04020_25	12	6.296862	0.01430143	GRIN1 ATP2A3 ATP2B3 P2RX3 CALML5 PRKCA RYR1 SLC8A3 TNNC1 VDAC1 CACNA1F CACNA1H	2902 489 492 5024 51806 5578 6261 6547 7134 7416 778 8912
antineoplastic-651744	-	Chemokine signaling pathway	path:04062_30	10	6.598639	0.00770077	GNAI3 PF4 PF4V1 CCL28 CCL3 CCL5 CCL8 CCL13 CCL18 CXCR4	2773 5196 5197 56477 6348 6352 6355 6357 6362 7852
antineoplastic-651744	-	FoxO signaling pathway	path:04068_27	16	7.103244	0.00440044	CHUK CSNK1E SGK3 GABARAPL1 IL7R FOXO4 PRKAG2 MAPK11 MAPK10 G6PC2 CCND1 MAPK12 BNIP3 STAT3 SETD7 ATG12	1147 1454 23678 23710 3575 4303 51422 5600 5602 57818 595 6300 664 6774 80854 9140
antineoplastic-651744	-	TGF-beta signaling pathway	path:04350_2	6	6.1954	0.01870187	EP300 SMAD2 SMAD4 SMAD7 ZFYVE9 RBX1	2033 4087 4089 4092 9372 9978
antineoplastic-651744	-	Focal adhesion	path:04510_37	6	6.238159	0.01870187	VAV3 PIK3R5 PAK1 MAPK10 RAC3 RAP1A	10451 23533 5058 5602 5881 5906
antineoplastic-651744	-	Jak-STAT signaling pathway	path:04630_23	16	8.007544	0.00110011	IL24 CSF2RB IFNL1 IL2 IL2RB IL5 IL7R IL9 IL10RA IL12A IL15RA LIFR IL22 PRLR TSLP OSMR	11009 1439 282618 3558 3560 3567 3575 3578 3587 3592 3601 3977 50616 5618 85480 9180
antineoplastic-651744	-	Leukocyte transendothelial migration	path:04670_7	6	5.894534	0.0330033	RAPGEF3 GNAI3 PIK3CA RAP1A CXCL12 CXCR4	10411 2773 5290 5906 6387 7852
antineoplastic-651744	-	Retrograde endocannabinoid signaling	path:04723_13	10	5.666118	0.04950495	ADCY2 ADCY8 ADCY4 GNAI3 GNG3 GNGT2 GNG13 MAPK11 MAPK10 MAPK12	108 114 196883 2773 2785 2793 51764 5600 5602 6300
antineoplastic-651744	-	Prolactin signaling pathway	path:04917_1	7	5.975837	0.03080308	NFKB1 PRLR CCND1 RELA STAT3 TNFSF11 SOCS3	4790 5618 595 5970 6774 8600 9021
antineoplastic-651744	-	Oxytocin signaling pathway	path:04921_14	8	5.94939	0.03190319	EGFR GNAI3 NRAS CALML5 PLCB3 PRKCA RAF1 CALM3	1956 2773 4893 51806 5331 5578 5894 808
antineoplastic-651744	-	Morphine addiction	path:05032_11	8	5.922183	0.0330033	ADCY2 ADCY8 GABBR1 GNAI3 GNG3 GNGT2 GNG13 PRKCA	108 114 2550 2773 2785 2793 51764 5578
antineoplastic-651744	-	Pathways in cancer	path:05200_17	4	5.761146	0.03630363	EP300 HIF1A VEGFB RBX1	2033 3091 7423 9978
antineoplastic-651744	-	Chemical carcinogenesis	path:05204_2	8	6.626751	0.00770077	CYP3A4 GSTA3 GSTM1 GSTM2 GSTM3 GSTM4 GSTM5 GSTP1	1576 2940 2944 2946 2947 2948 2949 2950
antineoplastic-651782	-	Purine metabolism	path:00230_47	6	6.393985	0.011198208	ADCY6 POLR1D PKLR POLR2L PRIM2 POLE4	112 51082 5313 5441 5558 56655
antineoplastic-651782	-	Pyruvate metabolism	path:00620_1	4	5.508585	0.045912654	ME2 PC PKLR PKM	4200 5091 5313 5315
antineoplastic-651782	-	Ras signaling pathway	path:04014_18	8	5.47393	0.048152296	RASSF1 RASGRP3 HRAS PLCE1 PLCG2 RALGDS RASGRF1 RASSF5	11186 25780 3265 51196 5336 5900 5923 83593
antineoplastic-651782	-	Jak-STAT signaling pathway	path:04630_24	13	6.352258	0.011198208	IFNLR1 IL19 IFNAR2 IL6ST IL9 LIFR IL20 IL23A IL20RA IL20RB PRLR CBL OSMR	163702 29949 3455 3572 3578 3977 50604 51561 53832 53833 5618 867 9180
antineoplastic-651782	-	Circadian entrainment	path:04713_17	7	5.921325	0.022396417	GNB5 ADCY1 ADCY6 ADCYAP1R1 GNG11 GNG12 PRKX	10681 107 112 117 2791 55970 5613
antineoplastic-651782	-	Retrograde endocannabinoid signaling	path:04723_14	9	6.630744	0.007838746	GNB5 ADCY1 ADCY6 MAPK14 GNG11 GNG12 MAPK8 MAPK13 PRKX	10681 107 112 1432 2791 55970 5599 5603 5613
antineoplastic-651782	-	Glutamatergic synapse	path:04724_11	13	6.594427	0.007838746	GNB5 ADCY1 ADCY6 GNAI1 GNG11 GRIA2 GRIK1 GRIK5 GRIN2B GRM7 GRM8 GNG12 PRKX	10681 107 112 2770 2791 2891 2897 2901 2904 2917 2918 55970 5613
antineoplastic-651782	-	Cholinergic synapse	path:04725_20	7	5.488843	0.047032475	GNB5 ADCY1 ADCY6 GNG11 PIK3CG GNG12 PRKX	10681 107 112 2791 5294 55970 5613
antineoplastic-651782	-	Morphine addiction	path:05032_12	11	5.754005	0.032474804	GNB5 ADCY1 ADCY6 ADCY8 ADCY9 GNG7 GNG11 PRKCB GNG12 PRKX GABBR2	10681 107 112 114 115 2788 2791 5579 55970 5613 9568
antineoplastic-651849	-	Purine metabolism	path:00230_48	6	6.436653	0.012127894	PDE10A POLR3A NPR2 POLR2E POLR2I POLR1B	10846 11128 4882 5434 5438 84172
antineoplastic-651849	-	Pyrimidine metabolism	path:00240_37	13	6.53556	0.008820287	POLR3G POLR3A DUT NME1 POLR1D POLR2E POLR2I CTPS2 RRM1 DCTPP1 NME5 POLR1B PNPT1	10622 11128 1854 4830 51082 5434 5438 56474 6240 79077 8382 84172 87178
antineoplastic-651849	-	cAMP signaling pathway	path:04024_11	15	5.88228	0.033076075	CREB3 CFTR CREB1 FOS GRIA2 GRIN1 GRIN2B GRIN2C RHOA NFKB1 PDE4C FXYD1 PRKACA BAD CREB5	10488 1080 1385 2353 2891 2902 2904 2905 387 4790 5143 5348 5566 572 9586
antineoplastic-651849	-	FoxO signaling pathway	path:04068_28	7	5.852498	0.035281147	AKT3 CHUK AKT1 AKT2 IKBKB FOXO4 PTEN	10000 1147 207 208 3551 4303 5728
antineoplastic-652524	-	Purine metabolism	path:00230_49	9	5.861639	0.042253521	ADCY2 NT5C3B DGUOK GUCY2D ITPA ENTPD8 RRM2B POLR2A ENTPD3	108 115024 1716 3000 3704 377841 50484 5430 956
antineoplastic-652524	-	Pyrimidine metabolism	path:00240_38	6	6.189783	0.02383532	NT5C3B ITPA CMPK1 TK2 ENTPD3 ENTPD5	115024 3704 51727 7084 956 957
antineoplastic-652524	-	Glycosphingolipid biosynthesis - lacto and neolacto series	path:00601_3	8	5.757522	0.045503792	B3GNT3 FUT1 FUT2 FUT3 FUT4 FUT6 B3GNT5 B4GALT4	10331 2523 2524 2525 2526 2528 84002 8702
antineoplastic-652524	-	MAPK signaling pathway	path:04010_13	7	5.696571	0.048754063	DUSP6 FLNC HSPA2 ARRB2 MAPK10 MAP2K7 MAP2K4	1848 2318 3306 409 5602 5609 6416
antineoplastic-652524	-	FoxO signaling pathway	path:04068_29	6	6.248205	0.019501625	AKT3 SGK2 FOXO1 PIK3R5 SGK3 PDPK1	10000 10110 2308 23533 23678 5170
antineoplastic-652524	-	PI3K-Akt signaling pathway	path:04151_28	6	5.891644	0.041170098	AKT3 PIK3R5 MDM2 PPP2R1A PPP2R2B PPP2R5A	10000 23533 4193 5518 5521 5525
antineoplastic-652524	-	AMPK signaling pathway	path:04152_9	6	6.780037	0.006500542	GYS1 LIPE PFKFB2 PPARG PRKAB1 ULK1	2997 3991 5208 5468 5564 8408
antineoplastic-652524	-	Adrenergic signaling in cardiomyocytes	path:04261_10	13	6.055443	0.032502709	ATP1A2 ATP1B2 ATP2B1 PPP2R1A PPP2R2B PPP2R5A PRKACB PRKX CACNA1C CACNA2D1 CACNB1 CACNB2 CACNB3	477 482 490 5518 5521 5525 5567 5613 775 781 782 783 784
antineoplastic-652524	-	Focal adhesion	path:04510_38	4	6.385471	0.010834236	FLNC ITGA2B ITGA5 PXN	2318 3674 3678 5829
antineoplastic-652524	-	Jak-STAT signaling pathway	path:04630_25	16	6.840242	0.004333694	CBLC IFNGR1 IL7 IL10RB IL12A JAK2 LEP LEPR LIFR MPL IL22 IL20RA IL21 STAT3 CBL OSMR	23624 3459 3574 3588 3592 3717 3952 3953 3977 4352 50616 53832 59067 6774 867 9180
antineoplastic-652524	-	Glutamatergic synapse	path:04724_12	8	6.449144	0.010834236	GNB5 GRK3 GNB3 GNG5 GRIK4 GRIN2D GRM2 CACNA1A	10681 157 2784 2787 2900 2906 2912 773
antineoplastic-652524	-	Morphine addiction	path:05032_13	9	5.684935	0.048754063	GNB5 GNAI1 GNB3 GNG5 PRKACB PRKCG PRKX CACNA1A GABBR2	10681 2770 2784 2787 5567 5582 5613 773 9568
antineoplastic-652525	-	Purine metabolism	path:00230_50	8	8.1193	0.00219539	POLR3A ADCY6 AK1 NME1 NT5E PDE6C PDE1B POLR3B	11128 112 203 4830 4907 5146 5153 55703
antineoplastic-652525	-	Pyrimidine metabolism	path:00240_39	10	7.335864	0.007683864	POLD3 POLR3A NME1 NME4 POLE3 POLE PRIM1 POLR3B POLR3GL ENTPD6	10714 11128 4830 4833 54107 5426 5557 55703 84265 955
antineoplastic-652525	-	FoxO signaling pathway	path:04068_30	11	6.120946	0.035126235	CDK2 CDKN2B GABARAPL2 GADD45A S1PR1 FOXO1 NLK PRKAB1 RBL2 CCND1 STAT3	1017 1030 11345 1647 1901 2308 51701 5564 5934 595 6774
antineoplastic-652525	-	Endocytosis	path:04144_5	7	6.904802	0.013172338	RNF41 WWP1 ERBB3 MDM2 SH3GLB1 ITCH CBL	10193 11059 2065 4193 51100 83737 867
antineoplastic-652525	-	AMPK signaling pathway	path:04152_10	5	5.880927	0.048298573	FASN GYS1 ACACA HMGCR PRKAB1	2194 2997 31 3156 5564
antineoplastic-652525	-	Hedgehog signaling pathway	path:04340_3	4	6.245688	0.035126235	GLI1 GLI3 GSK3B PRKACB	2735 2737 2932 5567
antineoplastic-652525	-	Focal adhesion	path:04510_39	5	8.010939	0.003293085	ITGA2B ITGA5 ITGB1 ITGB3 PXN	3674 3678 3688 3690 5829
antineoplastic-652525	-	Tight junction	path:04530_3	4	6.442907	0.026344676	PARD6A PPP2R1A PRKCZ MAGI1	50855 5518 5590 9223
antineoplastic-652525	-	Platelet activation	path:04611_6	9	6.24264	0.035126235	ADCY6 ADCY9 GNAI2 ITPR1 PIK3CG PLCB2 PRKACB PRKCZ RAP1B	112 115 2771 3708 5294 5330 5567 5590 5908
antineoplastic-652525	-	Jak-STAT signaling pathway	path:04630_26	7	6.691545	0.017563117	CBLC IL19 IL4 LEPR LIF MPL OSM	23624 29949 3565 3953 3976 4352 5008
antineoplastic-652525	-	Circadian entrainment	path:04713_18	8	6.475642	0.026344676	ADCY6 GNAI2 GNG5 GNGT2 PLCB2 PRKACB GNG12 GNB4	112 2771 2787 2793 5330 5567 55970 59345
antineoplastic-652525	-	Retrograde endocannabinoid signaling	path:04723_15	8	6.649014	0.019758507	ADCY6 GNAI2 GNAO1 GNG5 GNGT2 PRKACB GNG12 GNB4	112 2771 2775 2787 2793 5567 55970 59345
antineoplastic-652525	-	Glutamatergic synapse	path:04724_13	10	6.800833	0.015367728	ADCY6 ADCY9 GNAI2 GNAO1 GNG5 GNGT2 GRM4 PRKACB GNG12 GNB4	112 115 2771 2775 2787 2793 2914 5567 55970 59345
antineoplastic-652525	-	Cholinergic synapse	path:04725_21	9	6.856127	0.015367728	ADCY6 GNAI2 GNAO1 GNG5 GNGT2 PIK3CG PRKACB GNG12 GNB4	112 2771 2775 2787 2793 5294 5567 55970 59345
antineoplastic-652525	-	GABAergic synapse	path:04727_12	8	6.649014	0.019758507	ADCY6 GNAI2 GNAO1 GNG5 GNGT2 PRKACB GNG12 GNB4	112 2771 2775 2787 2793 5567 55970 59345
antineoplastic-652525	-	Melanogenesis	path:04916_3	5	6.432907	0.026344676	CTNNB1 GNAI2 GNAO1 GSK3B PLCB2	1499 2771 2775 2932 5330
antineoplastic-652525	-	Prolactin signaling pathway	path:04917_2	4	6.044637	0.037321625	GSK3B CCND1 STAT3 STAT5B	2932 595 6774 6777
antineoplastic-652525	-	Oxytocin signaling pathway	path:04921_15	7	5.905995	0.045005488	ADCY6 GNAI2 GNAO1 ITPR1 PIK3CG PLCB2 PRKACB	112 2771 2775 3708 5294 5330 5567
antineoplastic-652525	-	Morphine addiction	path:05032_14	8	6.649014	0.019758507	ADCY6 GNAI2 GNAO1 GNG5 GNGT2 PRKACB GNG12 GNB4	112 2771 2775 2787 2793 5567 55970 59345
antineoplastic-654376	-	Purine metabolism	path:00230_51	8	6.202619	0.032329989	POLR2J2 ZNRD1 ENTPD8 POLR1D POLR2B POLR2G POLR3B ENTPD2	246721 30834 377841 51082 5431 5436 55703 954
antineoplastic-654376	-	Pyrimidine metabolism	path:00240_40	10	6.405406	0.02787068	POLR3C ZNRD1 ENTPD8 POLR1D POLR2B POLR2G POLR2I PRIM1 POLR3B POLR1C	10623 30834 377841 51082 5431 5436 5438 5557 55703 9533
antineoplastic-654376	-	Alanine, aspartate and glutamate metabolism	path:00250_1	4	5.913307	0.046822742	CPS1 GAD1 GLS PPAT	1373 2571 2744 5471
antineoplastic-654376	-	Lysine degradation	path:00310_2	8	5.928665	0.046822742	EHMT2 SETD2 ASH1L NSD1 NSD2 COLGALT1 KMT2D PLOD3	10919 29072 55870 64324 7468 79709 8085 8985
antineoplastic-654376	-	Glycerolipid metabolism	path:00561_2	8	5.98592	0.045707915	AGPAT1 DGKA DGKG DGKH LPIN1 DGKZ DGKD DGKI	10554 1606 1608 160851 23175 8525 8527 9162
antineoplastic-654376	-	cGMP-PKG signaling pathway	path:04022_14	10	5.969924	0.045707915	ATF6B KCNMB4 ATP1A4 ATP1B3 PPP1CA PPP1CC PRKG2 BAD RAF1 CREB5	1388 27345 480 483 5499 5501 5593 572 5894 9586
antineoplastic-654376	-	Chemokine signaling pathway	path:04062_31	24	5.971795	0.045707915	CXCR6 CCR1 CCR3 CCR7 CCR8 CX3CR1 GRK2 CXCR3 GRK6 CXCL2 CXCL3 CXCL8 CXCR1 CXCR2 CXCL10 PF4 PF4V1 PPBP CCL2 CCL20 CXCL6 CXCL11 CXCL5 CXCL14	10663 1230 1232 1236 1237 1524 156 2833 2870 2920 2921 3576 3577 3579 3627 5196 5197 5473 6347 6364 6372 6373 6374 9547
antineoplastic-654376	-	PI3K-Akt signaling pathway	path:04151_29	5	7.479715	0.003344482	ITGA5 ITGAV ITGB1 ITGB3 ITGB5	3678 3685 3688 3690 3693
antineoplastic-654376	-	Focal adhesion	path:04510_40	7	7.404045	0.004459309	ILK ITGAV ITGB1 ITGB3 PRKCB PXN CAV1	3611 3685 3688 3690 5579 5829 857
antineoplastic-654379	-	Purine metabolism	path:00230_52	14	6.071481	0.028665932	ADCY1 ADCY3 ADCY9 ZNRD1 APRT AK3 PDE1C PDE1B PKM POLR2G POLR2L POLR3B PDE5A POLR1C	107 109 115 30834 353 50808 5137 5153 5315 5436 5441 55703 8654 9533
antineoplastic-654379	-	Glycerolipid metabolism	path:00561_3	8	6.072117	0.028665932	CEL DGKA DGKG LPIN1 DGKZ DGKE DGKD DGAT1	1056 1606 1608 23175 8525 8526 8527 8694
antineoplastic-654379	-	Glycerophospholipid metabolism	path:00564_10	9	5.725201	0.045203969	CDS1 DGKA DGKG LPIN1 PLD2 PLA2G12A DGKZ DGKE DGKD	1040 1606 1608 23175 5338 81579 8525 8526 8527
antineoplastic-654379	-	Ras signaling pathway	path:04014_19	8	6.643986	0.005512679	RASGRP2 ABL2 PIK3CG RALA RALGDS RRAS SYNGAP1 RIN1	10235 27 5294 5898 5900 6237 8831 9610
antineoplastic-654379	-	Rap1 signaling pathway	path:04015_27	14	6.044621	0.030871003	RASGRP2 CRKL EFNA3 EFNA5 EGF FGF2 FGF5 IGF1R MET PLCB2 PLCB4 PDGFC VEGFC PDGFD	10235 1399 1944 1946 1950 2247 2250 3480 4233 5330 5332 56034 7424 80310
antineoplastic-654379	-	FoxO signaling pathway	path:04068_31	17	6.757762	0.005512679	AKT3 CDKN1A PLK4 GABARAP FBXO32 MAPK14 FOXO1 GABARAPL1 IKBKB PRKAB1 PRKAB2 MAPK10 MAPK13 SGK1 BNIP3 SETD7 CCNG2	10000 1026 10733 11337 114907 1432 2308 23710 3551 5564 5565 5602 5603 6446 664 80854 901
antineoplastic-654379	-	AMPK signaling pathway	path:04152_11	5	5.746999	0.044101433	AKT3 LIPE PFKFB4 PRKAB1 PRKAB2	10000 3991 5210 5564 5565
antineoplastic-654379	-	Focal adhesion	path:04510_41	3	7.071357	0.001102536	ITGAV ITGB5 PXN	3685 3693 5829
antineoplastic-655901	-	Pyrimidine metabolism	path:00240_41	11	5.968234	0.04180418	POLR3G POLR3A POLR3H ENTPD8 POLR1D POLR2C POLR2D POLR2F POLR2G POLR2J PNPT1	10622 11128 171568 377841 51082 5432 5433 5435 5436 5439 87178
antineoplastic-655901	-	Rap1 signaling pathway	path:04015_28	9	6.503274	0.01650165	RASGRP2 KRAS PIK3R2 PRKCZ RAP1A BRAF VAV2 FARP2 CDC42	10235 3845 5296 5590 5906 673 7410 9855 998
antineoplastic-655901	-	NF-kappa B signaling pathway	path:04064_3	7	5.852487	0.04730473	TAB2 BIRC2 BIRC3 RELA TRAF2 TRAF3 RIPK1	23118 329 330 5970 7186 7187 8737
antineoplastic-655901	-	p53 signaling pathway	path:04115_7	12	6.725564	0.01320132	CHEK1 CHEK2 SESN3 SFN MDM4 ATM RRM2 PERP SIAH1 TP53 TP73 EI24	1111 11200 143686 2810 4194 472 6241 64065 6477 7157 7161 9538
antineoplastic-655901	-	PI3K-Akt signaling pathway	path:04151_30	9	6.621452	0.01430143	AKT1 NOS3 PIK3R2 PPP2CA PPP2R1B PPP2R5B PPP2R5D PPP2R5E BAD	207 4846 5296 5515 5519 5526 5528 5529 572
antineoplastic-655901	-	Apoptosis	path:04210_3	6	6.255501	0.02420242	BIRC2 BIRC3 NFKBIA BCL2 RELA BCL2L1	329 330 4792 596 5970 598
antineoplastic-655901	-	VEGF signaling pathway	path:04370_1	7	6.119167	0.03410341	AKT1 KDR PIK3R2 PLCG1 BAD PTK2 CDC42	207 3791 5296 5335 572 5747 998
antineoplastic-655901	-	Focal adhesion	path:04510_42	6	5.895937	0.04620462	FLNC ITGB1 PRKCA PRKCG PTK2 CAV1	2318 3688 5578 5582 5747 857
antineoplastic-655901	-	Insulin signaling pathway	path:04910_11	6	6.260983	0.02310231	AKT2 PHKB PPP1CA PYGB PYGM CALM1	208 5257 5499 5834 5837 801
antineoplastic-655901	-	Glucagon signaling pathway	path:04922_4	8	5.813608	0.04730473	CREB1 ITPR1 ATF4 PRKAG2 PHKB PRKAA1 PRKACA PRKAG1	1385 3708 468 51422 5257 5562 5566 5571
antineoplastic-655905	-	Glutathione metabolism	path:00480_4	7	9.45855	0	GGT7 GSTA4 GSTM1 GSTM2 GSTM3 GSTM4 GSTM5	2686 2941 2944 2946 2947 2948 2949
antineoplastic-655905	-	Metabolism of xenobiotics by cytochrome P450	path:00980_4	8	10.155401	0	CYP3A4 GSTA4 GSTM1 GSTM2 GSTM3 GSTM4 GSTM5 CYP2S1	1576 2941 2944 2946 2947 2948 2949 29785
antineoplastic-655905	-	Drug metabolism - cytochrome P450	path:00982_3	7	9.216779	0	ALDH3B1 GSTA4 GSTM1 GSTM2 GSTM3 GSTM4 GSTM5	221 2941 2944 2946 2947 2948 2949
antineoplastic-655905	-	Ras signaling pathway	path:04014_20	8	5.941047	0.041049031	RASGRP2 HRAS KRAS NF1 NRAS PIK3CG RASGRF1 RASSF5	10235 3265 3845 4763 4893 5294 5923 83593
antineoplastic-655905	-	Rap1 signaling pathway	path:04015_29	15	5.865501	0.043329532	CRKL CSF1 EPHA2 FGF8 FGF12 FGF13 PLCB1 GNAQ KDR NGFR PLCB3 PDGFC VEGFB VEGFC PDGFD	1399 1435 1969 2253 2257 2258 23236 2776 3791 4804 5331 56034 7423 7424 80310
antineoplastic-655905	-	cGMP-PKG signaling pathway	path:04022_15	10	6.217944	0.021664766	MRVI1 PLCB1 GUCY1A2 ITPR1 FXYD2 ATP2B1 PDE3A PRKG2 BAD TRPC6	10335 23236 2977 3708 486 490 5139 5593 572 7225
antineoplastic-655905	-	cAMP signaling pathway	path:04024_12	10	6.021121	0.033067275	CHRM1 CHRM2 DRD1 DRD2 GIPR GNAI3 HTR1D HTR1E SSTR2 VIPR2	1128 1129 1812 1813 2696 2773 3352 3354 6752 7434
antineoplastic-655905	-	Sphingolipid signaling pathway	path:04071_11	10	5.834536	0.046750285	ADORA3 PLCB1 GNAI3 KRAS NRAS PIK3CG PLCB3 PRKCG RAC2 GAB2	140 23236 2773 3845 4893 5294 5331 5582 5880 9846
antineoplastic-655905	-	Hippo signaling pathway	path:04390_17	3	6.045311	0.029646522	PPP1CA PPP2R1B BTRC	5499 5519 8945
antineoplastic-655905	-	Jak-STAT signaling pathway	path:04630_27	16	6.142631	0.028506271	IL24 CSF2RB CSF3 CTF1 CBLC IL19 IL5 IL10RA LEP LIFR IL20 IL23A IL22RA1 IL21 CBL CBLB	11009 1439 1440 1489 23624 29949 3567 3587 3952 3977 50604 51561 58985 59067 867 868
antineoplastic-655905	-	Circadian entrainment	path:04713_19	8	6.095868	0.029646522	GRIN2B GUCY1A2 ITPR1 NOS1 PRKG2 MAPK3 RYR2 CACNA1G	2904 2977 3708 4842 5593 5595 6262 8913
antineoplastic-655905	-	Glutamatergic synapse	path:04724_14	7	6.232349	0.021664766	GNAI3 GNG3 GNG11 GRM8 GNG12 GNB4 CACNA1A	2773 2785 2791 2918 55970 59345 773
antineoplastic-655905	-	Serotonergic synapse	path:04726_16	14	6.944376	0.006841505	ADCY5 PLCB1 GNAI3 GNG3 GNG5 GNG11 HTR1D HTR1E HTR5A ITPR1 PLCB3 GNG12 GNB4 CACNA1A	111 23236 2773 2785 2787 2791 3352 3354 3361 3708 5331 55970 59345 773
antineoplastic-655905	-	Chemical carcinogenesis	path:05204_3	7	9.839824	0	CYP3A4 GSTA4 GSTM1 GSTM2 GSTM3 GSTM4 GSTM5	1576 2941 2944 2946 2947 2948 2949
antineoplastic-655906	-	Rap1 signaling pathway	path:04015_30	20	5.687309	0.038251366	CRK CRKL EFNA1 EPHA2 FGFR2 FLT4 RASGRP3 FGF22 ANGPT2 HGF IGF1 INS MET NGF PLCB2 PLCB3 VEGFB FGF23 BCAR1 FGF19	1398 1399 1942 1969 2263 2324 25780 27006 285 3082 3479 3630 4233 4803 5330 5331 7423 8074 9564 9965
antineoplastic-655906	-	PI3K-Akt signaling pathway	path:04151_31	8	5.685613	0.038251366	CHRM1 CHRM2 PIK3R5 LPAR4 PIK3CG PIK3R2 LPAR5 GNB4	1128 1129 23533 2846 5294 5296 57121 59345
antineoplastic-655906	-	AMPK signaling pathway	path:04152_12	7	5.84753	0.029508197	CFTR ADRA1A GYS2 PFKFB1 PFKFB2 PRKAA1 CD36	1080 148 2998 5207 5208 5562 948
antineoplastic-655906	-	Proteoglycans in cancer	path:05205_4	7	5.564069	0.043715847	CTNNB1 ERBB2 HRAS MAPK1 MAPK3 MAP2K1 MAP2K2	1499 2064 3265 5594 5595 5604 5605
antineoplastic-656904	-	Purine metabolism	path:00230_53	8	6.650502	0.016703786	ADCY8 POLR2J2 NUDT2 POLR2J POLR2K POLR2L POLR3D ENTPD3	114 246721 318 5439 5440 5441 661 956
antineoplastic-656904	-	Inositol phosphate metabolism	path:00562_5	5	5.769558	0.042316258	INPP4A INPPL1 PIK3C2A PIK3CG PLCB4	3631 3636 5286 5294 5332
antineoplastic-656904	-	Ras signaling pathway	path:04014_21	16	6.557453	0.016703786	EFNA5 EGFR EPHA2 FGF3 FGF6 FGF20 ANGPT1 GRB2 INSR MET PDGFB SHC3 VEGFB PDGFD FGF23 FGF19	1946 1956 1969 2248 2251 26281 284 2885 3643 4233 5155 53358 7423 80310 8074 9965
antineoplastic-656904	-	Rap1 signaling pathway	path:04015_31	15	6.923069	0.012249443	CRKL EGFR EPHA2 FGF6 FGFR4 FGF20 ANGPT1 INSR MET PDGFB PLCB4 VEGFB PDGFD FGF23 FGF19	1399 1956 1969 2251 2264 26281 284 3643 4233 5155 5332 7423 80310 8074 9965
antineoplastic-656904	-	Chemokine signaling pathway	path:04062_32	6	5.87405	0.037861915	PIK3R2 SHC3 PTK2 SRC BCAR1 ELMO1	5296 53358 5747 6714 9564 9844
antineoplastic-656904	-	Phosphatidylinositol signaling system	path:04070_21	8	6.672277	0.016703786	INPP4A INPPL1 PIK3C2A PIK3CG PIK3R1 PIK3R2 PLCB4 PIP5K1B	3631 3636 5286 5294 5295 5296 5332 8395
antineoplastic-656904	-	Hippo signaling pathway	path:04390_18	5	6.259831	0.025612472	CSNK1E YWHAB YWHAG YWHAH YWHAZ	1454 7529 7532 7533 7534
antineoplastic-656904	-	Pathways in cancer	path:05200_18	8	6.134099	0.027839644	RASSF1 EGFR HRAS NTRK1 PIK3R1 PIK3R2 PTK2 CCND1	11186 1956 3265 4914 5295 5296 5747 595
antineoplastic-672552	-	Pyrimidine metabolism	path:00240_42	9	5.739265	0.049723757	CANT1 ENTPD8 NME1 CMPK1 POLE POLR2C POLR2G PRIM1 POLR3B	124583 377841 4830 51727 5426 5432 5436 5557 55703
antineoplastic-672552	-	Sphingolipid metabolism	path:00600_3	6	5.758838	0.049723757	SGPP2 ASAH1 GBA2 SMPD2 UGT8 CERS5	130367 427 57704 6610 7368 91012
antineoplastic-672552	-	p53 signaling pathway	path:04115_8	8	5.892039	0.040883978	CDKN2A SFN MDM2 SERPINB5 BAX PERP TP53 PPM1D	1029 2810 4193 5268 581 64065 7157 8493
antineoplastic-672552	-	Endocytosis	path:04144_6	5	6.737503	0.012154696	ERBB3 CBLC MDM2 EPN3 CBL	2065 23624 4193 55040 867
antineoplastic-672552	-	AMPK signaling pathway	path:04152_13	5	5.929369	0.038674033	GYS2 PFKFB2 PRKAB1 PRKAG1 STK11	2998 5208 5564 5571 6794
antineoplastic-672552	-	Jak-STAT signaling pathway	path:04630_28	8	7.809648	0.001104972	IFNLR1 CBLC IFNG IFNGR1 MPL IL22 IL20RA CBL	163702 23624 3458 3459 4352 50616 53832 867
antineoplastic-672552	-	Circadian entrainment	path:04713_20	10	5.840566	0.044198895	GNB5 ADCY6 PLCB1 GNAI2 GNB3 GNG5 MTNR1A MTNR1B MAPK1 GNB4	10681 112 23236 2771 2784 2787 4543 4544 5594 59345
antineoplastic-672552	-	Retrograde endocannabinoid signaling	path:04723_16	10	6.161327	0.030939227	GNB5 ADCY6 GNAI2 GNAO1 GNB3 GNG5 MAPK11 MAPK10 MAPK13 GNB4	10681 112 2771 2775 2784 2787 5600 5602 5603 59345
antineoplastic-672552	-	Glutamatergic synapse	path:04724_15	13	5.894515	0.040883978	GNB5 ADCY6 GNAI2 GNAO1 GNB3 GNG5 GNGT2 GRIA4 GRIN2B GRIN2D GRM2 GRM4 GNB4	10681 112 2771 2775 2784 2787 2793 2893 2904 2906 2912 2914 59345
antineoplastic-672552	-	Regulation of actin cytoskeleton	path:04810_17	5	5.829603	0.045303867	PAK4 GNA13 PAK1 PAK6 MYLK3	10298 10672 5058 56924 91807
antineoplastic-672552	-	Chronic myeloid leukemia	path:05220_5	8	6.196822	0.028729282	AKT3 CBLC MDM2 PIK3CG PTPN11 STAT5B CBL GAB2	10000 23624 4193 5294 5781 6777 867 9846
antineoplastic-672553	-	Purine metabolism	path:00230_54	17	8.404776	0.001086957	POLR3A CANT1 AK1 HPRT1 ENTPD8 NME1 NME4 AK3 POLE3 POLR2A POLR2C POLR2D PRIM1 POLR3B ENTPD2 ENTPD6 ENTPD5	11128 124583 203 3251 377841 4830 4833 50808 54107 5430 5432 5433 5557 55703 954 955 957
antineoplastic-672553	-	Pyrimidine metabolism	path:00240_43	15	7.129921	0.006521739	POLD3 CANT1 POLA2 ZNRD1 ENTPD8 NME1 POLE3 POLE POLR2A POLR2C POLR2H PRIM1 POLR3B ENTPD6 ENTPD5	10714 124583 23649 30834 377841 4830 54107 5426 5430 5432 5437 5557 55703 955 957
antineoplastic-672553	-	Sphingolipid signaling pathway	path:04071_12	4	6.140867	0.032608696	GNA13 S1PR1 S1PR3 GNAI2	10672 1901 1903 2771
antineoplastic-672553	-	AMPK signaling pathway	path:04152_14	6	6.636057	0.018478261	LIPE PFKFB2 PPARG PRKAB1 RPS6KB1 ULK1	3991 5208 5468 5564 6198 8408
antineoplastic-672553	-	Adherens junction	path:04520_6	6	6.885777	0.014130435	CSNK2A2 CTNNB1 CTNND1 ERBB2 ACP1 CDH1	1459 1499 1500 2064 52 999
antineoplastic-672553	-	Jak-STAT signaling pathway	path:04630_29	8	6.583592	0.019565217	IFNLR1 CBLC IFNGR1 MPL OSM IL20RA IL22RA1 CBL	163702 23624 3459 4352 5008 53832 58985 867
antineoplastic-689577	-	Purine metabolism	path:00230_55	8	5.915341	0.040223464	NME6 PDE10A NUDT16 HPRT1 IMPDH2 POLR1D ENTPD6 ENTPD3	10201 10846 131870 3251 3615 51082 955 956
antineoplastic-689577	-	PPAR signaling pathway	path:03320_3	10	7.7739	0	CPT1C CYP27A1 DBI EHHADH FABP3 ACADL PCK1 PLTP PPARG RXRA	126129 1593 1622 1962 2170 33 5105 5360 5468 6256
antineoplastic-689577	-	Chemokine signaling pathway	path:04062_33	9	6.402656	0.016759777	AKT3 PIK3R5 GNG4 GNG11 HCK PIK3CB GNG12 PTK2 SRC	10000 23533 2786 2791 3055 5291 55970 5747 6714
antineoplastic-689577	-	FoxO signaling pathway	path:04068_32	17	6.76576	0.008938547	AKT3 SGK2 PLK2 CHUK GADD45A SGK3 PRMT1 FOXO4 PCK1 PRKAA2 MAPK1 MAPK8 RBL2 SOD2 STK4 STK11 CCNB2	10000 10110 10769 1147 1647 23678 3276 4303 5105 5563 5594 5599 5934 6648 6789 6794 9133
antineoplastic-689577	-	PI3K-Akt signaling pathway	path:04151_32	3	6.168879	0.027932961	ITGB1 ITGB3 PTK2	3688 3690 5747
antineoplastic-689577	-	Hippo signaling pathway	path:04390_19	7	6.439717	0.015642458	BBC3 PPP1CB PPP2CA PPP2R1B YWHAB YWHAZ BTRC	27113 5500 5515 5519 7529 7534 8945
antineoplastic-689577	-	HTLV-I infection	path:05166_1	6	6.331977	0.022346369	AKT3 CHUK PIK3R5 GSK3B PIK3CB PIK3R1	10000 1147 23533 2932 5291 5295
antineoplastic-690266	-	Purine metabolism	path:00230_56	10	6.823795	0.016968326	POLR3A ADCY6 ATIC NME1 PDE6C PDE6G POLR2H GMPS ENTPD1 POLR1C	11128 112 471 4830 5146 5148 5437 8833 953 9533
antineoplastic-690266	-	Pyrimidine metabolism	path:00240_44	9	7.087536	0.005656109	POLR3A POLR2J2 ZNRD1 NME1 POLR2D POLR2H POLR2J POLR2K POLR3D	11128 246721 30834 4830 5433 5437 5439 5440 661
antineoplastic-690266	-	ErbB signaling pathway	path:04012_6	9	6.079655	0.042986425	EGFR ERBB2 GRB2 PLCG1 SRC STAT5A STAT5B TGFA CBL	1956 2064 2885 5335 6714 6776 6777 7039 867
antineoplastic-690266	-	Ras signaling pathway	path:04014_22	6	6.938818	0.009049774	CHUK AKT1 PIK3CG PAK6 RAC3 RRAS	1147 207 5294 56924 5881 6237
antineoplastic-690266	-	Chemokine signaling pathway	path:04062_34	9	5.913637	0.048642534	AKT1 PIK3CA PIK3CG PLCB3 PRKCB GNG12 PREX1 GNB4 SRC	207 5290 5294 5331 5579 55970 57580 59345 6714
antineoplastic-690266	-	FoxO signaling pathway	path:04068_33	15	6.066004	0.042986425	CDK2 PLK2 CHUK GADD45A S1PR1 AKT1 FOXO1 FOXO3 PRMT1 PRKAG1 MAPK8 MAPK13 RBL2 BCL6 ATG12	1017 10769 1147 1647 1901 207 2308 2309 3276 5571 5599 5603 5934 604 9140
antineoplastic-690266	-	PI3K-Akt signaling pathway	path:04151_33	9	7.319474	0.003393665	CREB3 CHUK AKT1 FOXO3 GSK3B PIK3CG PPP2R1A RBL2 YWHAG	10488 1147 207 2309 2932 5294 5518 5934 7532
antineoplastic-690266	-	ECM-receptor interaction	path:04512_11	3	6.633204	0.018099548	ITGA2 ITGB1 THBS1	3673 3688 7057
antineoplastic-690266	-	Tight junction	path:04530_4	4	6.178887	0.033936652	PPP2CB PPP2R1A PRKCB MAGI1	5516 5518 5579 9223
antineoplastic-690266	-	Jak-STAT signaling pathway	path:04630_30	11	5.908486	0.048642534	IFNLR1 IFNAR2 IL6R IL6ST MPL IL23A STAT5A STAT5B TSLP CBL SOCS3	163702 3455 3570 3572 4352 51561 6776 6777 85480 867 9021
antineoplastic-690268	-	Pyrimidine metabolism	path:00240_45	11	6.256928	0.019101124	POLR3H POLR2J2 ZNRD1 NME3 POLR1D POLR2D POLR2F POLR2H POLR1B POLR3GL POLR1C	171568 246721 30834 4832 51082 5433 5435 5437 84172 84265 9533
antineoplastic-690268	-	Inositol phosphate metabolism	path:00562_6	9	6.915817	0.007865169	INPP5D ITPKB PLCE1 PIK3CD PIK3CG PLCB2 PLCB3 PLCG1 ITPKC	3635 3707 51196 5293 5294 5330 5331 5335 80271
antineoplastic-690268	-	MAPK signaling pathway	path:04010_14	6	6.357579	0.016853933	RRAS2 PRKCA PRKCB MAP2K1 RRAS BRAF	22800 5578 5579 5604 6237 673
antineoplastic-690268	-	Ras signaling pathway	path:04014_23	10	7.644069	0.005617978	RASSF1 RRAS2 PLCE1 PIK3CD PIK3CG RALGDS RASA2 RRAS PIK3R3 SYNGAP1	11186 22800 51196 5293 5294 5900 5922 6237 8503 8831
antineoplastic-690268	-	Rap1 signaling pathway	path:04015_32	6	6.796876	0.008988764	NRAS PLCE1 MAP2K1 RAP1A RRAS BRAF	4893 51196 5604 5906 6237 673
antineoplastic-690268	-	Calcium signaling pathway	path:04020_26	6	6.508541	0.013483146	ERBB2 PLCE1 PLCB2 PLCB3 PLCG1 PRKCB	2064 51196 5330 5331 5335 5579
antineoplastic-690268	-	cAMP signaling pathway	path:04024_13	7	5.824713	0.033707865	RAPGEF3 ADCY2 PLCE1 PLD2 RAP1B RRAS CAMK4	10411 108 51196 5338 5908 6237 814
antineoplastic-690268	-	Chemokine signaling pathway	path:04062_35	8	5.669451	0.04494382	DOCK2 FGR GNAI3 GNG3 NRAS PRKCZ RAC1 PIK3R3	1794 2268 2773 2785 4893 5590 5879 8503
antineoplastic-690268	-	FoxO signaling pathway	path:04068_34	9	6.13841	0.02247191	CDKN1A CDKN2D PLK2 MAPK14 FOXO4 NLK PLK1 MAPK3 STAT3	1026 1032 10769 1432 4303 51701 5347 5595 6774
antineoplastic-690268	-	Phosphatidylinositol signaling system	path:04070_22	16	7.701546	0.005617978	CDIPT PIKFYVE INPP4A INPP5D ITPKB PLCE1 PIK3C2A PIK3CD PIK3CG PLCB2 PLCB3 PLCG1 ITPKC CALML3 PIK3R3 DGKZ	10423 200576 3631 3635 3707 51196 5286 5293 5294 5330 5331 5335 80271 810 8503 8525
antineoplastic-690268	-	Vascular smooth muscle contraction	path:04270_2	6	5.693652	0.043820225	ADCY6 ITPR2 KCNMA1 MYLK PLCB3 PRKX	112 3709 3778 4638 5331 5613
antineoplastic-690268	-	Hippo signaling pathway	path:04390_20	4	5.706019	0.043820225	BIRC2 SMAD3 TGFB2 TGFBR1	329 4088 7042 7046
antineoplastic-690268	-	ECM-receptor interaction	path:04512_12	3	6.208017	0.020224719	ITGAV ITGB1 THBS1	3685 3688 7057
antineoplastic-690268	-	Dopaminergic synapse	path:04728_21	8	5.651202	0.04494382	CREB3 FOS PLCB3 PRKACA PRKCA PRKCB PRKCG CALML3	10488 2353 5331 5566 5578 5579 5582 810
antineoplastic-690268	-	Regulation of actin cytoskeleton	path:04810_18	7	6.400518	0.016853933	RRAS2 NRAS PIK3CD PIK3CG RRAS BRAF VAV2	22800 4893 5293 5294 6237 673 7410
antineoplastic-690268	-	Oxytocin signaling pathway	path:04921_16	12	6.680375	0.011235955	GNAI1 GNAQ ITPR1 ITPR3 NRAS PLCB2 PLCB3 PRKCA PRKCB PRKCG RAF1 CALML3	2770 2776 3708 3710 4893 5330 5331 5578 5579 5582 5894 810
antineoplastic-690268	-	Proteoglycans in cancer	path:05205_5	7	5.662531	0.04494382	RRAS2 HRAS NRAS MAPK3 MAP2K1 RRAS BRAF	22800 3265 4893 5595 5604 6237 673
antineoplastic-690269	-	Purine metabolism	path:00230_57	14	6.078072	0.029284165	ADCY5 ADCY6 ADCY7 ZNRD1 NT5E PDE1C PDE3B PDE6C PKM POLR2D POLR2H POLR3B POLR3D POLR1C	111 112 113 30834 4907 5137 5140 5146 5315 5433 5437 55703 661 9533
antineoplastic-690269	-	Ras signaling pathway	path:04014_24	6	7.017279	0.007592191	CHUK AKT1 PIK3R1 RAC3 RRAS PIK3R3	1147 207 5295 5881 6237 8503
antineoplastic-690269	-	Rap1 signaling pathway	path:04015_33	11	5.684149	0.045553145	EFNA4 EFNA5 EGFR EPHA2 PDGFB PLCB3 PLCB4 PDGFC TEK VEGFA PDGFD	1945 1946 1956 1969 5155 5331 5332 56034 7010 7422 80310
antineoplastic-690269	-	Calcium signaling pathway	path:04020_27	13	7.556752	0.003253796	ITPKB ITPR3 MYLK PLCE1 PHKA2 PHKB PLCG1 PPP3CA PRKCA PRKCB ITPKC CALM3 CALML3	3707 3710 4638 51196 5256 5257 5335 5530 5578 5579 80271 808 810
antineoplastic-690269	-	cAMP signaling pathway	path:04024_14	7	5.829	0.042299349	RAPGEF3 ADCY6 ADCY7 ADCY9 CNGB1 CALM3 CAMK4	10411 112 113 115 1258 808 814
antineoplastic-690269	-	HIF-1 signaling pathway	path:04066_11	9	6.082415	0.029284165	HIF1A ARNT SERPINE1 PFKL SLC2A1 TEK TFRC VEGFA HKDC1	3091 405 5054 5211 6513 7010 7037 7422 80201
antineoplastic-690269	-	FoxO signaling pathway	path:04068_35	15	6.590708	0.01626898	CDKN2D PLK2 CHUK MAPK14 GADD45A AKT1 FOXO1 PRMT1 IKBKB FOXO4 NLK PLK1 PRKAG1 RBL2 ATG12	1032 10769 1147 1432 1647 207 2308 3276 3551 4303 51701 5347 5571 5934 9140
antineoplastic-690269	-	Phosphatidylinositol signaling system	path:04070_23	19	6.647963	0.015184382	CDIPT PIKFYVE INPP1 INPP5B INPP5D ITPKB ITPR3 MTM1 PLCE1 PIK3CG PI4KB PLCB3 PLCB4 PLCG1 ITPKC CALM3 CALML3 PIP5K1A DGKZ	10423 200576 3628 3633 3635 3707 3710 4534 51196 5294 5298 5331 5332 5335 80271 808 810 8394 8525
antineoplastic-690269	-	PI3K-Akt signaling pathway	path:04151_34	9	5.898511	0.039045553	EFNA4 EFNA5 EGFR EPHA2 GRB2 PDGFB SOS2 TEK PDGFD	1945 1946 1956 1969 2885 5155 6655 7010 80310
antineoplastic-690269	-	Hippo signaling pathway	path:04390_21	4	5.850906	0.041214751	SMAD3 SERPINE1 TGFB2 TGFBR1	4088 5054 7042 7046
antineoplastic-690269	-	Focal adhesion	path:04510_43	8	8.137477	0.001084599	FLNB PRKCB PRKCG PTK2 SRC THBS1 CAV2 CAV3	2317 5579 5582 5747 6714 7057 858 859
antineoplastic-690269	-	Jak-STAT signaling pathway	path:04630_31	11	6.463875	0.018438178	IL4R IL6R IL10 IL12B IL15 LIF LIFR MPL IL21 STAT5A CBL	3566 3570 3586 3593 3600 3976 3977 4352 59067 6776 867
antineoplastic-690269	-	Natural killer cell mediated cytotoxicity	path:04650_3	8	5.88716	0.039045553	LAT GRB2 NFATC1 NFATC2 PLCG1 PPP3CA PRKCB VAV2	27040 2885 4772 4773 5335 5530 5579 7410
antineoplastic-690269	-	Regulation of actin cytoskeleton	path:04810_19	4	6.080716	0.029284165	PAK4 PIK3CD RAC3 VAV2	10298 5293 5881 7410
antineoplastic-690269	-	Morphine addiction	path:05032_15	9	5.872717	0.039045553	ADCY6 ADCY7 ADCY9 GNG3 OPRM1 PRKCA PRKCB PRKCG GNG12	112 113 115 2785 4988 5578 5579 5582 55970
antineoplastic-690269	-	Pancreatic cancer	path:05212_4	7	6.045262	0.031453362	EGFR ERBB2 AKT1 PIK3CD PIK3CG RAC3 TGFA	1956 2064 207 5293 5294 5881 7039
antineoplastic-690269	-	Glioma	path:05214_5	7	5.701348	0.045553145	PLCG1 PRKCA PRKCB PRKCG CALM3 CALML3 CAMK2D	5335 5578 5579 5582 808 810 817
antineoplastic-690270	-	Ras signaling pathway	path:04014_25	10	5.876148	0.043918919	RGL1 NF1 PLCE1 PIK3CA PRKCB RALB RALGDS RRAS BRAP RASSF5	23179 4763 51196 5290 5579 5899 5900 6237 8315 83593
antineoplastic-690270	-	Calcium signaling pathway	path:04020_28	8	6.318405	0.021396396	PPIF PTK2B ITPKA P2RX1 PRKCB CACNA1D CACNA1S CALML3	10105 2185 3706 5023 5579 776 779 810
antineoplastic-690270	-	Phosphatidylinositol signaling system	path:04070_24	15	6.140456	0.029279279	IMPA2 ITPKA PLCE1 INPP5K PIK3C2A PIK3C2B PIK3CA PIK3CG PI4KB PLCB2 PLCB3 PI4K2A PIP5K1A DGKZ DGKE	3613 3706 51196 51763 5286 5287 5290 5294 5298 5330 5331 55361 8394 8525 8526
antineoplastic-690270	-	Adrenergic signaling in cardiomyocytes	path:04261_11	18	5.858623	0.043918919	CREB3 CACNG5 ATP1A1 ATP1B1 ATP1B2 ATP2B1 PPP1CC PPP2R3A PPP2R5A PPP2R5B PRKACA CACNA2D3 PRKX SLC9A1 CACNA1D CACNA1S CACNB3 CACNA2D2	10488 27091 476 481 482 490 5501 5523 5525 5526 5566 55799 5613 6548 776 779 784 9254
antineoplastic-690270	-	Focal adhesion	path:04510_44	7	7.3075	0.004504505	FLNB ITGA2 ITGB5 PRKCB THBS1 TLN1 CAV1	2317 3673 3693 5579 7057 7094 857
antineoplastic-690270	-	Jak-STAT signaling pathway	path:04630_32	7	6.267846	0.023648649	IL19 IL5RA IL6R IL10 IL20 TSLP CBLB	29949 3568 3570 3586 50604 85480 868
antineoplastic-690271	-	Pyrimidine metabolism	path:00240_46	15	7.438539	0.001111111	POLR3A ZNRD1 NME1 NT5E POLE PRIM1 POLR3B TK2 TYMS UCK2 UPP1 DCTPP1 POLR3GL ENTPD1 ENTPD6	11128 30834 4830 4907 5426 5557 55703 7084 7298 7371 7378 79077 84265 953 955
antineoplastic-690271	-	Phosphatidylinositol signaling system	path:04070_25	7	5.605434	0.031111111	DGKA OCRL PLCE1 PIK3C2A PI4K2A PIP5K1A DGKE	1606 4952 51196 5286 55361 8394 8526
antineoplastic-690271	-	AMPK signaling pathway	path:04152_15	5	6.163439	0.013333333	GYS1 PFKFB1 PRKAB1 RPS6KB1 ULK1	2997 5207 5564 6198 8408
antineoplastic-690271	-	Adrenergic signaling in cardiomyocytes	path:04261_12	8	7.081599	0.001111111	CACNG5 CACNG4 PPP1CC PPP2R1A PRKX CACNB3 CACNG1 CAMK2D	27091 27092 5501 5518 5613 784 786 817
antineoplastic-690271	-	Jak-STAT signaling pathway	path:04630_33	7	5.898629	0.024444444	CTF1 IL19 IFNG IL6R IL13RA1 LEPR CBL	1489 29949 3458 3570 3597 3953 867
antineoplastic-690271	-	Glutamatergic synapse	path:04724_16	12	5.811727	0.025555556	ADCY3 GNAO1 GNGT2 GRIK2 GRIK3 GRIK5 GRIN2D GRM4 GRM6 GRM8 GNG13 GNG12	109 2775 2793 2898 2899 2901 2906 2914 2916 2918 51764 55970
antineoplastic-690271	-	Long-term depression	path:04730_2	7	5.670771	0.028888889	GNA13 IGF1R PPP2R1A PRKCB MAP2K1 MAP2K2 PLA2G4C	10672 3480 5518 5579 5604 5605 8605
antineoplastic-690271	-	Dilated cardiomyopathy	path:05414_1	6	5.350088	0.042222222	ADCY3 CACNG5 CACNG4 PRKX CACNB3 CACNG1	109 27091 27092 5613 784 786
antineoplastic-92909	-	Purine metabolism	path:00230_58	7	7.29461	0.003325942	POLR2J2 NME1 NME3 PKLR POLR2C POLR3GL ENTPD6	246721 4830 4832 5313 5432 84265 955
antineoplastic-92909	-	Pyrimidine metabolism	path:00240_47	10	6.031861	0.024390244	NME1 NME3 POLE POLR2C POLR2D POLR3B NME5 POLR3GL PNPT1 ENTPD6	4830 4832 5426 5432 5433 55703 8382 84265 87178 955
antineoplastic-92909	-	Chemokine signaling pathway	path:04062_36	10	7.202459	0.003325942	GNB5 GNAI2 GNGT2 GNG13 PIK3CA PLCB2 PRKCZ PREX1 SRC CXCR4	10681 2771 2793 51764 5290 5330 5590 57580 6714 7852
antineoplastic-92909	-	Phosphatidylinositol signaling system	path:04070_26	7	5.667099	0.049889135	INPP1 INPP4A MTM1 PIK3C2B PI4KB PLCB3 IMPAD1	3628 3631 4534 5287 5298 5331 54928
antineoplastic-92909	-	Focal adhesion	path:04510_45	5	6.445396	0.013303769	PRKCA PTK2 PXN SRC TLN2	5578 5747 5829 6714 83660
antineoplastic-92915	-	Purine metabolism	path:00230_59	6	5.659626	0.042269188	PDE10A NUDT16 AMPD1 AMPD2 PDE4A NME5	10846 131870 270 271 5141 8382
antineoplastic-92915	-	Pyrimidine metabolism	path:00240_48	7	5.610634	0.047830923	POLR2J2 POLR2C POLR2F POLR2H POLR2I POLR2J POLR3GL	246721 5432 5435 5437 5438 5439 84265
antineoplastic-92915	-	ErbB signaling pathway	path:04012_7	8	6.763017	0.006674082	EGF EGFR NCK1 PLCG1 PRKCA PRKCG BTC CBL	1950 1956 4690 5335 5578 5582 685 867
antineoplastic-92915	-	Rap1 signaling pathway	path:04015_34	18	5.972232	0.03003337	CRK EFNA5 EGF EGFR EPHA2 FGF2 FGF9 FGF12 FGF14 ANGPT1 IGF1 KDR MET KITLG NGF NGFR PDGFB PDGFD	1398 1946 1950 1956 1969 2247 2254 2257 2259 284 3479 3791 4233 4254 4803 4804 5155 80310
antineoplastic-92915	-	Calcium signaling pathway	path:04020_29	10	7.575958	0.002224694	ATP2B1 PLCE1 PHKB PLCG1 PRKCA PRKCG CALM1 ORAI2 CALML3 SLC25A31	490 51196 5257 5335 5578 5582 801 80228 810 83447
antineoplastic-92915	-	FoxO signaling pathway	path:04068_36	18	5.729195	0.040044494	BCL2L11 CDK2 CDKN2D PLK4 PLK2 GABARAPL2 MAPK14 FOXO4 NLK PLK1 PRKAA2 PRKAG1 MAPK9 MAPK10 RBL2 BCL6 SETD7 G6PC3	10018 1017 1032 10733 10769 11345 1432 4303 51701 5347 5563 5571 5601 5602 5934 604 80854 92579
antineoplastic-92915	-	Phosphatidylinositol signaling system	path:04070_27	17	6.162822	0.027808676	CDS1 DGKG PIKFYVE INPP5A INPP5B INPP5D ITPKA ITPR2 OCRL PLCE1 PIK3CA PIK3CD PIP4K2A PLCG1 DGKZ DGKD DGKI	1040 1608 200576 3632 3633 3635 3706 3709 4952 51196 5290 5293 5305 5335 8525 8527 9162
antineoplastic-92915	-	p53 signaling pathway	path:04115_9	12	6.134828	0.03003337	CHEK2 RCHY1 SESN1 SFN SERPINE1 SERPINB5 ATR PIDD1 ZMAT3 SIAH1 TP53 TP73	11200 25898 27244 2810 5054 5268 545 55367 64393 6477 7157 7161
antineoplastic-92915	-	PI3K-Akt signaling pathway	path:04151_35	5	5.619409	0.047830923	EGF EGFR EPHA2 FGF2 FGF12	1950 1956 1969 2247 2257
antineoplastic-92915	-	Wnt signaling pathway	path:04310_11	5	5.864822	0.033370412	CSNK2A2 CSNK2B MAPK9 MAPK10 RAC1	1459 1460 5601 5602 5879
antineoplastic-92915	-	Jak-STAT signaling pathway	path:04630_34	13	6.921653	0.003337041	CSF3 CSF3R EPOR IFNAR1 IL2 IL10 IL12A IL15 JAK2 LIF LIFR IL22 IL21	1440 1441 2057 3454 3558 3586 3592 3600 3717 3976 3977 50616 59067
antineoplastic-92915	-	Legionellosis	path:05134_2	8	6.603635	0.010011123	CXCL1 CXCL2 CXCL3 IL1B CXCL8 IL12A MYD88 TLR4	2919 2920 2921 3553 3576 3592 4615 7099
antineoplastic-d613939 rep1	-	Purine metabolism	path:00230_60	9	5.979056	0.032967033	NUDT16 ADK ADSL PDE7B AMPD3 IMPDH1 GMPR2 PDE6D PDE8B	131870 132 158 27115 272 3614 51292 5147 8622
antineoplastic-d613939 rep1	-	Pyrimidine metabolism	path:00240_49	9	6.6051	0.00989011	POLR3H ZNRD1 NME1 NME3 POLR1D POLD4 POLR3D POLR1B PNPT1	171568 30834 4830 4832 51082 57804 661 84172 87178
antineoplastic-d613939 rep1	-	Valine, leucine and isoleucine degradation	path:00280_2	8	5.98219	0.032967033	ACAA2 ALDH3A2 HIBCH HADH AOX1 MUT PCCB MCEE	10449 224 26275 3033 316 4594 5096 84693
antineoplastic-d613939 rep1	-	Propanoate metabolism	path:00640_1	4	5.567696	0.048351648	MUT PCCB ACSS1 MCEE	4594 5096 84532 84693
antineoplastic-d613939 rep1	-	MAPK signaling pathway	path:04010_15	8	6.180269	0.023076923	MAPK14 DDIT3 DUSP4 ELK4 MAPK10 SRF DUSP16 RPS6KA5	1432 1649 1846 2005 5602 6722 80824 9252
antineoplastic-d613939 rep1	-	ErbB signaling pathway	path:04012_8	6	5.72138	0.041758242	PAK4 EGFR NCK1 MAPK8 MAPK10 MAP2K4	10298 1956 4690 5599 5602 6416
antineoplastic-d613939 rep1	-	cGMP-PKG signaling pathway	path:04022_16	5	6.843365	0.007692308	KCNU1 KCNMA1 PRKG2 BAD SLC8A1	157855 3778 5593 572 6546
antineoplastic-d613939 rep1	-	Chemokine signaling pathway	path:04062_37	10	5.963702	0.034065934	AKT3 GNB3 GNG3 HRAS PIK3CB PIK3R1 MAP2K1 PTK2 RAF1 SOS1	10000 2784 2785 3265 5291 5295 5604 5747 5894 6654
antineoplastic-d613939 rep1	-	Phosphatidylinositol signaling system	path:04070_28	12	5.611659	0.047252747	DGKA IMPA2 MTM1 PIK3C2A PIK3CB PIK3R1 PI4KA PI4KB PLCG1 PIP4K2C DGKD PLCZ1	1606 3613 4534 5286 5291 5295 5297 5298 5335 79837 8527 89869
antineoplastic-d613939 rep1	-	mTOR signaling pathway	path:04150_5	6	5.874374	0.03956044	AKT3 MTOR PRKAA1 PRKAA2 RPS6KA1 TSC2	10000 2475 5562 5563 6195 7249
antineoplastic-d613939 rep1	-	PI3K-Akt signaling pathway	path:04151_36	9	7.811227	0	AKT3 PIK3R1 PPP2CB PPP2R1B PPP2R2A PPP2R2B PPP2R5D BAD TSC2	10000 5295 5516 5519 5520 5521 5528 572 7249
antineoplastic-d613939 rep1	-	Apoptosis	path:04210_4	6	5.716171	0.041758242	AKT3 PPP3CA PPP3CB PPP3CC PRKACA BAD	10000 5530 5532 5533 5566 572
antineoplastic-d613939 rep1	-	VEGF signaling pathway	path:04370_2	7	6.124951	0.027472527	AKT3 PIK3R5 KDR PIK3CB PIK3R1 BAD SRC	10000 23533 3791 5291 5295 572 6714
antineoplastic-d613939 rep1	-	Jak-STAT signaling pathway	path:04630_35	8	6.965147	0.006593407	IL24 IFNAR2 IL20 IL22 IL26 CBL CBLB OSMR	11009 3455 50604 50616 55801 867 868 9180
antineoplastic-d613939 rep1	-	Neurotrophin signaling pathway	path:04722_3	8	6.6494	0.007692308	MAPK14 KRAS MAP3K3 PIK3R1 MAPK7 RAF1 RPS6KA1 SOS1	1432 3845 4215 5295 5598 5894 6195 6654
antineoplastic-d613939 rep1	-	Insulin signaling pathway	path:04910_12	7	5.913298	0.036263736	AKT3 MTOR PHKB BAD PYGB PYGM CALM3	10000 2475 5257 572 5834 5837 808
antineoplastic-d613939 rep1	-	Glucagon signaling pathway	path:04922_5	5	5.685541	0.041758242	ATF2 EP300 PCK2 PPARA PRKACA	1386 2033 5106 5465 5566
antineoplastic-d613939 rep1	-	Pathways in cancer	path:05200_19	10	7.049298	0.006593407	AKT3 EGFR HRAS KRAS PIK3CB PIK3R1 BAD RALGDS SOS1 CBLB	10000 1956 3265 3845 5291 5295 572 5900 6654 868
antineoplastic-d613939 rep1	-	Pancreatic cancer	path:05212_5	8	5.61347	0.047252747	AKT3 EGFR PIK3R5 KRAS PIK3R1 RAF1 RALGDS TGFA	10000 1956 23533 3845 5295 5894 5900 7039
antineoplastic-d613939 rep1	-	Glioma	path:05214_6	9	5.837861	0.03956044	AKT3 EGFR HRAS KRAS PIK3CB PIK3R1 RAF1 SOS1 CAMK2G	10000 1956 3265 3845 5291 5295 5894 6654 818
antineoplastic-d613939 rep1	-	Chronic myeloid leukemia	path:05220_6	6	6.420698	0.013186813	AKT3 PIK3R1 BAD PTPN11 CBLB GAB2	10000 5295 572 5781 868 9846
antineoplastic-d613939 rep1	-	Non-small cell lung cancer	path:05223_1	8	6.517331	0.013186813	AKT3 KRAS PIK3CB PIK3R1 PRKCA BAD RAF1 SOS1	10000 3845 5291 5295 5578 572 5894 6654
antineoplastic-d613939 rep1	-	Choline metabolism in cancer	path:05231_6	7	5.743035	0.040659341	HRAS KRAS PLCG1 MAPK10 RAF1 RALGDS SOS1	3265 3845 5335 5602 5894 5900 6654
antineoplastic-d613939 rep2	-	Purine metabolism	path:00230_61	7	6.555202	0.019629226	NUDT16 AMPD3 HPRT1 NME1 NT5E PDE6G ENTPD6	131870 272 3251 4830 4907 5148 955
antineoplastic-d613939 rep2	-	ErbB signaling pathway	path:04012_9	7	7.548022	0	AKT3 ERBB2 ERBB3 GRB2 GSK3B PIK3CB SHC3	10000 2064 2065 2885 2932 5291 53358
antineoplastic-d613939 rep2	-	Calcium signaling pathway	path:04020_30	9	5.826066	0.043620502	ERBB2 ERBB3 PLCB1 PDGFRA PLCG2 PRKCA TNNC1 ITPKC P2RX6	2064 2065 23236 5156 5336 5578 7134 80271 9127
antineoplastic-d613939 rep2	-	Chemokine signaling pathway	path:04062_38	8	7.032903	0.006543075	AKT3 GSK3B HCK PIK3CB PIK3R1 PRKCZ GNG12 GNB4	10000 2932 3055 5291 5295 5590 55970 59345
antineoplastic-d613939 rep2	-	Phosphatidylinositol signaling system	path:04070_29	11	6.37699	0.022900763	CDIPT PLCB1 PIK3C2A PIK3CA PIK3CB PI4KA PI4K2A PIP4K2C PIP5K1A PIP4K2B SYNJ2	10423 23236 5286 5290 5291 5297 55361 79837 8394 8396 8871
antineoplastic-d613939 rep2	-	Endocytosis	path:04144_7	10	6.264504	0.026172301	WWP1 ERBB3 CBLC SH3GLB1 PDGFRA EPN3 SH3GLB2 ITCH CBL CBLB	11059 2065 23624 51100 5156 55040 56904 83737 867 868
antineoplastic-d613939 rep2	-	PI3K-Akt signaling pathway	path:04151_37	5	7.579582	0	ITGA2B ITGA5 ITGB3 ITGB5 PTK2	3674 3678 3690 3693 5747
antineoplastic-d613939 rep2	-	AMPK signaling pathway	path:04152_16	7	6.229806	0.027262814	GYS1 ACACA HMGCR PFKFB2 PRKAG1 RPS6KB1 ULK1	2997 31 3156 5208 5571 6198 8408
antineoplastic-d613939 rep2	-	Wnt signaling pathway	path:04310_12	4	6.979619	0.006543075	CSNK2A2 CTNNB1 GSK3B PRKACB	1459 1499 2932 5567
antineoplastic-d613939 rep2	-	Focal adhesion	path:04510_46	6	7.499618	0.001090513	ITGA2B ITGA5 ITGB3 ITGB5 PRKCA CAV3	3674 3678 3690 3693 5578 859
antineoplastic-d613939 rep2	-	Adherens junction	path:04520_7	4	6.020011	0.033805889	CSNK2A2 CTNNB1 ERBB2 CDH1	1459 1499 2064 999
antineoplastic-d613939 rep2	-	Jak-STAT signaling pathway	path:04630_36	4	7.637017	0	IL21R STAT3 STAT5B SOCS3	50615 6774 6777 9021
antineoplastic-d613939 rep2	-	Neurotrophin signaling pathway	path:04722_4	8	5.835973	0.040348964	AKT3 GSK3B KRAS MAP3K3 NGFR PIK3CB PIK3CG SORT1	10000 2932 3845 4215 4804 5291 5294 6272
antineoplastic-d613939 rep2	-	Cholinergic synapse	path:04725_22	9	6.388323	0.022900763	GNB5 ADCY6 ADCY7 GNAI2 GNAO1 GNG5 PIK3CG PRKACB GNB4	10681 112 113 2771 2775 2787 5294 5567 59345
antineoplastic-d613939 rep2	-	Regulation of actin cytoskeleton	path:04810_20	6	6.350613	0.023991276	CRK ITGA2B ITGA5 ITGAM ITGB3 ITGB5	1398 3674 3678 3684 3690 3693
antineoplastic-d613939 rep2	-	Insulin signaling pathway	path:04910_13	6	7.427197	0.001090513	AKT3 MTOR GSK3B GYS1 PPP1CC PYGB	10000 2475 2932 2997 5501 5834
antineoplastic-d613939 rep2	-	Melanogenesis	path:04916_4	3	6.530066	0.019629226	PLCB1 GNAO1 GSK3B	23236 2775 2932
antineoplastic-d613939 rep2	-	Prolactin signaling pathway	path:04917_3	3	6.840761	0.009814613	STAT3 STAT5B SOCS3	6774 6777 9021
antineoplastic-d613939 rep2	-	Type II diabetes mellitus	path:04930_2	5	6.187273	0.028353326	PIK3CB PRKCE PRKCZ IRS2 SOCS3	5291 5581 5590 8660 9021
antineoplastic-d613939 rep2	-	Non-alcoholic fatty liver disease (NAFLD)	path:04932_1	5	5.771515	0.046892039	AKT3 GSK3B PIK3CB IRS2 SOCS3	10000 2932 5291 8660 9021
antineoplastic-d613939 rep2	-	Morphine addiction	path:05032_16	10	5.805886	0.044711014	GNB5 ADCY6 ADCY7 GNAI2 GNAO1 GNG5 OPRM1 PRKACB PRKCA GNB4	10681 112 113 2771 2775 2787 4988 5567 5578 59345
antineoplastic-d613939 rep2	-	Proteoglycans in cancer	path:05205_6	7	7.254039	0.005452563	CTNNB1 ERBB2 ERBB3 CBLC GRB2 KRAS CBLB	1499 2064 2065 23624 2885 3845 868
antineoplastic-d613939 rep2	-	Chronic myeloid leukemia	path:05220_7	10	6.769628	0.011995638	AKT3 AKT2 CBLC ABL1 GRB2 PIK3CB PIK3CG CBL CBLB GAB2	10000 208 23624 25 2885 5291 5294 867 868 9846
antineoplastic-d613939 rep3	-	Purine metabolism	path:00230_62	6	7.36299	0.011074197	AK8 AK1 AMPD1 NME1 PDE6C ENTPD6	158067 203 270 4830 5146 955
antineoplastic-d613939 rep3	-	Pyrimidine metabolism	path:00240_50	8	6.722764	0.015503876	TXNRD2 NT5C NME1 CMPK1 RRM1 TK1 TXNRD1 ENTPD6	10587 30833 4830 51727 6240 7083 7296 955
antineoplastic-d613939 rep3	-	PPAR signaling pathway	path:03320_4	7	6.545813	0.019933555	SORBS1 CYP27A1 ACSL3 PCK1 PPARG RXRA SCD	10580 1593 2181 5105 5468 6256 6319
antineoplastic-d613939 rep3	-	Endocytosis	path:04144_8	3	6.561659	0.018826135	WWP1 ERBB3 ITCH	11059 2065 83737
antineoplastic-d613939 rep3	-	Focal adhesion	path:04510_47	6	7.527167	0.008859358	ITGA5 ITGAV ITGB3 ITGB5 PRKCA CAV2	3678 3685 3690 3693 5578 858
antineoplastic-d613939 rep3	-	Proteoglycans in cancer	path:05205_7	5	7.388319	0.009966777	CTNNB1 ERBB2 ERBB3 CBLC GRB2	1499 2064 2065 23624 2885
antineoplastic-d613939 rep4	-	Purine metabolism	path:00230_63	11	6.414361	0.018952062	POLR3A ADCY6 NUDT16 AK1 HPRT1 NME4 PDE6C PDE6G PDE1B POLR3B ENTPD6	11128 112 131870 203 3251 4833 5146 5148 5153 55703 955
antineoplastic-d613939 rep4	-	Ras signaling pathway	path:04014_26	8	6.022274	0.040133779	RRAS2 PIK3R5 RASGRP3 NF1 PLCE1 RASAL1 SYNGAP1 RASAL2	22800 23533 25780 4763 51196 8437 8831 9462
antineoplastic-d613939 rep4	-	Rap1 signaling pathway	path:04015_35	9	6.016884	0.040133779	AKT3 RAPGEF3 ADCY6 PIK3R5 RASGRP3 PLCE1 RAP1B VAV2 FARP2	10000 10411 112 23533 25780 51196 5908 7410 9855
antineoplastic-d613939 rep4	-	Calcium signaling pathway	path:04020_31	12	6.548514	0.015607581	SLC25A4 ITPR1 ATP2A2 ATP2A3 ATP2B3 P2RX4 P2RX5 TNNC1 CACNA1C CACNA1F CACNA1H P2RX6	291 3708 488 489 492 5025 5026 7134 775 778 8912 9127
antineoplastic-d613939 rep4	-	cGMP-PKG signaling pathway	path:04022_17	6	5.969636	0.045707915	KCNMB3 KCNMB4 KCNMA1 PRKG2 CACNA1C CACNA1F	27094 27345 3778 5593 775 778
antineoplastic-d613939 rep4	-	cAMP signaling pathway	path:04024_15	8	6.012422	0.040133779	HCN4 RAPGEF3 ADCY6 RRAS2 PLCE1 CNGB3 MAPK10 RAP1B	10021 10411 112 22800 51196 54714 5602 5908
antineoplastic-d613939 rep4	-	FoxO signaling pathway	path:04068_37	26	6.195994	0.031215162	AKT3 SGK2 CDK2 CHUK S1PR1 FOXO1 FOXO3 SGK3 IL7R FOXO4 PCK1 NLK PRKAB1 PRKAG1 MAPK1 MAPK8 MAPK10 MAPK13 RAG1 RAG2 RBL2 BCL6 CAT CCNB3 CCNG2 ATG12	10000 10110 1017 1147 1901 2308 2309 23678 3575 4303 5105 51701 5564 5571 5594 5599 5602 5603 5896 5897 5934 604 847 85417 901 9140
antineoplastic-d613939 rep4	-	Endocytosis	path:04144_9	9	6.291768	0.026755853	RNF41 ERBB3 CBLC MDM2 EPN3 SH3GLB2 SMURF2 ITCH CBL	10193 2065 23624 4193 55040 56904 64750 83737 867
antineoplastic-d613939 rep4	-	AMPK signaling pathway	path:04152_17	9	6.719661	0.014492754	ADRA1A GYS1 GYS2 HMGCR LIPE PFKFB1 PFKFB2 PRKAB1 PRKAG1	148 2997 2998 3156 3991 5207 5208 5564 5571
antineoplastic-d613939 rep4	-	Adrenergic signaling in cardiomyocytes	path:04261_13	10	5.932747	0.045707915	CACNG5 PPP1CB PPP1CC PPP2R1A PPP2R5A PRKACB CACNA1C CACNA1F CACNA2D1 CAMK2D	27091 5500 5501 5518 5525 5567 775 778 781 817
antineoplastic-d613939 rep4	-	Hippo signaling pathway	path:04390_22	4	7.134566	0.005574136	PPP1CB PPP1CC PPP2R1A BTRC	5500 5501 5518 8945
antineoplastic-d613939 rep4	-	Jak-STAT signaling pathway	path:04630_37	12	6.297674	0.026755853	CSF2RB CBLC IFNAR2 IFNG IL9 JAK2 MPL OSM IL21R IL21 STAT2 CBL	1439 23624 3455 3458 3578 3717 4352 5008 50615 59067 6773 867
antineoplastic-d613939 rep4	-	Thyroid hormone signaling pathway	path:04919_10	4	7.017103	0.00780379	CTNNB1 EP300 PIK3R5 THRB	1499 2033 23533 7068
antineoplastic-d630679	-	Purine metabolism	path:00230_64	7	6.091713	0.02663707	ADCY7 GUCY1A2 PDE1A POLR2C POLR2H POLR1B POLR1C	113 2977 5136 5432 5437 84172 9533
antineoplastic-d630679	-	Pyrimidine metabolism	path:00240_51	9	5.785792	0.035516093	CTPS1 POLR2J2 NME3 POLR2C POLR2D POLR2E POLR2H POLR2J POLR1C	1503 246721 4832 5432 5433 5434 5437 5439 9533
antineoplastic-d630679	-	Terpenoid backbone biosynthesis	path:00900_1	6	6.087981	0.02663707	ZMPSTE24 FNTA ICMT MVD GGPS1 RCE1	10269 2339 23463 4597 9453 9986
antineoplastic-d630679	-	Calcium signaling pathway	path:04020_32	10	7.248684	0.003329634	SLC25A5 ATP2B3 P2RX7 PRKCG RYR2 TNNC2 TNNC1 CALML3 SLC25A31 CACNA1G	292 492 5027 5582 6262 7125 7134 810 83447 8913
antineoplastic-d630679	-	PI3K-Akt signaling pathway	path:04151_38	8	5.986458	0.027746948	CREB1 ATF2 AKT1 GNG4 PIK3CA PIK3CG PPP2CA IKBKG	1385 1386 207 2786 5290 5294 5515 8517
antineoplastic-d630679	-	Adrenergic signaling in cardiomyocytes	path:04261_14	9	5.580822	0.045504994	CACNG5 PPP2R5D PRKACA RYR2 CACNA1C CACNA1D CACNB2 CACNB3 CACNB4	27091 5528 5566 6262 775 776 783 784 785
antineoplastic-d630679	-	Circadian entrainment	path:04713_21	8	6.257307	0.02108768	ADCY6 ADCY7 GNB3 GNG4 GNGT1 MTNR1B PLCB4 PRKCG	112 113 2784 2786 2792 4544 5332 5582
antineoplastic-d630679	-	Retrograde endocannabinoid signaling	path:04723_17	6	6.460542	0.018867925	ADCY6 ADCY7 CNR1 GNB3 GNG4 MAPK10	112 113 1268 2784 2786 5602
antineoplastic-d630679	-	Glutamatergic synapse	path:04724_17	8	5.806843	0.033296337	ADCY6 ADCY7 GNB3 GNG4 GNGT1 GRIK5 GRIN2B GRM7	112 113 2784 2786 2792 2901 2904 2917
antineoplastic-d630679	-	Cholinergic synapse	path:04725_23	6	5.669112	0.042175361	ADCY6 ADCY7 CHRM4 CHRNB4 GNG4 PIK3CG	112 113 1132 1143 2786 5294
antineoplastic-d630679	-	GABAergic synapse	path:04727_13	7	6.400291	0.019977802	GABARAPL1 GABRB3 GABRD GABRR1 GABRR2 GNG4 GABBR2	23710 2562 2563 2569 2570 2786 9568
antineoplastic-d630679	-	Thyroid hormone synthesis	path:04918_2	4	5.549427	0.048834628	ATF2 PLCB4 PRKCG PRKX	1386 5332 5582 5613
antineoplastic-d630679	-	Adipocytokine signaling pathway	path:04920_2	4	5.647926	0.042175361	NFKBIB PRKCQ MAPK10 IKBKG	4793 5588 5602 8517
antineoplastic-d630679	-	Dilated cardiomyopathy	path:05414_2	9	5.597177	0.045504994	ADCY6 ADCY7 CACNG5 PRKX CACNG6 RYR2 CACNA1D CACNB2 CACNB3	112 113 27091 5613 59285 6262 776 783 784
antineoplastic-d640199	-	N-Glycan biosynthesis	path:00510_1	8	6.388992	0.02690583	ALG3 DPAGT1 DOLK ALG5 ALG1 DOLPP1 DPM1 DPM2	10195 1798 22845 29880 56052 57171 8813 8818
antineoplastic-d647752	-	Fructose and mannose metabolism	path:00051_2	7	7.029225	0.007751938	AKR1B1 HK2 HK3 PFKFB3 PFKP SORD HKDC1	231 3099 3101 5209 5214 6652 80201
antineoplastic-d647752	-	Purine metabolism	path:00230_65	9	6.062809	0.03654485	POLR3G ADCY7 GUK1 NME7 NT5E POLR1D PKLR POLR2F POLR2H	10622 113 2987 29922 4907 51082 5313 5435 5437
antineoplastic-d647752	-	Pyrimidine metabolism	path:00240_52	14	7.043494	0.007751938	POLR3F POLR3G POLR3H NME7 NUDT2 POLR1D POLR2C POLR2F POLR2H RRM2 POLR1E POLR1B PNPT1 ENTPD1	10621 10622 171568 29922 318 51082 5432 5435 5437 6241 64425 84172 87178 953
antineoplastic-d647752	-	MAPK signaling pathway	path:04010_16	8	6.768175	0.016611296	MAPK14 DUSP1 DUSP3 DUSP4 DUSP6 DUSP7 NFATC1 MAPK8	1432 1843 1845 1846 1848 1849 4772 5599
antineoplastic-d647752	-	Rap1 signaling pathway	path:04015_36	13	5.958296	0.044296788	EGFR EPHA2 FGF2 FGF11 FGFR1 PLCB1 FGF20 FGF22 PDGFA PDGFB PLCB4 PDGFC FGF17	1956 1969 2247 2256 2260 23236 26281 27006 5154 5155 5332 56034 8822
antineoplastic-d647752	-	Calcium signaling pathway	path:04020_33	8	6.255837	0.025470653	PPIF SLC25A5 ITPKB ATP2B4 P2RX7 PRKCA CACNA1F CALML3	10105 292 3707 493 5027 5578 778 810
antineoplastic-d647752	-	cGMP-PKG signaling pathway	path:04022_18	14	6.885214	0.013289037	KCNMB2 CNGB1 PLCB1 GTF2I KCNMA1 ATP1A1 ATP1B1 ATP1B3 ATP2B4 PRKCE PRKG1 RGS2 CACNA1S GTF2IRD1	10242 1258 23236 2969 3778 476 481 483 493 5581 5592 5997 779 9569
antineoplastic-d647752	-	Chemokine signaling pathway	path:04062_39	10	6.44688	0.021040975	AKT3 PLCB1 GNG4 GNG7 GNG11 GSK3B PIK3CA PIK3R1 PLCB4 PRKCD	10000 23236 2786 2788 2791 2932 5290 5295 5332 5580
antineoplastic-d647752	-	HIF-1 signaling pathway	path:04066_12	9	7.88342	0.002214839	EP300 HIF1A HK2 HK3 PFKFB3 STAT3 HKDC1 CAMK2G RBX1	2033 3091 3099 3101 5209 6774 80201 818 9978
antineoplastic-d647752	-	FoxO signaling pathway	path:04068_38	20	6.817797	0.015503876	AKT3 CDK2 PLK2 GADD45A S1PR1 AKT1 GABARAPL1 PRMT1 IL6 FOXO4 PRKAG2 PRKAA2 MAPK8 MAPK9 BCL6 STAT3 STK4 TNFSF10 CCNB2 G6PC3	10000 1017 10769 1647 1901 207 23710 3276 3569 4303 51422 5563 5599 5601 604 6774 6789 8743 9133 92579
antineoplastic-d647752	-	Phosphatidylinositol signaling system	path:04070_30	11	5.949299	0.046511628	DGKA PLCB1 INPP5D ITPKB PLCE1 PIK3CA PIK3R1 PLCB4 PI4K2A DGKE SYNJ2	1606 23236 3635 3707 51196 5290 5295 5332 55361 8526 8871
antineoplastic-d647752	-	AMPK signaling pathway	path:04152_18	5	5.914609	0.047619048	ADRA1A ACACA PRKAG2 PFKFB3 PRKAA2	148 31 51422 5209 5563
antineoplastic-d647752	-	Wnt signaling pathway	path:04310_13	6	6.186145	0.028792913	PLCB1 PLCB4 PPP3R1 PRKCA CAMK2A CAMK2G	23236 5332 5534 5578 815 818
antineoplastic-d647752	-	Focal adhesion	path:04510_48	7	7.347082	0.005537099	FLNA FLNB FLNC ITGB1 ITGB3 PRKCA THBS1	2316 2317 2318 3688 3690 5578 7057
antineoplastic-d647752	-	Gap junction	path:04540_2	5	5.982478	0.043189369	PLCB1 PLCB4 PRKCA PRKG1 SRC	23236 5332 5578 5592 6714
antineoplastic-d647752	-	Cholinergic synapse	path:04725_24	9	6.193104	0.028792913	AKT3 ADCY7 ADCY8 GNAO1 GNG4 GNG7 GNG11 PIK3CA PIK3R1	10000 113 114 2775 2786 2788 2791 5290 5295
antineoplastic-d647752	-	Serotonergic synapse	path:04726_17	9	5.92567	0.047619048	PLCB1 GNAI2 GNAO1 GNG4 GNG7 GNG11 HTR1D HTR2B PLCB4	23236 2771 2775 2786 2788 2791 3352 3357 5332
antineoplastic-d647752	-	Dopaminergic synapse	path:04728_22	7	6.208062	0.028792913	PLCB1 GNAO1 GNB1 GNG4 GNG11 PLCB4 PRKCA	23236 2775 2782 2786 2791 5332 5578
antineoplastic-d647752	-	Melanogenesis	path:04916_5	6	6.555783	0.018826135	PLCB1 GNAO1 PLCB4 PRKCA CALML3 CAMK2G	23236 2775 5332 5578 810 818
antineoplastic-d647752	-	Oxytocin signaling pathway	path:04921_17	6	7.458732	0.004429679	EGFR PLCB1 PIK3R1 PLCB4 PRKCA CALML3	1956 23236 5295 5332 5578 810
antineoplastic-d647752	-	Pancreatic cancer	path:05212_6	7	6.196573	0.028792913	AKT3 EGFR PIK3CA PIK3R1 BCL2L1 STAT3 TGFA	10000 1956 5290 5295 598 6774 7039
antineoplastic-d647753	-	Rap1 signaling pathway	path:04015_37	14	6.234268	0.037569061	CRK CSF1 EGFR EPHA2 FGF2 FGF12 FGF14 PLCB1 FGF20 MET PDGFB PLCB3 PLCB4 PDGFC	1398 1435 1956 1969 2247 2257 2259 23236 26281 4233 5155 5331 5332 56034
antineoplastic-d647753	-	Chemokine signaling pathway	path:04062_40	12	7.845154	0.002209945	AKT3 PLCB1 PIK3R5 GNB2 GNG3 GNG11 GNGT1 PIK3CB PIK3R1 PLCB3 PLCB4 GNG12	10000 23236 23533 2783 2785 2791 2792 5291 5295 5331 5332 55970
antineoplastic-d647753	-	Jak-STAT signaling pathway	path:04630_38	9	7.34349	0.009944751	CNTFR IFNLR1 IL2 IL6 IL6ST IL10RA IL15 LEP LIF	1271 163702 3558 3569 3572 3587 3600 3952 3976
antineoplastic-d647753	-	Circadian entrainment	path:04713_22	9	7.161147	0.013259669	ADCY9 PLCB1 GNB2 GNG3 GNG11 GNGT1 PLCB3 PLCB4 GNG12	115 23236 2783 2785 2791 2792 5331 5332 55970
antineoplastic-d647753	-	Retrograde endocannabinoid signaling	path:04723_18	6	6.616905	0.026519337	ADCY9 GNB2 GNG3 GNG11 GNGT1 GNG12	115 2783 2785 2791 2792 55970
antineoplastic-d647753	-	Glutamatergic synapse	path:04724_18	6	6.616905	0.026519337	ADCY9 GNB2 GNG3 GNG11 GNGT1 GNG12	115 2783 2785 2791 2792 55970
antineoplastic-d647753	-	Cholinergic synapse	path:04725_25	10	7.345901	0.009944751	AKT3 ADCY9 PIK3R5 GNB2 GNG3 GNG11 GNGT1 PIK3CB PIK3R1 GNG12	10000 115 23533 2783 2785 2791 2792 5291 5295 55970
antineoplastic-d647753	-	Serotonergic synapse	path:04726_18	9	7.401575	0.009944751	PLCB1 GNB2 GNG3 GNG11 GNGT1 HTR1D PLCB3 PLCB4 GNG12	23236 2783 2785 2791 2792 3352 5331 5332 55970
antineoplastic-d647753	-	GABAergic synapse	path:04727_14	9	7.101283	0.015469613	ADCY2 ADCY9 GABBR1 GABRE GNG3 GNG11 GNGT1 GNG13 GNG12	108 115 2550 2564 2785 2791 2792 51764 55970
antineoplastic-d647753	-	Dopaminergic synapse	path:04728_23	9	7.874992	0.001104972	ADCY5 DRD2 PLCB1 GNG3 GNG11 GNGT1 PLCB3 PLCB4 GNG12	111 1813 23236 2785 2791 2792 5331 5332 55970
antineoplastic-d647753	-	Regulation of actin cytoskeleton	path:04810_21	4	6.372697	0.033149171	PAK4 GNG12 RAC3 CDC42	10298 55970 5881 998
antineoplastic-d647753	-	Insulin signaling pathway	path:04910_14	5	6.557017	0.028729282	AKT3 MTOR PHKB PPP1CB CALML3	10000 2475 5257 5500 810
antineoplastic-d647753	-	Thyroid hormone signaling pathway	path:04919_11	10	6.49591	0.028729282	AKT3 PIK3R5 HIF1A ITGB3 ATP1B1 FXYD2 PIK3R1 PLCB4 SRC THRB	10000 23533 3091 3690 481 486 5295 5332 6714 7068
antineoplastic-d647753	-	Morphine addiction	path:05032_17	6	6.616905	0.026519337	ADCY9 GNB2 GNG3 GNG11 GNGT1 GNG12	115 2783 2785 2791 2792 55970
antineoplastic-d647753	-	Pathways in cancer	path:05200_20	6	6.210075	0.039779006	ETS1 TGFA TGFB2 TGFBR2 VEGFC VHL	2113 7039 7042 7048 7424 7428
antineoplastic-d648114	-	Purine metabolism	path:00230_66	8	6.615393	0.023333333	NUDT16 NME1 PDE1A PDE6C POLR2A POLR2H ENTPD1 ENTPD6	131870 4830 5136 5146 5430 5437 953 955
antineoplastic-d648114	-	Calcium signaling pathway	path:04020_34	12	6.189658	0.038888889	GRIN2A ATP2A3 ATP2B1 P2RX1 PRKCB TNNC1 CACNA1A CACNA1C CACNA1D ITPKC P2RX6 ORAI3	2903 489 490 5023 5579 7134 773 775 776 80271 9127 93129
antineoplastic-d648114	-	FoxO signaling pathway	path:04068_39	19	6.93323	0.013333333	AKT3 SGK2 CDK2 CDKN2B PLK4 CHUK FBXO32 MAPK14 FOXO1 FOXO3 SGK3 IL7R PCK1 NLK MAPK8 MAPK10 MAPK13 BCL6 STAT3	10000 10110 1017 1030 10733 1147 114907 1432 2308 2309 23678 3575 5105 51701 5599 5602 5603 604 6774
antineoplastic-d648114	-	Sphingolipid signaling pathway	path:04071_13	3	6.21309	0.036666667	GNA13 S1PR3 S1PR2	10672 1903 9294
antineoplastic-d648114	-	SNARE interactions in vesicular transport	path:04130_1	5	6.354361	0.028888889	STX2 STX3 VAMP1 VAMP2 VAMP3	2054 6809 6843 6844 9341
antineoplastic-d648114	-	AMPK signaling pathway	path:04152_19	5	6.530194	0.026666667	MTOR PPARG PRKAB1 RPS6KB1 ULK1	2475 5468 5564 6198 8408
antineoplastic-d648114	-	Jak-STAT signaling pathway	path:04630_39	13	6.496444	0.026666667	IFNLR1 IFNL1 IL2 IL4R IL7R IL10RB IL12A LEPR MPL OSM IL20RA IL21 CBL	163702 282618 3558 3566 3575 3588 3592 3953 4352 5008 53832 59067 867
antineoplastic-d648114	-	Proteoglycans in cancer	path:05205_8	4	6.231773	0.036666667	CTNNB1 ERBB2 ERBB3 GRB2	1499 2064 2065 2885
antineoplastic-d654830	-	Pyrimidine metabolism	path:00240_53	14	6.817604	0.007743363	POLR3F POLR3A CTPS1 POLR2J2 ZNRD1 NME1 POLR2A POLR2B POLR2C POLR2D POLR2K POLR1E POLR3D POLR3GL	10621 11128 1503 246721 30834 4830 5430 5431 5432 5433 5440 64425 661 84265
antineoplastic-d654830	-	RNA transport	path:03013_1	7	6.618329	0.009955752	UPF2 MAGOH NXF3 UPF3B UPF3A EIF4A3 RBM8A	26019 4116 56000 65109 65110 9775 9939
antineoplastic-d654830	-	Calcium signaling pathway	path:04020_35	9	6.430186	0.015486726	PPIF PTK2B SLC25A5 P2RX1 P2RX5 CALML5 PLCB4 PRKCG CACNA1D	10105 2185 292 5023 5026 51806 5332 5582 776
antineoplastic-d654830	-	FoxO signaling pathway	path:04068_40	20	6.070349	0.026548673	BCL2L11 CDKN2B PLK4 PLK2 GADD45G PLK3 FOXO3 PRMT1 FOXO4 PCK1 PLK1 PRKAA2 PRKAB2 RAG1 RBL2 CCND1 MAPK12 TNFSF10 CCNG2 CCNB2	10018 1030 10733 10769 10912 1263 2309 3276 4303 5105 5347 5563 5565 5896 5934 595 6300 8743 901 9133
antineoplastic-d654830	-	Hippo signaling pathway	path:04390_23	5	5.685994	0.047566372	RASSF1 PPP2CB PPP2R2A ACTB STK3	11186 5516 5520 60 6788
antineoplastic-d654830	-	Oxytocin signaling pathway	path:04921_18	4	6.064336	0.027654867	CALML5 PLCB4 PRKAB2 PRKCG	51806 5332 5565 5582
antineoplastic-d654830	-	Pathways in cancer	path:05200_21	7	6.288772	0.017699115	CDKN2B RASSF1 FOS JUN MYC NRAS CCND1	1030 11186 2353 3725 4609 4893 595
Arsenic trioxide rep1	FDA approved	Arachidonic acid metabolism	path:00590_3	10	5.840053	0.037610619	CYP2B6 CYP2C19 ALOX5 PLA2G2D LTA4H CYP4F3 PLA2G2A PLA2G5 PLA2G2F CYP4F2	1555 1557 240 26279 4048 4051 5320 5322 64600 8529
Arsenic trioxide rep1	FDA approved	Ras signaling pathway	path:04014_27	10	5.730311	0.046460177	RASSF1 KRAS PIK3CA PIK3CG RALGDS RASGRF1 RRAS RASSF5 SYNGAP1 RIN1	11186 3845 5290 5294 5900 5923 6237 83593 8831 9610
Arsenic trioxide rep1	FDA approved	PI3K-Akt signaling pathway	path:04151_39	6	6.471885	0.014380531	CSF1R EGFR EPHA2 FGFR4 IRS1 KITLG	1436 1956 1969 2264 3667 4254
Arsenic trioxide rep1	FDA approved	Focal adhesion	path:04510_49	6	6.116948	0.028761062	ITGA2 ITGB5 PRKCA PTK2 PXN SRC	3673 3693 5578 5747 5829 6714
Arsenic trioxide rep1	FDA approved	Jak-STAT signaling pathway	path:04630_40	13	5.884688	0.036504425	CSF3 CSF3R EPOR IL19 IFNAR1 IFNAR2 IL2RB IL2RG IL4 IL10RA JAK3 LEP LIF	1440 1441 2057 29949 3454 3455 3560 3561 3565 3587 3718 3952 3976
Arsenic trioxide rep1	FDA approved	Serotonergic synapse	path:04726_19	10	5.683523	0.049778761	GNAI1 GNAO1 GNB1 GNG3 GNG5 GNGT2 HTR1D PLCB4 GNB4 CACNA1A	2770 2775 2782 2785 2787 2793 3352 5332 59345 773
Arsenic trioxide rep2	FDA approved	Purine metabolism	path:00230_67	32	7.664596	0	PDE10A ADCY6 AK7 AK8 ADCY4 AMPD2 NT5C ZNRD1 HPRT1 APRT IMPDH1 HDDC3 NME3 GMPR2 PDE1A PDE3A PDE4C PDE6D PDE8A PDE9A PKM POLD1 POLE POLR2F POLR2J POLR1E POLR3D POLR3GL PDE8B POLR1C ENTPD5 GDA	10846 112 122481 158067 196883 271 30833 30834 3251 353 3614 374659 4832 51292 5136 5139 5143 5147 5151 5152 5315 5424 5426 5435 5439 64425 661 84265 8622 9533 957 9615
Arsenic trioxide rep2	FDA approved	Arachidonic acid metabolism	path:00590_4	9	6.550405	0.010011123	ALOX12B ALOX15 PLA2G2D CYP4F3 PLA2G2A PLA2G5 PLA2G2F PLA2G6 CYP4F2	242 246 26279 4051 5320 5322 64600 8398 8529
Arsenic trioxide rep2	FDA approved	Ras signaling pathway	path:04014_28	10	6.377849	0.014460512	RASGRP2 RASSF1 NRAS PIK3CD PIK3CG PIK3R1 RASGRF1 RASSF5 PIK3R3 SYNGAP1	10235 11186 4893 5293 5294 5295 5923 83593 8503 8831
Arsenic trioxide rep2	FDA approved	Rap1 signaling pathway	path:04015_38	10	6.426708	0.014460512	EFNA1 EFNA2 EFNA5 EGFR EPHA2 FGFR4 FLT4 IGF1R KITLG NGFR	1942 1943 1946 1956 1969 2264 2324 3480 4254 4804
Arsenic trioxide rep2	FDA approved	cAMP signaling pathway	path:04024_16	9	6.09222	0.025583982	ADRB2 DRD1 GABBR1 GNAI2 HTR1D HTR6 SSTR2 TSHR VIPR2	154 1812 2550 2771 3352 3362 6752 7253 7434
Arsenic trioxide rep2	FDA approved	Chemokine signaling pathway	path:04062_41	8	7.96448	0	FGR GNB1 NRAS PIK3CD PIK3CG PRKCZ PIK3R3 CDC42	2268 2782 4893 5293 5294 5590 8503 998
Arsenic trioxide rep2	FDA approved	FoxO signaling pathway	path:04068_41	11	5.986811	0.027808676	CDKN1A CDKN2D KLF2 MAPK14 S1PR1 FOXO4 PRKAG1 MAPK9 MAPK13 CCNB3 ATG12	1026 1032 10365 1432 1901 4303 5571 5601 5603 85417 9140
Arsenic trioxide rep2	FDA approved	Phosphatidylinositol signaling system	path:04070_31	10	6.471221	0.013348165	INPP1 INPP4A INPP5D PIK3C2A PIK3C2B PIK3CD PIK3CG PLCG1 PIP4K2C PIK3R3	3628 3631 3635 5286 5287 5293 5294 5335 79837 8503
Arsenic trioxide rep2	FDA approved	p53 signaling pathway	path:04115_10	7	5.780345	0.032258065	CDKN1A SFN STEAP3 PERP TP53 TP73 TP53I3	1026 2810 55240 64065 7157 7161 9540
Arsenic trioxide rep2	FDA approved	PI3K-Akt signaling pathway	path:04151_40	3	7.709134	0	ITGA2 ITGB1 PTK2	3673 3688 5747
Arsenic trioxide rep2	FDA approved	Jak-STAT signaling pathway	path:04630_41	10	6.095428	0.025583982	CNTFR IL19 IL2RA IL2RG IL6R JAK3 LEP LIF MPL IL22RA1	1271 29949 3559 3561 3570 3718 3952 3976 4352 58985
Arsenic trioxide rep2	FDA approved	Retrograde endocannabinoid signaling	path:04723_19	10	6.398047	0.014460512	ADCY6 MAPK14 ADCY4 GNAI2 GNB1 GNB2 MAPK9 MAPK13 GNB4 CACNA1A	112 1432 196883 2771 2782 2783 5601 5603 59345 773
Arsenic trioxide rep2	FDA approved	Cholinergic synapse	path:04725_26	10	5.900316	0.031145717	ADCY6 ADCY4 GNAI2 GNB1 GNB2 NRAS PIK3CG GNB4 CACNA1A PIK3R3	112 196883 2771 2782 2783 4893 5294 59345 773 8503
Arsenic trioxide rep2	FDA approved	Regulation of actin cytoskeleton	path:04810_22	8	5.660969	0.041156841	VAV3 NRAS PIK3CD PIK3CG PIK3R1 VAV1 VAV2 PIK3R3	10451 4893 5293 5294 5295 7409 7410 8503
Arsenic trioxide rep2	FDA approved	Insulin signaling pathway	path:04910_15	6	6.177554	0.024471635	PIK3CD PIK3CG PRKCZ MAPK9 IRS4 PIK3R3	5293 5294 5590 5601 8471 8503
Arsenic trioxide rep2	FDA approved	Type II diabetes mellitus	path:04930_3	7	6.393386	0.014460512	PIK3CD PIK3CG PRKCZ MAPK9 TNF IRS4 PIK3R3	5293 5294 5590 5601 7124 8471 8503
Arsenic trioxide rep2	FDA approved	Morphine addiction	path:05032_18	9	5.717375	0.0378198	ADCY6 ADCY4 GABBR1 GNAI2 GNB1 GNB2 PRKCG GNB4 CACNA1A	112 196883 2550 2771 2782 2783 5582 59345 773
Arsenic trioxide rep3	FDA approved	Purine metabolism	path:00230_68	9	6.431312	0.024122807	PDE10A AK2 AMPD2 NT5C GMPR2 PDE6D PDE8A PKM ENTPD6	10846 204 271 30833 51292 5147 5151 5315 955
Arsenic trioxide rep3	FDA approved	Glutathione metabolism	path:00480_5	9	5.989017	0.031798246	GGT7 GCLC GPX7 ANPEP GSR GSS MGST1 MGST3 TXNDC12	2686 2729 2882 290 2936 2937 4257 4259 51060
Arsenic trioxide rep3	FDA approved	ErbB signaling pathway	path:04012_10	7	5.72807	0.049342105	CRK EGFR EREG GRB2 SRC BTC TGFA	1398 1956 2069 2885 6714 685 7039
Arsenic trioxide rep3	FDA approved	Ras signaling pathway	path:04014_29	9	6.509435	0.023026316	RGL1 PIK3CG RAC3 RRAS RASSF5 PIK3R3 SYNGAP1 RASAL2 RIN1	23179 5294 5881 6237 83593 8503 8831 9462 9610
Arsenic trioxide rep3	FDA approved	Calcium signaling pathway	path:04020_36	9	5.808285	0.04495614	ITPKA ITPR3 ATP2B4 P2RX1 SLC8A3 VDAC1 CALM1 ORAI2 PLCZ1	3706 3710 493 5023 6547 7416 801 80228 89869
Arsenic trioxide rep3	FDA approved	Chemokine signaling pathway	path:04062_42	6	5.80754	0.04495614	FGR GNB1 GNB2 PIK3CG PRKCZ PIK3R3	2268 2782 2783 5294 5590 8503
Arsenic trioxide rep3	FDA approved	Focal adhesion	path:04510_50	4	6.985408	0.006578947	FLNB ITGA2 PTK2 PXN	2317 3673 5747 5829
Arsenic trioxide rep3	FDA approved	Regulation of actin cytoskeleton	path:04810_23	3	6.750044	0.012061404	CRK RAC1 VAV2	1398 5879 7410
Asparaginase	FDA approved	Purine metabolism	path:00230_69	10	6.08397	0.02640264	POLR3A ADCY7 POLR2J2 NME7 NME1 POLR2C POLR2H PNPT1 ENTPD2 ENTPD3	11128 113 246721 29922 4830 5432 5437 87178 954 956
Asparaginase	FDA approved	Pyrimidine metabolism	path:00240_54	8	6.326212	0.01430143	CTPS1 POLR2J2 NME7 NME1 POLR2C POLR2D POLR2H ENTPD5	1503 246721 29922 4830 5432 5433 5437 957
Asparaginase	FDA approved	Glycerophospholipid metabolism	path:00564_11	9	6.100165	0.02530253	CDS1 PLA2G4E DGKG PLD3 PLA2G15 PLA2G3 AGPAT3 PLA2G12A DGKD	1040 123745 1608 23646 23659 50487 56894 81579 8527
Axitinib	FDA approved	Purine metabolism	path:00230_70	10	7.189891	0.006764374	POLR3G POLR3A AK1 PKM POLE3 POLD2 POLE POLR3E POLE4 ENTPD6	10622 11128 203 5315 54107 5425 5426 55718 56655 955
Axitinib	FDA approved	PPAR signaling pathway	path:03320_5	11	6.061603	0.042841037	SORBS1 SLC27A4 CYP27A1 FABP1 ACSL3 ACSL6 APOC3 AQP7 PLIN1 RXRA UBC	10580 10999 1593 2168 2181 23305 345 364 5346 6256 7316
Axitinib	FDA approved	AMPK signaling pathway	path:04152_20	6	6.493466	0.019165727	ADRA1A MTOR HMGCR PRKAG3 STK11 TSC2	148 2475 3156 53632 6794 7249
Axitinib	FDA approved	Focal adhesion	path:04510_51	3	6.294313	0.027057497	ITGA2 ITGA5 PXN	3673 3678 5829
Axitinib	FDA approved	Platelet activation	path:04611_7	3	6.045388	0.042841037	ITGA2 PIK3CB PIK3R1	3673 5291 5295
Axitinib	FDA approved	Jak-STAT signaling pathway	path:04630_42	7	7.409059	0.005636979	EP300 IL6 IL6ST IL15RA IL21R CCND1 STAT2	2033 3569 3572 3601 50615 595 6773
Azacitidine rep1	FDA approved	Purine metabolism	path:00230_71	32	8.279231	0.001112347	POLR3F POLR3A ADCY7 CANT1 ADK DCK POLR3H AK1 AK9 NT5C2 POLA2 AMPD3 GUCY2C NT5C HPRT1 ITPA HDDC3 NME1 POLR1D PDE4A PDE8A PDE9A POLE3 POLD1 POLE POLR2A POLR2E POLR2J PRIM1 RRM2 POLR1C ENTPD6	10621 11128 113 124583 132 1633 171568 203 221264 22978 23649 272 2984 30833 3251 3704 374659 4830 51082 5141 5151 5152 54107 5424 5426 5430 5434 5439 5557 6241 9533 955
Azacitidine rep1	FDA approved	Sphingolipid metabolism	path:00600_4	6	6.652666	0.013348165	CERS3 SPHK2 GBA2 CERK SMPD2 CERS5	204219 56848 57704 64781 6610 91012
Azacitidine rep1	FDA approved	Calcium signaling pathway	path:04020_37	12	6.331629	0.026696329	PPIF GRIN2D ITPKA ITPKB ATP2A2 ATP2B1 ATP2B4 P2RX4 SLC8A2 VDAC2 CACNA1A CALM3	10105 2906 3706 3707 488 490 493 5025 6543 7417 773 808
Azacitidine rep1	FDA approved	FoxO signaling pathway	path:04068_42	19	6.797831	0.011123471	CDK2 CDKN2D CHUK MAPK14 AKT1 AKT2 FOXO3 GADD45B ATM PCK1 MAPK8 MAPK11 MAPK13 MAPK12 SGK1 BNIP3 STAT3 S1PR4 CCNB1	1017 1032 1147 1432 207 208 2309 4616 472 5105 5599 5600 5603 6300 6446 664 6774 8698 891
Azacitidine rep1	FDA approved	Phosphatidylinositol signaling system	path:04070_32	10	6.266816	0.026696329	DGKA INPP5J ITPKB PLCE1 PIK3R1 PI4KA PLCB2 PLCG1 PIP4K2B SYNJ2	1606 27124 3707 51196 5295 5297 5330 5335 8396 8871
Azacitidine rep1	FDA approved	PI3K-Akt signaling pathway	path:04151_41	7	6.058	0.034482759	CSH2 AKT2 IFNAR1 IL2RB JAK3 PRL PIK3R3	1443 208 3454 3560 3718 5617 8503
Azacitidine rep1	FDA approved	Jak-STAT signaling pathway	path:04630_43	8	6.420059	0.024471635	CSF2RB CBLC IFNAR1 IFNG IFNGR1 IL2RB IL22 OSMR	1439 23624 3454 3458 3459 3560 50616 9180
Azacitidine rep1	FDA approved	Retrograde endocannabinoid signaling	path:04723_20	11	6.286995	0.026696329	ADCY7 MAPK14 GNAI2 GNB1 GNB2 GNG11 MAPK8 MAPK11 MAPK13 MAPK12 CACNA1A	113 1432 2771 2782 2783 2791 5599 5600 5603 6300 773
Azacitidine rep2	FDA approved	Purine metabolism	path:00230_72	22	9.222087	0	POLR3F ADCY7 DCK AK9 POLA2 POLR2J2 AMPD3 GUCY2C GUCY2F HPRT1 ITPA PDE6D PDE8A PDE9A POLA1 POLE POLR2J PRIM1 POLR3E GMPS POLR1C ENTPD6	10621 113 1633 221264 23649 246721 272 2984 2986 3251 3704 5147 5151 5152 5422 5426 5439 5557 55718 8833 9533 955
Azacitidine rep2	FDA approved	Pyrimidine metabolism	path:00240_55	6	6.1222	0.038126362	TXNRD2 DCK AK9 PRIM1 RRM2 DCTPP1	10587 1633 221264 5557 6241 79077
Azacitidine rep2	FDA approved	Rap1 signaling pathway	path:04015_39	9	6.365742	0.02832244	RAPGEF3 ADCY7 MAP2K3 RALGDS RAP1B BRAF PIK3R3 KRIT1 FARP2	10411 113 5606 5900 5908 673 8503 889 9855
Azacitidine rep2	FDA approved	cAMP signaling pathway	path:04024_17	7	6.401905	0.027233115	RAPGEF3 ADCY7 CNGB1 MAPK8 MAP2K2 RAP1B BRAF	10411 113 1258 5599 5605 5908 673
Azacitidine rep2	FDA approved	FoxO signaling pathway	path:04068_43	14	6.041535	0.040305011	CDK2 CDKN2D GABARAP GABARAPL2 MAPK14 AKT1 FOXO4 ATM PCK1 PRKAG1 MAPK8 G6PC2 MAPK12 SGK1	1017 1032 11337 11345 1432 207 4303 472 5105 5571 5599 57818 6300 6446
Azacitidine rep2	FDA approved	Cell cycle	path:04110_6	10	6.094021	0.039215686	CDK2 CDK4 CDK6 CDKN1C CDKN2D MDM2 PCNA RB1 RBL1 CCNE2	1017 1019 1021 1028 1032 4193 5111 5925 5933 9134
Azacitidine rep2	FDA approved	Jak-STAT signaling pathway	path:04630_44	6	6.048225	0.040305011	AKT1 AKT2 IFNAR1 PIAS4 STAT2 PIK3R3	207 208 3454 51588 6773 8503
AZD-9291	FDA approved	Purine metabolism	path:00230_73	14	6.397134	0.01540154	ADCY1 ADCY5 ADCY9 NUDT16 AK2 GUCY2C APRT NME3 NPR1 NT5E PDE3B PDE9A POLR1E POLR3D	107 111 115 131870 204 2984 353 4832 4881 4907 5140 5152 64425 661
AZD-9291	FDA approved	Glycerolipid metabolism	path:00561_4	6	5.68725	0.04510451	AGPAT1 MGLL PNLIPRP1 PNLIPRP2 AGK GPAM	10554 11343 5407 5408 55750 57678
AZD-9291	FDA approved	Arachidonic acid metabolism	path:00590_5	9	6.124346	0.01980198	PLA2G4E CYP2B6 CYP2C19 CYP2C8 CYP2E1 PLA2G2D CYP4F3 PLA2G2F CYP4F2	123745 1555 1557 1558 1571 26279 4051 64600 8529
AZD-9291	FDA approved	MAPK signaling pathway	path:04010_17	9	6.609894	0.01210121	DUSP2 DUSP3 DUSP5 DUSP7 DUSP8 ELK1 MAPK3 MAPK10 PTPN5	1844 1845 1847 1849 1850 2002 5595 5602 84867
AZD-9291	FDA approved	Rap1 signaling pathway	path:04015_40	19	6.40965	0.01540154	EFNA2 FGF1 FGF6 FGF13 FGFR3 FGFR2 FGFR4 FLT4 IGF1 INS INSR KDR NGF PDGFA PDGFB PDGFRB PLCB3 VEGFA FGF17	1943 2246 2251 2258 2261 2263 2264 2324 3479 3630 3643 3791 4803 5154 5155 5159 5331 7422 8822
AZD-9291	FDA approved	Calcium signaling pathway	path:04020_38	14	5.950207	0.02310231	CHRNA7 PTK2B GRIN2A ITPR3 ATP2A1 ATP2B2 P2RX7 PLCB3 PLCG2 PRKCG CACNA1D CALML3 CACNA1H CACNA1G	1139 2185 2903 3710 487 491 5027 5331 5336 5582 776 810 8912 8913
AZD-9291	FDA approved	Chemokine signaling pathway	path:04062_43	12	6.245408	0.01650165	CCR1 CCR3 CCR4 CCR7 CCR8 GNAI2 GRK5 CCL5 CCL15 CCL23 CCL25 XCL2	1230 1232 1233 1236 1237 2771 2869 6352 6359 6368 6370 6846
AZD-9291	FDA approved	Axon guidance	path:04360_3	3	5.823769	0.0330033	NCK1 PAK1 RAC3	4690 5058 5881
AZD-9291	FDA approved	Natural killer cell mediated cytotoxicity	path:04650_4	6	6.185341	0.01760176	VAV3 ITGAL PAK1 PLCG2 RAC3 VAV1	10451 3683 5058 5336 5881 7409
AZD-9291	FDA approved	Fc epsilon RI signaling pathway	path:04664_4	9	5.644017	0.04510451	VAV3 PIK3CA PIK3CD PLCG2 PRKCB RAC3 SYK VAV1 PIK3R3	10451 5290 5293 5336 5579 5881 6850 7409 8503
AZD-9291	FDA approved	Glutamatergic synapse	path:04724_19	20	6.182619	0.01760176	ADCY1 ADCY5 ADCY7 ADCY8 ADCY9 GNAI2 GNAO1 GNB1 GNG5 GRIA3 GRIK3 GRIK5 GRIN1 GRIN2A GRIN2B GRIN2C GRM2 GRM4 GRM7 GNG13	107 111 113 114 115 2771 2775 2782 2787 2892 2899 2901 2902 2903 2904 2905 2912 2914 2917 51764
AZD-9291	FDA approved	Regulation of actin cytoskeleton	path:04810_24	8	5.578803	0.04730473	VAV3 RRAS2 PIK3R5 MYLK PAK1 RAC3 RAF1 VAV1	10451 22800 23533 4638 5058 5881 5894 7409
Belinostat rep1	FDA approved	Purine metabolism	path:00230_74	11	6.68109	0.008839779	AK7 CANT1 AK5 AMPD1 GUK1 NT5C IMPDH2 ATIC GMPR2 PDE6C ENTPD4	122481 124583 26289 270 2987 30833 3615 471 51292 5146 9583
Belinostat rep1	FDA approved	MAPK signaling pathway	path:04010_18	8	6.26017	0.01878453	DUSP2 MAPT MAX MEF2C MYC MAPK1 MAPK13 MAP2K6	1844 4137 4149 4208 4609 5594 5603 5608
Belinostat rep1	FDA approved	Ras signaling pathway	path:04014_30	14	6.26485	0.01878453	CSF1 EFNA3 EPHA2 FGF1 FGF6 FGF12 FGF13 FGF14 FLT4 FGF20 HGF SHC4 PDGFC FGF23	1435 1944 1969 2246 2251 2257 2258 2259 2324 26281 3082 399694 56034 8074
Belinostat rep1	FDA approved	Calcium signaling pathway	path:04020_39	15	7.731737	0.001104972	GRIN1 GRIN2C ATP2A1 ATP2A3 P2RX5 PDE1B PRKCB RYR1 RYR2 SLC8A2 ITPKC CALM3 CALML3 CACNA1H P2RX6	2902 2905 487 489 5026 5153 5579 6261 6262 6543 80271 808 810 8912 9127
Belinostat rep1	FDA approved	cAMP signaling pathway	path:04024_18	12	6.812419	0.006629834	ADCY9 DRD2 GIPR GLP1R GNAI3 GNAS HTR1D OXTR PTGER2 SSTR2 SSTR5 VIPR2	115 1813 2696 2740 2773 2778 3352 5021 5732 6752 6755 7434
Belinostat rep1	FDA approved	mTOR signaling pathway	path:04150_6	4	5.617643	0.044198895	MTOR PRKCA PRKCB PRKCG	2475 5578 5579 5582
Belinostat rep1	FDA approved	PI3K-Akt signaling pathway	path:04151_42	4	5.708347	0.034254144	ITGAV ITGB1 ITGB3 THBS1	3685 3688 3690 7057
Belinostat rep1	FDA approved	Adrenergic signaling in cardiomyocytes	path:04261_15	8	5.610135	0.044198895	CACNG5 CACNG4 PPP1CB PPP2R1A PRKACA RYR2 TNNI3 CALML3	27091 27092 5500 5518 5566 6262 7137 810
Belinostat rep1	FDA approved	Focal adhesion	path:04510_52	3	6.081607	0.020994475	ITGB1 PXN TLN1	3688 5829 7094
Belinostat rep1	FDA approved	Natural killer cell mediated cytotoxicity	path:04650_5	5	6.068149	0.022099448	VAV3 LAT GRB2 ITGAL RAC3	10451 27040 2885 3683 5881
Belinostat rep1	FDA approved	Gastric acid secretion	path:04971_2	6	5.641445	0.040883978	ADCY9 ADCY4 GNAI3 GNAS HRH2 SSTR2	115 196883 2773 2778 3274 6752
Belinostat rep1	FDA approved	Alcoholism	path:05034_4	7	5.593369	0.044198895	CREB3 GRIN1 GRIN2C GRIN2D PPP1CB PRKACA MAPK1	10488 2902 2905 2906 5500 5566 5594
Belinostat rep2	FDA approved	Purine metabolism	path:00230_75	7	6.860318	0.006586169	CANT1 AK5 AMPD3 GUK1 NT5C APRT PDE3B	124583 26289 272 2987 30833 353 5140
Belinostat rep2	FDA approved	Pyrimidine metabolism	path:00240_56	6	5.856382	0.03183315	CANT1 DPYD TYMP NT5C UCKL1 TK1	124583 1806 1890 30833 54963 7083
Belinostat rep2	FDA approved	Glycerophospholipid metabolism	path:00564_12	9	5.631744	0.045005488	CEPT1 LYPLA1 AGPAT2 LPIN1 PLD3 PLA2G2D PLA2G2F DGKE DGKI	10390 10434 10555 23175 23646 26279 64600 8526 9162
Belinostat rep2	FDA approved	FoxO signaling pathway	path:04068_44	14	6.208431	0.017563117	SGK2 PLK3 GADD45A FOXO3 GADD45B PCK2 PRKAG2 PRKAB1 MAPK1 MAPK11 MAPK9 MAPK13 TNFSF10 G6PC3	10110 1263 1647 2309 4616 5106 51422 5564 5594 5600 5601 5603 8743 92579
Belinostat rep2	FDA approved	PI3K-Akt signaling pathway	path:04151_43	19	5.735736	0.038419319	CSF1 EFNA3 EGFR EPHA2 FGF1 FGF5 FGF12 FGF13 FGF14 FGFR4 FLT4 FGF20 GRB2 HGF NGF PDGFC VEGFA VEGFC PDGFD	1435 1944 1956 1969 2246 2250 2257 2258 2259 2264 2324 26281 2885 3082 4803 56034 7422 7424 80310
Belinostat rep2	FDA approved	Adrenergic signaling in cardiomyocytes	path:04261_16	7	5.813782	0.032930845	CACNG5 CACNG4 PPP1CB PPP2R1A PPP2R5A CACNA2D1 CACNB1	27091 27092 5500 5518 5525 781 782
Belinostat rep2	FDA approved	Retrograde endocannabinoid signaling	path:04723_21	14	5.647714	0.043907794	ADCY1 ADCY2 ADCY8 ADCY9 GNAI3 GNB1 GNG4 GNG5 GNG13 PRKACB MAPK1 MAPK11 MAPK9 MAPK13	107 108 114 115 2773 2782 2786 2787 51764 5567 5594 5600 5601 5603
Belinostat rep2	FDA approved	Pathways in cancer	path:05200_22	9	6.344055	0.016465423	GRB2 RHOA NRAS PRKCA RAC2 RAC3 RALGDS SOS1 BRAF	2885 387 4893 5578 5880 5881 5900 6654 673
Bendamustine	FDA approved	Purine metabolism	path:00230_76	26	8.515414	0	POLD3 PDE10A POLR3A ADCY8 ADSL AK8 AK1 POLA2 GUK1 NME7 ITPA NME3 NPR1 NT5E GMPR2 PDE6C PDE8A PDE9A PDE1B POLE3 POLD1 POLR2L POLR1E POLR3D POLR3GL ENTPD4	10714 10846 11128 114 158 158067 203 23649 2987 29922 3704 4832 4881 4907 51292 5146 5151 5152 5153 54107 5424 5441 64425 661 84265 9583
Bendamustine	FDA approved	N-Glycan biosynthesis	path:00510_2	3	5.629259	0.040133779	DOLK DOLPP1 DPM2	22845 57171 8818
Bendamustine	FDA approved	Glycerophospholipid metabolism	path:00564_13	9	5.590521	0.043478261	PEMT PNPLA6 PLA2G16 PLD4 PLA2G15 PLA2G2D PLA2G2A LPCAT1 PLA2G4C	10400 10908 11145 122618 23659 26279 5320 79888 8605
Bendamustine	FDA approved	cGMP-PKG signaling pathway	path:04022_19	6	5.644172	0.039018952	MYH7 NFATC3 NFATC4 PPP3CC SRF TRPC6	4625 4775 4776 5533 6722 7225
Bendamustine	FDA approved	FoxO signaling pathway	path:04068_45	12	5.626157	0.040133779	BCL2L11 CDKN2B GABARAPL2 GADD45A FOXO1 IKBKB NLK MAPK8 CCND1 BNIP3 STAT3 STK11	10018 1030 11345 1647 2308 3551 51701 5599 595 664 6774 6794
Bendamustine	FDA approved	PI3K-Akt signaling pathway	path:04151_44	3	5.800051	0.033444816	ITGA5 ITGAV PTK2	3678 3685 5747
Bendamustine	FDA approved	Hippo signaling pathway	path:04390_24	6	5.869166	0.032329989	BBC3 PPP2R1A PPP2R2A PPP2R2C PPP2R2D CCND1	27113 5518 5520 5522 55844 595
Bendamustine	FDA approved	Focal adhesion	path:04510_53	3	6.204089	0.021181717	ITGA5 ITGAV PTK2	3678 3685 5747
Bendamustine	FDA approved	Tight junction	path:04530_5	4	5.669356	0.039018952	RHOA AFDN MYH7 PRKCG	387 4301 4625 5582
Bendamustine	FDA approved	Jak-STAT signaling pathway	path:04630_45	9	6.831172	0.00780379	EPOR IFNAR1 IFNGR2 IL10RB IL13RA1 LEPR MPL TSLP SOCS3	2057 3454 3460 3588 3597 3953 4352 85480 9021
Bleomycin rep1	FDA approved	Purine metabolism	path:00230_77	6	6.185081	0.023307436	POLR3G NME7 GUCY2D ZNRD1 POLR3K POLR2G	10622 29922 3000 30834 51728 5436
Bleomycin rep1	FDA approved	Pyrimidine metabolism	path:00240_57	8	6.281829	0.022197558	POLR3G POLR3H POLR2J2 NME7 ZNRD1 POLR3K POLR2G POLR1B	10622 171568 246721 29922 30834 51728 5436 84172
Bleomycin rep1	FDA approved	MAPK signaling pathway	path:04010_19	7	6.535179	0.018867925	AKT3 DUSP1 DUSP4 FLNA FLNC MAPK10 MAP2K4	10000 1843 1846 2316 2318 5602 6416
Bleomycin rep1	FDA approved	ErbB signaling pathway	path:04012_11	10	6.64683	0.017758047	CRKL EGFR CBLC ABL1 ABL2 GRB2 PLCG2 PRKCA STAT5A CAMK2G	1399 1956 23624 25 27 2885 5336 5578 6776 818
Bleomycin rep1	FDA approved	Rap1 signaling pathway	path:04015_41	13	6.836302	0.011098779	CRKL CSF1R FGF2 FGFR1 HGF IGF1R INSR KITLG PDGFA PDGFB PLCB4 PDGFC VEGFB	1399 1436 2247 2260 3082 3480 3643 4254 5154 5155 5332 56034 7423
Bleomycin rep1	FDA approved	Calcium signaling pathway	path:04020_40	11	6.166067	0.025527192	ITPKA ITPKB ATP2B1 ATP2B3 PRKCA TNNC2 CACNA1C CACNA1F CACNA1S CACNA1G P2RX6	3706 3707 490 492 5578 7125 775 778 779 8913 9127
Bleomycin rep1	FDA approved	FoxO signaling pathway	path:04068_46	6	6.187693	0.023307436	AKT3 CHUK SGK3 FOXO4 PDPK1 PIK3R3	10000 1147 23678 4303 5170 8503
Bleomycin rep1	FDA approved	Endocytosis	path:04144_10	9	5.808561	0.046614872	WWP1 CSF1R ERBB3 CBLC IGF1R SMAD3 EPN3 SMURF2 TGFBR1	11059 1436 2065 23624 3480 4088 55040 64750 7046
Bleomycin rep1	FDA approved	PI3K-Akt signaling pathway	path:04151_45	11	6.023933	0.029966704	CSF1R FGF2 FGFR1 HGF IGF1R INSR KITLG PDGFA PDGFB PDGFC VEGFB	1436 2247 2260 3082 3480 3643 4254 5154 5155 56034 7423
Bleomycin rep1	FDA approved	Adrenergic signaling in cardiomyocytes	path:04261_17	12	5.783367	0.04772475	CACNG5 CACNG4 PPP2R5A CACNA2D3 CACNG7 CACNA1C CACNA1F CACNA1S CACNA2D1 CACNB1 CACNB3 CACNG1	27091 27092 5525 55799 59284 775 778 779 781 782 784 786
Bleomycin rep1	FDA approved	Focal adhesion	path:04510_54	4	8.697544	0	FLNA FLNC ITGA5 VASP	2316 2318 3678 7408
Bleomycin rep1	FDA approved	Pathways in cancer	path:05200_23	9	6.090149	0.027746948	AKT3 CHUK CRKL CBLC ABL1 IGF1R NFKBIA STAT5A PIK3R3	10000 1147 1399 23624 25 3480 4792 6776 8503
Bleomycin rep1	FDA approved	Chronic myeloid leukemia	path:05220_8	7	5.945322	0.033296337	AKT3 CHUK CBLC ABL1 NFKBIA STAT5A PIK3R3	10000 1147 23624 25 4792 6776 8503
Bleomycin rep2	FDA approved	Pyrimidine metabolism	path:00240_58	10	6.164858	0.027654867	TXNRD2 POLD3 NME7 ZNRD1 RRM2B POLR3K POLE POLR2G POLR3E DCTPP1	10587 10714 29922 30834 50484 51728 5426 5436 55718 79077
Bleomycin rep2	FDA approved	Sphingolipid signaling pathway	path:04071_14	16	5.974571	0.037610619	GNA13 ADORA1 S1PR1 S1PR3 GNA12 GNAI1 GNAI2 GNAQ RHOA PIK3CB PLCB3 PLCB4 S1PR5 PRKCA BDKRB2 GAB2	10672 134 1901 1903 2768 2770 2771 2776 387 5291 5331 5332 53637 5578 624 9846
Bleomycin rep2	FDA approved	Apoptosis	path:04210_5	5	6.011864	0.033185841	CHUK IL1R1 IRAK1 NFKBIA MAP3K14	1147 3554 3654 4792 9020
Bleomycin rep2	FDA approved	Jak-STAT signaling pathway	path:04630_46	10	7.714134	0.002212389	CBLC IFNG IL6ST IL7 IL7R IL22 IL26 CBL SOCS3 OSMR	23624 3458 3572 3574 3575 50616 55801 867 9021 9180
Bleomycin rep2	FDA approved	Adipocytokine signaling pathway	path:04920_3	6	6.237287	0.027654867	CPT1A ACSL4 NPY PRKAG2 STAT3 SOCS3	1374 2182 4852 51422 6774 9021
Bleomycin rep2	FDA approved	Chronic myeloid leukemia	path:05220_9	6	5.816438	0.046460177	CBLC ABL1 PIK3CB SHC1 STAT5A CBL	23624 25 5291 6464 6776 867
Bortezomib	FDA approved	Purine metabolism	path:00230_78	16	8.087865	0.002207506	POLR3G ADCY5 ADCY7 DCK ADCY4 PDE4A PDE9A POLR2B POLR2C POLR2I ADCY10 POLR3D POLR1B PDE8B PDE5A POLR1C	10622 111 113 1633 196883 5141 5152 5431 5432 5438 55811 661 84172 8622 8654 9533
Bortezomib	FDA approved	cAMP signaling pathway	path:04024_19	11	6.848285	0.013245033	ADCY2 ADCY7 ADCY8 CNGB1 CNGA1 ADCY4 GNAS PDE4A ADCY10 CAMK2D CAMK2G	108 113 114 1258 1259 196883 2778 5141 55811 817 818
Bortezomib	FDA approved	Chemokine signaling pathway	path:04062_44	13	6.480842	0.020971302	CCR9 GNAI1 GRK4 CXCL1 CXCL2 CXCL8 PF4 PF4V1 PPBP CCL5 CCL14 CCL17 CXCL11	10803 2770 2868 2919 2920 3576 5196 5197 5473 6352 6358 6361 6373
Bortezomib	FDA approved	HIF-1 signaling pathway	path:04066_13	9	6.083559	0.038631347	EGF ENO1 ANGPT2 HIF1A HK2 HK3 PFKL BCL2 HKDC1	1950 2023 285 3091 3099 3101 5211 596 80201
Bortezomib	FDA approved	Circadian entrainment	path:04713_23	13	5.964074	0.046357616	ADCY1 ADCY2 ADCY5 ADCY7 ADCY4 GNB2 GNG3 GNG4 GNG7 MTNR1A MTNR1B PRKACB ADCY10	107 108 111 113 196883 2783 2785 2786 2788 4543 4544 5567 55811
Bosutinib	FDA approved	Purine metabolism	path:00230_79	7	6.062354	0.031007752	ADCY1 ADK NT5C2 AK3 PDE1C PDE3B RRM1	107 132 22978 50808 5137 5140 6240
Bosutinib	FDA approved	Pyrimidine metabolism	path:00240_59	11	6.477323	0.014396456	POLR3H NME3 POLE POLR2A POLR2I POLR2J POLR2L PRIM2 POLR3E CTPS2 ENTPD1	171568 4832 5426 5430 5438 5439 5441 5558 55718 56474 953
Bosutinib	FDA approved	Inositol phosphate metabolism	path:00562_7	7	5.659702	0.047619048	ITPK1 OCRL INPP5K PIK3CA PIP4K2A PLCB4 PLCZ1	3705 4952 51763 5290 5305 5332 89869
Bosutinib	FDA approved	Drug metabolism - cytochrome P450	path:00982_4	9	5.594215	0.049833887	GSTO2 ADH5 ADH6 GSTM1 GSTM2 GSTM3 GSTM4 GSTM5 GSTO1	119391 128 130 2944 2946 2947 2948 2949 9446
Bosutinib	FDA approved	Ras signaling pathway	path:04014_31	11	5.868044	0.03875969	AKT1 RRAS2 MRAS HRAS NF1 PIK3CA RAF1 RRAS SOS2 PIK3R3 RIN1	207 22800 22808 3265 4763 5290 5894 6237 6655 8503 9610
Bosutinib	FDA approved	Rap1 signaling pathway	path:04015_42	17	6.126766	0.027685493	CRK CRKL CSF1R EFNA1 EGF FGF8 FGF13 FGFR2 FGFR4 PLCB1 FLT4 IGF1 KDR KIT PDGFRB PLCB4 BCAR1	1398 1399 1436 1942 1950 2253 2258 2263 2264 23236 2324 3479 3791 3815 5159 5332 9564
Bosutinib	FDA approved	Phosphatidylinositol signaling system	path:04070_33	15	6.773302	0.008859358	INPP5B MTM1 OCRL INPP5K PIK3C2A PIK3C3 PIK3CA PI4KB PIP4K2A PLCB4 PI4K2B INPP5E PIK3R3 SYNJ2 PLCZ1	3633 4534 4952 51763 5286 5289 5290 5298 5305 5332 55300 56623 8503 8871 89869
Bosutinib	FDA approved	PI3K-Akt signaling pathway	path:04151_46	11	5.733645	0.045404208	CSF1R EFNA1 EGF FGF8 FGF13 FGFR2 FGFR4 FLT4 IGF1 KDR KIT	1436 1942 1950 2253 2258 2263 2264 2324 3479 3791 3815
Bosutinib	FDA approved	Jak-STAT signaling pathway	path:04630_47	9	5.576476	0.049833887	CREBBP IFNAR1 IL4 IL4R IL6ST IL11 JAK2 IL20RB STAT1	1387 3454 3565 3566 3572 3589 3717 53833 6772
Cabozantinib rep1	FDA approved	Purine metabolism	path:00230_80	26	8.715483	0	ADCY8 ADK DCK AK1 AK9 POLR2J2 AK5 AMPD2 GUCY2C ENTPD8 NPR2 NT5E RRM2B PDE9A PDE1B POLR2B POLR2C POLR2G POLR2I POLR2J POLR2K POLR2L POLR3E PDE5A ENTPD5 ENTPD4	114 132 1633 203 221264 246721 26289 271 2984 377841 4882 4907 50484 5152 5153 5431 5432 5436 5438 5439 5440 5441 55718 8654 957 9583
Cabozantinib rep1	FDA approved	Pyrimidine metabolism	path:00240_60	10	5.701134	0.04290429	AK9 POLR2B POLR2C POLR2G POLR2I POLR2J POLR2K POLR2L POLR3E POLR1B	221264 5431 5432 5436 5438 5439 5440 5441 55718 84172
Cabozantinib rep1	FDA approved	Metabolism of xenobiotics by cytochrome P450	path:00980_5	11	5.948881	0.03080308	AKR1C4 GSTO2 CYP1A1 CYP1A2 CYP2D6 CYP2E1 CYP3A4 CYP3A5 AKR1C2 GSTA4 MGST2	1109 119391 1543 1544 1565 1571 1576 1577 1646 2941 4258
Cabozantinib rep1	FDA approved	Ras signaling pathway	path:04014_32	17	5.711066	0.04290429	CSF1 FGF2 FGF5 FGF7 FGF9 FGFR2 FLT1 FGF21 ANGPT1 ANGPT2 INSR KDR MET PDGFRB VEGFA VEGFC FGF23	1435 2247 2250 2252 2254 2263 2321 26291 284 285 3643 3791 4233 5159 7422 7424 8074
Cabozantinib rep1	FDA approved	FoxO signaling pathway	path:04068_47	16	5.95044	0.03080308	BCL2L11 SGK2 CDKN1A GABARAP FBXO32 GADD45A AKT1 FOXO3 PCK1 MAPK13 G6PC2 RAG1 BCL6 SGK1 BNIP3 SOD2	10018 10110 1026 11337 114907 1647 207 2309 5105 5603 57818 5896 604 6446 664 6648
Cabozantinib rep1	FDA approved	Focal adhesion	path:04510_55	9	7.647069	0.00220022	FLNC ITGA5 ITGAV ITGB1 ITGB3 ITGB5 PTK2 VASP CAV1	2318 3678 3685 3688 3690 3693 5747 7408 857
Cabozantinib rep1	FDA approved	Small cell lung cancer	path:05222_6	3	6.524568	0.01210121	ITGAV ITGB1 PTK2	3685 3688 5747
Cabozantinib rep2	FDA approved	Purine metabolism	path:00230_81	8	6.438835	0.0330033	NME6 POLR3C NPR2 PKM POLR2B POLR2G POLR2J POLD4	10201 10623 4882 5315 5431 5436 5439 57804
Cabozantinib rep2	FDA approved	Pyrimidine metabolism	path:00240_61	7	6.774039	0.01870187	POLR3C ENTPD8 POLR2B POLR2C POLR2G POLR2I POLR3GL	10623 377841 5431 5432 5436 5438 84265
Cabozantinib rep2	FDA approved	Lysine degradation	path:00310_3	7	6.064333	0.04180418	EHMT2 KMT2E KMT2C NSD2 COLGALT1 SUV39H2 PLOD3	10919 55904 58508 7468 79709 79723 8985
Cabozantinib rep2	FDA approved	ErbB signaling pathway	path:04012_12	7	6.090414	0.04180418	AKT1 MTOR PIK3CB PIK3CG PIK3R2 BAD RPS6KB2	207 2475 5291 5294 5296 572 6199
Cabozantinib rep2	FDA approved	Ras signaling pathway	path:04014_33	6	7.283028	0.00990099	AKT1 KRAS PIK3CB PIK3CG PIK3R2 BAD	207 3845 5291 5294 5296 572
Cabozantinib rep2	FDA approved	Rap1 signaling pathway	path:04015_43	11	7.536025	0.00770077	AKT1 SIPA1L1 KRAS AFDN PLCE1 PIK3CB PIK3CG PIK3R2 RAP1B BRAF DOCK4	207 26037 3845 4301 51196 5291 5294 5296 5908 673 9732
Cabozantinib rep2	FDA approved	Calcium signaling pathway	path:04020_41	11	6.472858	0.03190319	PHKB PHKG1 PPP3CB PRKCG TNNC1 VDAC3 CACNA1C CALM1 ORAI2 CALM3 P2RX6	5257 5260 5532 5582 7134 7419 775 801 80228 808 9127
Cabozantinib rep2	FDA approved	HIF-1 signaling pathway	path:04066_14	7	6.143073	0.04070407	EGLN2 AKT1 MTOR PIK3CB PIK3CG PIK3R2 PRKCG	112398 207 2475 5291 5294 5296 5582
Cabozantinib rep2	FDA approved	p53 signaling pathway	path:04115_11	13	6.425392	0.03410341	CDKN1A BBC3 IGFBP3 FAS SERPINE1 ATR RPRM PTEN BAX SIAH1 TP53 SESN2 TNFRSF10B	1026 27113 3486 355 5054 545 56475 5728 581 6477 7157 83667 8795
Cabozantinib rep2	FDA approved	PI3K-Akt signaling pathway	path:04151_47	6	7.81288	0.00330033	AKT1 HRAS JAK2 PIK3CB PIK3R2 RAC1	207 3265 3717 5291 5296 5879
Cabozantinib rep2	FDA approved	Adrenergic signaling in cardiomyocytes	path:04261_18	9	6.893562	0.01320132	ATF2 PPP1CA PPP2R1B PPP2R5B PPP2R5C PPP2R5E PRKACA CACNA1C CAMK2D	1386 5499 5519 5526 5527 5529 5566 775 817
Cabozantinib rep2	FDA approved	Platelet activation	path:04611_8	9	6.563225	0.02530253	AKT1 GNAI2 ITGB1 PIK3CB PIK3CG PIK3R2 PLCB3 PLCG2 PRKCZ	207 2771 3688 5291 5294 5296 5331 5336 5590
Cabozantinib rep2	FDA approved	Jak-STAT signaling pathway	path:04630_48	8	7.978374	0.00330033	STAM2 AKT1 IL5RA JAK2 LEP PIK3CB PIK3R2 STAT3	10254 207 3568 3717 3952 5291 5296 6774
Cabozantinib rep2	FDA approved	Fc gamma R-mediated phagocytosis	path:04666_8	5	6.299746	0.03630363	AKT1 LAT PIK3CB PIK3R2 RPS6KB2	207 27040 5291 5296 6199
Cabozantinib rep2	FDA approved	Long-term potentiation	path:04720_2	10	6.027652	0.04290429	ADCY1 GRIN1 KRAS CALML5 PPP3CB RAF1 CACNA1C CALM1 CALM3 CAMK2G	107 2902 3845 51806 5532 5894 775 801 808 818
Cabozantinib rep2	FDA approved	Neurotrophin signaling pathway	path:04722_5	8	6.540136	0.02750275	AKT1 KRAS PIK3CB PIK3CG PIK3R2 BAD RAF1 BRAF	207 3845 5291 5294 5296 572 5894 673
Cabozantinib rep2	FDA approved	Cholinergic synapse	path:04725_27	6	7.191587	0.00990099	CHRM1 CHRM2 GNAO1 GNB2 GNG3 PIK3R2	1128 1129 2775 2783 2785 5296
Cabozantinib rep2	FDA approved	Dopaminergic synapse	path:04728_24	6	6.70971	0.02090209	ATF2 PPP3CB PRKCA CACNA1C CACNA1D CALM3	1386 5532 5578 775 776 808
Cabozantinib rep2	FDA approved	Regulation of actin cytoskeleton	path:04810_25	3	7.129582	0.00990099	PAK1 PPP1CA ROCK1	5058 5499 6093
Cabozantinib rep2	FDA approved	Insulin signaling pathway	path:04910_16	7	7.456391	0.00770077	AKT1 GYS1 PHKB PPP1CA PYGM CALM1 CALM3	207 2997 5257 5499 5837 801 808
Cabozantinib rep2	FDA approved	Estrogen signaling pathway	path:04915_3	8	6.321283	0.03520352	CREB3 ADCY2 ATF2 AKT1 KRAS NOS3 PRKACB RAF1	10488 108 1386 207 3845 4846 5567 5894
Cabozantinib rep2	FDA approved	Glucagon signaling pathway	path:04922_6	6	6.312629	0.03520352	PHKB PHKG1 PRKACA PYGM CALM1 CALM3	5257 5260 5566 5837 801 808
Cabozantinib rep2	FDA approved	Amphetamine addiction	path:05031_1	6	6.051394	0.04180418	ATF2 PPP1CA PPP3CB CALM1 CALM3 CAMK2D	1386 5499 5532 801 808 817
Cabozantinib rep2	FDA approved	Hepatitis B	path:05161_1	8	6.361112	0.03410341	AKT1 PIK3R5 PIK3CA PIK3CB PIK3CG PIK3R2 BAD CASP3	207 23533 5290 5291 5294 5296 572 836
Cabozantinib rep2	FDA approved	Pathways in cancer	path:05200_24	10	6.606423	0.02310231	CDKN1A RASSF1 AKT1 KRAS PDGFRB PIK3CB PIK3CG PIK3R2 PTEN CCND1	1026 11186 207 3845 5159 5291 5294 5296 5728 595
Cabozantinib rep2	FDA approved	Colorectal cancer	path:05210_2	8	6.540136	0.02750275	AKT1 KRAS PIK3CB PIK3CG PIK3R2 BAD RAF1 BRAF	207 3845 5291 5294 5296 572 5894 673
Cabozantinib rep2	FDA approved	Pancreatic cancer	path:05212_7	8	6.55066	0.02530253	AKT1 KRAS PIK3CB PIK3CG PIK3R2 BAD RAF1 BRAF	207 3845 5291 5294 5296 572 5894 673
Cabozantinib rep2	FDA approved	Acute myeloid leukemia	path:05221_2	8	6.629098	0.0220022	AKT1 MTOR KRAS PIK3CB PIK3CG PIK3R2 BAD RPS6KB2	207 2475 3845 5291 5294 5296 572 6199
Cabozantinib rep2	FDA approved	Non-small cell lung cancer	path:05223_2	9	6.696949	0.02090209	AKT1 KRAS PIK3CB PIK3CG PIK3R2 PRKCG BAD RAF1 BRAF	207 3845 5291 5294 5296 5582 572 5894 673
Calusterone	FDA approved	Purine metabolism	path:00230_82	9	6.077966	0.029180696	ADCY5 ADCY6 ADCY7 ZNRD1 NT5E PDE4C PDE9A POLR2J NME5	111 112 113 30834 4907 5143 5152 5439 8382
Calusterone	FDA approved	Rap1 signaling pathway	path:04015_44	17	7.520706	0.002244669	CRK CSF1R EFNA2 EFNA5 EGFR EPHA2 FGFR3 FGFR4 FLT4 MET NGFR ANGPT4 PDGFA PDGFB PLCB3 TEK FGF17	1398 1436 1943 1946 1956 1969 2261 2264 2324 4233 4804 51378 5154 5155 5331 7010 8822
Calusterone	FDA approved	Calcium signaling pathway	path:04020_42	9	6.478993	0.016835017	ITPR2 ATP2B4 P2RX1 P2RX7 PLCE1 PLCB3 ORAI2 ITPKC CACNA1G	3709 493 5023 5027 51196 5331 80228 80271 8913
Calusterone	FDA approved	Chemokine signaling pathway	path:04062_45	7	5.900729	0.037037037	CCL26 GNAI3 GRK6 CXCR2 CXCL16 CX3CL1 CXCR5	10344 2773 2870 3579 58191 6376 643
Calusterone	FDA approved	NF-kappa B signaling pathway	path:04064_4	7	6.087196	0.029180696	TAB2 IL1B IL1R1 IRAK4 RELA TRAF5 MAP3K14	23118 3553 3554 51135 5970 7188 9020
Calusterone	FDA approved	HIF-1 signaling pathway	path:04066_15	10	6.30992	0.019079686	EGF EP300 HK2 HK3 NOS3 ANGPT4 PDK1 BCL2 SLC2A1 TEK	1950 2033 3099 3101 4846 51378 5163 596 6513 7010
Calusterone	FDA approved	FoxO signaling pathway	path:04068_48	13	5.937225	0.034792368	CDKN2D PLK2 GABARAPL2 AKT2 FOXO4 GADD45B PRKAG3 PRKAG1 MAPK9 STAT3 SETD7 CAT S1PR4	1032 10769 11345 208 4303 4616 53632 5571 5601 6774 80854 847 8698
Calusterone	FDA approved	PI3K-Akt signaling pathway	path:04151_48	15	7.365456	0.003367003	CSF1R EFNA2 EFNA5 EGFR EPHA2 FGFR3 FGFR4 FLT4 MET NGFR ANGPT4 PDGFA PDGFB TEK FGF17	1436 1943 1946 1956 1969 2261 2264 2324 4233 4804 51378 5154 5155 7010 8822
Calusterone	FDA approved	Focal adhesion	path:04510_56	6	6.113512	0.028058361	EGFR IGF1 MET PRKCG PTK2 PIK3R3	1956 3479 4233 5582 5747 8503
Calusterone	FDA approved	Cholinergic synapse	path:04725_28	13	6.736696	0.011223345	GNB5 ADCY3 ADCY5 ADCY6 CHRM2 ADCY9 AKT2 GNG3 GNGT1 PIK3CG PIK3R2 PRKACA CACNA1A	10681 109 111 112 1129 115 208 2785 2792 5294 5296 5566 773
Calusterone	FDA approved	Pathways in cancer	path:05200_25	7	6.114596	0.028058361	CRK EGFR ERBB2 AKT2 PIK3CG PTK2 PIK3R3	1398 1956 2064 208 5294 5747 8503
Carboplatin	FDA approved	Purine metabolism	path:00230_83	27	6.06384	0.03200883	ADA NME6 ADCY2 ADCY6 CANT1 ADK AK1 AK9 AMPD2 GUCY1A2 NT5C APRT NME4 PDE3A PDE4D PDE6D PDE6G POLR3K POLE POLR2E POLR2H POLR2K POLR3E POLE4 RRM2 POLR3D ENTPD4	100 10201 108 112 124583 132 203 221264 271 2977 30833 353 4833 5139 5144 5147 5148 51728 5426 5434 5437 5440 55718 56655 6241 661 9583
Carboplatin	FDA approved	PPAR signaling pathway	path:03320_6	10	7.110796	0.006622517	NR1H3 SLC27A4 EHHADH FABP3 ACSL6 ME1 PLTP PPARG RXRA FADS2	10062 10999 1962 2170 23305 4199 5360 5468 6256 9415
Carboplatin	FDA approved	cAMP signaling pathway	path:04024_20	8	5.896047	0.04415011	ADCY6 CNGB1 PDE3A CALML5 ADCY10 PRKX CAMK4 CAMK2A	112 1258 5139 51806 55811 5613 814 815
Carboplatin	FDA approved	Chemokine signaling pathway	path:04062_46	11	7.739875	0.002207506	DOCK2 FGR PIK3R5 GNB1 HCK PIK3CA PIK3CD PLCB3 PRKCZ PTK2 GNB4	1794 2268 23533 2782 3055 5290 5293 5331 5590 5747 59345
Carboplatin	FDA approved	PI3K-Akt signaling pathway	path:04151_49	3	7.35606	0.005518764	ITGA2 ITGB5 PTK2	3673 3693 5747
Carboplatin	FDA approved	Focal adhesion	path:04510_57	5	7.492918	0.004415011	FLNB ITGA2 ITGA5 PTK2 PXN	2317 3673 3678 5747 5829
Carboplatin	FDA approved	Jak-STAT signaling pathway	path:04630_49	17	7.678417	0.002207506	CSF2 CBLC IL2RA IL4 IL4R IL5RA IL10RA IL12RB2 OSM IL21R IL20RA IL22RA1 STAT3 TSLP CBL CBLB SOCS3	1437 23624 3559 3565 3566 3568 3587 3595 5008 50615 53832 58985 6774 85480 867 868 9021
Carboplatin	FDA approved	Dopaminergic synapse	path:04728_25	8	6.124902	0.03200883	DRD1 DRD3 GNAQ GNB1 ITPR3 PLCB3 PRKCB GNB4	1812 1814 2776 2782 3710 5331 5579 59345
Carboplatin	FDA approved	Thyroid hormone signaling pathway	path:04919_12	9	5.86763	0.047461369	PIK3R5 HIF1A ATP1A2 ATP1A4 ATP1B1 ATP1B2 PIK3CA PIK3CD MAPK3	23533 3091 477 480 481 482 5290 5293 5595
Carfilzomib	FDA approved	One carbon pool by folate	path:00670_1	9	5.82823	0.042763158	MTHFS MTHFD2 DHFR MTHFD1L GART MTHFD1 MTHFR MTR SHMT1	10588 10797 1719 25902 2618 4522 4524 4548 6470
Carfilzomib	FDA approved	Chemokine signaling pathway	path:04062_47	9	6.850483	0.005482456	AKT3 GNG11 GNG13 PIK3CG PIK3R1 PLCB4 PRKCZ GNG12 SRC	10000 2791 51764 5294 5295 5332 5590 55970 6714
Carfilzomib	FDA approved	HIF-1 signaling pathway	path:04066_16	10	5.852956	0.042763158	HIF1A LTBR NFKB1 NPPA PFKL PGK1 EGLN1 ELOC VEGFA HKDC1	3091 4055 4790 4878 5211 5230 54583 6921 7422 80201
Carfilzomib	FDA approved	FoxO signaling pathway	path:04068_49	6	6.731677	0.009868421	AKT3 CHUK IKBKB FOXO4 PDPK1 PIK3CB	10000 1147 3551 4303 5170 5291
Carfilzomib	FDA approved	Phosphatidylinositol signaling system	path:04070_34	7	5.926712	0.036184211	DGKH MTM1 OCRL PIK3CG PIK3R1 PLCB4 DGKZ	160851 4534 4952 5294 5295 5332 8525
Carfilzomib	FDA approved	PI3K-Akt signaling pathway	path:04151_50	6	6.576957	0.014254386	AKT3 CHUK PIK3CG PIK3R1 PPP2R5D CREB5	10000 1147 5294 5295 5528 9586
Carfilzomib	FDA approved	Hippo signaling pathway	path:04390_25	6	6.632952	0.012061404	YWHAQ ITGB2 PPP2CA PPP2R1B PPP2R2A YWHAZ	10971 3689 5515 5519 5520 7534
Carfilzomib	FDA approved	Thyroid hormone signaling pathway	path:04919_13	9	7.023597	0.004385965	AKT3 ATP1B4 HIF1A ATP1B1 PFKFB2 PFKP PIK3CG PIK3R1 SRC	10000 23439 3091 481 5208 5214 5294 5295 6714
Carmustine	FDA approved	Pyrimidine metabolism	path:00240_62	8	7.211799	0.004333694	POLR2J2 ZNRD1 NME3 POLR2D POLR2F POLR1E POLR3D POLR3GL	246721 30834 4832 5433 5435 64425 661 84265
Carmustine	FDA approved	Arachidonic acid metabolism	path:00590_6	15	6.785543	0.01191766	PLA2G16 CYP2B6 CYP2C19 CYP2C8 CYP2J2 PLA2G2D GPX2 GPX3 GPX7 CYP4F3 PLA2G2A PLA2G5 PLA2G2F PLA2G6 CYP4F2	11145 1555 1557 1558 1573 26279 2877 2878 2882 4051 5320 5322 64600 8398 8529
Carmustine	FDA approved	Linoleic acid metabolism	path:00591_1	10	5.713848	0.048754063	PLA2G16 CYP2C19 CYP2C8 CYP2J2 CYP3A4 PLA2G2D PLA2G2A PLA2G5 PLA2G2F PLA2G6	11145 1557 1558 1573 1576 26279 5320 5322 64600 8398
Carmustine	FDA approved	PPAR signaling pathway	path:03320_7	10	5.741991	0.045503792	SORBS1 EHHADH FABP3 HMGCS2 ACADM ME1 PPARA PPARG RXRB ACSBG2	10580 1962 2170 3158 34 4199 5465 5468 6257 81616
Carmustine	FDA approved	Chemokine signaling pathway	path:04062_48	6	7.030324	0.004333694	FGR NRAS PIK3CA PRKCZ PTK2 PIK3R3	2268 4893 5290 5590 5747 8503
Carmustine	FDA approved	FoxO signaling pathway	path:04068_50	11	5.661883	0.049837486	CDKN2D GADD45G MAPK14 S1PR1 FOXO4 PRKAA2 PRKAG1 MAPK13 RBL2 CCND1 CCNG2	1032 10912 1432 1901 4303 5563 5571 5603 5934 595 901
Carmustine	FDA approved	Phosphatidylinositol signaling system	path:04070_35	21	6.969456	0.006500542	PIKFYVE INPP4A INPP5B INPP5D ITPKB ITPR3 PLCE1 CALML5 PIK3C2B PIK3CA PIK3CD PIK3CG PLCB4 PLCG1 PI4K2A PIP4K2C CALM1 ITPKC PIP5K1A PIK3R3 DGKZ	200576 3631 3633 3635 3707 3710 51196 51806 5287 5290 5293 5294 5332 5335 55361 79837 801 80271 8394 8503 8525
Carmustine	FDA approved	PI3K-Akt signaling pathway	path:04151_51	3	7.35741	0.003250271	ITGA5 ITGB5 PTK2	3678 3693 5747
Carmustine	FDA approved	Jak-STAT signaling pathway	path:04630_50	11	6.453901	0.021668472	CSF3R IFNLR1 CBLC IL19 IL2RG IL4 IL10RB LIF MPL IL22RA1 CBL	1441 163702 23624 29949 3561 3565 3588 3976 4352 58985 867
Carmustine	FDA approved	Regulation of actin cytoskeleton	path:04810_26	8	6.487633	0.020585049	NRAS PIK3CG PAK6 RRAS VAV1 VAV2 PIK3R3 CDC42	4893 5294 56924 6237 7409 7410 8503 998
Celecoxib	FDA approved	Purine metabolism	path:00230_84	8	6.499522	0.017621145	AMPD1 GUCY2F HPRT1 IMPDH1 NT5E PDE1A PDE4C PDE8A	270 2986 3251 3614 4907 5136 5143 5151
Celecoxib	FDA approved	Pyrimidine metabolism	path:00240_63	4	6.422043	0.018722467	NT5E POLD1 POLD2 DCTPP1	4907 5424 5425 79077
Celecoxib	FDA approved	Rap1 signaling pathway	path:04015_45	13	5.965393	0.035242291	CRK EFNA5 EGFR EPHA2 FGF3 FGF13 FGF21 FGF22 IGF1R INS INSR PLCB4 FGF23	1398 1946 1956 1969 2248 2258 26291 27006 3480 3630 3643 5332 8074
Celecoxib	FDA approved	Calcium signaling pathway	path:04020_43	10	6.788513	0.011013216	SLC25A5 ATP2B3 PLCB4 PRKCB PRKCG SLC8A2 CACNA1A CACNA1F ORAI2 CALM3	292 492 5332 5579 5582 6543 773 778 80228 808
Celecoxib	FDA approved	cAMP signaling pathway	path:04024_21	10	5.944785	0.036343612	GLI3 GRIA3 NFKBIA ATP2B3 PDE4C PRKACA PRKX RYR2 CACNA1F CREB3L3	2737 2892 4792 492 5143 5566 5613 6262 778 84699
Celecoxib	FDA approved	FoxO signaling pathway	path:04068_51	7	6.440152	0.017621145	AKT3 IKBKB IRS1 FOXO4 PIK3CG PIK3R2 PTEN	10000 3551 3667 4303 5294 5296 5728
Celecoxib	FDA approved	Adrenergic signaling in cardiomyocytes	path:04261_19	14	6.445419	0.017621145	CACNG2 ATP1B4 ATP1A2 FXYD2 ATP2B3 PPP2R1A PPP2R5D PPP2R5E PRKACA PRKX RYR2 CACNA1F CACNB3 CREB3L3	10369 23439 477 486 492 5518 5528 5529 5566 5613 6262 778 784 84699
Celecoxib	FDA approved	Jak-STAT signaling pathway	path:04630_51	5	6.933326	0.00660793	EPOR IL2RG IL7 IL13RA1 IL20	2057 3561 3574 3597 50604
Celecoxib	FDA approved	Cholinergic synapse	path:04725_29	9	6.969847	0.00660793	AKT3 ADCY1 CHRM2 GNB2 GNB3 HRAS PIK3CG GNG12 CACNA1A	10000 107 1129 2783 2784 3265 5294 55970 773
Celecoxib	FDA approved	GABAergic synapse	path:04727_15	9	5.99121	0.033039648	ADCY6 GABBR1 GABRB3 GNB2 GNB3 GNG3 GNGT1 CACNA1A CACNA1F	112 2550 2562 2783 2784 2785 2792 773 778
Celecoxib	FDA approved	Dopaminergic synapse	path:04728_26	6	6.211343	0.025330396	GRIA3 PLCB4 PRKACA PRKCG PRKX CREB3L3	2892 5332 5566 5582 5613 84699
Celecoxib	FDA approved	Regulation of actin cytoskeleton	path:04810_27	7	7.625441	0.001101322	PAK4 ARAF KRAS PIK3CG PIK3R2 RRAS VAV1	10298 369 3845 5294 5296 6237 7409
Celecoxib	FDA approved	Glucagon signaling pathway	path:04922_7	10	5.918705	0.039647577	GYS1 PHKA1 PHKA2 PHKB PHKG1 PHKG2 PRKACA PRKX CALM3 CREB3L3	2997 5255 5256 5257 5260 5261 5566 5613 808 84699
Celecoxib	FDA approved	Morphine addiction	path:05032_19	11	6.501969	0.017621145	ADCY1 GABBR1 GNB2 GNB3 GNG3 PRKACA PRKCB PRKCG GNG12 PRKX CACNA1A	107 2550 2783 2784 2785 5566 5579 5582 55970 5613 773
Celecoxib	FDA approved	Pathways in cancer	path:05200_26	9	6.562691	0.014317181	AKT3 CRK EGFR IGF1R KRAS PIK3CG PIK3R2 PTK2 IKBKG	10000 1398 1956 3480 3845 5294 5296 5747 8517
Celecoxib	FDA approved	Pancreatic cancer	path:05212_8	8	6.333287	0.02092511	AKT3 EGFR IKBKB ARAF KRAS PIK3CG PIK3R2 IKBKG	10000 1956 3551 369 3845 5294 5296 8517
Chlorambucil	FDA approved	Purine metabolism	path:00230_85	14	6.933096	0.012263099	AK1 AMPD2 HPRT1 IMPDH2 ENTPD8 NME4 PDE2A PDE1B PKLR POLE POLR2D XDH ENTPD6 ENTPD3	203 271 3251 3615 377841 4833 5138 5153 5313 5426 5433 7498 955 956
Chlorambucil	FDA approved	Sphingolipid metabolism	path:00600_5	9	5.937767	0.045707915	SGPP2 CERS3 ASAH1 ACER3 SMPD4 GBA2 SMPD2 UGT8 CERS5	130367 204219 427 55331 55627 57704 6610 7368 91012
Chlorambucil	FDA approved	Phosphatidylinositol signaling system	path:04070_36	10	7.284258	0.008918618	CDS1 DGKG PIKFYVE PIK3R5 INPP4A ITPR1 PLCG1 PIP4K2C ITPKC PIP5K1A	1040 1608 200576 23533 3631 3708 5335 79837 80271 8394
Chlorambucil	FDA approved	p53 signaling pathway	path:04115_12	6	6.397674	0.024526198	SFN SERPINB5 PERP TP53 PPM1D CCNG2	2810 5268 64065 7157 8493 901
Chlorambucil	FDA approved	Endocytosis	path:04144_11	10	5.854128	0.04793757	ERBB3 FGFR3 CBLC MET EPN3 SH3GLB2 SH3GL1 SMURF2 ITCH CBL	2065 2261 23624 4233 55040 56904 6455 64750 83737 867
Chlorambucil	FDA approved	AMPK signaling pathway	path:04152_21	4	5.852821	0.04793757	PPARG PRKAB1 RPS6KB1 ULK1	5468 5564 6198 8408
Chlorambucil	FDA approved	Focal adhesion	path:04510_58	6	9.405102	0	FLNB ITGA2 ITGA5 PXN VASP CAV2	2317 3673 3678 5829 7408 858
Chlorambucil	FDA approved	Jak-STAT signaling pathway	path:04630_52	20	7.226402	0.010033445	IFNLR1 PIK3R5 CBLC IL19 IFNAR2 IFNGR1 IL4 IL6R IL9 IL10RB JAK2 JAK3 LEP MPL OSM IL20RA PRLR IL22RA1 IL21 CBL	163702 23533 23624 29949 3455 3459 3565 3570 3578 3588 3717 3718 3952 4352 5008 53832 5618 58985 59067 867
Chlorambucil	FDA approved	Pathways in cancer	path:05200_27	3	8.007472	0	PIK3R5 ITGA2 PTK2	23533 3673 5747
Chlorambucil	FDA approved	Pancreatic cancer	path:05212_9	5	5.947416	0.043478261	AKT3 CHUK ERBB2 PIK3R5 BCL2L1	10000 1147 2064 23533 598
Cisplatin	FDA approved	Inositol phosphate metabolism	path:00562_8	9	6.332752	0.021978022	PIP5KL1 INPP5J INPP4A PIK3C2A PIK3CG PLCB3 PLCG1 ITPKC PIP5K1A	138429 27124 3631 5286 5294 5331 5335 80271 8394
Cisplatin	FDA approved	Glycerophospholipid metabolism	path:00564_14	8	5.846467	0.037362637	CDS1 AGPAT2 MBOAT2 DGKQ ADPRM GPAM DGKZ CDS2	1040 10555 129642 1609 56985 57678 8525 8760
Cisplatin	FDA approved	Sphingolipid metabolism	path:00600_6	7	5.87704	0.037362637	CERS1 ACER1 SGPP2 ARSA CERK SMPD2 UGT8	10715 125981 130367 410 64781 6610 7368
Cisplatin	FDA approved	PPAR signaling pathway	path:03320_8	9	7.472536	0.004395604	NR1H3 SLC27A4 EHHADH ME1 OLR1 PLTP PPARA PPARG FADS2	10062 10999 1962 4199 4973 5360 5465 5468 9415
Cisplatin	FDA approved	Phosphatidylinositol signaling system	path:04070_37	6	6.324438	0.021978022	PIKFYVE INPP4A PLCG1 IMPAD1 PI4K2B PIK3R3	200576 3631 5335 54928 55300 8503
Cisplatin	FDA approved	p53 signaling pathway	path:04115_13	10	6.952486	0.00989011	DDB2 SFN GTSE1 SERPINB5 ATR PERP ZMAT3 TP53 CCNB1 CCNG2	1643 2810 51512 5268 545 64065 64393 7157 891 901
Cisplatin	FDA approved	Endocytosis	path:04144_12	8	6.503107	0.01978022	WWP1 ERBB3 FGFR3 FGFR4 CBLC EPN3 SH3GLB2 CBL	11059 2065 2261 2264 23624 55040 56904 867
Cisplatin	FDA approved	PI3K-Akt signaling pathway	path:04151_52	3	9.179988	0.001098901	ITGA2 ITGA5 PTK2	3673 3678 5747
Cisplatin	FDA approved	Axon guidance	path:04360_4	5	6.055855	0.030769231	EFNA1 EFNA4 EPHA2 RAC2 RASA1	1942 1945 1969 5880 5921
Cisplatin	FDA approved	Focal adhesion	path:04510_59	3	9.868861	0	FLNB ITGA2 ITGA5	2317 3673 3678
Cisplatin	FDA approved	Jak-STAT signaling pathway	path:04630_53	15	7.277302	0.005494505	IFNLR1 CBLC IL19 IFNAR2 IL4 IL6R IL6ST IL12RB2 IL15RA JAK3 OSM IL20RA IL22RA1 IL21 CBL	163702 23624 29949 3455 3565 3570 3572 3595 3601 3718 5008 53832 58985 59067 867
Cisplatin	FDA approved	Retrograde endocannabinoid signaling	path:04723_22	6	5.730501	0.045054945	GNAI2 GNG3 MAPK11 MAPK13 GNB4 MAPK12	2771 2785 5600 5603 59345 6300
Cisplatin	FDA approved	Pathways in cancer	path:05200_28	7	6.131854	0.02967033	CRK EGFR ERBB2 PIK3R5 CBLC PIK3CG PTK2	1398 1956 2064 23533 23624 5294 5747
Cisplatin	FDA approved	Pancreatic cancer	path:05212_10	6	5.917054	0.034065934	AKT3 ERBB2 PIK3R5 PIK3CG RAC2 BCL2L1	10000 2064 23533 5294 5880 598
Cladribine	FDA approved	Purine metabolism	path:00230_86	9	6.142611	0.026431718	POLD3 GUCY2C NME4 POLD1 POLE POLR2C POLR2G PRIM1 NTPCR	10714 2984 4833 5424 5426 5432 5436 5557 84284
Cladribine	FDA approved	PI3K-Akt signaling pathway	path:04151_53	14	6.050863	0.035242291	CSF1 EGF FGF6 FGF7 FGF8 FGF11 FLT1 FLT4 KITLG ANGPT4 VEGFA VEGFB FGF23 FGF18	1435 1950 2251 2252 2253 2256 2321 2324 4254 51378 7422 7423 8074 8817
Cladribine	FDA approved	Jak-STAT signaling pathway	path:04630_54	14	6.930832	0.00660793	CSF2RB CBLC IFNAR1 IFNAR2 IFNGR2 IL7R JAK3 LEPR MPL IL22 PRLR IL21 CBL CBLB	1439 23624 3454 3455 3460 3575 3718 3953 4352 50616 5618 59067 867 868
Cladribine	FDA approved	Glutamatergic synapse	path:04724_20	7	6.074665	0.030837004	GRIA1 GRIK4 GRIK5 GRIN2A GRIN2B GRIN2D GRM7	2890 2900 2901 2903 2904 2906 2917
Clofarabine rep1	FDA approved	Purine metabolism	path:00230_87	17	7.184909	0.005506608	ADCY2 ADSS NT5C2 AMPD1 GUCY2F NME7 NME4 PDE6C PDE6B PKLR POLR2A POLR2C PRIM1 ADCY10 PDE5A ENTPD1 ENTPD6	108 159 22978 270 2986 29922 4833 5146 5158 5313 5430 5432 5557 55811 8654 953 955
Clofarabine rep1	FDA approved	Rap1 signaling pathway	path:04015_46	15	6.782351	0.009911894	EGF FGF2 FGF6 FGF7 FGF8 FGF11 FGF14 FLT1 FLT4 KDR ANGPT4 PLCB2 VEGFB FGF23 FGF18	1950 2247 2251 2252 2253 2256 2259 2321 2324 3791 51378 5330 7423 8074 8817
Clofarabine rep1	FDA approved	FoxO signaling pathway	path:04068_52	25	5.927803	0.04185022	AKT3 BCL2L11 CDK2 PLK4 GADD45G GABARAP FBXO32 PLK3 S1PR1 FOXO1 SGK3 FASLG IL7R PCK1 PLK1 MAPK8 MAPK10 G6PC2 RAG1 RAG2 RBL2 SOD2 SETD7 CCNB3 CCNG2	10000 10018 1017 10733 10912 11337 114907 1263 1901 2308 23678 356 3575 5105 5347 5599 5602 57818 5896 5897 5934 6648 80854 85417 901
Clofarabine rep1	FDA approved	PI3K-Akt signaling pathway	path:04151_54	6	6.296452	0.023127753	AKT3 PIK3R5 GNB3 PIK3CA LPAR5 PIK3R3	10000 23533 2784 5290 57121 8503
Clofarabine rep1	FDA approved	Jak-STAT signaling pathway	path:04630_55	13	6.183749	0.028634361	IFNAR1 IFNAR2 IL2 IL7 IL7R IL11RA JAK2 LEPR IL20RA IL20RB PRLR IL21 CBLB	3454 3455 3558 3574 3575 3590 3717 3953 53832 53833 5618 59067 868
Clofarabine rep1	FDA approved	Glutamatergic synapse	path:04724_21	10	8.292651	0	GNB3 GRIA1 GRIK1 GRIN2A GRM1 GRM2 GRM4 GRM6 GRM7 GRM8	2784 2890 2897 2903 2911 2912 2914 2916 2917 2918
Clofarabine rep2	FDA approved	Drug metabolism - cytochrome P450	path:00982_5	4	5.835048	0.036383682	ADH5 ADH6 GSTA4 GSTM3	128 130 2941 2947
Clofarabine rep2	FDA approved	Ras signaling pathway	path:04014_34	13	6.124831	0.025358324	EGF FGF2 FGF6 FGF8 FGF11 FGF13 FLT1 KDR KIT PDGFRA PGF VEGFC FGF23	1950 2247 2251 2253 2256 2258 2321 3791 3815 5156 5228 7424 8074
Clofarabine rep2	FDA approved	FoxO signaling pathway	path:04068_53	17	6.693902	0.007717751	AKT3 PLK4 GADD45G GABARAP CHUK AKT1 FOXO3 IL7R NLK PLK1 MAPK10 RAG2 RBL2 SETD7 CAT CCND2 CCNG2	10000 10733 10912 11337 1147 207 2309 3575 51701 5347 5602 5897 5934 80854 847 894 901
Clofarabine rep2	FDA approved	Cell cycle	path:04110_7	7	5.610168	0.046306505	ANAPC10 ANAPC4 MAD2L1 ANAPC1 BUB1B CDC14A CCNB1	10393 29945 4085 64682 701 8556 891
Clofarabine rep2	FDA approved	Jak-STAT signaling pathway	path:04630_56	9	5.9526	0.033076075	IFNAR1 IFNAR2 IL7R IL10RB JAK3 LEPR LIFR OSM IL21	3454 3455 3575 3588 3718 3953 3977 5008 59067
Clofarabine rep2	FDA approved	Glutamatergic synapse	path:04724_22	9	6.946745	0.006615215	GRIN3A GRIK1 GRIN2A GRIN2B GRIN2C GRIN2D GRM1 GRM2 PPP3CA	116443 2897 2903 2904 2905 2906 2911 2912 5530
Clofarabine rep2	FDA approved	Thyroid hormone signaling pathway	path:04919_14	5	5.816625	0.037486218	AKT3 AKT1 THRB CASP9 PIK3R3	10000 207 7068 842 8503
Clofarabine rep2	FDA approved	Pathways in cancer	path:05200_29	9	5.814428	0.037486218	AKT3 AKT1 FLT3 GRB2 KIT KRAS PDGFRA CASP9 PIK3R3	10000 207 2322 2885 3815 3845 5156 842 8503
Clofarabine rep2	FDA approved	Melanoma	path:05218_3	8	5.841833	0.036383682	EGF FGF2 FGF6 FGF8 FGF11 FGF13 PDGFRA FGF23	1950 2247 2251 2253 2256 2258 5156 8074
Cobimetinib (isomer 1)	-	Purine metabolism	path:00230_88	9	7.238528	0.003340757	ADCY3 AK8 GUCY1A2 HDDC3 PDE8A PKM POLR2F PNPT1 ENTPD6	109 158067 2977 374659 5151 5315 5435 87178 955
Cobimetinib (isomer 1)	-	Glutathione metabolism	path:00480_6	10	6.463154	0.0155902	GGT1 ANPEP GSR GSS GSTM4 GSTP1 IDH1 GSTK1 MGST2 GGCT	2678 290 2936 2937 2948 2950 3417 373156 4258 79017
Cobimetinib (isomer 1)	-	PPAR signaling pathway	path:03320_9	11	5.900094	0.040089087	NR1H3 CYP27A1 ACSL1 ACSL3 AQP7 LPL OLR1 PPARG RXRB SCD SCD5	10062 1593 2180 2181 364 4023 4973 5468 6257 6319 79966
Cobimetinib (isomer 1)	-	FoxO signaling pathway	path:04068_54	14	6.50521	0.0155902	PLK4 GABARAP FBXO32 PLK3 S1PR1 AKT1 FOXO3 SGK3 GADD45B ATM PRKAG3 MAPK10 G6PC2 SGK1	10733 11337 114907 1263 1901 207 2309 23678 4616 472 53632 5602 57818 6446
Cobimetinib (isomer 1)	-	Focal adhesion	path:04510_60	3	6.043775	0.030066815	FLNC ITGB3 THBS1	2318 3690 7057
Crizotinib	FDA approved	Inositol phosphate metabolism	path:00562_9	8	6.479017	0.019101124	INPP5A PLCE1 PIK3CG PLCB2 PLCB4 PIP5K1A PIP4K2B PLCZ1	3632 51196 5294 5330 5332 8394 8396 89869
Crizotinib	FDA approved	Rap1 signaling pathway	path:04015_47	15	6.965795	0.007865169	CRK EGFR EPHA2 FGF1 FGF2 FGF6 FGF12 FGFR1 FGFR2 INS NGF PDGFB PLCB4 PDGFC PDGFD	1398 1956 1969 2246 2247 2251 2257 2260 2263 3630 4803 5155 5332 56034 80310
Crizotinib	FDA approved	FoxO signaling pathway	path:04068_55	13	7.184917	0.005617978	CDKN1B PLK2 GADD45A S1PR1 FOXO3 GABARAPL1 FOXO4 GADD45B PRKAG2 PRKAA2 PRKAB2 CCND1 STAT3	1027 10769 1647 1901 2309 23710 4303 4616 51422 5563 5565 595 6774
Crizotinib	FDA approved	Phosphatidylinositol signaling system	path:04070_38	13	7.729317	0	PIKFYVE INPP5A INPP5D INPPL1 MTM1 PLCE1 PIK3CG PI4KA PLCB4 PIP5K1A PIP4K2B DGKZ PLCZ1	200576 3632 3635 3636 4534 51196 5294 5297 5332 8394 8396 8525 89869
Crizotinib	FDA approved	PI3K-Akt signaling pathway	path:04151_55	4	7.593071	0.002247191	ITGAV ITGB1 PTK2 THBS1	3685 3688 5747 7057
Crizotinib	FDA approved	Dopaminergic synapse	path:04728_27	7	5.864349	0.046067416	GNB3 GNG11 GNGT1 PLCB2 PLCB4 PRKCB GNG12	2784 2791 2792 5330 5332 5579 55970
Crizotinib	FDA approved	Prostate cancer	path:05215_5	9	6.010722	0.03258427	EGFR ERBB2 FGFR2 GRB2 INS PDGFB PIK3CG PDGFC PDGFD	1956 2064 2263 2885 3630 5155 5294 56034 80310
Crizotinib	FDA approved	Small cell lung cancer	path:05222_7	3	6.150283	0.029213483	ITGAV ITGB1 PTK2	3685 3688 5747
Cyclophosphamide	FDA approved	Purine metabolism	path:00230_89	31	9.047422	0	ADCY1 ADCY2 ADCY3 ADCY5 ADCY6 ADCY9 ADSSL1 ADSL AK8 AK2 POLR2J2 AK5 GUK1 GUCY2D HPRT1 NME4 NPR2 PDE1A PDE2A PDE3B PDE4B PDE4D PDE9A PDE6B PKLR POLR2G POLR2I POLR2J ADCY10 POLR3GL NTPCR	107 108 109 111 112 115 122622 158 158067 204 246721 26289 2987 3000 3251 4833 4882 5136 5138 5140 5142 5144 5152 5158 5313 5436 5438 5439 55811 84265 84284
Cyclophosphamide	FDA approved	Pyrimidine metabolism	path:00240_64	9	5.787412	0.025698324	CTPS1 NME4 CMPK1 POLR2F POLR2G POLR2I POLR2J PRIM1 POLR3GL	1503 4833 51727 5435 5436 5438 5439 5557 84265
Cyclophosphamide	FDA approved	Ras signaling pathway	path:04014_35	6	5.408111	0.043575419	AKT3 MRAS PAK1 PIK3CG PIK3R1 RAC2	10000 22808 5058 5294 5295 5880
Cyclophosphamide	FDA approved	Chemokine signaling pathway	path:04062_49	8	5.440566	0.043575419	CCL26 CCR1 CCR6 GRK2 GNAI2 GRK5 CXCR2 CCL25	10344 1230 1235 156 2771 2869 3579 6370
Cyclophosphamide	FDA approved	Phosphatidylinositol signaling system	path:04070_39	16	6.051159	0.018994413	DGKG DGKQ PLCB1 INPP5B ITPR2 MTM1 PLCE1 PIK3C2B PIK3CG PIK3R1 PI4KA PLCB3 PLCD1 PIP5K1B PIK3R3 DGKI	1608 1609 23236 3633 3709 4534 51196 5287 5294 5295 5297 5331 5333 8395 8503 9162
Cyclophosphamide	FDA approved	Adrenergic signaling in cardiomyocytes	path:04261_20	8	5.518015	0.039106145	CACNG2 PPP2R2C PPP2R5B CACNA2D3 PRKX CACNA1C CACNA1S CACNA2D2	10369 5522 5526 55799 5613 775 779 9254
Cyclophosphamide	FDA approved	Focal adhesion	path:04510_61	5	6.647269	0.004469274	FLNB ITGB3 PRKCA PTK2 THBS1	2317 3690 5578 5747 7057
Cyclophosphamide	FDA approved	Tight junction	path:04530_6	4	5.649622	0.033519553	MAGI3 PRKCE ACTB MAGI2	260425 5581 60 9863
Cyclophosphamide	FDA approved	Signaling pathways regulating pluripotency of stem cells	path:04550_2	9	5.378471	0.044692737	AKT3 FGFR1 FGFR3 FGFR2 IGF1R LIFR PIK3CG PIK3R1 PIK3R3	10000 2260 2261 2263 3480 3977 5294 5295 8503
Cyclophosphamide	FDA approved	Jak-STAT signaling pathway	path:04630_57	13	6.008408	0.020111732	IL24 CNTFR CSF3R IFNGR2 IL10RA IL11RA JAK2 LEPR LIFR IL21R IL22 CBLB OSMR	11009 1271 1441 3460 3587 3590 3717 3953 3977 50615 50616 868 9180
Cyclophosphamide	FDA approved	Circadian entrainment	path:04713_24	7	5.625441	0.03575419	GNB5 GNAQ MTNR1B PLCB2 PLCB3 PRKCA PRKCG	10681 2776 4544 5330 5331 5578 5582
Cyclophosphamide	FDA approved	Glutamatergic synapse	path:04724_23	10	5.486635	0.042458101	GNB5 ADCY1 ADCY2 ADCY3 ADCY6 ADCY7 GNAI2 GNAO1 GRM4 PRKACA	10681 107 108 109 112 113 2771 2775 2914 5566
Cyclophosphamide	FDA approved	Cholinergic synapse	path:04725_30	12	6.138588	0.018994413	AKT3 GNB5 ADCY1 ADCY2 ADCY3 ADCY9 FYN GNAO1 JAK2 PIK3CG PIK3R1 CACNA1A	10000 10681 107 108 109 115 2534 2775 3717 5294 5295 773
Cyclophosphamide	FDA approved	Serotonergic synapse	path:04726_20	7	6.084655	0.018994413	GNB5 GNAO1 GNAQ HTR5A ITPR2 GNG13 PLCB3	10681 2775 2776 3361 3709 51764 5331
Cyclophosphamide	FDA approved	Dopaminergic synapse	path:04728_28	9	5.599057	0.03575419	GNB5 DRD2 GNAI2 GNAO1 GNG13 PLCB3 PPP2R2B PPP2R5B CACNA1A	10681 1813 2771 2775 51764 5331 5521 5526 773
Cyclophosphamide	FDA approved	Thyroid hormone signaling pathway	path:04919_15	7	5.312499	0.049162011	AKT3 HIF1A ATP1A1 FXYD2 PIK3CG PIK3R1 THRB	10000 3091 476 486 5294 5295 7068
Cyclophosphamide	FDA approved	Pathways in cancer	path:05200_30	9	5.881409	0.023463687	CRKL CBLC IGF1R PDGFRA PIK3CG PIK3R1 PTK2 PIK3R3 CBLB	1399 23624 3480 5156 5294 5295 5747 8503 868
Cyclophosphamide	FDA approved	Prostate cancer	path:05215_6	10	5.403714	0.043575419	AKT3 FGFR1 FGFR2 IGF1R INS PDGFA PDGFRA PIK3CG PIK3R1 PIK3R3	10000 2260 2263 3480 3630 5154 5156 5294 5295 8503
Cytarabine rep1	FDA approved	Purine metabolism	path:00230_90	10	7.468817	0	ADCY1 POLR3A NT5C3B NME1 PDE1C PDE6C POLR2A POLR2D POLR3B POLR1B	107 11128 115024 4830 5137 5146 5430 5433 55703 84172
Cytarabine rep1	FDA approved	Pyrimidine metabolism	path:00240_65	16	7.28468	0.002185792	POLR3F POLD3 POLR3A ENTPD8 NME4 POLE3 POLE POLR2A POLR2C POLR2D PRIM1 POLR3B POLD4 RRM1 POLR1B PNPT1	10621 10714 11128 377841 4833 54107 5426 5430 5432 5433 5557 55703 57804 6240 84172 87178
Cytarabine rep1	FDA approved	FoxO signaling pathway	path:04068_56	18	6.314418	0.018579235	BCL2L11 CDKN2B PLK4 PLK2 GABARAP CHUK FBXO32 GADD45A FOXO1 FOXO3 PCK1 NLK PRKAG3 PRKAB1 RBL2 BCL6 CCNB3 CCNG2	10018 1030 10733 10769 11337 1147 114907 1647 2308 2309 5105 51701 53632 5564 5934 604 85417 901
Cytarabine rep2	FDA approved	Pyrimidine metabolism	path:00240_66	8	7.368587	0.010976948	CTPS1 NME1 POLD2 POLE POLR2B PRIM1 PNPT1 ENTPD1	1503 4830 5425 5426 5431 5557 87178 953
Cytarabine rep2	FDA approved	Focal adhesion	path:04510_62	5	6.65054	0.021953897	ITGA2B ITGA5 ITGB3 PRKCB TLN2	3674 3678 3690 5579 83660
Dabrafenib	FDA approved	Purine metabolism	path:00230_91	11	6.457495	0.017837235	POLR3F ADCY1 ADCY2 ADSL ADSS IMPDH1 ITPA ATIC PDE4B PDE6A PDE6B	10621 107 108 158 159 3614 3704 471 5142 5145 5158
Dabrafenib	FDA approved	Focal adhesion	path:04510_63	3	7.792332	0.002229654	FLNB FLNC THBS1	2317 2318 7057
Dacarbazine rep1	FDA approved	Purine metabolism	path:00230_92	33	6.82191	0.005458515	POLR3F POLD3 AK7 AK8 DGUOK ADCY4 AK2 AK5 AMPD1 AMPD2 GUCY2C GUCY2F GUK1 GUCY2D ITPA ENTPD8 RRM2B POLR1D PDE2A PDE4A PDE4C PDE6G PDE8A PKM POLD2 POLR2G PRIM1 POLD4 POLR1E POLR3GL NTPCR PNPT1 POLR1C	10621 10714 122481 158067 1716 196883 204 26289 270 271 2984 2986 2987 3000 3704 377841 50484 51082 5138 5141 5143 5148 5151 5315 5425 5436 5557 57804 64425 84265 84284 87178 9533
Dacarbazine rep1	FDA approved	Pyrimidine metabolism	path:00240_67	6	5.593229	0.045851528	POLR3F ENTPD8 POLR2A POLR2G POLR1E POLR3GL	10621 377841 5430 5436 64425 84265
Dacarbazine rep1	FDA approved	Rap1 signaling pathway	path:04015_48	6	5.79014	0.031659389	RASGRP2 FLT1 GNAQ PLCB4 LPAR5 LPAR2	10235 2321 2776 5332 57121 9170
Dacarbazine rep1	FDA approved	HIF-1 signaling pathway	path:04066_17	18	5.609391	0.043668122	ENO1 ENO2 ENO3 EP300 ALDOA FLT1 GAPDH ANGPT1 HMOX1 LTBR NOS2 NPPA BCL2 SLC2A1 TF HKDC1 CAMK2A CAMK2G	2023 2026 2027 2033 226 2321 2597 284 3162 4055 4843 4878 596 6513 7018 80201 815 818
Dacarbazine rep1	FDA approved	FoxO signaling pathway	path:04068_57	23	6.688705	0.008733624	BCL2L11 CDKN1B CDKN2D PLK4 GADD45G GABARAP GABARAPL2 MAPK14 GADD45A S1PR1 FOXO3 SGK3 PCK1 PCK2 PRKAA1 PRKAG1 MAPK3 MAPK13 MAP2K1 RBL2 STK4 CCND2 CCNB2	10018 1027 1032 10733 10912 11337 11345 1432 1647 1901 2309 23678 5105 5106 5562 5571 5595 5603 5604 5934 6789 894 9133
Dacarbazine rep1	FDA approved	p53 signaling pathway	path:04115_14	13	5.853797	0.029475983	GADD45G SESN3 DDB2 GADD45A SESN1 MDM2 RRM2B TP53 TP73 PPM1D TNFRSF10B CCNB2 EI24	10912 143686 1643 1647 27244 4193 50484 7157 7161 8493 8795 9133 9538
Dacarbazine rep2	FDA approved	Purine metabolism	path:00230_93	10	5.726031	0.045454545	CANT1 AK2 GUK1 NME3 AK3 PDE8A RRM2 PDE8B GMPS ENTPD6	124583 204 2987 4832 50808 5151 6241 8622 8833 955
Dacarbazine rep2	FDA approved	Inositol phosphate metabolism	path:00562_10	6	6.270269	0.023281596	INPP5J INPP5B PLCE1 PIP4K2A PLCB2 PIP4K2C	27124 3633 51196 5305 5330 79837
Dacarbazine rep2	FDA approved	MAPK signaling pathway	path:04010_20	5	5.974025	0.036585366	MAPK14 DUSP7 MAX MAPK13 MAPKAPK3	1432 1849 4149 5603 7867
Dacarbazine rep2	FDA approved	Ras signaling pathway	path:04014_36	17	5.929852	0.038802661	EFNA1 EFNA2 EFNA4 EPHA2 FGFR3 FGFR2 FGFR4 FLT4 FGF21 IGF1R MET PDGFA PDGFRA PDGFRB SHC3 FGF17 FGF19	1942 1943 1945 1969 2261 2263 2264 2324 26291 3480 4233 5154 5156 5159 53358 8822 9965
Dacarbazine rep2	FDA approved	Rap1 signaling pathway	path:04015_49	17	6.548268	0.013303769	CRK EFNA1 EFNA2 EFNA4 EPHA2 FGFR3 FGFR2 FGFR4 FLT4 FGF21 IGF1R MET PDGFA PDGFRB PLCB2 FGF17 FGF19	1398 1942 1943 1945 1969 2261 2263 2264 2324 26291 3480 4233 5154 5159 5330 8822 9965
Dacarbazine rep2	FDA approved	Calcium signaling pathway	path:04020_44	9	6.014276	0.034368071	ITPR2 ATP2B4 P2RX1 CALML5 TNNC1 CACNA1D ITPKC CALML3 CACNA1G	3709 493 5023 51806 7134 776 80271 810 8913
Dacarbazine rep2	FDA approved	Chemokine signaling pathway	path:04062_50	10	6.491008	0.013303769	CCL26 ADCY5 CCR7 FGR GNAI2 GNAI3 CXCR1 CXCR2 PTK2 GNB4	10344 111 1236 2268 2771 2773 3577 3579 5747 59345
Dacarbazine rep2	FDA approved	Sphingolipid signaling pathway	path:04071_15	9	5.650021	0.04767184	S1PR1 GNA12 GNAI2 GNAI3 RHOA PLCB2 S1PR5 ROCK1 BDKRB2	1901 2768 2771 2773 387 5330 53637 6093 624
Dacarbazine rep2	FDA approved	p53 signaling pathway	path:04115_15	10	6.153283	0.027716186	CDKN1A GADD45A SFN PMAIP1 RRM2 TP53 TP73 CCNB3 CCNG2 TP53I3	1026 1647 2810 5366 6241 7157 7161 85417 901 9540
Dacarbazine rep2	FDA approved	PI3K-Akt signaling pathway	path:04151_56	3	7.104944	0.001108647	ITGA2B ITGA5 PTK2	3674 3678 5747
Dacarbazine rep2	FDA approved	Jak-STAT signaling pathway	path:04630_58	12	6.265989	0.023281596	CSF3R IFNLR1 CBLC IFNAR1 IFNAR2 IL2RG IL6R IL10 IL10RB IL21R TSLP SOCS1	1441 163702 23624 3454 3455 3561 3570 3586 3588 50615 85480 8651
Dacarbazine rep2	FDA approved	Fc gamma R-mediated phagocytosis	path:04666_9	8	5.768553	0.043237251	CRK DOCK2 PLD2 RAC2 VAV1 WAS PIP5K1A CDC42	1398 1794 5338 5880 7409 7454 8394 998
Dacarbazine rep2	FDA approved	Retrograde endocannabinoid signaling	path:04723_23	9	5.789792	0.043237251	GNB5 ADCY5 ADCY6 MAPK14 GNAI2 GNAI3 GNGT2 MAPK13 GNB4	10681 111 112 1432 2771 2773 2793 5603 59345
Dacarbazine rep2	FDA approved	GABAergic synapse	path:04727_16	8	5.63594	0.04767184	GNB5 ADCY5 ADCY6 GNAI2 GNAI3 GNGT2 GNB4 CACNA1D	10681 111 112 2771 2773 2793 59345 776
Dacarbazine rep2	FDA approved	Dopaminergic synapse	path:04728_29	8	6.140299	0.028824834	GNB5 ADCY5 GNAI2 GNAI3 ITPR1 ITPR2 PLCB2 GNB4	10681 111 2771 2773 3708 3709 5330 59345
Dacarbazine rep2	FDA approved	Regulation of actin cytoskeleton	path:04810_28	5	7.210974	0.001108647	CRK ITGA2 ITGA2B ITGA5 ITGB2	1398 3673 3674 3678 3689
Dasatinib rep1	FDA approved	Citrate cycle (TCA cycle)	path:00020_2	6	6.161602	0.034482759	FH IDH3A MDH1 ACLY ACO1 ACO2	2271 3419 4190 47 48 50
Dasatinib rep1	FDA approved	Purine metabolism	path:00230_94	6	7.269278	0.006674082	ADSL ADSS AMPD3 ENTPD8 NT5E PDE4C	158 159 272 377841 4907 5143
Dasatinib rep1	FDA approved	Pyrimidine metabolism	path:00240_68	15	7.990597	0.001112347	POLR3H NME7 NME1 NME4 NT5E POLE3 POLA1 POLR2A POLR2E POLR2F POLR3E POLD4 DCTPP1 POLR1B ENTPD3	171568 29922 4830 4833 4907 54107 5422 5430 5434 5435 55718 57804 79077 84172 956
Dasatinib rep1	FDA approved	Sphingolipid metabolism	path:00600_7	10	6.08347	0.036707453	CERS1 ACER1 ASAH1 GBA2 CERK SMPD2 UGCG UGT8 DEGS1 SPHK1	10715 125981 427 57704 64781 6610 7357 7368 8560 8877
Dasatinib rep1	FDA approved	Ras signaling pathway	path:04014_37	13	6.655161	0.020022247	CSF1 EFNA5 EGFR EPHA2 FGF2 FGFR1 FGFR3 INSR MET PDGFA PDGFB PDGFC VEGFC	1435 1946 1956 1969 2247 2260 2261 3643 4233 5154 5155 56034 7424
Dasatinib rep1	FDA approved	Rap1 signaling pathway	path:04015_50	13	6.655161	0.020022247	CSF1 EFNA5 EGFR EPHA2 FGF2 FGFR1 FGFR3 INSR MET PDGFA PDGFB PDGFC VEGFC	1435 1946 1956 1969 2247 2260 2261 3643 4233 5154 5155 56034 7424
Dasatinib rep1	FDA approved	p53 signaling pathway	path:04115_16	12	7.919513	0.001112347	CHEK2 GADD45A BBC3 FAS GADD45B ATM SERPINE1 GTSE1 STEAP3 THBS1 TP53 TNFRSF10B	11200 1647 27113 355 4616 472 5054 51512 55240 7057 7157 8795
Dasatinib rep1	FDA approved	PI3K-Akt signaling pathway	path:04151_57	5	7.892708	0.001112347	ITGA5 ITGB1 ITGB3 PTK2 THBS1	3678 3688 3690 5747 7057
Dasatinib rep1	FDA approved	Focal adhesion	path:04510_64	10	10.017286	0	FLNB FLNC ITGA5 ITGAV ITGB1 ITGB3 PTK2 THBS1 VASP CAV3	2317 2318 3678 3685 3688 3690 5747 7057 7408 859
Dasatinib rep1	FDA approved	ECM-receptor interaction	path:04512_13	3	7.341087	0.005561735	ITGAV ITGB1 THBS1	3685 3688 7057
Dasatinib rep1	FDA approved	Jak-STAT signaling pathway	path:04630_59	12	5.983612	0.043381535	CSF2 CSF3 EPOR IL2 IL4R IL5RA IL7R IL10RB IL15 LIF SOCS3 OSMR	1437 1440 2057 3558 3566 3568 3575 3588 3600 3976 9021 9180
Dasatinib rep1	FDA approved	Thyroid hormone signaling pathway	path:04919_16	6	6.035193	0.040044494	ATP1B1 ATP1B3 FXYD2 SRC THRA PIK3R3	481 483 486 6714 7067 8503
Dasatinib rep1	FDA approved	Small cell lung cancer	path:05222_8	6	6.149783	0.034482759	AKT1 PIK3R5 ITGAV ITGB1 PTK2 PIK3R3	207 23533 3685 3688 5747 8503
Dasatinib rep2	FDA approved	Purine metabolism	path:00230_95	7	7.771863	0	ADSS AMPD3 ITPA NT5E PDE1A PDE3B PDE4C	159 272 3704 4907 5136 5140 5143
Dasatinib rep2	FDA approved	Ras signaling pathway	path:04014_38	8	7.012947	0.008839779	RRAS2 ABL1 HRAS PLCE1 PRKCA RRAS PIK3R3 RIN1	22800 25 3265 51196 5578 6237 8503 9610
Dasatinib rep2	FDA approved	NF-kappa B signaling pathway	path:04064_5	7	6.560962	0.025414365	TNFRSF13C BIRC2 BIRC3 RELA TRAF2 TRAF3 MAP3K14	115650 329 330 5970 7186 7187 9020
Dasatinib rep2	FDA approved	p53 signaling pathway	path:04115_17	15	6.464074	0.028729282	CHEK2 GADD45A RCHY1 BBC3 FAS MDM4 GADD45B ATM SERPINE1 GTSE1 STEAP3 THBS1 TP53 TSC2 TNFRSF10B	11200 1647 25898 27113 355 4194 4616 472 5054 51512 55240 7057 7157 7249 8795
Dasatinib rep2	FDA approved	PI3K-Akt signaling pathway	path:04151_58	4	7.026879	0.008839779	ITGA5 ITGB1 PTK2 THBS1	3678 3688 5747 7057
Dasatinib rep2	FDA approved	Focal adhesion	path:04510_65	7	7.81877	0	FLNA FLNC ITGA5 ITGAV ITGB1 THBS1 VASP	2316 2318 3678 3685 3688 7057 7408
Dasatinib rep2	FDA approved	ECM-receptor interaction	path:04512_14	3	6.218882	0.040883978	ITGAV ITGB1 THBS1	3685 3688 7057
Dasatinib rep2	FDA approved	Pathways in cancer	path:05200_31	8	6.597343	0.02320442	AKT3 CHUK EGFR HRAS IGF1R PRKCA PTK2 PIK3R3	10000 1147 1956 3265 3480 5578 5747 8503
Daunorubicin rep1	FDA approved	Purine metabolism	path:00230_96	14	7.963522	0	POLR3A ADCY6 NUDT16 AK8 AK1 IMPDH2 NME1 NT5E PDE6C PDE1B POLR2K POLR2L POLR3GL ENTPD6	11128 112 131870 158067 203 3615 4830 4907 5146 5153 5440 5441 84265 955
Daunorubicin rep1	FDA approved	ErbB signaling pathway	path:04012_13	9	6.079371	0.03765227	AKT3 ERBB2 ERBB3 PIK3R5 GAB1 GRB2 PIK3CG SHC3 NRG2	10000 2064 2065 23533 2549 2885 5294 53358 9542
Daunorubicin rep1	FDA approved	FoxO signaling pathway	path:04068_58	24	6.262747	0.025470653	SGK2 CDK2 GADD45G GABARAP GABARAPL2 CHUK FBXO32 CSNK1E S1PR1 FOXO1 SGK3 ATM PCK1 NLK PRKAB1 MAPK1 MAPK8 MAP2K2 RBL2 CCND1 BCL6 MAPK12 SGK1 STK4	10110 1017 10912 11337 11345 1147 114907 1454 1901 2308 23678 472 5105 51701 5564 5594 5599 5605 5934 595 604 6300 6446 6789
Daunorubicin rep1	FDA approved	PI3K-Akt signaling pathway	path:04151_59	6	6.317347	0.024363234	ITGA2B ITGA5 ITGAV ITGB1 ITGB3 PTK2	3674 3678 3685 3688 3690 5747
Daunorubicin rep1	FDA approved	Hippo signaling pathway	path:04390_26	7	6.029543	0.03875969	CSNK1E PPP1CC PPP2CA YWHAB YWHAG YWHAZ BTRC	1454 5501 5515 7529 7532 7534 8945
Daunorubicin rep1	FDA approved	Focal adhesion	path:04510_66	8	7.02678	0.008859358	ITGA2B ITGA5 ITGAV ITGB3 ITGB5 PTK2 PXN CAV1	3674 3678 3685 3690 3693 5747 5829 857
Daunorubicin rep1	FDA approved	Circadian entrainment	path:04713_25	10	5.99233	0.03986711	ADCY6 GNAI2 GNAO1 GNG5 GNG11 MTNR1B PRKACB MAPK1 GNG12 RPS6KA5	112 2771 2775 2787 2791 4544 5567 5594 55970 9252
Daunorubicin rep1	FDA approved	Retrograde endocannabinoid signaling	path:04723_24	10	5.858795	0.045404208	ADCY6 GNAI2 GNAO1 GNG5 GNG11 PRKACB MAPK1 GNG12 MAPK8 MAPK12	112 2771 2775 2787 2791 5567 5594 55970 5599 6300
Daunorubicin rep1	FDA approved	Glutamatergic synapse	path:04724_24	9	5.800967	0.047619048	ADCY6 GNAI2 GNAO1 GNG5 GNG11 GRIA3 GRM4 PRKACB GNG12	112 2771 2775 2787 2791 2892 2914 5567 55970
Daunorubicin rep1	FDA approved	Cholinergic synapse	path:04725_31	9	5.787111	0.049833887	ADCY6 GNAI2 GNAO1 GNG5 GNG11 PIK3CG PRKACB MAPK1 GNG12	112 2771 2775 2787 2791 5294 5567 5594 55970
Daunorubicin rep1	FDA approved	Dopaminergic synapse	path:04728_30	9	5.819725	0.046511628	ADCY5 DRD4 GNG5 GNG11 GRIA3 PRKACB GNG12 MAPK8 MAPK12	111 1815 2787 2791 2892 5567 55970 5599 6300
Daunorubicin rep2	FDA approved	Purine metabolism	path:00230_97	12	7.095423	0.007692308	PDE10A POLR3A ADCY6 NUDT16 AK1 AMPD3 HPRT1 ATIC NME1 GMPR2 PDE8A ENTPD6	10846 11128 112 131870 203 272 3251 471 4830 51292 5151 955
Daunorubicin rep2	FDA approved	PPAR signaling pathway	path:03320_10	8	7.041072	0.007692308	SORBS1 DBI EHHADH ILK ME1 PPARG RXRA FADS2	10580 1622 1962 3611 4199 5468 6256 9415
Daunorubicin rep2	FDA approved	Ras signaling pathway	path:04014_39	10	5.617075	0.049450549	RALBP1 RRAS2 MRAS NF1 PAK1 PIK3CB PIK3CG RAC2 RASSF5 RASAL1	10928 22800 22808 4763 5058 5291 5294 5880 83593 8437
Daunorubicin rep2	FDA approved	Chemokine signaling pathway	path:04062_51	7	6.438542	0.012087912	GNAI2 GNB2 HCK PIK3CG PRKCZ GNG12 SRC	2771 2783 3055 5294 5590 55970 6714
Daunorubicin rep2	FDA approved	Phosphatidylinositol signaling system	path:04070_40	13	5.631494	0.049450549	CDIPT PIKFYVE INPPL1 PIK3C2A PIK3C2B PIK3CB PIK3CG PI4KA PI4KB PLCB4 PIP4K2C PIP5K1A SYNJ2	10423 200576 3636 5286 5287 5291 5294 5297 5298 5332 79837 8394 8871
Daunorubicin rep2	FDA approved	PI3K-Akt signaling pathway	path:04151_60	3	6.065727	0.028571429	ITGAV ITGB5 PTK2	3685 3693 5747
Daunorubicin rep2	FDA approved	AMPK signaling pathway	path:04152_22	4	5.744857	0.042857143	ACACA PFKFB2 PFKFB4 PRKAB1	31 5208 5210 5564
Daunorubicin rep2	FDA approved	Hippo signaling pathway	path:04390_27	4	8.189532	0.001098901	SMAD7 PPP1CC PPP2CB YWHAZ	4092 5501 5516 7534
Daunorubicin rep2	FDA approved	Jak-STAT signaling pathway	path:04630_60	20	6.425071	0.015384615	EP300 IFNL1 IL19 IFNG IFNGR1 IL2RG IL4 IL10 IL10RA IL13RA1 LEPR OSM IL20 IL22 IL23A CCND1 STAT5B CBL CBLB SOCS3	2033 282618 29949 3458 3459 3561 3565 3586 3587 3597 3953 5008 50604 50616 51561 595 6777 867 868 9021
Daunorubicin rep2	FDA approved	Dopaminergic synapse	path:04728_31	4	6.202141	0.025274725	AKT2 GRIN2A GSK3B PPP1CC	208 2903 2932 5501
Daunorubicin rep2	FDA approved	Insulin signaling pathway	path:04910_17	4	5.67646	0.047252747	GSK3B GYS1 PPP1CC PYGB	2932 2997 5501 5834
Daunorubicin rep2	FDA approved	Melanogenesis	path:04916_6	3	5.899446	0.034065934	GNAI2 GNAO1 PLCB4	2771 2775 5332
Daunorubicin rep2	FDA approved	Pancreatic cancer	path:05212_11	7	5.698964	0.047252747	RALBP1 ERBB2 NFKB1 PIK3CB PIK3CG RAC2 RALB	10928 2064 4790 5291 5294 5880 5899
Daunorubicin rep3	FDA approved	Purine metabolism	path:00230_98	10	5.947199	0.03674833	ADA PDE10A ADCY5 ADCY6 NUDT16 NME1 NT5E AK3 POLR2K POLR3D	100 10846 111 112 131870 4830 4907 50808 5440 661
Daunorubicin rep3	FDA approved	Pyrimidine metabolism	path:00240_69	8	6.110248	0.030066815	POLR3A DUT AK9 NME1 POLE3 POLR2K TK1 POLR3GL	11128 1854 221264 4830 54107 5440 7083 84265
Daunorubicin rep3	FDA approved	Glycerolipid metabolism	path:00561_5	6	6.675387	0.0155902	CEL MGLL LPIN1 PNPLA3 DGKZ DGAT1	1056 11343 23175 80339 8525 8694
Daunorubicin rep3	FDA approved	PPAR signaling pathway	path:03320_11	6	6.588925	0.016703786	SORBS1 CPT1A MMP1 PPARG RXRA CD36	10580 1374 4312 5468 6256 948
Daunorubicin rep3	FDA approved	Phosphatidylinositol signaling system	path:04070_41	16	6.197608	0.026726058	DGKH IMPA1 INPP4A INPP5B INPP5D OCRL PLCE1 PIK3C2A PIK3CG PI4KA PLCB3 PLCB4 PI4K2A PIP4K2B DGKZ SYNJ2	160851 3612 3631 3633 3635 4952 51196 5286 5294 5297 5331 5332 55361 8396 8525 8871
Daunorubicin rep3	FDA approved	PI3K-Akt signaling pathway	path:04151_61	4	6.418252	0.021158129	ITGA2B ITGB1 ITGB5 PTK2	3674 3688 3693 5747
Daunorubicin rep3	FDA approved	AMPK signaling pathway	path:04152_23	4	5.95626	0.03674833	HMGCR PFKFB2 PRKAG3 CD36	3156 5208 53632 948
Daunorubicin rep3	FDA approved	Hippo signaling pathway	path:04390_28	4	8.813574	0	RASSF1 PPP2CB PPP2R1B STK3	11186 5516 5519 6788
Daunorubicin rep3	FDA approved	Focal adhesion	path:04510_67	3	7.614519	0.002227171	ITGB1 PTK2 CAV2	3688 5747 858
Daunorubicin rep3	FDA approved	Thyroid hormone signaling pathway	path:04919_17	4	5.90623	0.038975501	PIK3CG RXRA THRA THRB	5294 6256 7067 7068
Daunorubicin rep3	FDA approved	Pathways in cancer	path:05200_32	3	6.298312	0.023385301	ITGA2B ITGB1 PTK2	3674 3688 5747
Daunorubicin rep3	FDA approved	Proteoglycans in cancer	path:05205_9	5	6.581485	0.016703786	ITGB1 PRKACA PTK2 PXN SRC	3688 5566 5747 5829 6714
Decitabine	FDA approved	Purine metabolism	path:00230_99	6	6.420367	0.018099548	ADCY4 POLR2J2 ZNRD1 NME4 PRIM2 NTPCR	196883 246721 30834 4833 5558 84284
Decitabine	FDA approved	Inositol phosphate metabolism	path:00562_11	10	5.691878	0.045248869	INPP4A ITPKB OCRL PIK3C2A PIK3CG PI4KB PLCB2 IMPAD1 PIP4K2C ITPKC	3631 3707 4952 5286 5294 5298 5330 54928 79837 80271
Decitabine	FDA approved	cGMP-PKG signaling pathway	path:04022_20	6	6.040526	0.028280543	ADRA1B ADRA2C EDNRA GNA11 PLCB2 PRKG2	147 152 1909 2767 5330 5593
Decitabine	FDA approved	NF-kappa B signaling pathway	path:04064_6	8	5.977734	0.029411765	TAB2 NFKB1 MAP3K7 BTK TNFRSF1A TRAF2 TRAF5 CD40	23118 4790 6885 695 7132 7186 7188 958
Decitabine	FDA approved	HIF-1 signaling pathway	path:04066_18	4	5.649203	0.048642534	CREBBP NOS2 PFKFB3 PFKL	1387 4843 5209 5211
Decitabine	FDA approved	FoxO signaling pathway	path:04068_59	20	7.533315	0.005656109	AKT3 CDKN2D KLF2 PLK4 PLK2 FOXO3 FOXO4 PCK2 PRKAG3 PRKAB1 PRKAB2 MAPK11 MAPK10 RAG2 MAPK12 SOD2 STK4 SETD7 S1PR4 CCNG2	10000 1032 10365 10733 10769 2309 4303 5106 53632 5564 5565 5600 5602 5897 6300 6648 6789 80854 8698 901
Decitabine	FDA approved	Phosphatidylinositol signaling system	path:04070_42	8	6.417012	0.018099548	INPP4A PIK3C2A PIK3CG PIK3R2 PI4KB PLCB2 IMPAD1 PIP4K2C	3631 5286 5294 5296 5298 5330 54928 79837
Decitabine	FDA approved	Hippo signaling pathway	path:04390_29	4	6.028757	0.028280543	ITGB2 PPP1CC STK3 YWHAG	3689 5501 6788 7532
Decitabine	FDA approved	Focal adhesion	path:04510_68	4	7.654738	0.005656109	ITGAV ITGB3 PXN VASP	3685 3690 5829 7408
Decitabine	FDA approved	Tight junction	path:04530_7	3	5.714549	0.044117647	RHOA AFDN PRKCQ	387 4301 5588
Decitabine	FDA approved	Platelet activation	path:04611_9	10	6.28355	0.020361991	AKT3 ADCY6 ADCY9 ADCY4 GNAI1 ITPR2 PIK3CG PLCB2 PRKCI BTK	10000 112 115 196883 2770 3709 5294 5330 5584 695
Decitabine	FDA approved	Jak-STAT signaling pathway	path:04630_61	10	6.826667	0.009049774	IFNAR1 IFNGR2 IL2RA IL6ST IL10RB IL12B IL13RA1 JAK3 LIF CBLB	3454 3460 3559 3572 3588 3593 3597 3718 3976 868
Decitabine	FDA approved	Circadian entrainment	path:04713_26	4	8.702979	0	ADCY9 GNAI1 GNGT2 PLCB2	115 2770 2793 5330
Decitabine	FDA approved	Retrograde endocannabinoid signaling	path:04723_25	7	7.347751	0.005656109	ADCY9 ADCY4 GNAI1 GNAO1 GNB2 GNGT2 GNG13	115 196883 2770 2775 2783 2793 51764
Decitabine	FDA approved	Glutamatergic synapse	path:04724_25	4	6.58831	0.013574661	ADCY9 GNAI1 GNGT2 GNG13	115 2770 2793 51764
Decitabine	FDA approved	Cholinergic synapse	path:04725_32	8	7.48958	0.005656109	CHRM4 ADCY9 ADCY4 GNAI1 GNAO1 GNB2 GNGT2 GNG13	1132 115 196883 2770 2775 2783 2793 51764
Decitabine	FDA approved	Serotonergic synapse	path:04726_21	3	8.466545	0.001131222	GNAI1 GNGT2 PLCB2	2770 2793 5330
Decitabine	FDA approved	GABAergic synapse	path:04727_17	7	7.222826	0.00678733	ADCY9 ADCY4 GNAI1 GNAO1 GNB2 GNGT2 GNG13	115 196883 2770 2775 2783 2793 51764
Decitabine	FDA approved	Dopaminergic synapse	path:04728_32	3	8.466545	0.001131222	GNAI1 GNGT2 PLCB2	2770 2793 5330
Decitabine	FDA approved	Oxytocin signaling pathway	path:04921_19	5	7.334954	0.00678733	ADCY9 ADCY4 GNAI1 PLCB2 SRC	115 196883 2770 5330 6714
Decitabine	FDA approved	Morphine addiction	path:05032_20	6	7.896095	0.003393665	ADCY7 ADCY9 GABBR1 GNAI1 GNAO1 GNGT2	113 115 2550 2770 2775 2793
Denileukin Diftitox Ontak	FDA approved	Purine metabolism	path:00230_100	9	7.40666	0.001114827	ADCY6 ADCY4 POLR2J2 GMPR2 PDE6G POLR2H POLR2J POLR3D ENTPD3	112 196883 246721 51292 5148 5437 5439 661 956
Denileukin Diftitox Ontak	FDA approved	Pyrimidine metabolism	path:00240_70	9	5.922249	0.016722408	POLR3A POLR2J2 POLR2C POLR2E POLR2H POLR2J POLR3B POLR3D ENTPD3	11128 246721 5432 5434 5437 5439 55703 661 956
Denileukin Diftitox Ontak	FDA approved	Inositol phosphate metabolism	path:00562_12	9	6.230817	0.011148272	PIP5KL1 INPP4A INPP5B INPPL1 PIK3C2A PIK3C2B PIK3CA PIP4K2A SYNJ2	138429 3631 3633 3636 5286 5287 5290 5305 8871
Denileukin Diftitox Ontak	FDA approved	Calcium signaling pathway	path:04020_45	8	7.356027	0.001114827	ITPR2 ATP2B4 CALML5 PLCG2 TNNC2 CACNA1S ORAI2 ORAI3	3709 493 51806 5336 7125 779 80228 93129
Denileukin Diftitox Ontak	FDA approved	cAMP signaling pathway	path:04024_22	7	5.515005	0.03567447	CREBBP NFATC1 NFKBIA ATP2B4 PDE3B PRKACB CACNA1S	1387 4772 4792 493 5140 5567 779
Denileukin Diftitox Ontak	FDA approved	HIF-1 signaling pathway	path:04066_19	15	5.523198	0.03567447	CREBBP ENO3 EP300 ALDOA ANGPT1 ANGPT2 HIF1A HK1 SERPINE1 ANGPT4 PFKFB3 PFKL SLC2A1 TEK TFRC	1387 2027 2033 226 284 285 3091 3098 5054 51378 5209 5211 6513 7010 7037
Denileukin Diftitox Ontak	FDA approved	Phosphatidylinositol signaling system	path:04070_43	9	6.613315	0.006688963	INPP4A INPP5B INPPL1 PIK3C2B PIK3R2 PIP4K2A PLCG2 IMPAD1 SYNJ2	3631 3633 3636 5287 5296 5305 5336 54928 8871
Denileukin Diftitox Ontak	FDA approved	Adrenergic signaling in cardiomyocytes	path:04261_21	11	6.812306	0.003344482	PPP1CB PPP2R3C PPP2CB PPP2R1B PPP2R2A PPP2R5A PRKACB CACNA1S CACNB2 CACNB3 CACNG1	5500 55012 5516 5519 5520 5525 5567 779 783 784 786
Denileukin Diftitox Ontak	FDA approved	Cholinergic synapse	path:04725_33	10	5.934003	0.015607581	GNB5 ADCY6 CHRM4 GNB2 GNG4 GNG7 GNGT2 PIK3R2 PRKACB GNB4	10681 112 1132 2783 2786 2788 2793 5296 5567 59345
Denileukin Diftitox Ontak	FDA approved	Oxytocin signaling pathway	path:04921_20	6	6.075964	0.013377926	NFATC1 NFATC3 CALML5 PPP3CB PPP3CC CALML3	4772 4775 51806 5532 5533 810
Docetaxel rep1	FDA approved	Sphingolipid metabolism	path:00600_8	9	6.413142	0.023385301	CERS1 ACER1 GLB1 SMPD2 UGCG CERS4 DEGS1 SPHK1 CERS5	10715 125981 2720 6610 7357 79603 8560 8877 91012
Docetaxel rep1	FDA approved	FoxO signaling pathway	path:04068_60	16	7.412597	0.004454343	AKT3 CDK2 CDKN1A PLK2 PLK3 GADD45A FOXO1 GABARAPL1 IKBKB PRKAA1 PRKAA2 RAG2 CCND1 S1PR4 CCNB2 ATG12	10000 1017 1026 10769 1263 1647 2308 23710 3551 5562 5563 5897 595 8698 9133 9140
Docetaxel rep1	FDA approved	Focal adhesion	path:04510_69	3	7.370733	0.005567929	FLNC ITGB3 PXN	2318 3690 5829
Docetaxel rep2	FDA approved	Purine metabolism	path:00230_101	8	7.157011	0.004347826	AK5 GUCY2F HPRT1 ATIC NT5E PDE2A PDE6D ENTPD4	26289 2986 3251 471 4907 5138 5147 9583
Docetaxel rep2	FDA approved	Chemokine signaling pathway	path:04062_52	7	7.453729	0.002173913	GNB2 GNG5 GNG11 GNGT1 PIK3CG PLCB4 GNG12	2783 2787 2791 2792 5294 5332 55970
Docetaxel rep2	FDA approved	FoxO signaling pathway	path:04068_61	11	6.083919	0.044565217	AKT3 CDKN1A PLK2 PLK3 GADD45A GABARAPL1 IKBKB FOXO4 PRKAB2 CCND1 SGK1	10000 1026 10769 1263 1647 23710 3551 4303 5565 595 6446
Docetaxel rep2	FDA approved	Focal adhesion	path:04510_70	4	7.808094	0.002173913	FLNA ITGAV ITGB1 PXN	2316 3685 3688 5829
Docetaxel rep2	FDA approved	Circadian entrainment	path:04713_27	8	7.643945	0.002173913	ADCY9 GNB2 GNG5 GNG11 GNGT1 PLCB4 GNG12 PRKX	115 2783 2787 2791 2792 5332 55970 5613
Docetaxel rep2	FDA approved	Retrograde endocannabinoid signaling	path:04723_26	7	7.153906	0.005434783	ADCY9 GNB2 GNG5 GNG11 GNGT1 GNG12 PRKX	115 2783 2787 2791 2792 55970 5613
Docetaxel rep2	FDA approved	Glutamatergic synapse	path:04724_26	8	7.298305	0.004347826	ADCY9 GNB2 GNG3 GNG5 GNG11 GNGT1 GRM4 GNG12	115 2783 2785 2787 2791 2792 2914 55970
Docetaxel rep2	FDA approved	Cholinergic synapse	path:04725_34	8	7.766999	0.002173913	CHRM2 ADCY9 GNB2 GNG5 GNG11 GNGT1 PIK3CG GNG12	1129 115 2783 2787 2791 2792 5294 55970
Docetaxel rep2	FDA approved	Serotonergic synapse	path:04726_22	6	7.432842	0.002173913	GNB2 GNG5 GNG11 GNGT1 PLCB4 GNG12	2783 2787 2791 2792 5332 55970
Docetaxel rep2	FDA approved	GABAergic synapse	path:04727_18	9	7.741931	0.002173913	ADCY4 GABBR1 GNB2 GNG5 GNG11 GNGT1 GNG12 PRKX CACNA1F	196883 2550 2783 2787 2791 2792 55970 5613 778
Docetaxel rep2	FDA approved	Dopaminergic synapse	path:04728_33	6	7.432842	0.002173913	GNB2 GNG5 GNG11 GNGT1 PLCB4 GNG12	2783 2787 2791 2792 5332 55970
Docetaxel rep2	FDA approved	Regulation of actin cytoskeleton	path:04810_29	4	6.959411	0.007608696	CHRM2 PAK3 GNG12 BDKRB1	1129 5063 55970 623
Docetaxel rep2	FDA approved	Morphine addiction	path:05032_21	8	7.459083	0.002173913	ADCY9 GABBR1 GNB2 GNG5 GNG11 GNGT1 GNG12 PRKX	115 2550 2783 2787 2791 2792 55970 5613
Doxorubicin rep1	FDA approved	Inositol phosphate metabolism	path:00562_13	6	6.286322	0.030201342	INPP5J PLCE1 PIK3CG PLCB3 PLCG1 PIP4K2B	27124 51196 5294 5331 5335 8396
Doxorubicin rep1	FDA approved	Rap1 signaling pathway	path:04015_51	12	5.955893	0.045861298	EFNA1 EGFR EPHA2 FGF2 KDR NGFR PDGFA PDGFB PLCB3 VEGFB PDGFD FGF19	1942 1956 1969 2247 3791 4804 5154 5155 5331 7423 80310 9965
Doxorubicin rep1	FDA approved	Calcium signaling pathway	path:04020_46	6	5.976299	0.043624161	EGFR ERBB2 PLCE1 PLCB3 PLCG1 PRKCG	1956 2064 51196 5331 5335 5582
Doxorubicin rep1	FDA approved	Chemokine signaling pathway	path:04062_53	7	7.404762	0.003355705	GNB5 PIK3R5 GNAI2 GNG3 PIK3R1 PLCB3 PTK2	10681 23533 2771 2785 5295 5331 5747
Doxorubicin rep1	FDA approved	FoxO signaling pathway	path:04068_62	14	7.07934	0.006711409	CDKN2B CDKN2D PLK4 PLK2 FOXO1 SGK3 NLK PRKAG1 MAPK13 RBL2 CCND1 STAT3 CCNG2 G6PC3	1030 1032 10733 10769 2308 23678 51701 5571 5603 5934 595 6774 901 92579
Doxorubicin rep1	FDA approved	Phosphatidylinositol signaling system	path:04070_44	7	6.828372	0.012304251	PIKFYVE PIK3R5 INPPL1 PIK3C2A PI4KB PLCB3 PIP4K2B	200576 23533 3636 5286 5298 5331 8396
Doxorubicin rep1	FDA approved	p53 signaling pathway	path:04115_18	11	6.055458	0.03803132	SESN3 DDB2 SFN MDM2 SERPINB5 PERP SIAH1 THBS1 TP53 PPM1D CCNG2	143686 1643 2810 4193 5268 64065 6477 7057 7157 8493 901
Doxorubicin rep1	FDA approved	AMPK signaling pathway	path:04152_24	5	6.208876	0.032438479	GYS1 HMGCR PFKFB2 PRKAG1 CD36	2997 3156 5208 5571 948
Doxorubicin rep1	FDA approved	Circadian entrainment	path:04713_28	11	6.619756	0.022371365	GNB5 ADCY1 ADCY6 GNAI1 GNAI2 GNB2 GNG3 MTNR1A MTNR1B PLCB3 PRKACA	10681 107 112 2770 2771 2783 2785 4543 4544 5331 5566
Doxorubicin rep1	FDA approved	Cholinergic synapse	path:04725_35	11	6.030311	0.039149888	GNB5 ADCY1 ADCY6 PIK3R5 GNAI1 GNAI2 GNB2 GNG3 PIK3CG PIK3R1 PRKACA	10681 107 112 23533 2770 2771 2783 2785 5294 5295 5566
Doxorubicin rep1	FDA approved	Dopaminergic synapse	path:04728_34	7	6.044511	0.03803132	GNB5 DRD2 GNAI2 GNB2 GNG3 PLCB3 PPP2R5B	10681 1813 2771 2783 2785 5331 5526
Doxorubicin rep1	FDA approved	Inflammatory mediator regulation of TRP channels	path:04750_2	7	6.451407	0.025727069	PIK3R5 PIK3CA PIK3CG PIK3R1 PLCB3 PRKCD PIK3R3	23533 5290 5294 5295 5331 5580 8503
Doxorubicin rep1	FDA approved	Regulation of actin cytoskeleton	path:04810_30	4	7.077125	0.006711409	MYL9 PPP1CA ROCK1 PIP4K2B	10398 5499 6093 8396
Doxorubicin rep1	FDA approved	Pathways in cancer	path:05200_33	5	9.019833	0.001118568	ERBB2 PIK3R5 ITGA2B PIK3R1 PTK2	2064 23533 3674 5295 5747
Doxorubicin rep1	FDA approved	Small cell lung cancer	path:05222_9	4	8.549806	0.001118568	PIK3R5 ITGA2B PIK3R1 PTK2	23533 3674 5295 5747
Doxorubicin rep2	FDA approved	Purine metabolism	path:00230_102	18	6.896921	0.007692308	PDE10A ADCY5 ADCY6 ADCY8 ADCY9 NUDT16 GUCY2D ENTPD8 NME1 NT5E RRM2B PDE6C PDE6D POLR2A POLR2K PDE8B PDE5A ENTPD3	10846 111 112 114 115 131870 3000 377841 4830 4907 50484 5146 5147 5430 5440 8622 8654 956
Doxorubicin rep2	FDA approved	Glycerolipid metabolism	path:00561_6	11	6.853232	0.012087912	MGLL MBOAT2 DGKG DGKH LIPC PNLIPRP2 PNPLA2 PNPLA3 DGKZ DGAT1 LIPG	11343 129642 1608 160851 3990 5408 57104 80339 8525 8694 9388
Doxorubicin rep2	FDA approved	Sphingolipid metabolism	path:00600_9	3	6.043271	0.034065934	SGPP2 ASAH1 UGT8	130367 427 7368
Doxorubicin rep2	FDA approved	Ras signaling pathway	path:04014_40	10	6.110253	0.028571429	GNB5 RRAS2 MRAS PIK3R5 HTR7 PLCE1 PIK3R1 GNG12 RASGRF2 CALM1	10681 22800 22808 23533 3363 51196 5295 55970 5924 801
Doxorubicin rep2	FDA approved	FoxO signaling pathway	path:04068_63	17	7.157306	0.005494505	SGK2 CDKN2D PLK2 GABARAP CHUK FOXO1 FOXO3 SGK3 IKBKB MAPK8 MAPK13 G6PC2 RBL2 CCND1 STAT3 CCNB1 CCNG2	10110 1032 10769 11337 1147 2308 2309 23678 3551 5599 5603 57818 5934 595 6774 891 901
Doxorubicin rep2	FDA approved	Endocytosis	path:04144_13	5	6.105096	0.028571429	WWP1 EPS15 ERBB3 ITCH CBLB	11059 2060 2065 83737 868
Doxorubicin rep2	FDA approved	PI3K-Akt signaling pathway	path:04151_62	3	8.000648	0.002197802	ITGB5 PIK3R1 PTK2	3693 5295 5747
Doxorubicin rep2	FDA approved	Hippo signaling pathway	path:04390_30	7	6.710568	0.013186813	YWHAQ BIRC2 SMAD7 PPP1CC PPP2CB YWHAE YWHAZ	10971 329 4092 5501 5516 7531 7534
Doxorubicin rep2	FDA approved	Tight junction	path:04530_8	5	6.83863	0.012087912	RRAS2 AFDN PPP2CB PPP2R1B PRKCE	22800 4301 5516 5519 5581
Doxorubicin rep2	FDA approved	Small cell lung cancer	path:05222_10	4	7.250523	0.004395604	PIK3R5 ITGA2B PIK3R1 PTK2	23533 3674 5295 5747
Dromostanolone Propionate	FDA approved	Purine metabolism	path:00230_103	9	7.238955	0.006571742	ADCY6 ADCY9 GUK1 HDDC3 NME1 POLR1D POLD1 POLR3B NME5	112 115 2987 374659 4830 51082 5424 55703 8382
Dromostanolone Propionate	FDA approved	Pyrimidine metabolism	path:00240_71	12	6.083397	0.026286966	POLR3A DUT ZNRD1 NME1 NME4 POLR1D POLR3K POLD1 PRIM1 PRIM2 DCTPP1 POLR1B	11128 1854 30834 4830 4833 51082 51728 5424 5557 5558 79077 84172
Dromostanolone Propionate	FDA approved	Chemokine signaling pathway	path:04062_54	9	5.94465	0.032858708	ADCY6 CCR7 GRK2 GNAI3 GRK6 GNG12 CCL20 CCL25 CXCR5	112 1236 156 2773 2870 55970 6364 6370 643
Dromostanolone Propionate	FDA approved	FoxO signaling pathway	path:04068_64	17	5.951865	0.032858708	AKT3 CDKN1A PLK2 GADD45A PRMT1 FOXO4 GADD45B PCK2 PRKAG2 PRKAG3 PRKAA2 MAPK9 RAG2 CCND1 BCL6 MAPK12 STAT3	10000 1026 10769 1647 3276 4303 4616 5106 51422 53632 5563 5601 5897 595 604 6300 6774
Dromostanolone Propionate	FDA approved	PI3K-Akt signaling pathway	path:04151_63	4	5.791771	0.0449069	ITGAV ITGB1 PTK2 THBS1	3685 3688 5747 7057
Dromostanolone Propionate	FDA approved	AMPK signaling pathway	path:04152_25	4	6.541591	0.014238773	GYS2 PRKAG2 PRKAA2 RPS6KB1	2998 51422 5563 6198
Dromostanolone Propionate	FDA approved	Focal adhesion	path:04510_71	12	7.735291	0.004381161	FLNA FLNC ILK ITGA2B ITGAV ITGB5 PXN SRC TLN1 CAV1 CAV2 CAV3	2316 2318 3611 3674 3685 3693 5829 6714 7094 857 858 859
Dromostanolone Propionate	FDA approved	Platelet activation	path:04611_10	5	5.912763	0.035049288	GNAI3 ITGB1 LCP2 PIK3CG BTK	2773 3688 3937 5294 695
Dromostanolone Propionate	FDA approved	Estrogen signaling pathway	path:04915_4	7	6.069226	0.027382256	CREB3 ADCY6 ADCY9 ATF4 NOS3 PRKACA PRKX	10488 112 115 468 4846 5566 5613
Dromostanolone Propionate	FDA approved	Pathways in cancer	path:05200_34	8	5.962357	0.032858708	AKT3 ERBB2 FLT3 GRB2 NRAS PIK3CG PTEN PTK2	10000 2064 2322 2885 4893 5294 5728 5747
Epirubicin rep1	FDA approved	Purine metabolism	path:00230_104	15	6.005142	0.043093923	ADCY1 ADCY6 ADCY9 NUDT16 POLR2J2 GUCY2D NT5E PDE1C PDE4D PDE6A POLR2A POLR2J POLR2K PDE8B ENTPD3	107 112 115 131870 246721 3000 4907 5137 5144 5145 5430 5439 5440 8622 956
Epirubicin rep1	FDA approved	Ras signaling pathway	path:04014_41	9	5.86602	0.049723757	RRAS2 PIK3R5 NF1 PLCE1 PIK3CG PIK3R1 RASGRF2 SOS1 RASAL2	22800 23533 4763 51196 5294 5295 5924 6654 9462
Epirubicin rep1	FDA approved	Calcium signaling pathway	path:04020_47	8	6.123331	0.037569061	P2RX1 PPP3CA PRKCG TNNC1 CACNA1C CALM1 ITPKC P2RX6	5023 5530 5582 7134 775 801 80271 9127
Epirubicin rep1	FDA approved	cGMP-PKG signaling pathway	path:04022_21	10	6.002275	0.043093923	CNGA1 GTF2I ATP1B1 ATP1B2 PLCB3 PPP1CA PRKG2 CACNA1C CACNA1D GTF2IRD1	1259 2969 481 482 5331 5499 5593 775 776 9569
Epirubicin rep1	FDA approved	NF-kappa B signaling pathway	path:04064_7	9	6.656467	0.01878453	DDX58 CXCL2 CXCL8 LTBR NFKB1 BCL2A1 BCL2L1 TRAF2 CD40	23586 2920 3576 4055 4790 597 598 7186 958
Epirubicin rep1	FDA approved	FoxO signaling pathway	path:04068_65	10	7.316768	0.015469613	SGK2 CDKN2D PLK4 PLK2 FOXO1 SGK3 MAPK13 CCND1 STAT3 CCNG2	10110 1032 10733 10769 2308 23678 5603 595 6774 901
Epirubicin rep1	FDA approved	Phosphatidylinositol signaling system	path:04070_45	19	7.503181	0.012154696	CDS1 DGKH PIKFYVE PIK3R5 INPP5J IMPA1 INPP5A INPP5D ITPR3 PLCE1 PIK3C2A PIK3CG PIK3R1 PI4KA PLCB3 PLCG1 PIP4K2B DGKZ DGKD	1040 160851 200576 23533 27124 3612 3632 3635 3710 51196 5286 5294 5295 5297 5331 5335 8396 8525 8527
Epirubicin rep1	FDA approved	Sphingolipid signaling pathway	path:04071_16	9	5.954989	0.045303867	GNA13 ADORA1 S1PR3 PIK3R5 GNAI1 GNAI2 PIK3CG PIK3R1 PLCB3	10672 134 1903 23533 2770 2771 5294 5295 5331
Epirubicin rep1	FDA approved	AMPK signaling pathway	path:04152_26	4	5.967254	0.045303867	PPARG PRKAG1 TSC2 ULK1	5468 5571 7249 8408
Epirubicin rep1	FDA approved	Hippo signaling pathway	path:04390_31	5	6.55361	0.024309392	PPP2R1B STK3 YWHAB YWHAG YWHAZ	5519 6788 7529 7532 7534
Epirubicin rep1	FDA approved	Focal adhesion	path:04510_72	6	9.207201	0.001104972	PIK3R5 ITGB1 PIK3R1 PRKCB PTK2 VAV2	23533 3688 5295 5579 5747 7410
Epirubicin rep1	FDA approved	Tight junction	path:04530_9	4	6.721364	0.01878453	AFDN PRKCD PRKCG PRKCQ	4301 5580 5582 5588
Epirubicin rep1	FDA approved	Platelet activation	path:04611_11	8	6.056567	0.039779006	ADCY1 ADCY6 ADCY7 ADCY9 GNAI2 ITPR3 PLCB2 PLCB3	107 112 113 115 2771 3710 5330 5331
Epirubicin rep1	FDA approved	Jak-STAT signaling pathway	path:04630_62	9	7.146615	0.016574586	IFNLR1 CBLC IFNL1 IL6ST IL15 MPL IL22 IL22RA1 IL21	163702 23624 282618 3572 3600 4352 50616 58985 59067
Epirubicin rep1	FDA approved	Natural killer cell mediated cytotoxicity	path:04650_6	8	6.42163	0.026519337	PIK3R5 LAT PIK3R1 PLCG1 PPP3CA PRKCG VAV1 VAV2	23533 27040 5295 5335 5530 5582 7409 7410
Epirubicin rep1	FDA approved	Thyroid hormone signaling pathway	path:04919_18	5	6.037277	0.043093923	PIK3R5 ATP1B2 PIK3R1 CCND1 THRB	23533 482 5295 595 7068
Epirubicin rep1	FDA approved	Pathways in cancer	path:05200_35	6	8.53591	0.003314917	CRKL ERBB2 HRAS ITGB1 PIK3R1 PTK2	1399 2064 3265 3688 5295 5747
Epirubicin rep2	FDA approved	Purine metabolism	path:00230_105	10	7.296481	0.00441989	POLR3A ADCY6 ADCY9 NUDT16 AK1 HPRT1 IMPDH2 NME1 PDE6C ENTPD3	11128 112 115 131870 203 3251 3615 4830 5146 956
Epirubicin rep2	FDA approved	ErbB signaling pathway	path:04012_14	8	6.281583	0.027624309	ERBB2 ERBB3 PIK3R5 GRB2 PIK3CB PIK3CD PIK3CG NRG2	2064 2065 23533 2885 5291 5293 5294 9542
Epirubicin rep2	FDA approved	Ras signaling pathway	path:04014_42	10	5.917274	0.047513812	RRAS2 PIK3R5 AFDN NF1 PIK3CB PIK3CD PIK3CG RASA2 RASSF5 RASAL1	22800 23533 4301 4763 5291 5293 5294 5922 83593 8437
Epirubicin rep2	FDA approved	cGMP-PKG signaling pathway	path:04022_22	10	6.074811	0.038674033	GNA13 ADRA1B ADRA2B GNA11 RHOA MEF2D NFATC2 NFATC3 RGS2 TRPC6	10672 147 151 2767 387 4209 4773 4775 5997 7225
Epirubicin rep2	FDA approved	Chemokine signaling pathway	path:04062_55	7	6.466143	0.019889503	DOCK2 GNAI2 GNGT2 HCK PIK3CD GNG12 GNB4	1794 2771 2793 3055 5293 55970 59345
Epirubicin rep2	FDA approved	Phosphatidylinositol signaling system	path:04070_46	9	5.975639	0.044198895	PIK3R5 INPPL1 PIK3C2A PIK3CB PIK3CG PLCD1 PI4K2B PTEN PIP4K2B	23533 3636 5286 5291 5294 5333 55300 5728 8396
Epirubicin rep2	FDA approved	SNARE interactions in vesicular transport	path:04130_2	6	6.478338	0.01878453	STX2 STX1A STX3 VAMP1 VAMP2 VAMP3	2054 6804 6809 6843 6844 9341
Epirubicin rep2	FDA approved	AMPK signaling pathway	path:04152_27	7	6.360149	0.024309392	MTOR GYS1 HMGCR PFKFB2 PRKAG3 PPARG RPS6KB1	2475 2997 3156 5208 53632 5468 6198
Epirubicin rep2	FDA approved	Focal adhesion	path:04510_73	4	8.099607	0.002209945	ITGA2B ITGA5 ITGB5 PTK2	3674 3678 3693 5747
Epirubicin rep2	FDA approved	Platelet activation	path:04611_12	9	6.147692	0.035359116	ADCY7 PIK3R5 GNAI2 ITGB1 LCP2 PIK3CB PIK3CD PIK3CG PLCG2	113 23533 2771 3688 3937 5291 5293 5294 5336
Epirubicin rep2	FDA approved	Cholinergic synapse	path:04725_36	10	6.27	0.028729282	GNB5 ADCY6 ADCY9 PIK3R5 GNAI2 GNGT2 PIK3CG PRKACB GNG12 GNB4	10681 112 115 23533 2771 2793 5294 5567 55970 59345
Epirubicin rep2	FDA approved	Regulation of actin cytoskeleton	path:04810_31	5	6.663736	0.013259669	RRAS2 MRAS PIK3CG VAV1 VAV2	22800 22808 5294 7409 7410
Epirubicin rep2	FDA approved	Thyroid hormone signaling pathway	path:04919_19	9	6.294667	0.027624309	AKT2 PIK3R5 ATP1B2 PIK3CD PIK3CG RXRA SRC THRA THRB	208 23533 482 5293 5294 6256 6714 7067 7068
Epirubicin rep2	FDA approved	Pancreatic cancer	path:05212_12	4	6.240252	0.033149171	ERBB2 PIK3R5 PIK3CB PIK3CG	2064 23533 5291 5294
Epirubicin rep2	FDA approved	Small cell lung cancer	path:05222_11	3	7.383705	0.00441989	ITGA2B ITGB1 PTK2	3674 3688 5747
Eribulin mesilate	FDA approved	Ras signaling pathway	path:04014_43	9	6.120399	0.03080308	AKT3 PIK3R5 PLCE1 PIK3CA PIK3CB RAC1 RALGDS RRAS RIN1	10000 23533 51196 5290 5291 5879 5900 6237 9610
Eribulin mesilate	FDA approved	Rap1 signaling pathway	path:04015_52	11	6.689459	0.00990099	CRK EGFR EPHA2 FGF2 FGF9 FGFR1 PLCB1 INSR PDGFB PLCB4 PDGFC	1398 1956 1969 2247 2254 2260 23236 3643 5155 5332 56034
Eribulin mesilate	FDA approved	cAMP signaling pathway	path:04024_23	18	5.874551	0.04510451	ADCY6 ADCY7 ADCY8 ADCY9 CNGB1 ADORA1 ADORA2A ADRB2 GABBR1 GNAI1 GNAS HTR4 HTR6 OXTR CALML5 SUCNR1 SSTR5 CALML3	112 113 114 115 1258 134 135 154 2550 2770 2778 3360 3362 5021 51806 56670 6755 810
Eribulin mesilate	FDA approved	Chemokine signaling pathway	path:04062_56	7	8.269069	0.00110011	FGR PLCB1 GNAI1 GNG11 PIK3CG PLCB4 GNG12	2268 23236 2770 2791 5294 5332 55970
Eribulin mesilate	FDA approved	FoxO signaling pathway	path:04068_66	11	8.877604	0.00110011	AKT3 PLK2 MAPK14 GADD45A GABARAPL1 FOXO4 PRKAA2 CCND1 STAT3 CCNB2 G6PC3	10000 10769 1432 1647 23710 4303 5563 595 6774 9133 92579
Eribulin mesilate	FDA approved	Phosphatidylinositol signaling system	path:04070_47	18	5.981244	0.04070407	DGKH PLCB1 PIK3R5 INPP5J INPP4A INPP5A INPP5D INPPL1 PLCE1 PIK3CA PIK3CB PIK3CG PLCB4 PI4K2A PTEN PIP4K2C DGKD PLCZ1	160851 23236 23533 27124 3631 3632 3635 3636 51196 5290 5291 5294 5332 55361 5728 79837 8527 89869
Eribulin mesilate	FDA approved	mTOR signaling pathway	path:04150_7	7	5.984823	0.04070407	AKT3 PIK3R5 MTOR PDPK1 PIK3CA PIK3CB PIK3CG	10000 23533 2475 5170 5290 5291 5294
Eribulin mesilate	FDA approved	Wnt signaling pathway	path:04310_14	3	5.975952	0.04070407	PLCB1 PLCB4 PPP3R1	23236 5332 5534
Eribulin mesilate	FDA approved	Hippo signaling pathway	path:04390_32	4	6.847384	0.00880088	ITGB2 SERPINE1 PPP2R2A YWHAZ	3689 5054 5520 7534
Eribulin mesilate	FDA approved	Focal adhesion	path:04510_74	6	5.745662	0.04950495	CRK ERBB2 PIK3CA PTK2 PXN VEGFA	1398 2064 5290 5747 5829 7422
Eribulin mesilate	FDA approved	Platelet activation	path:04611_13	7	5.816857	0.04730473	AKT3 PIK3R5 GNAI1 ITGB1 PIK3CB PIK3CG BTK	10000 23533 2770 3688 5291 5294 695
Eribulin mesilate	FDA approved	Circadian entrainment	path:04713_29	8	7.346474	0.00660066	ADCY7 PLCB1 GNAS GNB1 GNG4 GNG11 PLCB4 GNG12	113 23236 2778 2782 2786 2791 5332 55970
Eribulin mesilate	FDA approved	Retrograde endocannabinoid signaling	path:04723_27	11	6.73175	0.00990099	ADCY6 ADCY7 ADCY9 MAPK14 GNAI1 GNAO1 GNG4 GNG11 GNGT1 GNG12 PRKX	112 113 115 1432 2770 2775 2786 2791 2792 55970 5613
Eribulin mesilate	FDA approved	Glutamatergic synapse	path:04724_27	11	6.600001	0.0110011	ADCY6 ADCY7 ADCY9 GNAI1 GNAO1 GNAS GNG4 GNG11 GNGT1 GNG12 PRKX	112 113 115 2770 2775 2778 2786 2791 2792 55970 5613
Eribulin mesilate	FDA approved	Cholinergic synapse	path:04725_37	9	7.395669	0.00550055	ADCY9 PIK3R5 GNAI1 GNAO1 GNG4 GNG11 GNGT1 GNG12 PRKX	115 23533 2770 2775 2786 2791 2792 55970 5613
Eribulin mesilate	FDA approved	Serotonergic synapse	path:04726_23	8	7.010975	0.00770077	PLCB1 GNAI1 GNAO1 GNG4 GNG11 GNGT1 PLCB4 GNG12	23236 2770 2775 2786 2791 2792 5332 55970
Eribulin mesilate	FDA approved	GABAergic synapse	path:04727_19	10	6.485472	0.01320132	ADCY6 ADCY7 ADCY9 GNAI1 GNAO1 GNG4 GNG11 GNGT1 GNG12 PRKX	112 113 115 2770 2775 2786 2791 2792 55970 5613
Eribulin mesilate	FDA approved	Dopaminergic synapse	path:04728_35	8	7.010975	0.00770077	PLCB1 GNAI1 GNAO1 GNG4 GNG11 GNGT1 PLCB4 GNG12	23236 2770 2775 2786 2791 2792 5332 55970
Eribulin mesilate	FDA approved	Regulation of actin cytoskeleton	path:04810_32	6	5.998603	0.03850385	PAK3 GNG12 RAC1 WAS MYLK3 CDC42	5063 55970 5879 7454 91807 998
Eribulin mesilate	FDA approved	Insulin signaling pathway	path:04910_18	4	6.106728	0.03190319	AKT3 PHKA2 PHKB CALML3	10000 5256 5257 810
Eribulin mesilate	FDA approved	Oxytocin signaling pathway	path:04921_21	16	7.244749	0.00660066	ADCY6 ADCY7 ADCY9 EGFR PLCB1 PIK3R5 GNAI1 GNAO1 GNAS OXTR PIK3CA PIK3CB PIK3CG PLCB4 PRKX CACNB4	112 113 115 1956 23236 23533 2770 2775 2778 5021 5290 5291 5294 5332 5613 785
Eribulin mesilate	FDA approved	Morphine addiction	path:05032_22	13	6.693842	0.00990099	ADCY6 ADCY7 ADCY9 GABBR1 GABRD GNAI1 GNAO1 GNAS GNG4 GNG11 GNGT1 GNG12 PRKX	112 113 115 2550 2563 2770 2775 2778 2786 2791 2792 55970 5613
Erlotinib	FDA approved	Sphingolipid metabolism	path:00600_10	8	6.881034	0.010022272	ACER1 GALC GBA SPHK2 UGCG DEGS1 SPHK1 GAL3ST1	125981 2581 2629 56848 7357 8560 8877 9514
Erlotinib	FDA approved	PPAR signaling pathway	path:03320_12	11	5.880182	0.041202673	SORBS1 APOA5 CPT1A ACAA1 ACADL APOA2 ACADM PCK2 ANGPTL4 ACSL5 RXRA	10580 116519 1374 30 33 336 34 5106 51129 51703 6256
Erlotinib	FDA approved	MAPK signaling pathway	path:04010_21	7	5.920927	0.037861915	DUSP1 DUSP2 DUSP3 DUSP5 HSPA6 MAPK8 MAP2K7	1843 1844 1845 1847 3310 5599 5609
Erlotinib	FDA approved	Rap1 signaling pathway	path:04015_53	24	6.73154	0.0155902	CSF1 EFNA1 EFNA3 EFNA4 EFNA5 EGFR EPHA2 FGF2 FGF6 FGF9 FGF14 FGFR1 FGFR2 FLT1 PLCB1 FGF21 INSR NGF PDGFA PDGFB PLCB2 PLCB4 PDGFC FGF19	1435 1942 1944 1945 1946 1956 1969 2247 2251 2254 2259 2260 2263 2321 23236 26291 3643 4803 5154 5155 5330 5332 56034 9965
Erlotinib	FDA approved	NF-kappa B signaling pathway	path:04064_8	10	7.093482	0.006681514	TNFSF13B BIRC3 GADD45B NFKB1 NFKB2 NFKBIA PLAU RELB BCL2L1 CFLAR	10673 330 4616 4790 4791 4792 5328 5971 598 8837
Erlotinib	FDA approved	FoxO signaling pathway	path:04068_67	11	6.052128	0.033407572	CDKN2D KLF2 PLK2 FOXO1 GABARAPL1 GADD45B PCK2 PRKAA2 BNIP3 STAT3 STK4	1032 10365 10769 2308 23710 4616 5106 5563 664 6774 6789
Erlotinib	FDA approved	Phosphatidylinositol signaling system	path:04070_48	16	6.128243	0.028953229	DGKH PLCB1 INPP5A ITPKB PLCE1 INPP5K PIK3CG PIK3R2 PI4KA PLCB4 PI4K2A PTEN CALM3 PIP5K1A DGKZ PLCZ1	160851 23236 3632 3707 51196 51763 5294 5296 5297 5332 55361 5728 808 8394 8525 89869
Erlotinib	FDA approved	PI3K-Akt signaling pathway	path:04151_64	5	6.482189	0.021158129	ITGA2B ITGAV ITGB1 ITGB3 THBS1	3674 3685 3688 3690 7057
Erlotinib	FDA approved	Apoptosis	path:04210_6	6	6.362587	0.024498886	CHUK IL1R1 IRAK1 MYD88 IRAK4 MAP3K14	1147 3554 3654 4615 51135 9020
Erlotinib	FDA approved	ECM-receptor interaction	path:04512_15	5	6.533216	0.020044543	ITGA2B ITGAV ITGB1 ITGB3 THBS1	3674 3685 3688 3690 7057
Erlotinib	FDA approved	Jak-STAT signaling pathway	path:04630_63	8	5.91956	0.037861915	CBLC JAK3 MYC PIK3R1 STAT3 STAT5A SOCS3 OSMR	23624 3718 4609 5295 6774 6776 9021 9180
Erlotinib	FDA approved	Adipocytokine signaling pathway	path:04920_4	9	6.53131	0.020044543	CPT1A NFKB1 NFKBIA NFKBIB PCK2 ACSL5 PRKAA2 STAT3 SOCS3	1374 4790 4792 4793 5106 51703 5563 6774 9021
Erlotinib	FDA approved	Melanoma	path:05218_4	10	5.949517	0.037861915	EGFR FGF2 FGF6 FGF9 FGF14 FGFR1 FGF21 PDGFA PDGFB PDGFC	1956 2247 2251 2254 2259 2260 26291 5154 5155 56034
Estramustine rep1	FDA approved	Valine, leucine and isoleucine degradation	path:00280_3	5	6.570285	0.017758047	EHHADH ACSF3 ALDH2 ACADM ACADS	1962 197322 217 34 35
Estramustine rep1	FDA approved	PPAR signaling pathway	path:03320_13	7	5.883928	0.04772475	NR1H3 SORBS1 ACSL4 PCK2 ANGPTL4 PPARG RXRG	10062 10580 2182 5106 51129 5468 6258
Estramustine rep1	FDA approved	Ras signaling pathway	path:04014_44	10	6.395787	0.022197558	MRAS KRAS NF1 NRAS PIK3CA PIK3R1 PIK3R2 RAC3 BRAP PIK3R3	22808 3845 4763 4893 5290 5295 5296 5881 8315 8503
Estramustine rep1	FDA approved	Chemokine signaling pathway	path:04062_57	9	6.323044	0.023307436	ADCY6 GNAI2 GNG4 GNG7 KRAS NRAS PIK3CA PIK3R1 GNB4	112 2771 2786 2788 3845 4893 5290 5295 59345
Estramustine rep1	FDA approved	Leukocyte transendothelial migration	path:04670_8	6	6.114996	0.033296337	GNAI3 PIK3CA PIK3R1 PIK3R2 VCAM1 PIK3R3	2773 5290 5295 5296 7412 8503
Estramustine rep1	FDA approved	Long-term potentiation	path:04720_3	8	5.839853	0.048834628	GRIN2B KRAS NRAS CALML5 PPP1CC CACNA1C CAMK4 CAMK2G	2904 3845 4893 51806 5501 775 814 818
Estramustine rep1	FDA approved	Cholinergic synapse	path:04725_38	9	5.876325	0.04772475	ADCY3 GNAI1 GNAI2 GNB3 GNG7 PIK3R1 PRKACA GNB4 CAMK2G	109 2770 2771 2784 2788 5295 5566 59345 818
Estramustine rep1	FDA approved	Regulation of actin cytoskeleton	path:04810_33	7	5.921027	0.045504994	HRAS KRAS NRAS PIK3CA PIK3CD PIK3R1 PIK3R2	3265 3845 4893 5290 5293 5295 5296
Estramustine rep1	FDA approved	Alcoholism	path:05034_5	8	6.108182	0.033296337	CREB1 GRIN2B KRAS NRAS CALML5 PPP1CC PRKACA CAMK4	1385 2904 3845 4893 51806 5501 5566 814
Estramustine rep2	FDA approved	Pyrimidine metabolism	path:00240_72	6	7.250178	0.002207506	POLR3A ZNRD1 POLR1D POLR1E POLR3D POLR1C	11128 30834 51082 64425 661 9533
Estramustine rep2	FDA approved	Inositol phosphate metabolism	path:00562_14	6	5.718344	0.045253863	INPP5A INPP5D PLCE1 PIK3CG PLCB4 PIP5K1A	3632 3635 51196 5294 5332 8394
Estramustine rep2	FDA approved	Ras signaling pathway	path:04014_45	10	6.356841	0.015452539	RASSF1 ABL2 GRB2 PLCE1 PIK3CG RALGDS RRAS SOS1 RASSF5 RIN1	11186 27 2885 51196 5294 5900 6237 6654 83593 9610
Estramustine rep2	FDA approved	Rap1 signaling pathway	path:04015_54	13	7.553181	0.001103753	EFNA5 EGFR EPHA2 FGF1 FGFR4 FLT4 FGF20 IGF1 NGF PDGFB PLCB4 PDGFC FGF17	1946 1956 1969 2246 2264 2324 26281 3479 4803 5155 5332 56034 8822
Estramustine rep2	FDA approved	Calcium signaling pathway	path:04020_48	9	5.67672	0.049668874	ADRA1B ADRA1A EGFR ERBB2 GNA11 OXTR PLCE1 PLCB4 PLCG1	147 148 1956 2064 2767 5021 51196 5332 5335
Estramustine rep2	FDA approved	FoxO signaling pathway	path:04068_68	15	6.117374	0.020971302	AKT3 CDKN1A CDKN2D PLK2 MAPK14 GADD45A GABARAPL1 PRMT1 FOXO4 GADD45B PCK2 PRKAA2 RAG2 CCND1 STAT3	10000 1026 1032 10769 1432 1647 23710 3276 4303 4616 5106 5563 5897 595 6774
Estramustine rep2	FDA approved	Phosphatidylinositol signaling system	path:04070_49	7	5.963221	0.028697572	INPP5A INPP5D PLCE1 PIK3CG PLCB4 PIP5K1A DGKZ	3632 3635 51196 5294 5332 8394 8525
Estramustine rep2	FDA approved	PI3K-Akt signaling pathway	path:04151_65	3	6.390604	0.015452539	ITGB1 PTK2 THBS1	3688 5747 7057
Estramustine rep2	FDA approved	Focal adhesion	path:04510_75	5	6.565144	0.011037528	FLT4 PDGFA PDGFB PDGFC PTK2	2324 5154 5155 56034 5747
Estramustine rep2	FDA approved	Jak-STAT signaling pathway	path:04630_64	8	5.765191	0.041942605	IFNG IL6 IL6ST IL10RB IL12B IL12RB2 LIF OSM	3458 3569 3572 3588 3593 3595 3976 5008
Estramustine rep2	FDA approved	Natural killer cell mediated cytotoxicity	path:04650_7	8	6.564241	0.011037528	PTK2B ITGB2 PIK3CG PLCG1 PPP3CC PPP3R1 VAV1 VAV2	2185 3689 5294 5335 5533 5534 7409 7410
Estramustine rep2	FDA approved	Circadian entrainment	path:04713_30	9	5.988766	0.027593819	ADCY8 ADCY9 GNB2 GNG11 GNGT1 MTNR1B PLCB4 GNG12 PRKX	114 115 2783 2791 2792 4544 5332 55970 5613
Estramustine rep2	FDA approved	Glucagon signaling pathway	path:04922_8	9	5.763326	0.041942605	CPT1A ATF4 PCK2 PHKG1 PPARA PRKAA2 PRKX PYGL CREB5	1374 468 5106 5260 5465 5563 5613 5836 9586
Etoposide rep1	FDA approved	Purine metabolism	path:00230_106	12	6.309984	0.028384279	ADA ADCY6 NT5C3B NUDT16 AK1 NME1 NPR1 NT5E PDE3B PDE6C POLE ENTPD6	100 112 115024 131870 203 4830 4881 4907 5140 5146 5426 955
Etoposide rep1	FDA approved	ErbB signaling pathway	path:04012_15	10	6.378913	0.02510917	EGFR EREG GRB2 PTK2 SRC STAT5A STAT5B BTC CBL CBLB	1956 2069 2885 5747 6714 6776 6777 685 867 868
Etoposide rep1	FDA approved	Rap1 signaling pathway	path:04015_55	20	6.178437	0.033842795	CRKL EFNA1 EFNA4 EGFR EPHA2 FGF2 FGF5 FGF6 FGF8 HGF KDR MET KITLG NGFR PLCB2 PLCB3 VEGFB PDGFD FGF18 BCAR1	1399 1942 1945 1956 1969 2247 2250 2251 2253 3082 3791 4233 4254 4804 5330 5331 7423 80310 8817 9564
Etoposide rep1	FDA approved	cGMP-PKG signaling pathway	path:04022_23	9	6.579532	0.018558952	ADRA1B GTF2I NFATC1 ATP2B1 PRKG2 TRPC6 CACNA1C CACNA1F GTF2IRD1	147 2969 4772 490 5593 7225 775 778 9569
Etoposide rep1	FDA approved	cAMP signaling pathway	path:04024_24	5	6.047605	0.040393013	RAPGEF3 ADCY6 RRAS2 PLCE1 CAMK2D	10411 112 22800 51196 817
Etoposide rep1	FDA approved	FoxO signaling pathway	path:04068_69	18	6.984635	0.009825328	SGK2 CDKN2D CHUK GADD45A FOXO1 FOXO3 SGK3 FASLG PRKAB1 PRKAG1 MAPK9 MAPK13 RBL2 CCND1 STAT3 S1PR4 CCNG2 G6PC3	10110 1032 1147 1647 2308 2309 23678 356 5564 5571 5601 5603 5934 595 6774 8698 901 92579
Etoposide rep1	FDA approved	Phosphatidylinositol signaling system	path:04070_50	8	6.62824	0.017467249	PIKFYVE PIK3R5 PLCE1 PIK3C2A PIK3CG PI4KA PI4KB PIP4K2B	200576 23533 51196 5286 5294 5297 5298 8396
Etoposide rep1	FDA approved	Endocytosis	path:04144_14	9	6.035726	0.040393013	EGFR ERBB3 CBLC MET SH3GLB2 SMURF2 ITCH CBL CBLB	1956 2065 23624 4233 56904 64750 83737 867 868
Etoposide rep1	FDA approved	PI3K-Akt signaling pathway	path:04151_66	3	9.618282	0	ITGA2B ITGA5 THBS1	3674 3678 7057
Etoposide rep1	FDA approved	AMPK signaling pathway	path:04152_28	6	7.647589	0.003275109	HMGCR PFKFB2 PPARG PRKAB1 RPS6KB1 ULK1	3156 5208 5468 5564 6198 8408
Etoposide rep1	FDA approved	Focal adhesion	path:04510_76	5	10.471404	0	FLNB ITGA2B PXN THBS1 CAV2	2317 3674 5829 7057 858
Etoposide rep1	FDA approved	Jak-STAT signaling pathway	path:04630_65	7	6.412285	0.021834061	IL9 LEPR MPL OSM IL20RA CBL CBLB	3578 3953 4352 5008 53832 867 868
Etoposide rep1	FDA approved	Pathways in cancer	path:05200_36	7	5.940278	0.043668122	EGFR PIK3R5 CBLC ABL1 PIK3CG CBL CBLB	1956 23533 23624 25 5294 867 868
Etoposide rep2	FDA approved	Purine metabolism	path:00230_107	9	6.5994	0.013215859	ADCY6 NUDT16 AK1 NME7 HPRT1 PDE6C PDE1B ENTPD1 ENTPD6	112 131870 203 29922 3251 5146 5153 953 955
Etoposide rep2	FDA approved	ErbB signaling pathway	path:04012_16	8	6.435614	0.018722467	AKT3 ERBB2 ERBB3 GAB1 GRB2 PIK3CB PIK3CG NRG2	10000 2064 2065 2549 2885 5291 5294 9542
Etoposide rep2	FDA approved	FoxO signaling pathway	path:04068_70	23	6.998621	0.005506608	AKT3 SGK2 CDK2 CDKN2B GABARAPL2 CHUK MAPK14 S1PR1 FOXO1 SGK3 FASLG GADD45B ATM PCK1 NLK PRKAG1 MAPK1 MAPK8 MAPK13 RBL2 CCND1 MAPK12 STAT3	10000 10110 1017 1030 11345 1147 1432 1901 2308 23678 356 4616 472 5105 51701 5571 5594 5599 5603 5934 595 6300 6774
Etoposide rep2	FDA approved	Phosphatidylinositol signaling system	path:04070_51	20	5.766751	0.044052863	CDIPT DGKG INPP5A INPPL1 PLCE1 PIK3C2A PIK3C2B PIK3CB PIK3CG PIK3R1 PI4KA PLCB2 PLCG1 PI4K2A PIP4K2C ITPKC PIP5K1A DGKZ SYNJ2 PLCZ1	10423 1608 3632 3636 51196 5286 5287 5291 5294 5295 5297 5330 5335 55361 79837 80271 8394 8525 8871 89869
Etoposide rep2	FDA approved	Endocytosis	path:04144_15	5	6.220763	0.02092511	WWP1 ERBB3 CBLC ITCH CBLB	11059 2065 23624 83737 868
Etoposide rep2	FDA approved	PI3K-Akt signaling pathway	path:04151_67	5	8.838602	0	ITGA2B ITGA5 ITGB3 ITGB5 PTK2	3674 3678 3690 3693 5747
Etoposide rep2	FDA approved	AMPK signaling pathway	path:04152_29	5	6.191163	0.02092511	MTOR PPARG PRKAG1 RPS6KB1 ULK1	2475 5468 5571 6198 8408
Etoposide rep2	FDA approved	Hippo signaling pathway	path:04390_33	6	6.0662	0.023127753	CSNK1E SERPINE1 PPP1CA PPP2R1A YWHAB YWHAZ	1454 5054 5499 5518 7529 7534
Etoposide rep2	FDA approved	Adherens junction	path:04520_8	8	5.915445	0.030837004	CTNNB1 CTNND1 ERBB2 RHOA MAPK1 RAC2 SRC FARP2	1499 1500 2064 387 5594 5880 6714 9855
Etoposide rep2	FDA approved	Jak-STAT signaling pathway	path:04630_66	11	6.53455	0.013215859	CBLC IL19 IFNG IL6 LEPR MPL OSM IL21R STAT3 CBLB SOCS3	23624 29949 3458 3569 3953 4352 5008 50615 6774 868 9021
Etoposide rep2	FDA approved	Prolactin signaling pathway	path:04917_4	6	5.863928	0.039647577	MAPK14 FOS MAPK1 MAPK8 MAPK13 CCND1	1432 2353 5594 5599 5603 595
Etoposide rep2	FDA approved	HTLV-I infection	path:05166_2	6	6.832424	0.00660793	AKT3 CHUK CTNNB1 GSK3B PIK3CB PIK3CG	10000 1147 1499 2932 5291 5294
Etoposide rep2	FDA approved	Prostate cancer	path:05215_7	6	5.980048	0.026431718	AKT3 ERBB2 FGFR1 PIK3CB PIK3CG PDGFD	10000 2064 2260 5291 5294 80310
Everolimus	FDA approved	Purine metabolism	path:00230_108	6	7.862056	0.002207506	POLR3G ADCY2 NPR1 NPR2 POLR1D PDE3B	10622 108 4881 4882 51082 5140
Everolimus	FDA approved	PPAR signaling pathway	path:03320_14	17	6.347696	0.035320088	NR1H3 SORBS1 CYP27A1 FABP1 ACSL1 ACSL3 ACAA1 ACADM ILK LPL PCK2 ANGPTL4 ACSL5 PLIN1 RXRB RXRG SCD	10062 10580 1593 2168 2180 2181 30 34 3611 4023 5106 51129 51703 5346 6257 6258 6319
Everolimus	FDA approved	MAPK signaling pathway	path:04010_22	8	6.130405	0.04415011	CRKL DUSP1 DUSP8 HSPA1A MAPK11 MAPK10 PTPN7 PTPN5	1399 1843 1850 3303 5600 5602 5778 84867
Everolimus	FDA approved	Rap1 signaling pathway	path:04015_56	19	7.583543	0.005518764	CRKL CSF1 EFNA4 FGF2 FGF5 FGF13 FGFR1 FLT1 FGF20 ANGPT2 HGF IGF1R INSR PDGFA PDGFB PDGFRA PLCB2 PDGFC VEGFC	1399 1435 1945 2247 2250 2258 2260 2321 26281 285 3082 3480 3643 5154 5155 5156 5330 56034 7424
Everolimus	FDA approved	FoxO signaling pathway	path:04068_71	16	6.335551	0.036423841	CDK2 PLK2 MAPK14 S1PR1 SGK3 IL7R FOXO4 GADD45B PCK2 PRKAA2 PRKAB1 PRKAB2 MAPK1 MAPK10 BNIP3 STK4	1017 10769 1432 1901 23678 3575 4303 4616 5106 5563 5564 5565 5594 5602 664 6789
Everolimus	FDA approved	p53 signaling pathway	path:04115_19	9	6.609832	0.022075055	RCHY1 FAS GADD45B RRM2B SHISA5 PIDD1 THBS1 TP53 TP73	25898 355 4616 50484 51246 55367 7057 7157 7161
Everolimus	FDA approved	PI3K-Akt signaling pathway	path:04151_68	3	6.986271	0.009933775	ITGAV ITGB3 THBS1	3685 3690 7057
Everolimus	FDA approved	TGF-beta signaling pathway	path:04350_3	3	6.497697	0.028697572	TGFB2 TGFB3 THBS1	7042 7043 7057
Everolimus	FDA approved	Focal adhesion	path:04510_77	4	8.298305	0	FLNA ITGB3 THBS1 TLN2	2316 3690 7057 83660
Everolimus	FDA approved	Choline metabolism in cancer	path:05231_7	7	6.202965	0.040838852	CHKA FOS PDGFA PDGFB PDGFRA PIK3CB PDGFC	1119 2353 5154 5155 5156 5291 56034
Floxuridine rep1	FDA approved	Purine metabolism	path:00230_109	9	6.804844	0.006651885	POLD3 NME1 POLR1D POLE3 POLE POLR2D POLR2F PRIM2 ENTPD6	10714 4830 51082 54107 5426 5433 5435 5558 955
Floxuridine rep1	FDA approved	Pyrimidine metabolism	path:00240_73	6	6.778625	0.006651885	POLR3H NME1 POLR2C POLR2D POLR2F POLR1C	171568 4830 5432 5433 5435 9533
Floxuridine rep1	FDA approved	MAPK signaling pathway	path:04010_23	6	7.579613	0	DUSP1 DUSP3 DUSP4 DUSP6 MAPK1 MAPK10	1843 1845 1846 1848 5594 5602
Floxuridine rep1	FDA approved	Rap1 signaling pathway	path:04015_57	8	5.960105	0.034368071	CRK EPHA2 RAPGEF1 AFDN PLCE1 RAP1B PIK3R3 SKAP1	1398 1969 2889 4301 51196 5908 8503 8631
Floxuridine rep1	FDA approved	Cell cycle	path:04110_8	9	6.094954	0.028824834	CDC26 ANAPC4 ANAPC11 CDC14B CDC23 CDC16 CCNB1 CDC20 CDC27	246184 29945 51529 8555 8697 8881 891 991 996
Floxuridine rep1	FDA approved	Adrenergic signaling in cardiomyocytes	path:04261_22	11	6.135775	0.026607539	CACNG5 CACNG4 PPP1CC PPP2CA PPP2CB PPP2R1A PRKACA CACNG7 CACNA2D1 CACNB1 CACNB3	27091 27092 5501 5515 5516 5518 5566 59284 781 782 784
Floxuridine rep1	FDA approved	Hedgehog signaling pathway	path:04340_4	3	5.929133	0.034368071	CSNK1E PRKACA BTRC	1454 5566 8945
Floxuridine rep1	FDA approved	Focal adhesion	path:04510_78	6	6.743927	0.006651885	FLNC ITGA2B ITGA5 ITGB3 PRKCA VASP	2318 3674 3678 3690 5578 7408
Floxuridine rep1	FDA approved	Jak-STAT signaling pathway	path:04630_67	6	5.746881	0.045454545	EPOR IFNG IL9 LIF MPL IL22	2057 3458 3578 3976 4352 50616
Floxuridine rep1	FDA approved	Long-term depression	path:04730_3	7	6.068019	0.029933481	PPP2CA PPP2CB PPP2R1A PRKCA MAPK1 MAP2K2 PLA2G4C	5515 5516 5518 5578 5594 5605 8605
Floxuridine rep1	FDA approved	Pathways in cancer	path:05200_37	8	6.159626	0.026607539	CRK CRKL FLT3 ABL1 GRB2 STAT5A STAT5B PIK3R3	1398 1399 2322 25 2885 6776 6777 8503
Floxuridine rep2	FDA approved	Purine metabolism	path:00230_110	17	7.754232	0.002178649	AK1 NT5C2 APRT IMPDH2 ENTPD8 NME4 PDE6C POLR2A POLR2C POLR2D POLR2G POLR3B RRM2 POLR1E POLR3D ENTPD2 ENTPD5	203 22978 353 3615 377841 4833 5146 5430 5432 5433 5436 55703 6241 64425 661 954 957
Floxuridine rep2	FDA approved	Pyrimidine metabolism	path:00240_74	24	8.312829	0.001089325	POLR3F POLD3 POLR3A CTPS1 NT5C2 ENTPD8 NME1 NME4 POLR1D CMPK1 POLE3 POLR2A POLR2C POLR2D UCKL1 PRIM1 POLR3B RRM2 POLR1E POLR3D TK2 UCK2 ENTPD3 ENTPD5	10621 10714 11128 1503 22978 377841 4830 4833 51082 51727 54107 5430 5432 5433 54963 5557 55703 6241 64425 661 7084 7371 956 957
Floxuridine rep2	FDA approved	cGMP-PKG signaling pathway	path:04022_24	9	6.322497	0.026143791	MRVI1 MYL9 ATP1B1 ATP1B2 PPP1CB PRKG1 SLC8A2 TRPC6 CACNA1F	10335 10398 481 482 5500 5592 6543 7225 778
Floxuridine rep2	FDA approved	FoxO signaling pathway	path:04068_72	23	6.825314	0.010893246	AKT3 BCL2L11 SGK2 CDKN2B GADD45G CHUK FOXO1 FOXO3 SGK3 IL7R PCK1 NLK PLK1 PRKAB1 MAPK11 MAPK10 RAG2 RBL2 CCND1 BNIP3 STK4 SETD7 CCNG2	10000 10018 10110 1030 10912 1147 2308 2309 23678 3575 5105 51701 5347 5564 5600 5602 5897 5934 595 664 6789 80854 901
Floxuridine rep2	FDA approved	Sphingolipid signaling pathway	path:04071_17	7	5.883034	0.045751634	GNA13 S1PR3 PIK3R5 GNAI2 GNAQ OPRD1 PIK3R3	10672 1903 23533 2771 2776 4985 8503
Floxuridine rep2	FDA approved	Tight junction	path:04530_10	4	6.257761	0.027233115	MYL9 RHOA AFDN PRKCQ	10398 387 4301 5588
Fludarabine rep1	FDA approved	Purine metabolism	path:00230_111	9	6.71143	0.012222222	NME6 ADCY1 ADCY8 PDE1C POLE POLR2A POLR2C PRIM1 POLR1B	10201 107 114 5137 5426 5430 5432 5557 84172
Fludarabine rep1	FDA approved	Tyrosine metabolism	path:00350_1	6	5.723345	0.048888889	DDC IL4I1 GOT1 GOT2 HPD TAT	1644 259307 2805 2806 3242 6898
Fludarabine rep1	FDA approved	Glycerophospholipid metabolism	path:00564_15	7	5.917106	0.037777778	CDS1 DGKG PLD3 PLA2G3 CHPT1 PLA2G4C PCYT1B	1040 1608 23646 50487 56994 8605 9468
Fludarabine rep1	FDA approved	Calcium signaling pathway	path:04020_49	12	6.933241	0.008888889	CHRNA7 ATP2A1 ATP2A2 P2RX7 RYR2 SLC8A2 TNNC1 VDAC1 CACNA1D ORAI2 CALM3 P2RX6	1139 487 488 5027 6262 6543 7134 7416 776 80228 808 9127
Fludarabine rep1	FDA approved	cAMP signaling pathway	path:04024_25	8	6.564139	0.012222222	ADCYAP1R1 GPR119 EDNRA HCAR1 GNAI2 NPY SSTR2 HCAR3	117 139760 1909 27198 2771 4852 6752 8843
Fludarabine rep1	FDA approved	FoxO signaling pathway	path:04068_73	19	5.723304	0.048888889	AKT3 BCL2L11 PLK4 GADD45G GABARAP CHUK FOXO3 GABARAPL1 IKBKB PLK1 PRKAB1 PRKAB2 MAPK11 MAPK10 RBL2 BNIP3 SETD7 CCNB3 ATG12	10000 10018 10733 10912 11337 1147 2309 23710 3551 5347 5564 5565 5600 5602 5934 664 80854 85417 9140
Fludarabine rep1	FDA approved	Cell cycle	path:04110_9	6	5.856068	0.038888889	GADD45G MAD2L1 ANAPC5 PLK1 ANAPC1 CCNB3	10912 4085 51433 5347 64682 85417
Fludarabine rep1	FDA approved	Glutamatergic synapse	path:04724_28	9	6.224207	0.022222222	ADCY1 ADCY2 GNAO1 GNB3 GRIK1 GRIN2C GRM1 GRM2 GRM6	107 108 2775 2784 2897 2905 2911 2912 2916
Fludarabine rep2	FDA approved	Purine metabolism	path:00230_112	14	7.177394	0.002239642	POLR3F ADCY2 NT5C3B ADSL DCK GUK1 NME4 AK3 POLE POLR2A POLR2B POLR2C PDE5A ENTPD1	10621 108 115024 158 1633 2987 4833 50808 5426 5430 5431 5432 8654 953
Fludarabine rep2	FDA approved	Pyrimidine metabolism	path:00240_75	8	6.635396	0.01343785	NT5C3B UPRT CTPS1 NME4 POLE PRIM1 UCK2 ENTPD4	115024 139596 1503 4833 5426 5557 7371 9583
Fludarabine rep2	FDA approved	Calcium signaling pathway	path:04020_50	10	5.927693	0.033594625	ITPR1 ATP2A3 ATP2B4 P2RX5 PLCB2 PLCG1 PRKCB PRKCG TNNC1 CALM3	3708 489 493 5026 5330 5335 5579 5582 7134 808
Fludarabine rep2	FDA approved	cAMP signaling pathway	path:04024_26	10	7.386254	0.001119821	RAPGEF3 ADCY2 ADCYAP1R1 GPR119 GABBR1 GNAI2 SSTR5 CAMK4 CAMK2G HCAR3	10411 108 117 139760 2550 2771 6755 814 818 8843
Fludarabine rep2	FDA approved	Chemokine signaling pathway	path:04062_58	6	5.880143	0.034714446	CCR3 GNAI2 CXCL8 ARRB2 CCL8 CCL18	1232 2771 3576 409 6355 6362
Fludarabine rep2	FDA approved	AMPK signaling pathway	path:04152_30	5	5.666975	0.048152296	GYS1 GYS2 PFKFB1 PFKFB3 PRKAB1	2997 2998 5207 5209 5564
Fludarabine rep2	FDA approved	Jak-STAT signaling pathway	path:04630_68	7	6.014171	0.032474804	CBLC JAK2 MPL PTPN11 STAT3 STAT5A CBL	23624 3717 4352 5781 6774 6776 867
Fludarabine rep2	FDA approved	Circadian entrainment	path:04713_31	9	6.734299	0.008958567	ADCY2 ADCYAP1R1 GNAI1 GNAI2 GNB1 GNG4 GNGT2 PLCB2 GNB4	108 117 2770 2771 2782 2786 2793 5330 59345
Fludarabine rep2	FDA approved	Serotonergic synapse	path:04726_24	7	5.822025	0.038073908	GNAI2 GNB1 GNG4 GNGT2 ITPR1 PLCB2 GNB4	2771 2782 2786 2793 3708 5330 59345
Fludarabine rep2	FDA approved	GABAergic synapse	path:04727_20	8	5.796138	0.039193729	ADCY2 GABBR1 GABRG3 GNAI2 GNB1 GNG4 GNGT2 GNB4	108 2550 2567 2771 2782 2786 2793 59345
Fludarabine rep2	FDA approved	Dopaminergic synapse	path:04728_36	6	6.879855	0.007838746	PLCB2 PPP3CB PRKCB PRKCG CALM3 CREB5	5330 5532 5579 5582 808 9586
Fludarabine rep2	FDA approved	Long-term depression	path:04730_4	9	5.665241	0.048152296	CRHR1 PLCB1 GNAI1 GNAI2 IGF1R PLCB2 PPP2R1A PRKCG PLA2G4C	1394 23236 2770 2771 3480 5330 5518 5582 8605
Fludarabine rep2	FDA approved	Oxytocin signaling pathway	path:04921_22	6	6.530131	0.015677492	PLCB2 PPP3CA PPP3CB PRKCG RAF1 CALML3	5330 5530 5532 5582 5894 810
Fludarabine rep2	FDA approved	Morphine addiction	path:05032_23	10	6.378112	0.023516237	ADCY2 GABBR1 GABRG3 GNAI2 GNB1 GNG4 GNGT2 PRKCB PRKCG GNB4	108 2550 2567 2771 2782 2786 2793 5579 5582 59345
Fludarabine rep3	FDA approved	cAMP signaling pathway	path:04024_27	9	6.922654	0.006772009	ADCYAP1R1 ADORA2A GPR119 ADRB2 DRD2 GABBR1 GNAI2 NPY OXTR	117 135 139760 154 1813 2550 2771 4852 5021
Fludarabine rep3	FDA approved	Chemokine signaling pathway	path:04062_59	9	7.22206	0.004514673	ADCY6 GNAI2 GNGT2 CCL28 CXCL16 CXCL6 CXCL5 CXCL12 CXCR5	112 2771 2793 56477 58191 6372 6374 6387 643
Fludarabine rep3	FDA approved	HIF-1 signaling pathway	path:04066_20	9	5.922627	0.0496614	CREBBP ALDOA HMOX1 PGK1 SLC2A1 VEGFA HKDC1 CAMK2D CAMK2G	1387 226 3162 5230 6513 7422 80201 817 818
Fludarabine rep3	FDA approved	Phosphatidylinositol signaling system	path:04070_52	6	6.853561	0.007900677	INPP5J ITPKA ITPR1 PLCB2 ITPKC CALML3	27124 3706 3708 5330 80271 810
Fludarabine rep3	FDA approved	Wnt signaling pathway	path:04310_15	3	6.48415	0.016930023	PLCB2 PLCB3 CAMK2D	5330 5331 817
Fludarabine rep3	FDA approved	Platelet activation	path:04611_14	6	6.371342	0.020316027	AKT3 ADCY6 GNAI2 PIK3CD BTK PIK3R3	10000 112 2771 5293 695 8503
Fludarabine rep3	FDA approved	Jak-STAT signaling pathway	path:04630_69	8	6.996176	0.005643341	CBLC IL2RA IL6R IL12RB2 LIF OSM SOCS1 CBL	23624 3559 3570 3595 3976 5008 8651 867
Fludarabine rep3	FDA approved	Serotonergic synapse	path:04726_25	7	5.988675	0.045146727	GNAI2 GNGT2 ITPR1 ITPR3 PLCB2 PLCB3 GNB4	2771 2793 3708 3710 5330 5331 59345
Fludarabine rep3	FDA approved	Dopaminergic synapse	path:04728_37	6	6.859549	0.007900677	DRD2 GNAI2 GNG5 GNGT2 PLCB2 GNB4	1813 2771 2787 2793 5330 59345
Fludarabine rep3	FDA approved	Oxytocin signaling pathway	path:04921_23	7	7.245225	0.003386005	ADCY6 GNAI2 ITPR1 OXTR PLCB2 PLCB3 PIK3R3	112 2771 3708 5021 5330 5331 8503
Fludarabine rep3	FDA approved	Pathways in cancer	path:05200_38	3	6.141401	0.03724605	GLI1 GLI3 HHIP	2735 2737 64399
Fludarabine rep3	FDA approved	Basal cell carcinoma	path:05217_2	3	6.038238	0.042889391	GLI1 GLI3 HHIP	2735 2737 64399
Fluorouracil rep1	FDA approved	Purine metabolism	path:00230_113	7	6.755216	0.00780379	ADCY8 AK8 AK5 AMPD2 PDE4B PDE4D PDE8B	114 158067 26289 271 5142 5144 8622
Fluorouracil rep1	FDA approved	Glutathione metabolism	path:00480_7	10	5.539476	0.04793757	GSTO2 GSTA5 GGT1 GGT5 GPX7 GSR GSTM1 GSTM2 GSTM3 GSTM5	119391 221357 2678 2687 2882 2936 2944 2946 2947 2949
Fluorouracil rep1	FDA approved	Arachidonic acid metabolism	path:00590_7	13	5.955416	0.02787068	CYP2C19 CYP2C8 CYP2E1 CYP2J2 EPHX2 ALOX12B ALOX15 ALOX15B GPX6 GPX7 PTGS1 CYP4F2 PLA2G4C	1557 1558 1571 1573 2053 242 246 247 257202 2882 5742 8529 8605
Fluorouracil rep1	FDA approved	Ras signaling pathway	path:04014_46	21	6.682285	0.008918618	CSF1 EFNA3 EFNA4 EGFR FGF3 FGF6 FGF8 FGFR1 FGFR3 FGF20 FGF21 ANGPT2 INSR SHC4 PDGFRB SHC3 PDGFC TEK VEGFC FGF23 FGF17	1435 1944 1945 1956 2248 2251 2253 2260 2261 26281 26291 285 3643 399694 5159 53358 56034 7010 7424 8074 8822
Fluorouracil rep1	FDA approved	Calcium signaling pathway	path:04020_51	11	6.001935	0.02787068	GRIN2D ATP2B4 P2RX1 P2RX4 P2RX7 SLC8A2 SLC8A3 VDAC3 CACNA1A CACNA1S SLC25A31	2906 493 5023 5025 5027 6543 6547 7419 773 779 83447
Fluorouracil rep1	FDA approved	cAMP signaling pathway	path:04024_28	12	5.688762	0.041248606	CHRM2 ADORA2A GPR119 ADRB2 EDNRA FSHR GNAI3 HTR6 NPY OXTR PTGER3 GABBR2	1129 135 139760 154 1909 2492 2773 3362 4852 5021 5733 9568
Fluorouracil rep1	FDA approved	Chemokine signaling pathway	path:04062_60	8	5.893587	0.031215162	ADCY6 CX3CR1 FGR GNAI3 GNG5 SHC3 GNG12 PIK3R3	112 1524 2268 2773 2787 53358 55970 8503
Fluorouracil rep1	FDA approved	FoxO signaling pathway	path:04068_74	14	5.876375	0.031215162	GABARAPL2 CHUK GADD45A FOXO3 IKBKB GADD45B NLK PRKAA2 MAPK3 G6PC2 CCND1 SETD7 CCNB3 CCNB1	11345 1147 1647 2309 3551 4616 51701 5563 5595 57818 595 80854 85417 891
Fluorouracil rep1	FDA approved	Cell cycle	path:04110_10	9	5.879836	0.031215162	GADD45A CDC26 ANAPC2 ANAPC5 PLK1 CDC14B CDC14A CCNB1 CDC20	1647 246184 29882 51433 5347 8555 8556 891 991
Fluorouracil rep1	FDA approved	Endocytosis	path:04144_16	10	6.59438	0.012263099	EGFR EPS15 FGFR3 EPN2 CBLC SH3KBP1 SH3GLB1 SH3GLB2 SH3GL2 ITCH	1956 2060 2261 22905 23624 30011 51100 56904 6456 83737
Fluorouracil rep1	FDA approved	Adrenergic signaling in cardiomyocytes	path:04261_23	10	6.177105	0.023411371	PPP1CB PPP2CB PPP2R1A PPP2R2A PRKACB CACNA1S CACNB3 CACNB4 CACNG1 CAMK2A	5500 5516 5518 5520 5567 779 784 785 786 815
Fluorouracil rep1	FDA approved	Hippo signaling pathway	path:04390_34	5	6.053002	0.026755853	PPP2CB PPP2R1A PPP2R2A YWHAE BTRC	5516 5518 5520 7531 8945
Fluorouracil rep1	FDA approved	Focal adhesion	path:04510_79	5	5.895527	0.031215162	FLNA ITGA5 ITGB3 TLN1 TLN2	2316 3678 3690 7094 83660
Fluorouracil rep1	FDA approved	Jak-STAT signaling pathway	path:04630_70	14	5.965949	0.02787068	CNTFR CSF3R CBLC IFNG IFNGR2 IL2RG IL5 IL6ST IL11RA IL12B IL12RB2 JAK2 LEP MPL	1271 1441 23624 3458 3460 3561 3567 3572 3590 3593 3595 3717 3952 4352
Fluorouracil rep1	FDA approved	Circadian entrainment	path:04713_32	14	6.241845	0.021181717	ADCY5 ADCY6 ADCY8 ADCYAP1R1 GNAI3 GNG5 GNG7 GNG11 MTNR1A MTNR1B PRKACB ADCY10 MAPK3 GNG12	111 112 114 117 2773 2787 2788 2791 4543 4544 5567 55811 5595 55970
Fluorouracil rep1	FDA approved	Cholinergic synapse	path:04725_39	9	5.985932	0.02787068	ADCY5 CHRM4 ADCY8 GNAI3 GNG5 GNG11 GNG12 CACNA1A PIK3R3	111 1132 114 2773 2787 2791 55970 773 8503
Fluorouracil rep1	FDA approved	Serotonergic synapse	path:04726_26	8	5.792551	0.033444816	ADCY5 GNAI3 GNG5 GNG7 GNG11 GNG12 PTGS1 CACNA1A	111 2773 2787 2788 2791 55970 5742 773
Fluorouracil rep1	FDA approved	GABAergic synapse	path:04727_21	10	6.008894	0.02787068	ADCY5 GNAI3 GNG5 GNG7 GNG11 PRKACB GNG12 CACNA1A CACNA1S GABBR2	111 2773 2787 2788 2791 5567 55970 773 779 9568
Fluorouracil rep1	FDA approved	Morphine addiction	path:05032_24	9	5.840815	0.032329989	ADCY5 GNAI3 GNG5 GNG7 GNG11 PRKACB GNG12 CACNA1A GABBR2	111 2773 2787 2788 2791 5567 55970 773 9568
Fluorouracil rep2	FDA approved	Purine metabolism	path:00230_114	10	6.044868	0.026229508	ADCY9 AMPD2 AMPD3 ATIC PNP NT5E PDE1C PDE6C PDE1B PDE5A	115 271 272 471 4860 4907 5137 5146 5153 8654
Fluorouracil rep2	FDA approved	Pyrimidine metabolism	path:00240_76	9	5.681273	0.042622951	ZNRD1 NME3 NT5E POLR1D PRIM1 RRM2 DCTPP1 PNPT1 ENTPD3	30834 4832 4907 51082 5557 6241 79077 87178 956
Fluorouracil rep2	FDA approved	Glutathione metabolism	path:00480_8	9	6.066837	0.025136612	GSTO2 GPX6 GGT7 GCLM GPX7 GSR GSTM1 GSTM2 GSTM3	119391 257202 2686 2730 2882 2936 2944 2946 2947
Fluorouracil rep2	FDA approved	cAMP signaling pathway	path:04024_29	17	6.551512	0.013114754	ADCYAP1R1 GPR119 ADRB1 ADRB2 FSHR HCAR1 GNAI3 HTR1E HTR4 NPY1R OXTR PTGER3 SSTR2 SSTR5 VIPR2 HCAR3 GABBR2	117 139760 153 154 2492 27198 2773 3354 3360 4886 5021 5733 6752 6755 7434 8843 9568
Fluorouracil rep2	FDA approved	mTOR signaling pathway	path:04150_8	7	6.519467	0.01420765	MTOR PRKAA2 PRKCB MAPK3 RPS6KB1 TSC2 ULK1	2475 5563 5579 5595 6198 7249 8408
Fluorouracil rep2	FDA approved	Focal adhesion	path:04510_80	9	7.281298	0.004371585	FLNA ITGAV ITGB3 PRKCB SRC THBS1 TLN1 TLN2 CAV3	2316 3685 3690 5579 6714 7057 7094 83660 859
Fluorouracil rep2	FDA approved	Jak-STAT signaling pathway	path:04630_71	7	6.333402	0.020765027	CTF1 IFNG IL5RA IL6ST IL12RB2 LEPR STAM	1489 3458 3568 3572 3595 3953 8027
Fluorouracil rep2	FDA approved	Natural killer cell mediated cytotoxicity	path:04650_8	5	5.606997	0.048087432	LAT SHC4 RAC3 SYK PIK3R3	27040 399694 5881 6850 8503
Fluorouracil rep2	FDA approved	Circadian entrainment	path:04713_33	9	7.315441	0.004371585	ADCY9 PLCB1 GNAI3 GNG5 GNG11 MTNR1B PRKCB MAPK3 GNG12	115 23236 2773 2787 2791 4544 5579 5595 55970
Fluorouracil rep2	FDA approved	Retrograde endocannabinoid signaling	path:04723_28	8	6.763941	0.010928962	ADCY9 GNAI3 GNG5 GNG11 PRKACB MAPK3 GNG12 MAPK12	115 2773 2787 2791 5567 5595 55970 6300
Fluorouracil rep2	FDA approved	Glutamatergic synapse	path:04724_29	6	6.800348	0.010928962	ADCY9 GNAI3 GNG5 GNG11 GRM7 GNG12	115 2773 2787 2791 2917 55970
Fluorouracil rep2	FDA approved	Cholinergic synapse	path:04725_40	5	6.328186	0.020765027	ADCY9 GNAI3 GNG5 GNG11 GNG12	115 2773 2787 2791 55970
Fluorouracil rep2	FDA approved	Serotonergic synapse	path:04726_27	8	6.221399	0.02295082	PLCB1 GNAI3 GNG5 GNG11 HTR1E HTR4 GNG12 GNB4	23236 2773 2787 2791 3354 3360 55970 59345
Fluorouracil rep2	FDA approved	GABAergic synapse	path:04727_22	7	6.124722	0.025136612	GABARAPL2 GABRA1 GABRA3 GABRA6 GABRB2 GABRE GABBR2	11345 2554 2556 2559 2561 2564 9568
Fluorouracil rep2	FDA approved	Dopaminergic synapse	path:04728_38	6	6.301819	0.020765027	PLCB1 GNAI3 GNG5 GNG11 PRKCB GNG12	23236 2773 2787 2791 5579 55970
Fluorouracil rep2	FDA approved	Oxytocin signaling pathway	path:04921_24	8	5.823994	0.038251366	ADCY9 EGFR PLCB1 GNAI3 OXTR PRKACB PRKCB SRC	115 1956 23236 2773 5021 5567 5579 6714
Fluorouracil rep2	FDA approved	Morphine addiction	path:05032_25	9	7.130007	0.005464481	ADCY9 GNAI3 GNG5 GNG11 PRKACB PRKCB GNG12 PRKX GABBR2	115 2773 2787 2791 5567 5579 55970 5613 9568
Gefitinib rep1	FDA approved	mRNA surveillance pathway	path:03015_1	3	6.751831	0.011074197	SMG6 PPP2CA PPP2R5A	23293 5515 5525
Gefitinib rep1	FDA approved	MAPK signaling pathway	path:04010_24	8	6.423753	0.026578073	DUSP10 DUSP5 DUSP7 ELK1 MAPK3 MAPK9 MAP2K2 SRF	11221 1847 1849 2002 5595 5601 5605 6722
Gefitinib rep1	FDA approved	Ras signaling pathway	path:04014_47	9	5.912702	0.048726467	RALBP1 RHOA NF1 NRAS PIK3CA RGL2 RAC1 RASGRF1 SYNGAP1	10928 387 4763 4893 5290 5863 5879 5923 8831
Gefitinib rep1	FDA approved	Sphingolipid signaling pathway	path:04071_18	7	6.323351	0.029900332	AKT3 MAPK14 PPP2R3C PPP2CA PPP2R1A PPP2R5A PPP2R5D	10000 1432 55012 5515 5518 5525 5528
Gefitinib rep1	FDA approved	Adrenergic signaling in cardiomyocytes	path:04261_24	8	6.365464	0.027685493	PPP1CC PPP2R3C PPP2CA PPP2R1A PPP2R5A PPP2R5D CACNA2D3 CACNA2D1	5501 55012 5515 5518 5525 5528 55799 781
Gefitinib rep1	FDA approved	Signaling pathways regulating pluripotency of stem cells	path:04550_3	6	5.943589	0.047619048	MAPK14 SMAD4 MAPK3 MAP2K2 BMPR2 ACVR1	1432 4089 5595 5605 659 90
Gefitinib rep1	FDA approved	Long-term depression	path:04730_5	8	5.985329	0.042081949	NRAS PPP2CA PPP2R1A PRKCB MAPK3 MAP2K2 RAF1 CACNA1A	4893 5515 5518 5579 5595 5605 5894 773
Gefitinib rep2	FDA approved	Fructose and mannose metabolism	path:00051_3	10	5.606222	0.027777778	ALDOC HK2 HK3 KHK PFKFB3 PFKL PFKM PFKP PMM1 TPI1	230 3099 3101 3795 5209 5211 5213 5214 5372 7167
Gefitinib rep2	FDA approved	Pyrimidine metabolism	path:00240_77	7	5.43275	0.034444444	POLR3F POLR2J2 NME3 POLR2C POLR2F POLR2J POLR3D	10621 246721 4832 5432 5435 5439 661
Gefitinib rep2	FDA approved	HIF-1 signaling pathway	path:04066_21	9	5.658534	0.025555556	CREBBP ENO2 HK2 HK3 PFKFB3 PFKL TFRC VEGFA CAMK2A	1387 2026 3099 3101 5209 5211 7037 7422 815
Gefitinib rep2	FDA approved	Jak-STAT signaling pathway	path:04630_72	9	5.96818	0.016666667	IFNAR1 IFNAR2 IL5 IL10RA IL15 JAK2 IL20RB IL21 CBLB	3454 3455 3567 3587 3600 3717 53833 59067 868
Gemcitabine	FDA approved	Purine metabolism	path:00230_115	25	7.089812	0.002197802	POLR3A ADCY7 CANT1 NUDT16 AK1 AK9 NT5C2 GUCY2F ENTPD8 NME1 NME4 PDE6C PDE6G PDE6B POLD2 POLR2A POLR2C POLR2D POLR2G POLR2H POLR3B POLR3D PDE5A ENTPD1 ENTPD2	11128 113 124583 131870 203 221264 22978 2986 377841 4830 4833 5146 5148 5158 5425 5430 5432 5433 5436 5437 55703 661 8654 953 954
Gemcitabine	FDA approved	Pyrimidine metabolism	path:00240_78	13	5.750362	0.040659341	CANT1 CTPS1 ENTPD8 NME1 NME4 POLR2A POLR2C POLR2D POLR2H UCKL1 POLR3B POLR3D TYMS	124583 1503 377841 4830 4833 5430 5432 5433 5437 54963 55703 661 7298
Gemcitabine	FDA approved	Chemokine signaling pathway	path:04062_61	8	6.250492	0.01978022	AKT3 PIK3R5 GNAI3 GNB3 GNG13 GNB4 CXCR4 PIK3R3	10000 23533 2773 2784 51764 59345 7852 8503
Gemcitabine	FDA approved	PI3K-Akt signaling pathway	path:04151_69	8	6.013232	0.028571429	AKT3 GNB5 CHRM1 PIK3R5 GNB3 LPAR4 PDPK1 RPS6KB1	10000 10681 1128 23533 2784 2846 5170 6198
Gemcitabine	FDA approved	Glutamatergic synapse	path:04724_30	8	6.545237	0.013186813	GNB3 GRIA1 GRIK1 GRIN2A GRM2 GRM4 GNG13 GNB4	2784 2890 2897 2903 2912 2914 51764 59345
Gemcitabine	FDA approved	Regulation of actin cytoskeleton	path:04810_34	3	6.053964	0.026373626	CRK ITGA5 ITGAM	1398 3678 3684
Homoharringtonine rep1	FDA approved	Glycolysis / Gluconeogenesis	path:00010_2	4	6.025207	0.041125541	ALDOC GPI PFKL PGM2	230 2821 5211 55276
Homoharringtonine rep1	FDA approved	Citrate cycle (TCA cycle)	path:00020_3	7	5.914366	0.046536797	CS DLAT DLD IDH3A IDH3G MDH2 OGDH	1431 1737 1738 3419 3421 4191 4967
Homoharringtonine rep1	FDA approved	Pentose phosphate pathway	path:00030_1	4	6.162526	0.035714286	ALDOC G6PD GPI PFKL	230 2539 2821 5211
Homoharringtonine rep1	FDA approved	Purine metabolism	path:00230_116	6	6.137155	0.035714286	PDE10A AMPD3 GUK1 ITPA NT5E PDE3B	10846 272 2987 3704 4907 5140
Homoharringtonine rep1	FDA approved	Lysine degradation	path:00310_4	3	6.104264	0.036796537	KMT2E KMT2C PLOD3	55904 58508 8985
Homoharringtonine rep1	FDA approved	Sphingolipid metabolism	path:00600_11	5	6.234348	0.035714286	CERS1 GALC GLA SPHK2 SGPP1	10715 2581 2717 56848 81537
Homoharringtonine rep1	FDA approved	Ras signaling pathway	path:04014_48	19	7.200909	0.004329004	AKT3 RALBP1 RASSF1 AKT2 RRAS2 PIK3R5 KRAS PIK3CG PIK3R1 PIK3R2 BAD RALGDS RASGRF2 SOS2 BRAP RASAL1 IKBKG RASAL2 RIN1	10000 10928 11186 208 22800 23533 3845 5294 5295 5296 572 5900 5924 6655 8315 8437 8517 9462 9610
Homoharringtonine rep1	FDA approved	Chemokine signaling pathway	path:04062_62	9	6.432486	0.023809524	AKT3 GNB2 GNG3 GNG11 GNGT1 KRAS PIK3CG PIK3R1 PIK3R2	10000 2783 2785 2791 2792 3845 5294 5295 5296
Homoharringtonine rep1	FDA approved	PI3K-Akt signaling pathway	path:04151_70	7	6.236598	0.035714286	AKT3 PIK3CG PPP2CA PPP2R5B PPP2R5E BAD BCL2L1	10000 5294 5515 5526 5529 572 598
Homoharringtonine rep1	FDA approved	Focal adhesion	path:04510_81	3	6.268161	0.032467532	ITGB1 PXN THBS1	3688 5829 7057
Homoharringtonine rep1	FDA approved	Cholinergic synapse	path:04725_41	8	6.334838	0.027056277	AKT3 GNB2 GNG3 GNGT1 KRAS PIK3CG PIK3R1 PIK3R2	10000 2783 2785 2792 3845 5294 5295 5296
Homoharringtonine rep1	FDA approved	Pancreatic cancer	path:05212_13	6	6.019921	0.041125541	AKT3 PIK3R5 KRAS PIK3CG PIK3R1 PIK3R2	10000 23533 3845 5294 5295 5296
Homoharringtonine rep1	FDA approved	Chronic myeloid leukemia	path:05220_10	8	6.093338	0.036796537	AKT3 CRK CRKL CBLC ABL1 MYC PIK3R1 PIK3R2	10000 1398 1399 23624 25 4609 5295 5296
Homoharringtonine rep2	FDA approved	Nicotinate and nicotinamide metabolism	path:00760_4	3	5.590505	0.044742729	NAMPT NNMT NT5E	10135 4837 4907
Homoharringtonine rep2	FDA approved	Rap1 signaling pathway	path:04015_58	13	6.414801	0.013422819	CRK EFNA4 EFNA5 EGFR EPHA2 FGF8 MET NGF PDGFRB PLCB4 TEK VEGFC PDGFD	1398 1945 1946 1956 1969 2253 4233 4803 5159 5332 7010 7424 80310
Homoharringtonine rep2	FDA approved	Calcium signaling pathway	path:04020_52	6	6.492156	0.010067114	ADRA1B GNA11 PLCE1 PLCB4 PRKCB GNA14	147 2767 51196 5332 5579 9630
Homoharringtonine rep2	FDA approved	Chemokine signaling pathway	path:04062_63	6	5.705033	0.03803132	DOCK2 PTK2B FGR ITK PIK3CG PXN	1794 2185 2268 3702 5294 5829
Homoharringtonine rep2	FDA approved	Phosphatidylinositol signaling system	path:04070_53	6	5.982987	0.024608501	PLCE1 PIK3C2A PIK3C3 PIK3CG PLCB4 DGKZ	51196 5286 5289 5294 5332 8525
Homoharringtonine rep2	FDA approved	p53 signaling pathway	path:04115_20	10	5.598194	0.044742729	CHEK2 SESN3 GADD45A MDM4 GADD45B SERPINE1 SIAH1 THBS1 TP53 TNFRSF10B	11200 143686 1647 4194 4616 5054 6477 7057 7157 8795
Homoharringtonine rep2	FDA approved	Hippo signaling pathway	path:04390_35	3	7.909335	0.001118568	SMAD3 SMAD4 SERPINE1	4088 4089 5054
Homoharringtonine rep2	FDA approved	Focal adhesion	path:04510_82	11	5.579859	0.045861298	FLNB ITGA2 ITGB5 PRKCA PRKCB PRKCG PTK2 PXN THBS1 VASP CAV2	2317 3673 3693 5578 5579 5582 5747 5829 7057 7408 858
Homoharringtonine rep2	FDA approved	T cell receptor signaling pathway	path:04660_1	5	5.537981	0.049217002	AKT3 GSK3B NFATC1 NFATC2 PIK3CG	10000 2932 4772 4773 5294
Homoharringtonine rep2	FDA approved	Circadian entrainment	path:04713_34	14	5.712612	0.03803132	ADCY5 ADCY6 ADCY7 ADCY8 ADCY9 GNB2 GNG3 GNG11 GNGT1 PLCB4 PRKACA PRKCB GNG12 PRKX	111 112 113 114 115 2783 2785 2791 2792 5332 5566 5579 55970 5613
Homoharringtonine rep2	FDA approved	Cholinergic synapse	path:04725_42	12	6.339326	0.014541387	ADCY5 ADCY6 ADCY8 ADCY9 GNAO1 GNB2 GNG3 GNG11 GNGT1 PIK3CG GNG12 PRKX	111 112 114 115 2775 2783 2785 2791 2792 5294 55970 5613
Homoharringtonine rep2	FDA approved	Dopaminergic synapse	path:04728_39	7	5.774245	0.033557047	ADCY5 GNAO1 GNB2 GNG11 GNGT1 PLCB4 GNG12	111 2775 2783 2791 2792 5332 55970
Homoharringtonine rep2	FDA approved	Regulation of actin cytoskeleton	path:04810_35	6	5.711669	0.03803132	RRAS2 CYFIP2 PIK3CG RAC3 RRAS VAV2	22800 26999 5294 5881 6237 7410
Homoharringtonine rep2	FDA approved	Estrogen signaling pathway	path:04915_5	8	6.10563	0.022371365	AKT3 CREB3 ADCY6 GNAO1 NOS3 PIK3CG PRKX CREB3L3	10000 10488 112 2775 4846 5294 5613 84699
Homoharringtonine rep2	FDA approved	Oxytocin signaling pathway	path:04921_25	6	5.739274	0.03803132	EGFR GNAO1 PIK3CG PLCB4 PRKCB CALML3	1956 2775 5294 5332 5579 810
Homoharringtonine rep2	FDA approved	Morphine addiction	path:05032_26	12	5.706542	0.03803132	ADCY5 ADCY6 ADCY8 GNAO1 GNB2 GNG3 GNG11 GNGT1 OPRM1 PRKCB GNG12 GABBR2	111 112 114 2775 2783 2785 2791 2792 4988 5579 55970 9568
Homoharringtonine rep2	FDA approved	Proteoglycans in cancer	path:05205_10	6	5.704815	0.03803132	ITGB1 PRKACA PRKX PTK2 PXN SRC	3688 5566 5613 5747 5829 6714
Homoharringtonine rep2	FDA approved	Small cell lung cancer	path:05222_12	3	5.759056	0.036912752	AKT3 PIK3CG PTK2	10000 5294 5747
Homoharringtonine rep2	FDA approved	Choline metabolism in cancer	path:05231_8	6	6.288777	0.014541387	CHKB HIF1A JUN PIK3CG PLD2 RALGDS	1120 3091 3725 5294 5338 5900
Hydroxyurea	FDA approved	Purine metabolism	path:00230_117	9	6.948719	0.004357298	AK1 AMPD3 IMPDH2 ENTPD8 NME1 PDE1B POLR2F POLR3B ENTPD6	203 272 3615 377841 4830 5153 5435 55703 955
Hydroxyurea	FDA approved	Pyrimidine metabolism	path:00240_79	10	6.291788	0.01416122	NME1 NME3 POLE3 POLR2D PRIM1 PRIM2 POLR3B DCTPP1 POLR3GL ENTPD6	4830 4832 54107 5433 5557 5558 55703 79077 84265 955
Hydroxyurea	FDA approved	MAPK signaling pathway	path:04010_25	7	5.720847	0.049019608	DUSP10 DUSP4 DUSP6 NFATC3 MAPK1 MAPK10 PTPN7	11221 1846 1848 4775 5594 5602 5778
Hydroxyurea	FDA approved	cGMP-PKG signaling pathway	path:04022_25	11	5.738738	0.047930283	PLCB1 GTF2I ITPR2 PPP1R12A PLCB2 PPP1CC PRKCE PRKG2 RGS2 SLC8A2 TRPC6	23236 2969 3709 4659 5330 5501 5581 5593 5997 6543 7225
Hydroxyurea	FDA approved	FoxO signaling pathway	path:04068_75	13	5.815899	0.043572985	CDK2 CDKN1B S1PR1 FOXO1 PCK1 PRKAB1 PRKAG1 MAPK1 MAPK10 RBL2 CCND1 BCL6 TNFSF10	1017 1027 1901 2308 5105 5564 5571 5594 5602 5934 595 604 8743
Hydroxyurea	FDA approved	AMPK signaling pathway	path:04152_31	7	6.92362	0.006535948	ADRA1A MTOR GYS1 ACACA PFKFB2 PRKAB1 PRKAG1	148 2475 2997 31 5208 5564 5571
Hydroxyurea	FDA approved	Focal adhesion	path:04510_83	3	6.262231	0.018518519	ITGA5 ITGAV PXN	3678 3685 5829
Hydroxyurea	FDA approved	Adherens junction	path:04520_9	5	6.454275	0.010893246	CSNK2A2 CTNNB1 ERBB2 SRC CDH1	1459 1499 2064 6714 999
Hydroxyurea	FDA approved	Jak-STAT signaling pathway	path:04630_73	3	6.883252	0.006535948	IL21R CCND1 STAT5B	50615 595 6777
Ibrutinib	FDA approved	Purine metabolism	path:00230_118	13	7.428441	0.003318584	POLR3F POLR3H ITPA POLR1D POLR3K POLR2C POLR2D POLR2E POLR2F POLR2I POLR1E POLR1B PNPT1	10621 171568 3704 51082 51728 5432 5433 5434 5435 5438 64425 84172 87178
Ibrutinib	FDA approved	Pyrimidine metabolism	path:00240_80	8	6.163151	0.021017699	POLR3H AK9 POLR1D POLR3K POLR2C POLR2D POLR2G POLR1B	171568 221264 51082 51728 5432 5433 5436 84172
Ibrutinib	FDA approved	Inositol phosphate metabolism	path:00562_15	10	6.112046	0.022123894	INPP1 INPP5A ITPK1 ITPKB PLCE1 INPP5K PI4KA PLCB3 PLCB4 PIP5K1A	3628 3632 3705 3707 51196 51763 5297 5331 5332 8394
Ibrutinib	FDA approved	Glycerophospholipid metabolism	path:00564_16	14	6.004487	0.026548673	AGPAT2 DGKH DGKQ PLA2G15 LCAT PLD2 CRLS1 LPCAT2 AGPAT4 CHPT1 GPAM PLA2G6 CDS2 PTDSS1	10555 160851 1609 23659 3931 5338 54675 54947 56895 56994 57678 8398 8760 9791
Ibrutinib	FDA approved	MAPK signaling pathway	path:04010_26	8	6.678135	0.011061947	DUSP1 DUSP3 DUSP4 DUSP6 DUSP8 MAPK8 MAPK11 PTPN5	1843 1845 1846 1848 1850 5599 5600 84867
Ibrutinib	FDA approved	Rap1 signaling pathway	path:04015_59	12	6.548909	0.014380531	EFNA4 EGFR FGF2 FGFR2 FGFR4 ANGPT4 PDGFA PDGFB PLCB3 PLCB4 PDGFC VEGFB	1945 1956 2247 2263 2264 51378 5154 5155 5331 5332 56034 7423
Ibrutinib	FDA approved	Calcium signaling pathway	path:04020_53	9	6.105938	0.022123894	SLC25A5 ATP2A2 P2RX7 PLCE1 PLCB3 PLCB4 PRKCG VDAC1 CALML3	292 488 5027 51196 5331 5332 5582 7416 810
Ibrutinib	FDA approved	FoxO signaling pathway	path:04068_76	6	6.484105	0.01659292	CHUK AKT2 SGK3 IKBKB FOXO4 PDPK1	1147 208 23678 3551 4303 5170
Ibrutinib	FDA approved	Phosphatidylinositol signaling system	path:04070_54	12	6.673609	0.012168142	DGKH DGKQ PIKFYVE INPP1 INPP5A ITPKB PLCE1 INPP5K PLCB3 PLCB4 PIP5K1A CDS2	160851 1609 200576 3628 3632 3707 51196 51763 5331 5332 8394 8760
Ibrutinib	FDA approved	Wnt signaling pathway	path:04310_16	3	6.590338	0.014380531	PLCB3 PLCB4 PPP3R1	5331 5332 5534
Ibrutinib	FDA approved	Thyroid hormone signaling pathway	path:04919_20	5	5.837524	0.033185841	HDAC1 MYC PIK3R2 THRA THRB	3065 4609 5296 7067 7068
Ibrutinib	FDA approved	Oxytocin signaling pathway	path:04921_26	5	5.864128	0.032079646	MYLK PPP3R1 PRKCA CALML3 CAMK2A	4638 5534 5578 810 815
Idarubicin	FDA approved	MAPK signaling pathway	path:04010_27	6	5.836112	0.042458101	DUSP2 DUSP4 MYC MAPK1 MAPK8 RPS6KA3	1844 1846 4609 5594 5599 6197
Idarubicin	FDA approved	Ras signaling pathway	path:04014_49	8	6.495874	0.008938547	GRB2 NF1 PLCE1 PIK3CB PRKCA PRKCB RRAS SOS2	2885 4763 51196 5291 5578 5579 6237 6655
Idarubicin	FDA approved	PI3K-Akt signaling pathway	path:04151_71	3	7.082783	0.002234637	ITGA2B ITGA5 PTK2	3674 3678 5747
Idarubicin	FDA approved	Jak-STAT signaling pathway	path:04630_74	6	6.294025	0.016759777	GRB2 MPL MYC SOS2 STAT5B SOCS3	2885 4352 4609 6655 6777 9021
Idarubicin	FDA approved	Long-term depression	path:04730_6	9	5.911815	0.037988827	GNA13 CRHR1 GNAO1 PPP2R1A PRKCA PRKCB MAP2K2 CACNA1A PLA2G4C	10672 1394 2775 5518 5578 5579 5605 773 8605
Idelalisib	FDA approved	Steroid hormone biosynthesis	path:00140_2	6	6.03898	0.024608501	COMT CYP1A1 CYP2E1 CYP19A1 HSD3B1 STS	1312 1543 1571 1588 3283 412
Idelalisib	FDA approved	Purine metabolism	path:00230_119	22	8.345824	0.001118568	ADCY5 ADCY8 ADCY9 GMPR GUCY1A2 GUCY2C NT5C ZNRD1 IMPDH1 HDDC3 NPR2 RRM2B AK3 PDE3A PDE8A PDE9A PDE1B PKM POLR2C POLR2K POLR1B PDE8B	111 114 115 2766 2977 2984 30833 30834 3614 374659 4882 50484 50808 5139 5151 5152 5153 5315 5432 5440 84172 8622
Idelalisib	FDA approved	Rap1 signaling pathway	path:04015_60	14	5.556945	0.042505593	CSF1R EFNA2 EGFR FGF3 FGF5 FGF7 FLT1 RASGRP3 ANGPT1 IGF1R KITLG PLCB4 VEGFC FGF23	1436 1943 1956 2248 2250 2252 2321 25780 284 3480 4254 5332 7424 8074
Idelalisib	FDA approved	p53 signaling pathway	path:04115_21	12	5.551924	0.042505593	CHEK1 SFN IGFBP3 FAS RRM2B SERPINB5 PMAIP1 STEAP3 PTEN SIAH1 TP53 CCNB2	1111 2810 3486 355 50484 5268 5366 55240 5728 6477 7157 9133
Ifosfamide	FDA approved	Purine metabolism	path:00230_120	10	7.218347	0.008879023	ADSL AK1 HPRT1 APRT IMPDH2 PDE8A RRM1 ENTPD6 ENTPD3 ENTPD5	158 203 3251 353 3615 5151 6240 955 956 957
Ifosfamide	FDA approved	PI3K-Akt signaling pathway	path:04151_72	3	5.961335	0.049944506	ITGA2 ITGB1 THBS1	3673 3688 7057
Ifosfamide	FDA approved	Hippo signaling pathway	path:04390_36	5	6.2421	0.032186459	PPP2CB PPP2R1A PPP2R1B STK3 YWHAZ	5516 5518 5519 6788 7534
Ifosfamide	FDA approved	Focal adhesion	path:04510_84	3	5.953992	0.049944506	ITGB1 PTK2 CAV2	3688 5747 858
Ifosfamide	FDA approved	Pathways in cancer	path:05200_39	4	7.355045	0.006659267	FOS MYC PGF CCND1	2353 4609 5228 595
Ifosfamide	FDA approved	Proteoglycans in cancer	path:05205_11	8	6.018265	0.046614872	CTNNB1 ERBB2 GAB1 GRB2 MET MYC THBS1 CBL	1499 2064 2549 2885 4233 4609 7057 867
Ifosfamide	FDA approved	Small cell lung cancer	path:05222_13	6	6.767578	0.009988901	CDK6 MYC NFKB1 NFKBIA CCND1 BCL2L1	1021 4609 4790 4792 595 598
Imatinib	FDA approved	Purine metabolism	path:00230_121	8	7.775931	0.001083424	ADCY6 ADCY7 POLR2J2 POLR1D PDE4A POLR2C POLR2J POLR3GL	112 113 246721 51082 5141 5432 5439 84265
Imatinib	FDA approved	Pyrimidine metabolism	path:00240_81	7	7.696253	0.001083424	POLR3H POLR2J2 NME1 POLR1D POLR2C POLR2H POLR2J	171568 246721 4830 51082 5432 5437 5439
Imatinib	FDA approved	Inositol phosphate metabolism	path:00562_16	5	6.583787	0.017334778	INPP5A PLCE1 INPP5K PIK3CG PLCB4	3632 51196 51763 5294 5332
Imatinib	FDA approved	Glycerophospholipid metabolism	path:00564_17	10	6.555502	0.018418202	PEMT LYPLA1 PLA2G15 LCAT PLA2G3 PLD1 PLD2 AGPAT3 DGKZ PTDSS1	10400 10434 23659 3931 50487 5337 5338 56894 8525 9791
Imatinib	FDA approved	Rap1 signaling pathway	path:04015_61	6	6.872612	0.013001083	AKT1 AKT2 PIK3R5 PIK3CG PIK3R2 RAP1B	207 208 23533 5294 5296 5908
Imatinib	FDA approved	cAMP signaling pathway	path:04024_30	8	6.016507	0.040086674	AKT3 AKT1 AKT2 PIK3R5 PIK3CA PIK3CG PIK3R2 RAP1B	10000 207 208 23533 5290 5294 5296 5908
Imatinib	FDA approved	Phosphatidylinositol signaling system	path:04070_55	10	8.321545	0.001083424	PIKFYVE INPP4A INPP5A PLCE1 INPP5K PIK3CG PIK3R2 PI4KA PLCB4 DGKZ	200576 3631 3632 51196 51763 5294 5296 5297 5332 8525
Imatinib	FDA approved	Sphingolipid signaling pathway	path:04071_19	10	6.554147	0.018418202	PIK3R5 GNAI1 PIK3CG PIK3R2 PLCB4 PLD1 PLD2 RAC1 RAC2 GAB2	23533 2770 5294 5296 5332 5337 5338 5879 5880 9846
Imatinib	FDA approved	Fc epsilon RI signaling pathway	path:04664_5	12	6.161077	0.034669556	PIK3R5 PDPK1 PIK3CA PIK3CG PIK3R2 MAPK9 MAP2K7 RAC1 RAC2 MAP2K4 VAV1 VAV2	23533 5170 5290 5294 5296 5601 5609 5879 5880 6416 7409 7410
Imatinib	FDA approved	Fc gamma R-mediated phagocytosis	path:04666_10	11	6.696126	0.014084507	AKT3 AKT1 AKT2 LAT PIK3CA PIK3CG PIK3R2 PLD1 PLD2 PIP5K1A GAB2	10000 207 208 27040 5290 5294 5296 5337 5338 8394 9846
Imatinib	FDA approved	Cholinergic synapse	path:04725_43	7	6.50672	0.020585049	AKT3 AKT1 AKT2 PIK3R5 GNB2 PIK3CG PIK3R2	10000 207 208 23533 2783 5294 5296
Imatinib	FDA approved	Epstein-Barr virus infection	path:05169_1	9	5.95315	0.042253521	AKT3 AKT1 AKT2 PIK3R5 PIK3CG PIK3R2 TRAF3 TRADD MAP3K14	10000 207 208 23533 5294 5296 7187 8717 9020
Imatinib	FDA approved	Choline metabolism in cancer	path:05231_9	10	6.422047	0.02383532	CHKB PIK3R5 PDPK1 PIK3CA PIK3CG PIK3R2 PLD1 PLD2 MAPK9 RALGDS	1120 23533 5170 5290 5294 5296 5337 5338 5601 5900
Irinotecan rep1	FDA approved	Pyrimidine metabolism	path:00240_82	7	7.919131	0	POLD3 ENTPD8 POLE3 POLD1 POLE PRIM1 POLD4	10714 377841 54107 5424 5426 5557 57804
Irinotecan rep1	FDA approved	N-Glycan biosynthesis	path:00510_3	8	5.704415	0.04271632	ALG3 DOLK ALG1 DOLPP1 RPN2 ALG2 DPM1 DPM2	10195 22845 56052 57171 6185 85365 8813 8818
Irinotecan rep1	FDA approved	Glycerophospholipid metabolism	path:00564_18	8	5.905378	0.033953998	PEMT PLA2G16 PLA2G15 PLA2G3 CHPT1 LPCAT1 PTDSS2 PLA2G4C	10400 11145 23659 50487 56994 79888 81490 8605
Irinotecan rep1	FDA approved	Ether lipid metabolism	path:00565_3	7	5.68804	0.0449069	PLA2G16 PAFAH1B1 PLA2G3 PLD2 CHPT1 LPCAT1 PLA2G4C	11145 5048 50487 5338 56994 79888 8605
Irinotecan rep1	FDA approved	Rap1 signaling pathway	path:04015_62	8	5.832886	0.037239869	CRK CTNND1 FGFR1 FGF21 RAPGEF1 KITLG RAP1B CDH1	1398 1500 2260 26291 2889 4254 5908 999
Irinotecan rep1	FDA approved	FoxO signaling pathway	path:04068_77	16	6.646497	0.008762322	AKT3 CDKN2B KLF2 GABARAP GABARAPL2 CHUK PLK3 IL7R FOXO4 NLK PLK1 RAG2 RBL2 MAPK12 BNIP3 CCNB2	10000 1030 10365 11337 11345 1147 1263 3575 4303 51701 5347 5897 5934 6300 664 9133
Irinotecan rep1	FDA approved	Cell cycle	path:04110_11	8	6.029825	0.028477547	ANAPC10 CDC26 ANAPC4 ANAPC5 ANAPC11 CDC14B CCNB2 BUB3	10393 246184 29945 51433 51529 8555 9133 9184
Irinotecan rep1	FDA approved	Focal adhesion	path:04510_85	3	6.883131	0.005476451	ITGA2B ITGA5 VASP	3674 3678 7408
Irinotecan rep1	FDA approved	Jak-STAT signaling pathway	path:04630_75	12	6.744125	0.008762322	CBLC IFNG IFNGR1 IL2RB IL7 IL7R JAK2 LEPR LIFR MPL OSM SOCS3	23624 3458 3459 3560 3574 3575 3717 3953 3977 4352 5008 9021
Irinotecan rep1	FDA approved	Chronic myeloid leukemia	path:05220_11	7	6.138878	0.020810515	CRK PIK3R5 CBLC ABL1 GRB2 SHC3 GAB2	1398 23533 23624 25 2885 53358 9846
Irinotecan rep2	FDA approved	Purine metabolism	path:00230_122	9	6.075457	0.034714446	POLR3F POLR3A GUK1 NUDT2 ITPA PKM POLE3 PRIM1 ENTPD6	10621 11128 2987 318 3704 5315 54107 5557 955
Irinotecan rep2	FDA approved	Inositol phosphate metabolism	path:00562_17	9	6.444913	0.016797312	INPP5J INPP1 INPP5A ITPK1 INPP5K PLCB4 IPPK ITPKC MINPP1	27124 3628 3632 3705 51763 5332 64768 80271 9562
Irinotecan rep2	FDA approved	MAPK signaling pathway	path:04010_28	8	6.488609	0.01343785	DUSP10 DUSP4 DUSP6 ELK4 MAPK1 MAPK8 MAPK11 PTPN7	11221 1846 1848 2005 5594 5599 5600 5778
Irinotecan rep2	FDA approved	FoxO signaling pathway	path:04068_78	17	6.764508	0.007838746	AKT3 CDK2 S1PR1 FOXO1 FOXO3 SGK3 IL7R NLK PRKAB1 MAPK1 MAPK8 MAPK10 RBL2 CCND1 BNIP3 SOD2 CCNG2	10000 1017 1901 2308 2309 23678 3575 51701 5564 5594 5599 5602 5934 595 664 6648 901
Irinotecan rep2	FDA approved	Focal adhesion	path:04510_86	3	6.598678	0.012318029	ITGA5 ITGAV PRKCA	3678 3685 5578
Irinotecan rep2	FDA approved	Gap junction	path:04540_3	4	5.927731	0.043673012	TUBA1B PRKCA MAPK1 MAP2K1	10376 5578 5594 5604
Irinotecan rep2	FDA approved	Jak-STAT signaling pathway	path:04630_76	11	6.382703	0.019036954	IFNLR1 CBLC IFNG IFNGR1 IL7R LEPR LIFR MPL OSM IL22 PRLR	163702 23624 3458 3459 3575 3953 3977 4352 5008 50616 5618
Irinotecan rep2	FDA approved	Regulation of actin cytoskeleton	path:04810_36	6	6.717687	0.011198208	PAK4 GNA13 RRAS2 CYFIP1 PAK6 RAC2	10298 10672 22800 23191 56924 5880
Irinotecan rep3	FDA approved	Purine metabolism	path:00230_123	6	6.822036	0.013363029	AK1 NME7 PDE6C RRM1 ENTPD6 ENTPD5	203 29922 5146 6240 955 957
Irinotecan rep3	FDA approved	Pyrimidine metabolism	path:00240_83	6	7.018903	0.0077951	POLD3 POLA2 POLE3 POLE PRIM1 ENTPD1	10714 23649 54107 5426 5557 953
Irinotecan rep3	FDA approved	FoxO signaling pathway	path:04068_79	21	6.775389	0.014476615	AKT3 BCL2L11 CDK2 GABARAP GABARAPL2 CHUK S1PR1 FOXO1 SGK3 IL7R PCK2 NLK PLK1 PRKAB1 MAPK1 MAPK8 MAPK11 MAPK10 RBL2 CCND1 CCNB2	10000 10018 1017 11337 11345 1147 1901 2308 23678 3575 5106 51701 5347 5564 5594 5599 5600 5602 5934 595 9133
Irinotecan rep3	FDA approved	Focal adhesion	path:04510_87	5	6.129757	0.034521158	ITGA5 ITGB3 PRKCA PTK2 PXN	3678 3690 5578 5747 5829
Irofulven	FDA approved	Rap1 signaling pathway	path:04015_63	22	7.67719	0.00441989	EFNA1 EFNA2 EFNA3 EFNA4 EGFR EPHA2 FGF13 FGFR3 FGFR2 FGFR4 PLCB1 FLT4 FGF22 ANGPT4 PDGFA PDGFB PDGFRB PGF PLCB2 PLCB3 PDGFC VEGFB	1942 1943 1944 1945 1956 1969 2258 2261 2263 2264 23236 2324 27006 51378 5154 5155 5159 5228 5330 5331 56034 7423
Irofulven	FDA approved	Calcium signaling pathway	path:04020_54	10	5.586373	0.049723757	ADCY3 CHRNA7 PLCD1 SLC8A3 TNNC1 CACNA1D CACNA1S CALM1 CACNA1H CACNA1G	109 1139 5333 6547 7134 776 779 801 8912 8913
Irofulven	FDA approved	Phosphatidylinositol signaling system	path:04070_56	14	6.072231	0.030939227	PLCB1 INPP5J PLCE1 INPP5K PIK3C2B PLCB2 PLCD1 PLCG1 PI4K2A CALM1 ITPKC PIP5K1A DGKD SYNJ2	23236 27124 51196 51763 5287 5330 5333 5335 55361 801 80271 8394 8527 8871
Irofulven	FDA approved	Sphingolipid signaling pathway	path:04071_20	11	5.827259	0.04198895	S1PR3 PLCB1 GNA12 GNAI2 GNAI3 NRAS PIK3CG PLCB2 PLCB3 S1PR5 BDKRB2	1903 23236 2768 2771 2773 4893 5294 5330 5331 53637 624
Irofulven	FDA approved	Hippo signaling pathway	path:04390_37	4	5.662595	0.04640884	RASSF1 PPP2R2C ACTB STK3	11186 5522 60 6788
Irofulven	FDA approved	Focal adhesion	path:04510_88	4	6.253475	0.022099448	FLNB ITGB1 PTK2 SRC	2317 3688 5747 6714
Ixabepilone	FDA approved	Pyrimidine metabolism	path:00240_84	8	7.42444	0.004459309	POLR3C ZNRD1 NME1 POLR1D POLR3K POLR2D POLR1E POLR3D	10623 30834 4830 51082 51728 5433 64425 661
Ixabepilone	FDA approved	Rap1 signaling pathway	path:04015_64	9	6.186138	0.036789298	CRK EGFR EPHA2 FGF6 FGF8 FLT1 FGF20 PLCB4 PDGFC	1398 1956 1969 2251 2253 2321 26281 5332 56034
Ixabepilone	FDA approved	FoxO signaling pathway	path:04068_80	13	7.657773	0.002229654	AKT3 PLK2 FBXO32 GADD45A FOXO3 GABARAPL1 PRKAA2 PRKAB2 CCND1 MAPK12 SGK1 CCNB1 CCNG2	10000 10769 114907 1647 2309 23710 5563 5565 595 6300 6446 891 901
Ixabepilone	FDA approved	Focal adhesion	path:04510_89	11	7.012104	0.00780379	FLNC ITGA2 ITGA2B ITGAV ITGB1 PRKCB PTK2 THBS1 TLN1 CAPN2 CAV2	2318 3673 3674 3685 3688 5579 5747 7057 7094 824 858
Ixabepilone	FDA approved	ECM-receptor interaction	path:04512_16	4	7.063774	0.00780379	ITGA2 ITGAV ITGB1 THBS1	3673 3685 3688 7057
Ixabepilone	FDA approved	Thyroid hormone signaling pathway	path:04919_21	6	7.2824	0.004459309	AKT3 HIF1A ATP1B1 PIK3CG PIK3R1 THRB	10000 3091 481 5294 5295 7068
Ixazomib citrate	FDA approved	Purine metabolism	path:00230_124	6	6.97614	0.00326087	ADCY7 AK2 AMPD2 PDE4A PDE8B ENTPD6	113 204 271 5141 8622 955
Ixazomib citrate	FDA approved	Calcium signaling pathway	path:04020_55	7	5.573564	0.043478261	RYR1 TNNC2 CALM1 ORAI2 SLC25A31 CACNA1G CD38	6261 7125 801 80228 83447 8913 952
Ixazomib citrate	FDA approved	cGMP-PKG signaling pathway	path:04022_26	9	6.889759	0.00326087	CNGB1 CNGA1 ATP1B1 ATP1B3 PRKCE PRKG2 RGS2 SLC8A2 TRPC6	1258 1259 481 483 5581 5593 5997 6543 7225
Ixazomib citrate	FDA approved	FoxO signaling pathway	path:04068_81	18	5.929913	0.029347826	CDKN1A CDKN2B GABARAP MAPK14 FOXO1 PCK2 PLK1 PRKAA2 PRKAG1 MAPK11 MAPK10 MAPK13 RBL2 CCND1 STK4 SETD7 CCNB3 TNFSF10	1026 1030 11337 1432 2308 5106 5347 5563 5571 5600 5602 5603 5934 595 6789 80854 85417 8743
Ixazomib citrate	FDA approved	Phosphatidylinositol signaling system	path:04070_57	6	6.40543	0.011956522	INPP5B PIK3CA PIK3CB PIK3CD PLCG1 PIP5K1A	3633 5290 5291 5293 5335 8394
Ixazomib citrate	FDA approved	Cell cycle	path:04110_12	9	6.095986	0.02173913	CDK4 CDKN1A CDKN2B SMAD2 SMAD3 SMAD4 TGFB2 CUL1 CCNA2	1019 1026 1030 4087 4088 4089 7042 8454 890
Ixazomib citrate	FDA approved	p53 signaling pathway	path:04115_22	11	6.699427	0.008695652	CDKN1A CHEK2 SESN3 RCHY1 SFN CD82 SERPINB5 ATR ZMAT3 SIAH1 TP53	1026 11200 143686 25898 2810 3732 5268 545 64393 6477 7157
Ixazomib citrate	FDA approved	Hippo signaling pathway	path:04390_38	5	5.956304	0.027173913	SMAD2 SMAD3 SMAD4 BMP2 BMPR1B	4087 4088 4089 650 658
Ixazomib citrate	FDA approved	Insulin signaling pathway	path:04910_19	4	5.854976	0.032608696	PHKB PHKG1 PYGL CALM1	5257 5260 5836 801
Ixazomib citrate	FDA approved	Thyroid hormone signaling pathway	path:04919_22	5	6.222495	0.016304348	HIF1A ATP1B1 ATP1B3 PIK3CB PIK3CD	3091 481 483 5291 5293
Ixazomib citrate	FDA approved	Glucagon signaling pathway	path:04922_9	4	5.854976	0.032608696	PHKB PHKG1 PYGL CALM1	5257 5260 5836 801
Lapatinib rep1	FDA approved	Purine metabolism	path:00230_125	7	6.288318	0.030769231	NUDT16 AK2 APRT ATIC NME3 NT5E PDE4D	131870 204 353 471 4832 4907 5144
Lapatinib rep1	FDA approved	FoxO signaling pathway	path:04068_82	16	6.126089	0.038461538	CDKN2B KLF2 S1PR1 AKT2 SGK3 FOXO4 PDPK1 MAPK3 MAPK8 MAPK11 MAPK9 RAG2 BCL6 TNFSF10 ATG12 G6PC3	1030 10365 1901 208 23678 4303 5170 5595 5599 5600 5601 5897 604 8743 9140 92579
Lapatinib rep1	FDA approved	Cell cycle	path:04110_13	8	6.440792	0.026373626	STAG1 ANAPC2 ANAPC11 ANAPC1 CDC23 SMC3 PTTG1 ESPL1	10274 29882 51529 64682 8697 9126 9232 9700
Lapatinib rep1	FDA approved	Wnt signaling pathway	path:04310_17	6	6.213189	0.032967033	CSNK2A2 GSK3B PLCB3 PPP3CB PRKACA PRKCB	1459 2932 5331 5532 5566 5579
Lapatinib rep1	FDA approved	Hippo signaling pathway	path:04390_39	5	6.12281	0.038461538	FGF1 SERPINE1 PPP2CA PPP2R1A PPP2R2D	2246 5054 5515 5518 55844
Lapatinib rep2	FDA approved	Purine metabolism	path:00230_126	11	6.527632	0.01880531	ADCY7 GUK1 GUCY2D APRT NT5E PDE6A PKM POLR2C POLR3E POLR1E ENTPD4	113 2987 3000 353 4907 5145 5315 5432 55718 64425 9583
Lapatinib rep2	FDA approved	PI3K-Akt signaling pathway	path:04151_73	10	6.354316	0.019911504	AKT3 PIK3R5 IKBKB JAK2 PIK3R2 PPP2R3C PPP2CA PPP2R2D BAD IKBKG	10000 23533 3551 3717 5296 55012 5515 55844 572 8517
Lapatinib rep2	FDA approved	Focal adhesion	path:04510_90	4	5.840388	0.044247788	ITGA5 ITGB5 PRKCB PXN	3678 3693 5579 5829
Lapatinib rep2	FDA approved	GABAergic synapse	path:04727_23	7	5.849282	0.043141593	GABARAP GABARAPL2 GABBR1 GABRA1 GABRA6 GABRB2 GABRG2	11337 11345 2550 2554 2559 2561 2566
LDK-378 rep1	FDA approved	Purine metabolism	path:00230_127	6	6.28204	0.013667426	AK9 POLR2J2 HDDC3 POLR1D PKM PNPT1	221264 246721 374659 51082 5315 87178
LDK-378 rep1	FDA approved	Rap1 signaling pathway	path:04015_65	17	8.015813	0	CSF1 EPHA2 FGF2 FGF5 FGF12 FGF13 FGFR1 FLT1 FGF20 IGF1R KIT NGF PDGFRA PDGFRB PLCB4 PDGFC VEGFC	1435 1969 2247 2250 2257 2258 2260 2321 26281 3480 3815 4803 5156 5159 5332 56034 7424
LDK-378 rep1	FDA approved	FoxO signaling pathway	path:04068_83	13	7.659363	0.002277904	AKT3 PLK2 GADD45A S1PR1 FOXO1 FOXO3 GADD45B PCK2 PDPK1 PRKAA2 MAPK13 G6PC2 BNIP3	10000 10769 1647 1901 2308 2309 4616 5106 5170 5563 5603 57818 664
LDK-378 rep1	FDA approved	Hippo signaling pathway	path:04390_40	3	6.219778	0.018223235	SMAD3 SERPINE1 BMPR2	4088 5054 659
LDK-378 rep1	FDA approved	Focal adhesion	path:04510_91	5	7.396603	0.002277904	FLNA FLNC ITGB1 THBS1 TLN1	2316 2318 3688 7057 7094
LDK-378 rep1	FDA approved	Tight junction	path:04530_11	3	6.351678	0.013667426	RHOA PPP2CB PRKCD	387 5516 5580
LDK-378 rep1	FDA approved	Jak-STAT signaling pathway	path:04630_77	12	5.710154	0.039863326	CNTFR CBLC IL5RA IL6 IL6R IL6ST IL12B IL12RB2 LEPR LIFR STAT5A OSMR	1271 23624 3568 3569 3570 3572 3593 3595 3953 3977 6776 9180
LDK-378 rep1	FDA approved	Retrograde endocannabinoid signaling	path:04723_29	9	5.854243	0.034168565	ADCY3 GNAI3 GNAO1 GNB1 GNG11 GNGT1 GNG12 MAPK13 GNB4	109 2773 2775 2782 2791 2792 55970 5603 59345
LDK-378 rep1	FDA approved	Cholinergic synapse	path:04725_44	10	5.746714	0.037585421	ADCY1 ADCY3 ADCY8 GNAI3 GNAO1 GNB1 GNG11 PIK3R2 GNG12 GNB4	107 109 114 2773 2775 2782 2791 5296 55970 59345
LDK-378 rep1	FDA approved	Serotonergic synapse	path:04726_28	10	5.661707	0.043280182	GNAI3 GNAO1 GNB1 GNG11 GNGT1 HTR1E ITPR3 PLCB4 GNG12 GNB4	2773 2775 2782 2791 2792 3354 3710 5332 55970 59345
LDK-378 rep1	FDA approved	GABAergic synapse	path:04727_24	8	6.344403	0.013667426	ADCY8 GNAI3 GNAO1 GNG11 GNG12 GNB4 CACNA1D GABBR2	114 2773 2775 2791 55970 59345 776 9568
LDK-378 rep1	FDA approved	Morphine addiction	path:05032_27	8	5.99807	0.0261959	ADCY3 GNAO1 GNB1 GNG11 GNGT1 GNG12 GNB4 GABBR2	109 2775 2782 2791 2792 55970 59345 9568
LDK-378 rep2	FDA approved	Purine metabolism	path:00230_128	10	6.578067	0.010940919	DGUOK AK5 AMPD2 AMPD3 IMPDH1 HDDC3 NT5E PDE1C RRM2 PNPT1	1716 26289 271 272 3614 374659 4907 5137 6241 87178
LDK-378 rep2	FDA approved	Pyrimidine metabolism	path:00240_85	12	6.285256	0.01750547	NME6 CTPS1 POLR2J2 NT5C NT5E POLR1D CMPK1 POLR2J RRM2 DCTPP1 POLR3GL PNPT1	10201 1503 246721 30833 4907 51082 51727 5439 6241 79077 84265 87178
LDK-378 rep2	FDA approved	Rap1 signaling pathway	path:04015_66	15	6.896809	0.004376368	CSF1 EFNA4 FGF2 FGF3 FGF5 FGF6 FGF9 FGF12 FGF14 FGFR1 NGF PLCB4 PDGFC VEGFB VEGFC	1435 1945 2247 2248 2250 2251 2254 2257 2259 2260 4803 5332 56034 7423 7424
LDK-378 rep2	FDA approved	Calcium signaling pathway	path:04020_56	7	6.745182	0.00547046	EDNRB GNA15 OXTR PLCB4 PRKCB PTGFR CCKBR	1910 2769 5021 5332 5579 5737 887
LDK-378 rep2	FDA approved	Chemokine signaling pathway	path:04062_64	7	6.578005	0.010940919	CCR9 CX3CR1 GNAI3 GRK5 CXCL12 CXCR5 XCL2	10803 1524 2773 2869 6387 643 6846
LDK-378 rep2	FDA approved	FoxO signaling pathway	path:04068_84	10	6.624259	0.010940919	AKT3 PLK2 GADD45A S1PR1 FOXO3 GABARAPL1 PRKAA2 MAPK13 G6PC2 BNIP3	10000 10769 1647 1901 2309 23710 5563 5603 57818 664
LDK-378 rep2	FDA approved	Tight junction	path:04530_12	3	6.07019	0.026258206	PRKCB ACTB MAGI2	5579 60 9863
LDK-378 rep2	FDA approved	Jak-STAT signaling pathway	path:04630_78	7	5.93422	0.032822757	IFNGR2 IL5RA IL6 IL6ST IL12RB2 LEPR OSMR	3460 3568 3569 3572 3595 3953 9180
LDK-378 rep2	FDA approved	Circadian entrainment	path:04713_35	12	7.631703	0.003282276	ADCY1 ADCY3 ADCY8 ADCY9 GNAI3 GNG5 GNG11 GNGT1 PLCB4 GNG12 PRKX GNB4	107 109 114 115 2773 2787 2791 2792 5332 55970 5613 59345
LDK-378 rep2	FDA approved	Retrograde endocannabinoid signaling	path:04723_30	13	6.950284	0.004376368	ADCY1 ADCY3 ADCY8 ADCY9 GNAI3 GNAO1 GNG5 GNG11 GNGT1 GNG12 MAPK13 PRKX GNB4	107 109 114 115 2773 2775 2787 2791 2792 55970 5603 5613 59345
LDK-378 rep2	FDA approved	Glutamatergic synapse	path:04724_31	9	7.846858	0.003282276	ADCY8 ADCY9 GNAI3 GNG11 GNGT1 GRM7 GNG12 PRKX GNB4	114 115 2773 2791 2792 2917 55970 5613 59345
LDK-378 rep2	FDA approved	Cholinergic synapse	path:04725_45	13	6.730366	0.00547046	ADCY1 ADCY3 ADCY8 ADCY9 GNAI3 GNAO1 GNG5 GNG11 GNGT1 PIK3CG GNG12 PRKX GNB4	107 109 114 115 2773 2775 2787 2791 2792 5294 55970 5613 59345
LDK-378 rep2	FDA approved	Serotonergic synapse	path:04726_29	9	6.98787	0.004376368	GNAI3 GNG5 GNG11 GNGT1 HTR1E HTR5A PLCB4 GNG12 GNB4	2773 2787 2791 2792 3354 3361 5332 55970 59345
LDK-378 rep2	FDA approved	GABAergic synapse	path:04727_25	9	6.920171	0.004376368	ADCY8 GNAI3 GNG5 GNG11 GNGT2 GNG12 PRKX GNB4 GABBR2	114 2773 2787 2791 2793 55970 5613 59345 9568
LDK-378 rep2	FDA approved	Dopaminergic synapse	path:04728_40	10	7.226215	0.004376368	ADCY5 GNAI3 GNB2 GNG11 GNGT1 PLCB4 PRKCB GNG12 PRKX GNB4	111 2773 2783 2791 2792 5332 5579 55970 5613 59345
LDK-378 rep2	FDA approved	Melanogenesis	path:04916_7	5	6.088729	0.024070022	EDNRB GNAI3 GNAO1 PLCB4 PRKCB	1910 2773 2775 5332 5579
LDK-378 rep2	FDA approved	Oxytocin signaling pathway	path:04921_27	6	6.738719	0.00547046	GNAI3 OXTR PLCB4 PRKCB RAF1 CACNB4	2773 5021 5332 5579 5894 785
LDK-378 rep2	FDA approved	Morphine addiction	path:05032_28	11	7.668535	0.003282276	ADCY9 GNAI3 GNG5 GNG11 GNGT1 PRKACA PRKCB GNG12 PRKX GNB4 GABBR2	115 2773 2787 2791 2792 5566 5579 55970 5613 59345 9568
Lenvatinib	FDA approved	Purine metabolism	path:00230_129	10	6.683861	0.005518764	ADCY8 DCK POLR3H AK9 AMPD1 GUCY1A2 ZNRD1 POLR1D PDE1C POLR2I	114 1633 171568 221264 270 2977 30834 51082 5137 5438
Lenvatinib	FDA approved	Pyrimidine metabolism	path:00240_86	9	5.740144	0.034216336	CTPS1 POLR3H AK9 ZNRD1 POLR1D POLR2I POLR1B PNPT1 POLR1C	1503 171568 221264 30834 51082 5438 84172 87178 9533
Lenvatinib	FDA approved	Glutathione metabolism	path:00480_9	5	5.797195	0.033112583	GPX2 GSTM1 GSTM2 GSTM3 GSTP1	2877 2944 2946 2947 2950
Lenvatinib	FDA approved	Inositol phosphate metabolism	path:00562_18	11	5.559076	0.039735099	PLCB1 IMPA2 INPP4A INPP5A INPP5B INPP5D PIK3C2B PIK3CA PIK3CB PLCB3 PLCB4	23236 3613 3631 3632 3633 3635 5287 5290 5291 5331 5332
Lenvatinib	FDA approved	Glycerophospholipid metabolism	path:00564_19	7	6.322575	0.006622517	CEPT1 PLA2G4E PLA2G2D LCAT CRLS1 LPCAT2 PTDSS1	10390 123745 26279 3931 54675 54947 9791
Lenvatinib	FDA approved	Metabolism of xenobiotics by cytochrome P450	path:00980_6	4	5.669327	0.035320088	GSTM1 GSTM2 GSTM3 GSTP1	2944 2946 2947 2950
Lenvatinib	FDA approved	Ras signaling pathway	path:04014_50	9	5.624416	0.036423841	MRAS HRAS NF1 NRAS PIK3CA PIK3CB RAC1 RALGDS RASA1	22808 3265 4763 4893 5290 5291 5879 5900 5921
Lenvatinib	FDA approved	Rap1 signaling pathway	path:04015_67	13	7.123296	0.002207506	CSF1 EGFR FGF2 FGF7 FGF14 FLT1 PLCB1 KDR PLCB3 PLCB4 PDGFC VEGFA VEGFB	1435 1956 2247 2252 2259 2321 23236 3791 5331 5332 56034 7422 7423
Lenvatinib	FDA approved	cGMP-PKG signaling pathway	path:04022_27	12	5.985313	0.022075055	CNGA1 PLCB1 GUCY1A2 ATP1A2 ATP2B4 PLCB3 PLCB4 PPP1CA PRKG2 CACNA1S GTF2IRD1 CREB5	1259 23236 2977 477 493 5331 5332 5499 5593 779 9569 9586
Lenvatinib	FDA approved	Chemokine signaling pathway	path:04062_65	12	7.043966	0.002207506	PLCB1 GNAI3 GNG5 GNG11 HRAS NRAS PIK3CA PIK3CB PLCB3 PLCB4 GNG12 PIK3R3	23236 2773 2787 2791 3265 4893 5290 5291 5331 5332 55970 8503
Lenvatinib	FDA approved	Phosphatidylinositol signaling system	path:04070_58	15	6.301888	0.007726269	DGKQ PLCB1 IMPA2 INPP4A INPP5A INPP5B INPP5D PIK3C2B PIK3CA PIK3CB PLCB3 PLCB4 PIK3R3 DGKZ DGKE	1609 23236 3613 3631 3632 3633 3635 5287 5290 5291 5331 5332 8503 8525 8526
Lenvatinib	FDA approved	Sphingolipid signaling pathway	path:04071_21	7	5.604058	0.037527594	GNAI3 PDPK1 PIK3CB PIK3CD PIK3R1 RAC1 PIK3R3	2773 5170 5291 5293 5295 5879 8503
Lenvatinib	FDA approved	PI3K-Akt signaling pathway	path:04151_74	3	7.383552	0.002207506	ITGA2 ITGAV THBS1	3673 3685 7057
Lenvatinib	FDA approved	Focal adhesion	path:04510_92	5	8.237896	0	FLNC ITGA2 ITGAV THBS1 TLN1	2318 3673 3685 7057 7094
Lenvatinib	FDA approved	ECM-receptor interaction	path:04512_17	3	6.674371	0.005518764	ITGA2 ITGAV THBS1	3673 3685 7057
Lenvatinib	FDA approved	Signaling pathways regulating pluripotency of stem cells	path:04550_4	8	5.631903	0.036423841	FGF2 FGFR1 HRAS IL6ST NRAS PIK3CA PIK3CB PIK3R3	2247 2260 3265 3572 4893 5290 5291 8503
Lenvatinib	FDA approved	Jak-STAT signaling pathway	path:04630_79	9	6.722748	0.004415011	CTF1 IFNGR1 IL5RA IL6 IL6ST IL12A IL12RB2 LEPR SOCS3	1489 3459 3568 3569 3572 3592 3595 3953 9021
Lenvatinib	FDA approved	Fc gamma R-mediated phagocytosis	path:04666_11	9	6.048234	0.017660044	VAV3 ARF6 PAK1 PIK3CA PIK3CB ASAP3 RAC1 SYK PIK3R3	10451 382 5058 5290 5291 55616 5879 6850 8503
Lenvatinib	FDA approved	Circadian entrainment	path:04713_36	10	6.15596	0.014348786	ADCY8 ADCYAP1R1 PLCB1 GNAI3 GNG5 GNG11 GNG13 PLCB3 PLCB4 GNG12	114 117 23236 2773 2787 2791 51764 5331 5332 55970
Lenvatinib	FDA approved	Glutamatergic synapse	path:04724_32	6	6.497284	0.006622517	ADCY8 GNAO1 GNG5 GNG11 GRM7 GNG12	114 2775 2787 2791 2917 55970
Lenvatinib	FDA approved	Cholinergic synapse	path:04725_46	9	5.663044	0.036423841	ADCY8 GNAI3 GNG5 GNG11 HRAS NRAS GNG13 GNG12 PIK3R3	114 2773 2787 2791 3265 4893 51764 55970 8503
Lenvatinib	FDA approved	GABAergic synapse	path:04727_26	5	5.701336	0.034216336	GABRA4 GABRA5 GABRG1 GABRQ GABBR2	2557 2558 2565 55879 9568
Lenvatinib	FDA approved	Dopaminergic synapse	path:04728_41	9	5.767858	0.034216336	DRD3 PLCB1 GNAI3 GNG5 GNG11 GNG13 PLCB3 PLCB4 GNG12	1814 23236 2773 2787 2791 51764 5331 5332 55970
Lenvatinib	FDA approved	Regulation of actin cytoskeleton	path:04810_37	5	6.698808	0.005518764	VAV3 PAK1 GNG12 PAK6 RAC1	10451 5058 55970 56924 5879
Lenvatinib	FDA approved	Morphine addiction	path:05032_29	7	6.406972	0.006622517	ADCY8 GNAI3 GNG5 GNG11 GNG13 GNG12 GABBR2	114 2773 2787 2791 51764 55970 9568
Lenvatinib	FDA approved	Chemical carcinogenesis	path:05204_4	5	5.505016	0.04415011	CYP1A1 GSTM1 GSTM2 GSTM3 GSTP1	1543 2944 2946 2947 2950
Lomustine	FDA approved	Chemokine signaling pathway	path:04062_66	9	7.11141	0.011866235	FGR GNAI2 GNG3 PIK3CG PRKCZ PTK2 SRC PIK3R3 CDC42	2268 2771 2785 5294 5590 5747 6714 8503 998
Lomustine	FDA approved	Phosphatidylinositol signaling system	path:04070_59	13	6.21599	0.030204962	PIKFYVE INPP4A INPP5B INPP5D ITPKB PLCE1 PIK3CG PLCB2 PLCG1 PIP4K2C PIP5K1A PIK3R3 DGKZ	200576 3631 3633 3635 3707 51196 5294 5330 5335 79837 8394 8503 8525
Lomustine	FDA approved	Cell cycle	path:04110_14	4	5.799697	0.047464941	MAD2L2 SFN ANAPC5 CCNB3	10459 2810 51433 85417
Lomustine	FDA approved	Tight junction	path:04530_13	3	6.839033	0.01618123	PPP2R1B PRKCG PRKCZ	5519 5582 5590
Lomustine	FDA approved	T cell receptor signaling pathway	path:04660_2	5	5.835858	0.046386192	LCP2 PLCG1 VAV1 VAV2 CDC42	3937 5335 7409 7410 998
Lomustine	FDA approved	Regulation of actin cytoskeleton	path:04810_38	6	6.005452	0.037756203	PAK2 RAC1 TIAM1 VAV1 VAV2 CDC42	5062 5879 7074 7409 7410 998
Melphalan rep1	FDA approved	Purine metabolism	path:00230_130	27	8.796153	0.001091703	POLD3 ADCY6 CANT1 AK1 AMPD1 GUCY1A2 ZNRD1 HPRT1 IMPDH2 HDDC3 ENTPD8 NME1 NME3 NME4 PDE2A PDE8A PDE1B PKM POLE POLR2C POLR2D POLR2K PRIM1 POLR3B POLD4 POLR3D ENTPD6	10714 112 124583 203 270 2977 30834 3251 3615 374659 377841 4830 4832 4833 5138 5151 5153 5315 5426 5432 5433 5440 5557 55703 57804 661 955
Melphalan rep1	FDA approved	Pyrimidine metabolism	path:00240_87	27	7.862198	0.001091703	POLD3 POLR3A CANT1 UPRT DPYD DUT TYMP ZNRD1 NUDT2 ENTPD8 NME1 NME3 NME4 CMPK1 POLE POLR2C POLR2D POLR2K PRIM1 POLR3B POLD4 POLR3D TK1 TK2 TYMS UCK2 ENTPD6	10714 11128 124583 139596 1806 1854 1890 30834 318 377841 4830 4832 4833 51727 5426 5432 5433 5440 5557 55703 57804 661 7083 7084 7298 7371 955
Melphalan rep1	FDA approved	PPAR signaling pathway	path:03320_15	7	6.465272	0.022925764	NR1H3 CPT1A ACSBG1 OLR1 PCK2 PPARA PPARG	10062 1374 23205 4973 5106 5465 5468
Melphalan rep1	FDA approved	Ras signaling pathway	path:04014_51	15	6.035363	0.045851528	FGF2 FGF3 FGF7 FGF12 FGFR3 HGF IGF1R KIT MET KITLG NGFR PDGFRA SHC3 VEGFB FGF23	2247 2248 2252 2257 2261 3082 3480 3815 4233 4254 4804 5156 53358 7423 8074
Melphalan rep1	FDA approved	Rap1 signaling pathway	path:04015_68	16	6.186356	0.034934498	FGF2 FGF3 FGF7 FGF12 FGFR3 HGF IGF1R KIT MET KITLG NGFR PDGFRA PLCB2 PLCB3 VEGFB FGF23	2247 2248 2252 2257 2261 3082 3480 3815 4233 4254 4804 5156 5330 5331 7423 8074
Melphalan rep1	FDA approved	Endocytosis	path:04144_17	13	6.151875	0.036026201	WWP1 ERBB3 FGFR3 CBLC IGF1R KIT MET SH3GLB1 PDGFRA EPN3 SH3GL3 ITCH CBL	11059 2065 2261 23624 3480 3815 4233 51100 5156 55040 6457 83737 867
Melphalan rep1	FDA approved	Focal adhesion	path:04510_93	3	7.301996	0.005458515	ITGA5 PTK2 SRC	3678 5747 6714
Melphalan rep1	FDA approved	Pathways in cancer	path:05200_40	10	6.112286	0.038209607	ERBB2 CBLC IGF1R KIT PDGFRA PIK3CA PIK3R2 PTEN PTK2 CBL	2064 23624 3480 3815 5156 5290 5296 5728 5747 867
Melphalan rep2	FDA approved	Purine metabolism	path:00230_131	10	6.317695	0.028634361	AK1 IMPDH2 ENTPD8 NME1 PDE6C PDE8A PDE1B POLR3B POLR3GL ENTPD6	203 3615 377841 4830 5146 5151 5153 55703 84265 955
Melphalan rep2	FDA approved	Pyrimidine metabolism	path:00240_88	14	6.97054	0.013215859	NT5C3B DUT ENTPD8 NME1 NME3 POLE PRIM1 POLR3B TK1 TK2 TYMS UCK2 POLR3GL ENTPD6	115024 1854 377841 4830 4832 5426 5557 55703 7083 7084 7298 7371 84265 955
Melphalan rep2	FDA approved	cAMP signaling pathway	path:04024_31	5	5.940257	0.038546256	CREB1 GRIN2D PPP1CC PRKACB SOX9	1385 2906 5501 5567 6662
Melphalan rep2	FDA approved	Chemokine signaling pathway	path:04062_67	6	5.807829	0.044052863	CCR9 CCR7 GNAI2 CCR10 CCL11 CXCR4	10803 1236 2771 2826 6356 7852
Melphalan rep2	FDA approved	Sphingolipid signaling pathway	path:04071_22	6	5.989821	0.038546256	GNA13 S1PR1 S1PR3 GNAI2 PLCB2 PRKCA	10672 1901 1903 2771 5330 5578
Melphalan rep2	FDA approved	PI3K-Akt signaling pathway	path:04151_75	4	7.879704	0.004405286	ITGA2 ITGA5 ITGB3 PTK2	3673 3678 3690 5747
Melphalan rep2	FDA approved	AMPK signaling pathway	path:04152_32	5	6.417317	0.026431718	GYS1 PFKFB2 PRKAB1 RPS6KB1 ULK1	2997 5208 5564 6198 8408
Melphalan rep2	FDA approved	Focal adhesion	path:04510_94	7	8.467684	0.002202643	ITGA2 ITGA5 ITGB3 PRKCA PTK2 PXN CAV2	3673 3678 3690 5578 5747 5829 858
Melphalan rep2	FDA approved	Jak-STAT signaling pathway	path:04630_80	10	6.665554	0.018722467	CBLC IL19 IFNG IL6 IL6R OSM IL20RA TSLP CBL SOCS3	23624 29949 3458 3569 3570 5008 53832 85480 867 9021
Melphalan rep2	FDA approved	Circadian entrainment	path:04713_37	10	6.293055	0.028634361	ADCY3 GNAI2 GNAS GNB3 GNG5 GNGT2 PLCB2 PLCB3 PRKCA GNB4	109 2771 2778 2784 2787 2793 5330 5331 5578 59345
Melphalan rep2	FDA approved	Morphine addiction	path:05032_30	7	6.140837	0.033039648	GNAI2 GNAO1 GNG5 GNGT2 PRKACB PRKCA GNB4	2771 2775 2787 2793 5567 5578 59345
Methotrexate	FDA approved	Purine metabolism	path:00230_132	21	9.816045	0	POLR3A ADCY9 DCK AK5 ZNRD1 NME1 NME4 POLR1D PDE1C POLR3K POLE POLR2A POLR2C POLR2D POLR2K PRIM1 POLR3B RRM2 POLR1B PNPT1 ENTPD3	11128 115 1633 26289 30834 4830 4833 51082 5137 51728 5426 5430 5432 5433 5440 5557 55703 6241 84172 87178 956
Methotrexate	FDA approved	Pyrimidine metabolism	path:00240_89	31	10.158444	0	POLR3F POLD3 POLR3A CTPS1 DCK DUT ZNRD1 NME1 NME3 NME4 POLR1D CMPK1 POLR3K POLD1 POLD2 POLR2A POLR2B POLR2C POLR2D POLR2K PRIM1 POLR3B RRM2 TYMS UCK2 UMPS DCTPP1 POLR1B PNPT1 POLR1C ENTPD3	10621 10714 11128 1503 1633 1854 30834 4830 4832 4833 51082 51727 51728 5424 5425 5430 5431 5432 5433 5440 5557 55703 6241 7298 7371 7372 79077 84172 87178 9533 956
Methotrexate	FDA approved	FoxO signaling pathway	path:04068_85	18	6.336222	0.020044543	BCL2L11 CDKN2B PLK4 PLK2 GABARAP GADD45A FOXO3 PRMT1 GADD45B PCK1 PLK1 PRKAG3 PRKAA2 PRKAB1 G6PC2 RBL2 CCNG2 CCNB2	10018 1030 10733 10769 11337 1647 2309 3276 4616 5105 5347 53632 5563 5564 57818 5934 901 9133
Methotrexate	FDA approved	PI3K-Akt signaling pathway	path:04151_76	3	6.003848	0.037861915	ITGB1 ITGB3 THBS1	3688 3690 7057
Methotrexate	FDA approved	Focal adhesion	path:04510_95	8	7.476143	0.004454343	FLNA ITGB1 ITGB3 PRKCB THBS1 TLN1 TLN2 CAV1	2316 3688 3690 5579 7057 7094 83660 857
Methotrexate	FDA approved	Cholinergic synapse	path:04725_47	10	5.851324	0.04454343	ADCY1 ADCY9 GNAI1 GNAI2 GNAI3 GNG5 GNG11 PRKACA GNG12 PIK3R3	107 115 2770 2771 2773 2787 2791 5566 55970 8503
Midostaurin	-	Purine metabolism	path:00230_133	7	6.418241	0.016629712	PDE10A ADSL AK2 NT5C2 AMPD3 PDE2A GMPS	10846 158 204 22978 272 5138 8833
Midostaurin	-	Pyrimidine metabolism	path:00240_90	15	7.278949	0.00443459	POLR3G POLR3C POLR3H NME7 ZNRD1 ENTPD8 POLR3K POLD1 POLR2A POLR2F POLR2G POLR2H POLR3E POLR1B POLR1C	10622 10623 171568 29922 30834 377841 51728 5424 5430 5435 5436 5437 55718 84172 9533
Midostaurin	-	MAPK signaling pathway	path:04010_29	8	5.933911	0.027716186	MAPK14 DUSP1 DUSP6 ATF4 MAPK10 RPS6KA2 RPS6KA5 MAPKAPK2	1432 1843 1848 468 5602 6196 9252 9261
Midostaurin	-	ErbB signaling pathway	path:04012_17	6	6.919537	0.007760532	AKT3 ERBB3 MTOR GAB1 PIK3CB PIK3R3	10000 2065 2475 2549 5291 8503
Midostaurin	-	Rap1 signaling pathway	path:04015_69	9	6.040875	0.026607539	CRKL EGFR FGF2 GNAQ KITLG PLCB3 VEGFB VEGFC FGF17	1399 1956 2247 2776 4254 5331 7423 7424 8822
Midostaurin	-	cGMP-PKG signaling pathway	path:04022_28	6	6.670812	0.009977827	KCNU1 KCNMB3 KCNMA1 PRKG2 CACNA1C CACNA1F	157855 27094 3778 5593 775 778
Midostaurin	-	Chemokine signaling pathway	path:04062_68	9	5.790193	0.041019956	AKT3 DOCK2 AKT1 FGR GNB3 GSK3B PIK3CB PREX1 PIK3R3	10000 1794 207 2268 2784 2932 5291 57580 8503
Midostaurin	-	HIF-1 signaling pathway	path:04066_22	7	5.612849	0.049889135	AKT3 EGFR AKT1 MTOR PIK3CB PRKCA PIK3R3	10000 1956 207 2475 5291 5578 8503
Midostaurin	-	Platelet activation	path:04611_15	5	6.032408	0.027716186	AKT3 AKT1 ITGB1 PIK3CB PIK3R3	10000 207 3688 5291 8503
Midostaurin	-	Pathways in cancer	path:05200_41	9	5.893622	0.031042129	AKT3 CRKL EGFR AKT1 MTOR GSK3B PIK3CB CASP9 PIK3R3	10000 1399 1956 207 2475 2932 5291 842 8503
Midostaurin	-	Prostate cancer	path:05215_8	9	6.023031	0.027716186	AKT3 EGFR FGFR1 MTOR GSK3B PDGFA PIK3CB CASP9 PIK3R3	10000 1956 2260 2475 2932 5154 5291 842 8503
Midostaurin	-	Choline metabolism in cancer	path:05231_10	7	5.696799	0.048780488	CHKA CHKB EGFR MTOR PIK3CB RAF1 PIK3R3	1119 1120 1956 2475 5291 5894 8503
Mithramycin rep1	-	Pyrimidine metabolism	path:00240_91	7	7.851097	0.002150538	DUT NT5E TK1 TK2 ENTPD6 ENTPD3 ENTPD4	1854 4907 7083 7084 955 956 9583
Mithramycin rep1	-	FoxO signaling pathway	path:04068_86	14	6.787902	0.011827957	SGK2 CDKN2D PLK2 FOXO3 GABARAPL1 FOXO4 PRKAG2 PRKAB1 PRKAG1 MAPK13 CCND1 CCNG2 CCNB2 ATG12	10110 1032 10769 2309 23710 4303 51422 5564 5571 5603 595 901 9133 9140
Mithramycin rep1	-	Adrenergic signaling in cardiomyocytes	path:04261_25	5	5.870633	0.04516129	PPP1CC PPP2CB PRKACA CACNG1 CAMK2D	5501 5516 5566 786 817
Mithramycin rep1	-	Focal adhesion	path:04510_96	8	8.921909	0	ITGA5 ITGB1 PRKCB PTK2 THBS1 CAPN2 TLN2 CAV2	3678 3688 5579 5747 7057 824 83660 858
Mithramycin rep1	-	ECM-receptor interaction	path:04512_18	3	7.694846	0.002150538	ITGAV ITGB1 THBS1	3685 3688 7057
Mithramycin rep1	-	Regulation of actin cytoskeleton	path:04810_39	4	6.567073	0.016129032	CRK ITGA5 ITGB1 PTK2	1398 3678 3688 5747
Mithramycin rep1	-	Small cell lung cancer	path:05222_14	3	6.607776	0.015053763	ITGB1 PIK3CG PTK2	3688 5294 5747
Mithramycin rep2	-	Purine metabolism	path:00230_134	14	7.578525	0.003333333	POLR3F ADCY1 ADCY7 NUDT16 DCK AMPD2 PDE4A POLR3K POLR2C POLR2F POLR2G POLR2I POLR2K NME5	10621 107 113 131870 1633 271 5141 51728 5432 5435 5436 5438 5440 8382
Mithramycin rep2	-	Pyrimidine metabolism	path:00240_92	6	6.193394	0.021111111	POLR3F POLR2C POLR2G POLR2H POLR2K NME5	10621 5432 5436 5437 5440 8382
Mithramycin rep2	-	cAMP signaling pathway	path:04024_32	7	6.659729	0.011111111	ADCY1 ADCY7 CNGB1 CNGA1 GNAI3 CALM3 CAMK2G	107 113 1258 1259 2773 808 818
Mithramycin rep2	-	Phosphatidylinositol signaling system	path:04070_60	6	5.834546	0.047777778	OCRL PIK3CA PI4KB PI4K2B PIP4K2B PLCZ1	4952 5290 5298 55300 8396 89869
Mithramycin rep2	-	Wnt signaling pathway	path:04310_18	3	6.212351	0.021111111	CSNK2A1 CSNK2A2 RAC1	1457 1459 5879
Mithramycin rep2	-	Jak-STAT signaling pathway	path:04630_81	8	5.982767	0.031111111	IFNLR1 IL6ST IL15 IL15RA MPL IL22 IL23A IL21	163702 3572 3600 3601 4352 50616 51561 59067
Mithramycin rep2	-	Fc gamma R-mediated phagocytosis	path:04666_12	7	6.481265	0.014444444	DNM2 PIK3CA PLD1 RAC1 SYK VAV1 GAB2	1785 5290 5337 5879 6850 7409 9846
Mithramycin rep2	-	Morphine addiction	path:05032_31	8	6.421725	0.015555556	ADCY1 ADCY7 GNAO1 GNG4 OPRM1 PRKCB PRKCG GABBR2	107 113 2775 2786 4988 5579 5582 9568
Mithramycin rep3	-	Purine metabolism	path:00230_135	7	6.546485	0.01750547	POLR3G POLD3 ADCY7 POLR2D POLR2F POLR2G NME5	10622 10714 113 5433 5435 5436 8382
Mithramycin rep3	-	Pyrimidine metabolism	path:00240_93	8	5.995137	0.041575492	POLR3G POLR1D POLR2C POLR2D POLR2F POLR2G POLR3D NME5	10622 51082 5432 5433 5435 5436 661 8382
Mithramycin rep3	-	Rap1 signaling pathway	path:04015_70	11	6.574592	0.016411379	EGF EGFR FGF2 ANGPT1 ANGPT2 INSR KDR PDGFA PLCB3 VEGFB PDGFD	1950 1956 2247 284 285 3643 3791 5154 5331 7423 80310
Mithramycin rep3	-	Calcium signaling pathway	path:04020_57	12	6.781329	0.009846827	SLC25A5 P2RX3 CALML5 PHKB PHKG1 PPP3CA PPP3R1 PRKCG TNNC1 CALM3 P2RX6 MYLK3	292 5024 51806 5257 5260 5530 5534 5582 7134 808 9127 91807
Mithramycin rep3	-	cGMP-PKG signaling pathway	path:04022_29	10	6.050398	0.039387309	CNGB1 CNGA1 AGTR1 FXYD2 PLCB3 PPP1CA PRKG1 BAD TRPC6 CACNA1D	1258 1259 185 486 5331 5499 5592 572 7225 776
Mithramycin rep3	-	Phosphatidylinositol signaling system	path:04070_61	8	6.237348	0.032822757	DGKA INPP5A PI4KB PIP4K2A PLCB3 PI4K2B PIP4K2B DGKE	1606 3632 5298 5305 5331 55300 8396 8526
Mithramycin rep3	-	p53 signaling pathway	path:04115_23	13	6.325051	0.026258206	CHEK1 SESN3 DDB2 SFN MDM2 ATM RPRM BAX SIAH1 TP53 CCNG2 EI24 TP53I3	1111 143686 1643 2810 4193 472 56475 581 6477 7157 901 9538 9540
Mithramycin rep3	-	Jak-STAT signaling pathway	path:04630_82	7	6.151416	0.037199125	IL15 IL15RA MPL IL21R IL22 IL20RB CBL	3600 3601 4352 50615 50616 53833 867
Mithramycin rep3	-	Dopaminergic synapse	path:04728_42	7	6.059007	0.039387309	ATF2 FOS CALML5 PLCB3 PPP3CA PRKCG CALM3	1386 2353 51806 5331 5530 5582 808
Mithramycin rep3	-	Oxytocin signaling pathway	path:04921_28	9	6.071166	0.039387309	EGFR FOS GNAI1 MEF2C PLCB3 PRKCG MAPK1 MAPK3 MAPK7	1956 2353 2770 4208 5331 5582 5594 5595 5598
Mithramycin rep4	-	Purine metabolism	path:00230_136	31	9.419046	0	POLR3F POLR3G ADCY1 POLD3 PDE10A ADCY5 ADCY7 ADCY8 ADK DCK POLA2 AMPD3 ITPA NME4 PNP PDE1C PDE2A PDE4A PDE6B POLD1 POLD2 POLR2B POLR2C POLR2G POLR2H ADCY10 POLR3D NME5 PDE5A GMPS ENTPD4	10621 10622 107 10714 10846 111 113 114 132 1633 23649 272 3704 4833 4860 5137 5138 5141 5158 5424 5425 5431 5432 5436 5437 55811 661 8382 8654 8833 9583
Mithramycin rep4	-	Ras signaling pathway	path:04014_52	19	6.115701	0.036871508	EGF EGFR FGF2 FGF3 FGF5 FGF6 FGF12 FGF13 FGF22 ANGPT2 INSR KDR SHC4 NGFR PDGFA PGF SHC1 PDGFD FGF23	1950 1956 2247 2248 2250 2251 2257 2258 27006 285 3643 3791 399694 4804 5154 5228 6464 80310 8074
Mithramycin rep4	-	Rap1 signaling pathway	path:04015_71	13	6.208437	0.032402235	EGF EGFR FGF2 FGF5 FGF6 FGF12 FGF13 ANGPT2 INSR KDR NGFR PGF PLCB3	1950 1956 2247 2250 2251 2257 2258 285 3643 3791 4804 5228 5331
Mithramycin rep4	-	cAMP signaling pathway	path:04024_33	12	6.163575	0.03575419	RAPGEF3 ADCY1 ADCY5 ADCY7 ADCY8 CNGB1 CNGA1 PDE4A ADCY10 MAPK10 CAMK4 CAMK2G	10411 107 111 113 114 1258 1259 5141 55811 5602 814 818
Mithramycin rep4	-	FoxO signaling pathway	path:04068_87	14	6.384204	0.025698324	PLK4 GABARAP FBXO32 AKT1 FASLG FOXO4 PRKAB1 PRKAG1 MAPK10 RBL2 BCL6 SGK1 TNFSF10 G6PC3	10733 11337 114907 207 356 4303 5564 5571 5602 5934 604 6446 8743 92579
Mithramycin rep4	-	AMPK signaling pathway	path:04152_33	6	6.18781	0.033519553	ADRA1A PRKAB1 PRKAB2 PRKAG1 CCNA2 CD36	148 5564 5565 5571 890 948
Mithramycin rep4	-	Circadian entrainment	path:04713_38	9	5.868258	0.048044693	ADCY1 ADCY5 ADCY7 ADCY8 ADCYAP1R1 GNG3 GNG13 PLCB3 ADCY10	107 111 113 114 117 2785 51764 5331 55811
Mithramycin rep4	-	Insulin signaling pathway	path:04910_20	6	6.008795	0.040223464	AKT1 PHKB PHKG1 PPP1CA BAD PYGM	207 5257 5260 5499 572 5837
Mithramycin rep4	-	Pancreatic cancer	path:05212_14	9	6.108618	0.036871508	EGF EGFR AKT1 PIK3CA PIK3R1 BAD RAC2 RELA BCL2L1	1950 1956 207 5290 5295 572 5880 5970 598
Mitomycin rep1	FDA approved	Purine metabolism	path:00230_137	15	6.697977	0.007918552	ADCY3 POLR3A NT5C3B AK5 GMPR GUCY2D ENTPD8 NME1 POLR2A POLR2C POLR2I RRM2 PNPT1 ENTPD2 ENTPD6	109 11128 115024 26289 2766 3000 377841 4830 5430 5432 5438 6241 87178 954 955
Mitomycin rep1	FDA approved	Pyrimidine metabolism	path:00240_94	19	6.207024	0.015837104	POLD3 POLR3A NT5C3B ZNRD1 ENTPD8 NME1 CMPK1 POLE POLR2A POLR2C POLR2I POLR2K PRIM1 POLE4 RRM2 TYMS PNPT1 ENTPD6 ENTPD3	10714 11128 115024 30834 377841 4830 51727 5426 5430 5432 5438 5440 5557 56655 6241 7298 87178 955 956
Mitomycin rep1	FDA approved	Glycerolipid metabolism	path:00561_7	8	5.519241	0.048642534	MBOAT2 DGKG DGKQ LIPC PNLIPRP1 GPAM DGAT1 LIPG	129642 1608 1609 3990 5407 57678 8694 9388
Mitomycin rep1	FDA approved	Chemokine signaling pathway	path:04062_69	10	6.264918	0.013574661	GNB5 AKT2 FGR FOXO3 GNG5 GNGT2 KRAS PIK3CD GNG12 PIK3R3	10681 208 2268 2309 2787 2793 3845 5293 55970 8503
Mitomycin rep1	FDA approved	FoxO signaling pathway	path:04068_88	19	6.7454	0.007918552	CDK2 CDKN2B GABARAPL2 PLK3 GADD45A AKT2 FOXO1 FOXO3 SGK3 NLK PRKAA2 PRKAB1 MAPK10 MAPK13 G6PC2 RBL2 STAT3 CCNB2 G6PC3	1017 1030 11345 1263 1647 208 2308 2309 23678 51701 5563 5564 5602 5603 57818 5934 6774 9133 92579
Mitomycin rep1	FDA approved	Endocytosis	path:04144_18	12	5.958841	0.024886878	EPS15 ERBB3 FGFR3 FLT1 MDM2 NEDD4 NTRK1 SH3GLB1 EPN3 SMURF2 TGFBR1 ITCH	2060 2065 2261 2321 4193 4734 4914 51100 55040 64750 7046 83737
Mitomycin rep1	FDA approved	Adrenergic signaling in cardiomyocytes	path:04261_26	12	5.712169	0.03959276	CACNG5 PPP1CB PPP2R3A PPP2R5B PRKACB CACNG7 RYR2 CACNA1C CACNA1S CACNA2D1 CACNB2 CACNB3	27091 5500 5523 5526 5567 59284 6262 775 779 781 783 784
Mitomycin rep1	FDA approved	Vascular smooth muscle contraction	path:04270_3	8	6.229163	0.015837104	MYL9 ADCY3 KCNMB4 PPP1R12A PPP1CB PRKACB CALML3 MYLK3	10398 109 27345 4659 5500 5567 810 91807
Mitomycin rep1	FDA approved	Glutamatergic synapse	path:04724_33	7	5.974569	0.023755656	GNB5 ADCY3 GNG5 GNGT2 GRM2 PRKACB CACNA1A	10681 109 2787 2793 2912 5567 773
Mitomycin rep1	FDA approved	Cholinergic synapse	path:04725_48	8	5.781785	0.033936652	GNB5 ADCY3 GNG5 GNGT2 PRKACB GNG12 CACNA1A PIK3R3	10681 109 2787 2793 5567 55970 773 8503
Mitomycin rep1	FDA approved	Morphine addiction	path:05032_32	9	5.854139	0.030542986	GNB5 ADCY3 GNG5 GNGT2 PRKACB PRKCA GNG12 CACNA1A GABBR2	10681 109 2787 2793 5567 5578 55970 773 9568
Mitomycin rep2	FDA approved	Purine metabolism	path:00230_138	8	5.602379	0.045504994	POLA2 GUCY1A2 NME7 GUCY2D POLR2C POLR2G NME5 ENTPD1	23649 2977 29922 3000 5432 5436 8382 953
Mitomycin rep2	FDA approved	Nicotinate and nicotinamide metabolism	path:00760_5	4	5.53163	0.049944506	NT5C3B NNT NMNAT1 NAPRT	115024 23530 64802 93100
Mitomycin rep2	FDA approved	Ras signaling pathway	path:04014_53	12	7.235934	0.004439512	EGFR EPHA2 FGF2 FGF12 FGF13 FGFR3 KITLG PDGFA PDGFB SHC1 VEGFB PDGFD	1956 1969 2247 2257 2258 2261 4254 5154 5155 6464 7423 80310
Mitomycin rep2	FDA approved	Rap1 signaling pathway	path:04015_72	15	6.579309	0.009988901	EGFR EPHA2 FGF2 FGF12 FGF13 FGFR3 INSR KDR KITLG PDGFA PDGFB PLCB3 PDGFC VEGFB PDGFD	1956 1969 2247 2257 2258 2261 3643 3791 4254 5154 5155 5331 56034 7423 80310
Mitomycin rep2	FDA approved	PI3K-Akt signaling pathway	path:04151_77	3	5.793811	0.035516093	ITGA2B ITGA5 ITGB3	3674 3678 3690
Mitomycin rep2	FDA approved	Adrenergic signaling in cardiomyocytes	path:04261_27	9	6.416905	0.013318535	CACNG4 ATP2B1 PPP1CB PPP2CA PPP2R1B PPP2R2C PRKACB CACNA1D CACNA2D1	27092 490 5500 5515 5519 5522 5567 776 781
Mitomycin rep2	FDA approved	Hedgehog signaling pathway	path:04340_5	3	6.38432	0.013318535	CSNK1E GLI3 PRKACB	1454 2737 5567
Mitomycin rep2	FDA approved	TGF-beta signaling pathway	path:04350_4	7	5.847512	0.034406215	CDKN2B E2F5 EP300 SMAD3 SMAD4 MAPK1 RBL1	1030 1875 2033 4088 4089 5594 5933
Mitomycin rep2	FDA approved	Focal adhesion	path:04510_97	4	6.659907	0.007769145	FLNB ITGA2B ITGA5 PRKCA	2317 3674 3678 5578
Mitomycin rep2	FDA approved	Gap junction	path:04540_4	6	6.49718	0.011098779	TUBA1B PLCB3 PRKACB PRKCA MAPK1 MAPK7	10376 5331 5567 5578 5594 5598
Mitomycin rep2	FDA approved	Jak-STAT signaling pathway	path:04630_83	20	7.449062	0.003329634	PIAS3 CSF2 EP300 IFNG IL2RB IL2RG IL4 IL5 IL9 IL10 IL13RA1 IL15RA LIF IL22 IL23A IL20RB IL26 STAT3 STAT5A SOCS3	10401 1437 2033 3458 3560 3561 3565 3567 3578 3586 3597 3601 3976 50616 51561 53833 55801 6774 6776 9021
Mitomycin rep2	FDA approved	Prolactin signaling pathway	path:04917_5	5	6.05241	0.027746948	JAK2 SHC1 STAT3 STAT5A SOCS3	3717 6464 6774 6776 9021
Mitomycin rep2	FDA approved	Melanoma	path:05218_5	7	5.524848	0.049944506	EGFR FGF2 FGF12 FGF13 PDGFA PDGFB PDGFD	1956 2247 2257 2258 5154 5155 80310
Mitomycin rep3	FDA approved	Pyrimidine metabolism	path:00240_95	16	5.692548	0.040130152	POLR3A NT5C3B ENTPD8 NME1 NME4 NT5E CMPK1 POLE POLR2A POLR2C PRIM1 POLE4 RRM1 TK1 PNPT1 ENTPD3	11128 115024 377841 4830 4833 4907 51727 5426 5430 5432 5557 56655 6240 7083 87178 956
Mitomycin rep3	FDA approved	Chemokine signaling pathway	path:04062_70	15	9.017197	0	CX3CR1 CCR10 JAK3 CCL2 CCL3 CCL5 CCL8 CCL11 CCL13 CCL14 CCL15 CCL18 CCL19 CCL23 CX3CL1	1524 2826 3718 6347 6348 6352 6355 6356 6357 6358 6359 6362 6363 6368 6376
Mitomycin rep3	FDA approved	FoxO signaling pathway	path:04068_89	16	6.669877	0.009761388	AKT3 CDK2 CDKN2B GABARAPL2 GADD45A AKT1 FOXO1 FOXO3 GABARAPL1 PRKAG2 NLK PRKAG3 MAPK13 RBL2 STAT3 G6PC3	10000 1017 1030 11345 1647 207 2308 2309 23710 51422 51701 53632 5603 5934 6774 92579
Mitomycin rep3	FDA approved	PI3K-Akt signaling pathway	path:04151_78	8	6.180971	0.017353579	AKT1 FOXO3 PIK3R5 LPAR3 GNG5 MDM2 PPP2R5C LPAR2	207 2309 23533 23566 2787 4193 5527 9170
Mitomycin rep3	FDA approved	Adrenergic signaling in cardiomyocytes	path:04261_28	15	5.615371	0.044468547	ATP1A2 ATP1A4 PPP1CB PPP2R1A PPP2R2B PPP2R3A PPP2R5B PRKACB PRKX SLC8A1 CACNA1C CACNA1S CACNA2D1 CACNB2 CACNB3	477 480 5500 5518 5521 5523 5526 5567 5613 6546 775 779 781 783 784
Mitomycin rep3	FDA approved	Focal adhesion	path:04510_98	4	6.12198	0.020607375	FLNB ITGA2B ITGA5 TLN2	2317 3674 3678 83660
Mitomycin rep3	FDA approved	Circadian entrainment	path:04713_39	7	5.719257	0.040130152	GNB5 GNG5 GNGT2 MTNR1B PRKACB ADCY10 PRKX	10681 2787 2793 4544 5567 55811 5613
Mitomycin rep3	FDA approved	Cholinergic synapse	path:04725_49	9	5.75094	0.039045553	AKT3 ADCY3 AKT1 PIK3R5 GNG5 GNGT2 KRAS GNG12 CACNA1A	10000 109 207 23533 2787 2793 3845 55970 773
Mitoxantrone rep1	FDA approved	Glutathione metabolism	path:00480_10	5	5.850977	0.042763158	GGT1 GGT7 GPX4 GSS MGST3	2678 2686 2879 2937 4259
Mitoxantrone rep1	FDA approved	N-Glycan biosynthesis	path:00510_4	4	5.905656	0.039473684	ALG3 DOLPP1 RPN2 DPM1	10195 57171 6185 8813
Mitoxantrone rep1	FDA approved	Inositol phosphate metabolism	path:00562_19	3	5.827028	0.04495614	PIK3C2A PIK3CB SYNJ2	5286 5291 8871
Mitoxantrone rep1	FDA approved	MAPK signaling pathway	path:04010_30	8	6.842153	0.009868421	DUSP10 DUSP4 DUSP6 ELK4 MAPT MAPK1 MAP2K2 RAF1	11221 1846 1848 2005 4137 5594 5605 5894
Mitoxantrone rep1	FDA approved	ErbB signaling pathway	path:04012_18	8	7.460505	0.005482456	AKT3 ERBB2 ERBB3 GAB1 NRG1 PIK3CA PIK3CB PIK3CG	10000 2064 2065 2549 3084 5290 5291 5294
Mitoxantrone rep1	FDA approved	Ras signaling pathway	path:04014_54	9	6.395763	0.021929825	MRAS PIK3R5 HRAS NF1 PIK3CB PIK3CG RAF1 STK4 RASSF5	22808 23533 3265 4763 5291 5294 5894 6789 83593
Mitoxantrone rep1	FDA approved	Calcium signaling pathway	path:04020_58	7	5.821906	0.04495614	SLC25A4 PRKCA TNNC2 TNNC1 CACNA1C ORAI2 CACNA1H	291 5578 7125 7134 775 80228 8912
Mitoxantrone rep1	FDA approved	Phosphatidylinositol signaling system	path:04070_62	3	5.827028	0.04495614	PIK3C2A PIK3CB SYNJ2	5286 5291 8871
Mitoxantrone rep1	FDA approved	Sphingolipid signaling pathway	path:04071_23	7	6.26997	0.023026316	S1PR1 S1PR3 GNA12 GNAI2 GNAQ PLCB2 S1PR4	1901 1903 2768 2771 2776 5330 8698
Mitoxantrone rep1	FDA approved	PI3K-Akt signaling pathway	path:04151_79	4	8.214116	0.001096491	ITGA2B ITGA5 ITGB3 ITGB5	3674 3678 3690 3693
Mitoxantrone rep1	FDA approved	Focal adhesion	path:04510_99	5	8.811531	0	ITGA2B ITGA5 ITGB3 ITGB5 PRKCA	3674 3678 3690 3693 5578
Mitoxantrone rep1	FDA approved	Jak-STAT signaling pathway	path:04630_84	7	5.99106	0.035087719	IL19 IL6 MPL IL22 IL20RA IL20RB CBLB	29949 3569 4352 50616 53832 53833 868
Mitoxantrone rep1	FDA approved	Regulation of actin cytoskeleton	path:04810_40	6	6.223378	0.025219298	PAK4 MYL9 MRAS GIT1 PAK6 MYLK2	10298 10398 22808 28964 56924 85366
Mitoxantrone rep1	FDA approved	Insulin signaling pathway	path:04910_21	8	5.882603	0.042763158	AKT2 PIK3R5 MTOR PIK3CB PRKCI PRKCZ RPS6KB1 PIK3R3	208 23533 2475 5291 5584 5590 6198 8503
Mitoxantrone rep1	FDA approved	Melanogenesis	path:04916_8	5	6.014996	0.035087719	EP300 GNAO1 PLCB2 PRKACB PRKCA	2033 2775 5330 5567 5578
Mitoxantrone rep1	FDA approved	Prolactin signaling pathway	path:04917_6	7	5.93818	0.038377193	AKT3 AKT2 GSK3B PIK3CA PIK3CB RAF1 CCND1	10000 208 2932 5290 5291 5894 595
Mitoxantrone rep1	FDA approved	Thyroid hormone signaling pathway	path:04919_23	7	6.896864	0.00877193	CTNNB1 AKT2 GSK3B ATP1B2 PFKFB2 PIK3CA PIK3CB	1499 208 2932 482 5208 5290 5291
Mitoxantrone rep1	FDA approved	Oxytocin signaling pathway	path:04921_29	7	6.212151	0.025219298	ADCY1 PLCB1 GNAO1 GNAS PIK3CA PIK3CB PRKACB	107 23236 2775 2778 5290 5291 5567
Mitoxantrone rep1	FDA approved	Prostate cancer	path:05215_9	7	6.438525	0.020833333	ERBB2 AKT2 PIK3R5 PDGFA PDGFRA PIK3CA PIK3CB	2064 208 23533 5154 5156 5290 5291
Mitoxantrone rep1	FDA approved	Chronic myeloid leukemia	path:05220_12	10	5.974765	0.035087719	PIK3R5 CBLC ABL1 PIK3CA PIK3CB PIK3CG STAT5B CBL CBLB GAB2	23533 23624 25 5290 5291 5294 6777 867 868 9846
Mitoxantrone rep1	FDA approved	Choline metabolism in cancer	path:05231_11	6	5.937077	0.038377193	EIF4EBP1 MTOR RAC2 RAF1 RPS6KB1 PIP5K1A	1978 2475 5880 5894 6198 8394
Mitoxantrone rep2	FDA approved	N-Glycan biosynthesis	path:00510_5	5	6.362298	0.01659292	ALG3 DOLPP1 RPN1 RPN2 DPM1	10195 57171 6184 6185 8813
Mitoxantrone rep2	FDA approved	PPAR signaling pathway	path:03320_16	6	5.821849	0.038716814	DBI EHHADH ACSL6 ME1 PPARA FADS2	1622 1962 23305 4199 5465 9415
Mitoxantrone rep2	FDA approved	ErbB signaling pathway	path:04012_19	8	6.251988	0.019911504	ERBB3 AKT2 GAB1 GRB2 NRG1 PIK3CA PIK3CB SHC3	2065 208 2549 2885 3084 5290 5291 53358
Mitoxantrone rep2	FDA approved	FoxO signaling pathway	path:04068_90	7	6.002288	0.029867257	CDK2 CHUK S1PR1 FOXO1 SGK3 CCND1 STAT3	1017 1147 1901 2308 23678 595 6774
Mitoxantrone rep2	FDA approved	SNARE interactions in vesicular transport	path:04130_3	7	5.94358	0.03539823	STX2 STX1A STX3 VAMP1 VAMP2 VAMP4 VAMP3	2054 6804 6809 6843 6844 8674 9341
Mitoxantrone rep2	FDA approved	Endocytosis	path:04144_19	6	6.627494	0.012168142	WWP1 ERBB3 CBLC EPN3 ITCH CBLB	11059 2065 23624 55040 83737 868
Mitoxantrone rep2	FDA approved	PI3K-Akt signaling pathway	path:04151_80	5	9.736821	0	ITGA2B ITGA5 ITGB3 ITGB5 PTK2	3674 3678 3690 3693 5747
Mitoxantrone rep2	FDA approved	AMPK signaling pathway	path:04152_34	6	5.659149	0.047566372	EIF4EBP1 MTOR PRKAG3 PPARG RPS6KB1 ULK1	1978 2475 53632 5468 6198 8408
Mitoxantrone rep2	FDA approved	Hippo signaling pathway	path:04390_41	4	6.60048	0.012168142	CSNK1E CTNNB1 GSK3B YWHAZ	1454 1499 2932 7534
Mitoxantrone rep2	FDA approved	Focal adhesion	path:04510_100	5	9.856756	0	ITGA2B ITGA5 ITGB3 ITGB5 PTK2	3674 3678 3690 3693 5747
Mitoxantrone rep2	FDA approved	Fc gamma R-mediated phagocytosis	path:04666_13	8	5.647389	0.048672566	FCGR2A PIK3R5 HCK PIK3CA PIK3CB PLD1 SYK GAB2	2212 23533 3055 5290 5291 5337 6850 9846
Mitoxantrone rep2	FDA approved	Dopaminergic synapse	path:04728_43	7	6.609214	0.012168142	ADCY5 DRD3 GNAI2 GNAO1 GNG5 PRKACB GNB4	111 1814 2771 2775 2787 5567 59345
Mitoxantrone rep2	FDA approved	Regulation of actin cytoskeleton	path:04810_41	5	5.66797	0.047566372	RRAS2 MRAS PIK3CA PIK3CB RAF1	22800 22808 5290 5291 5894
Mitoxantrone rep2	FDA approved	Prolactin signaling pathway	path:04917_7	6	6.050095	0.027654867	FOS GSK3B CCND1 STAT3 STAT5B SOCS3	2353 2932 595 6774 6777 9021
Mitoxantrone rep2	FDA approved	Thyroid hormone signaling pathway	path:04919_24	7	5.849554	0.037610619	AKT2 ATP1B1 ATP1B2 ATP1B3 PIK3CA PIK3CB MAPK1	208 481 482 483 5290 5291 5594
Mitoxantrone rep2	FDA approved	Small cell lung cancer	path:05222_15	3	6.144721	0.025442478	ITGA2B ITGAV PTK2	3674 3685 5747
Nilotinib	FDA approved	Purine metabolism	path:00230_139	6	7.140739	0.007847534	ADSSL1 ADK ADSL ADSS IMPDH1 ENTPD1	122622 132 158 159 3614 953
Nilotinib	FDA approved	Pyrimidine metabolism	path:00240_96	12	6.860603	0.011210762	POLR3G POLR3H DUT NME7 ITPA NME1 NME3 POLR1D POLR3K POLD1 POLR2E POLR2F	10622 171568 1854 29922 3704 4830 4832 51082 51728 5424 5434 5435
Nilotinib	FDA approved	Inositol phosphate metabolism	path:00562_20	10	6.168319	0.023542601	INPP5J INPP5A ITPK1 ITPKB PLCE1 PI4KA PI4KB PIP4K2A PIP5K1A PLCZ1	27124 3632 3705 3707 51196 5297 5298 5305 8394 89869
Nilotinib	FDA approved	MAPK signaling pathway	path:04010_31	6	5.702913	0.041479821	AKT2 FLNA FLNB FLNC MAPK9 MAP2K4	208 2316 2317 2318 5601 6416
Nilotinib	FDA approved	Ras signaling pathway	path:04014_55	11	6.090334	0.025784753	EFNA4 EGFR EPHA2 FGF2 FLT4 ANGPT4 PDGFA PDGFB PDGFC SHC1 FGF17	1945 1956 1969 2247 2324 51378 5154 5155 56034 6464 8822
Nilotinib	FDA approved	Rap1 signaling pathway	path:04015_73	9	5.851721	0.035874439	ID1 PLCE1 PIK3R1 RALGDS RAP1A RAP1B RAP1GAP THBS1 FARP2	3397 51196 5295 5900 5906 5908 5909 7057 9855
Nilotinib	FDA approved	Calcium signaling pathway	path:04020_59	9	5.829528	0.038116592	SLC25A5 ITPKB ATP2B1 ATP2B4 P2RX1 PRKCA CACNA1F CALML3 CACNA1G	292 3707 490 493 5023 5578 778 810 8913
Nilotinib	FDA approved	cGMP-PKG signaling pathway	path:04022_30	12	5.887407	0.034753363	CNGB1 KCNMA1 PPP1R12A ATF4 ATP1A1 ATP1B1 ATP2B4 PDE3B PRKG1 CACNA1F CACNA1S CREB3L3	1258 3778 4659 468 476 481 493 5140 5592 778 779 84699
Nilotinib	FDA approved	cAMP signaling pathway	path:04024_34	10	6.70462	0.013452915	CREBBP EP300 NFKBIA ATP2B4 PDE3B PPARA PRKACA RELA CACNA1S CAMK2A	1387 2033 4792 493 5140 5465 5566 5970 779 815
Nilotinib	FDA approved	NF-kappa B signaling pathway	path:04064_9	7	5.932077	0.033632287	TAB1 CHUK TAB2 IL1R1 NFKB2 IRAK4 MAP3K14	10454 1147 23118 3554 4791 51135 9020
Nilotinib	FDA approved	HIF-1 signaling pathway	path:04066_23	8	5.584515	0.048206278	CREBBP EP300 HIF1A ARNT NPPA SERPINE1 ANGPT4 CAMK2G	1387 2033 3091 405 4878 5054 51378 818
Nilotinib	FDA approved	FoxO signaling pathway	path:04068_91	11	6.038328	0.02690583	CDKN2B SGK3 FASLG FOXO4 GADD45B PRKAA1 MAPK1 MAPK9 STAT3 CAT ATG12	1030 23678 356 4303 4616 5562 5594 5601 6774 847 9140
Nilotinib	FDA approved	Phosphatidylinositol signaling system	path:04070_63	10	6.240241	0.022421525	INPP5J INPP5A ITPKB PLCE1 PIK3R1 PI4KA PI4KB PIP4K2A PIP5K1A PLCZ1	27124 3632 3707 51196 5295 5297 5298 5305 8394 89869
Nilotinib	FDA approved	PI3K-Akt signaling pathway	path:04151_81	4	5.932363	0.033632287	ITGA2B ITGB1 PTK2 THBS1	3674 3688 5747 7057
Nilotinib	FDA approved	Focal adhesion	path:04510_101	5	5.921659	0.033632287	ILK ITGB1 PIK3R1 PRKCA PTK2	3611 3688 5295 5578 5747
Nilotinib	FDA approved	Fc gamma R-mediated phagocytosis	path:04666_14	6	5.671892	0.043721973	DNM2 PIK3CG PIK3R1 PLCG2 PLD2 PRKCD	1785 5294 5295 5336 5338 5580
Nilotinib	FDA approved	Hepatitis B	path:05161_2	6	6.330379	0.021300448	EP300 FASLG ATF4 PCNA MAPK1 CREB3L3	2033 356 468 5111 5594 84699
Nitrogen mustard rep1	FDA approved	Purine metabolism	path:00230_140	7	5.981418	0.028921023	POLR3A GUK1 NME7 NME1 POLE POLR3B PNPT1	11128 2987 29922 4830 5426 55703 87178
Nitrogen mustard rep1	FDA approved	Inositol phosphate metabolism	path:00562_21	7	6.017957	0.028921023	ITPKA PLCB2 PTEN PIP4K2C PIP5K1A PIP4K2B MINPP1	3706 5330 5728 79837 8394 8396 9562
Nitrogen mustard rep1	FDA approved	Rap1 signaling pathway	path:04015_74	6	5.764647	0.042269188	EFNA3 EFNA4 FGF8 NGFR PLCB2 PDGFD	1944 1945 2253 4804 5330 80310
Nitrogen mustard rep1	FDA approved	Chemokine signaling pathway	path:04062_71	6	5.69081	0.046718576	GNAI3 GNG4 GNG5 PLCB2 PRKCB GNG12	2773 2786 2787 5330 5579 55970
Nitrogen mustard rep1	FDA approved	Phosphatidylinositol signaling system	path:04070_64	8	6.516151	0.011123471	PIK3C2A PIK3C2B PI4KB PLCB2 PI4K2A PTEN PIP5K1A PIP4K2B	5286 5287 5298 5330 55361 5728 8394 8396
Nitrogen mustard rep1	FDA approved	AMPK signaling pathway	path:04152_35	6	5.684785	0.046718576	FASN GYS1 LIPE PFKFB3 PRKAB1 PRKAG1	2194 2997 3991 5209 5564 5571
Nitrogen mustard rep1	FDA approved	Wnt signaling pathway	path:04310_19	5	5.672087	0.046718576	PLCB2 PLCB4 PPP3CB PRKCA CAMK2A	5330 5332 5532 5578 815
Nitrogen mustard rep1	FDA approved	Focal adhesion	path:04510_102	8	7.429836	0.003337041	ILK ITGA2B ITGB3 ITGB5 PRKCB PXN THBS1 VASP	3611 3674 3690 3693 5579 5829 7057 7408
Nitrogen mustard rep1	FDA approved	Oxytocin signaling pathway	path:04921_30	8	5.951315	0.031145717	MYLK NFATC2 NFATC3 PLCB2 PPP3CB PRKCB RGS2 CALML3	4638 4773 4775 5330 5532 5579 5997 810
Nitrogen mustard rep2	FDA approved	Pyrimidine metabolism	path:00240_97	8	6.925742	0.002242152	NME3 NT5E POLR1D POLE POLR2L PRIM1 DCTPP1 POLR3GL	4832 4907 51082 5426 5441 5557 79077 84265
Nitrogen mustard rep2	FDA approved	Ras signaling pathway	path:04014_56	9	6.430807	0.006726457	RRAS2 RASGRP3 NF1 PLCE1 PRKCB RRAS BRAP RASAL1 RASAL2	22800 25780 4763 51196 5579 6237 8315 8437 9462
Nitrogen mustard rep2	FDA approved	cAMP signaling pathway	path:04024_35	9	5.991677	0.02690583	CREB3 CREBBP GRIA4 GRIN2D PDE4B PRKACA PRKACB SOX9 CAMK2D	10488 1387 2893 2906 5142 5566 5567 6662 817
Nitrogen mustard rep2	FDA approved	FoxO signaling pathway	path:04068_92	19	6.139632	0.016816143	CDK2 GABARAPL2 CHUK GADD45A S1PR1 FOXO1 FOXO3 ATM NLK PRKAA2 PRKAB1 PRKAG1 MAPK1 MAPK8 MAPK10 CCND1 MAPK12 TNFSF10 G6PC3	1017 11345 1147 1647 1901 2308 2309 472 51701 5563 5564 5571 5594 5599 5602 595 6300 8743 92579
Nitrogen mustard rep2	FDA approved	Hippo signaling pathway	path:04390_42	5	7.748737	0.001121076	PPP1CC PPP2R1A YWHAG YWHAZ BTRC	5501 5518 7532 7534 8945
Nitrogen mustard rep2	FDA approved	Focal adhesion	path:04510_103	6	6.672027	0.002242152	ITGB5 PRKCB PTK2 PXN THBS1 TLN2	3693 5579 5747 5829 7057 83660
Nitrogen mustard rep2	FDA approved	Tight junction	path:04530_14	3	5.799384	0.040358744	MAGI3 PRKCB ACTG1	260425 5579 71
Nitrogen mustard rep2	FDA approved	Jak-STAT signaling pathway	path:04630_85	4	5.77194	0.044843049	CREBBP MYC CCND1 STAT5B	1387 4609 595 6777
Nitrogen mustard rep2	FDA approved	Circadian entrainment	path:04713_40	9	6.658199	0.002242152	ADCY6 GNG5 MTNR1A MTNR1B NOS1 GNG13 MAPK1 GNG12 CAMK2D	112 2787 4543 4544 4842 51764 5594 55970 817
Nitrogen mustard rep2	FDA approved	Retrograde endocannabinoid signaling	path:04723_31	7	5.861648	0.035874439	ADCY6 GNG5 GNG13 PRKACA PRKACB GNG12 MAPK8	112 2787 51764 5566 5567 55970 5599
Nitrogen mustard rep2	FDA approved	Dopaminergic synapse	path:04728_44	7	5.800607	0.039237668	CREB3 GRIA4 PRKACA PRKACB PRKCB MAPK8 CALM3	10488 2893 5566 5567 5579 5599 808
Nitrogen mustard rep2	FDA approved	Morphine addiction	path:05032_33	7	5.954836	0.031390135	ADCY6 GNG5 GNG13 PRKACA PRKACB PRKCB GNG12	112 2787 51764 5566 5567 5579 55970
Olaparib rep1	FDA approved	Steroid hormone biosynthesis	path:00140_3	12	6.466143	0.033407572	CYP2E1 CYP3A4 CYP3A5 HSD3B1 HSD11B1 HSD17B2 STS HSD17B12 HSD17B7 AKR1D1 UGT2B7 SRD5A3	1571 1576 1577 3283 3290 3294 412 51144 51478 6718 7364 79644
Olaparib rep1	FDA approved	Purine metabolism	path:00230_141	12	8.975532	0.001113586	ADCY1 DCK AK9 POLR2J2 NPR1 PDE1A PDE1C PKLR POLD2 POLR2J ADCY10 ENTPD3	107 1633 221264 246721 4881 5136 5137 5313 5425 5439 55811 956
Olaparib rep1	FDA approved	Metabolism of xenobiotics by cytochrome P450	path:00980_7	9	8.017402	0.003340757	CYP2B6 CYP3A4 CYP3A5 EPHX1 GSTM1 GSTM2 GSTM4 GSTM5 GSTK1	1555 1576 1577 2052 2944 2946 2948 2949 373156
Olaparib rep1	FDA approved	Chemokine signaling pathway	path:04062_72	8	6.7194	0.017817372	CCR9 GNAI1 GNB2 GNG11 GNGT1 CXCL1 JAK3 PIK3CG	10803 2770 2783 2791 2792 2919 3718 5294
Olaparib rep1	FDA approved	Phosphatidylinositol signaling system	path:04070_65	8	6.468435	0.033407572	INPP1 INPP5A PIK3C2B PIK3CG PI4KB PLCD1 PIP5K1A DGKI	3628 3632 5287 5294 5298 5333 8394 9162
Olaparib rep1	FDA approved	Jak-STAT signaling pathway	path:04630_86	17	8.626893	0.001113586	IL24 IL19 IFNAR1 IFNAR2 IL6 IL6R IL6ST IL10 IL10RB LEP LIFR IL20 IL20RB PRLR CBLB SOCS3 OSMR	11009 29949 3454 3455 3569 3570 3572 3586 3588 3952 3977 50604 53833 5618 868 9021 9180
Olaparib rep1	FDA approved	Circadian entrainment	path:04713_41	6	6.475295	0.033407572	ADCY1 GNAI1 GNB2 GNG11 GNGT1 ADCY10	107 2770 2783 2791 2792 55811
Olaparib rep1	FDA approved	Retrograde endocannabinoid signaling	path:04723_32	5	6.38651	0.034521158	ADCY1 GNAI1 GNB2 GNG11 GNGT1	107 2770 2783 2791 2792
Olaparib rep1	FDA approved	Glutamatergic synapse	path:04724_34	8	6.374712	0.035634744	ADCY1 GNAI1 GNB2 GNG11 GNGT1 GRIA3 GRIA4 GRM8	107 2770 2783 2791 2792 2892 2893 2918
Olaparib rep1	FDA approved	Cholinergic synapse	path:04725_50	8	6.695186	0.018930958	ADCY1 CHRM2 CHRNB2 GNAI1 GNB2 GNG11 GNGT1 PIK3CG	107 1129 1141 2770 2783 2791 2792 5294
Olaparib rep1	FDA approved	Morphine addiction	path:05032_34	5	6.38651	0.034521158	ADCY1 GNAI1 GNB2 GNG11 GNGT1	107 2770 2783 2791 2792
Olaparib rep1	FDA approved	Chemical carcinogenesis	path:05204_5	7	6.870612	0.0155902	CYP3A4 EPHX1 GSTM1 GSTM2 GSTM4 GSTM5 GSTK1	1576 2052 2944 2946 2948 2949 373156
Olaparib rep2	FDA approved	Purine metabolism	path:00230_142	10	7.085228	0.013114754	CANT1 ADSL ADSS DCK AK9 GUK1 PDE1A PDE1C PDE3B PDE5A	124583 158 159 1633 221264 2987 5136 5137 5140 8654
Olaparib rep2	FDA approved	Inositol phosphate metabolism	path:00562_22	8	8.314997	0.001092896	CDIPT INPP5D OCRL PIK3C2B PI4KA PI4KB PLCB2 PIP5K1A	10423 3635 4952 5287 5297 5298 5330 8394
Olaparib rep2	FDA approved	MAPK signaling pathway	path:04010_32	7	5.964654	0.046994536	CRKL NFATC3 MAPK8 MAPK9 MAPK10 PTPN7 MAPK8IP1	1399 4775 5599 5601 5602 5778 9479
Olaparib rep2	FDA approved	Rap1 signaling pathway	path:04015_75	17	7.240174	0.009836066	CRKL EFNA1 EFNA3 EFNA4 FGF2 FGF5 FGF7 FGF12 FGF13 FGFR2 FGFR4 HGF KDR KIT MET PLCB2 VEGFC	1399 1942 1944 1945 2247 2250 2252 2257 2258 2263 2264 3082 3791 3815 4233 5330 7424
Olaparib rep2	FDA approved	Phosphatidylinositol signaling system	path:04070_66	10	8.314997	0.001092896	CDIPT INPP1 INPP5A ITPKA OCRL PIK3C2B PI4KA PI4KB PLCB2 PIP5K1A	10423 3628 3632 3706 4952 5287 5297 5298 5330 8394
Olaparib rep2	FDA approved	Cell cycle	path:04110_15	8	6.237312	0.03715847	DBF4 MCM3 MCM5 MCM6 MCM7 ORC5 CDC45 CDC6	10926 4172 4174 4175 4176 5001 8318 990
Olaparib rep2	FDA approved	Axon guidance	path:04360_5	4	6.876905	0.015300546	EFNA1 EFNA3 EFNA4 RASA1	1942 1944 1945 5921
Olaparib rep2	FDA approved	Jak-STAT signaling pathway	path:04630_87	8	6.982518	0.01420765	IL19 IL6R IL10 LEP IL20 IL20RA IL26 SOCS3	29949 3570 3586 3952 50604 53832 55801 9021
Olaparib rep2	FDA approved	Circadian entrainment	path:04713_42	6	6.450402	0.029508197	GNB2 GNG11 GNGT1 PLCB2 ADCY10 MAPK1	2783 2791 2792 5330 55811 5594
Olaparib rep2	FDA approved	Retrograde endocannabinoid signaling	path:04723_33	8	6.670436	0.019672131	MAPK14 GNAI1 GNB2 GNG11 GNGT1 MAPK1 MAPK10 MAPK13	1432 2770 2783 2791 2792 5594 5602 5603
Oxaliplatin	FDA approved	Pyrimidine metabolism	path:00240_98	7	7.393628	0.002254791	UPRT NT5E TYMS UCK1 ENTPD6 ENTPD3 ENTPD5	139596 4907 7298 83549 955 956 957
Oxaliplatin	FDA approved	Hippo signaling pathway	path:04390_43	4	8.20177	0	PPP1CB PPP2R1A PPP2R1B YWHAZ	5500 5518 5519 7534
Oxaliplatin	FDA approved	Focal adhesion	path:04510_104	8	7.795232	0	FLNA ITGA2 ITGAV ITGB5 PXN TLN1 TLN2 CAV2	2316 3673 3685 3693 5829 7094 83660 858
Oxaliplatin	FDA approved	Dopaminergic synapse	path:04728_45	6	6.618814	0.012401353	ADCY5 GNAI1 GNG11 PLCB4 PRKCB GNG12	111 2770 2791 5332 5579 55970
Oxaliplatin	FDA approved	Insulin signaling pathway	path:04910_22	7	6.774956	0.006764374	GSK3B GYS2 PHKG1 PPP1CB PYGB PYGL CALM1	2932 2998 5260 5500 5834 5836 801
Oxaliplatin	FDA approved	GnRH signaling pathway	path:04912_4	7	6.119982	0.036076663	MAP3K3 MAP3K4 PLCB4 PLD1 PRKCB MAPK7 MAP2K3	4215 4216 5332 5337 5579 5598 5606
Oxaliplatin	FDA approved	Pathways in cancer	path:05200_42	5	6.898936	0.006764374	E2F3 FOS MYC PGF CCND1	1871 2353 4609 5228 595
Oxaliplatin	FDA approved	Proteoglycans in cancer	path:05205_12	7	6.442097	0.019165727	CTNNB1 ERBB2 ERBB3 HIF1A MYC CBL CBLB	1499 2064 2065 3091 4609 867 868
Oxaliplatin	FDA approved	Basal cell carcinoma	path:05217_3	3	5.891208	0.049605411	GLI1 GLI3 BMP2	2735 2737 650
Paclitaxel rep1	FDA approved	Purine metabolism	path:00230_143	11	6.508519	0.018743109	POLR3G ADCY8 ADCY9 POLR1D PDE4D POLR2C POLR2D POLR2K ADCY10 PDE8B PNPT1	10622 114 115 51082 5144 5432 5433 5440 55811 8622 87178
Paclitaxel rep1	FDA approved	Ras signaling pathway	path:04014_57	11	7.227363	0.004410143	AKT3 RRAS2 AFDN PLCE1 PIK3CG PIK3R1 RALGDS RASGRF2 RRAS SOS1 RIN1	10000 22800 4301 51196 5294 5295 5900 5924 6237 6654 9610
Paclitaxel rep1	FDA approved	Chemokine signaling pathway	path:04062_73	8	7.229102	0.004410143	AKT3 GNB5 PLCB1 GNG11 PIK3CG PIK3R1 PLCB4 GNG12	10000 10681 23236 2791 5294 5295 5332 55970
Paclitaxel rep1	FDA approved	FoxO signaling pathway	path:04068_93	6	8.768658	0	AKT3 FOXO4 PDPK1 PIK3CG PIK3R1 HOMER1	10000 4303 5170 5294 5295 9456
Paclitaxel rep1	FDA approved	Phosphatidylinositol signaling system	path:04070_67	8	6.397943	0.019845645	PLCB1 INPP5D INPPL1 PLCE1 PIK3CG PIK3R1 PLCB4 DGKZ	23236 3635 3636 51196 5294 5295 5332 8525
Paclitaxel rep1	FDA approved	Wnt signaling pathway	path:04310_20	4	6.986472	0.007717751	PLCB1 PLCB4 PPP3R1 CAMK2A	23236 5332 5534 815
Paclitaxel rep1	FDA approved	Hippo signaling pathway	path:04390_44	4	7.019148	0.006615215	ITGB2 SMAD3 SERPINE1 YWHAZ	3689 4088 5054 7534
Paclitaxel rep1	FDA approved	Focal adhesion	path:04510_105	5	7.658571	0.001102536	FLNA ITGB3 PXN THBS1 TLN2	2316 3690 5829 7057 83660
Paclitaxel rep1	FDA approved	Signaling pathways regulating pluripotency of stem cells	path:04550_5	5	6.047967	0.033076075	AKT3 IL6ST LIF PIK3CG PIK3R1	10000 3572 3976 5294 5295
Paclitaxel rep1	FDA approved	Circadian entrainment	path:04713_43	12	6.634863	0.017640573	GNB5 ADCY8 ADCY9 PLCB1 GNG11 GNGT1 MTNR1B PLCB4 ADCY10 MAPK1 GNG12 CAMK2A	10681 114 115 23236 2791 2792 4544 5332 55811 5594 55970 815
Paclitaxel rep1	FDA approved	Cholinergic synapse	path:04725_51	7	6.651617	0.017640573	AKT3 GNB5 ADCY9 GNG11 PIK3CG PIK3R1 GNG12	10000 10681 115 2791 5294 5295 55970
Paclitaxel rep1	FDA approved	Thyroid hormone signaling pathway	path:04919_25	7	7.43348	0.003307607	AKT3 HIF1A ATP1A2 ATP1A4 PIK3CG PIK3R1 THRA	10000 3091 477 480 5294 5295 7067
Paclitaxel rep1	FDA approved	Prostate cancer	path:05215_10	10	6.087665	0.031973539	AKT3 CHUK EGFR NFKB1 NFKBIA PDPK1 PIK3CG PIK3R1 PDGFC TGFA	10000 1147 1956 4790 4792 5170 5294 5295 56034 7039
Paclitaxel rep1	FDA approved	Small cell lung cancer	path:05222_16	3	6.102405	0.030871003	ITGA2 ITGAV PTK2	3673 3685 5747
Paclitaxel rep1	FDA approved	Choline metabolism in cancer	path:05231_12	6	5.827683	0.049614112	AKT3 EGFR PDPK1 PIK3CG PIK3R1 PDGFC	10000 1956 5170 5294 5295 56034
Paclitaxel rep2	FDA approved	Purine metabolism	path:00230_144	10	6.453695	0.025414365	ADCY6 ADCY9 POLR3H ZNRD1 NME1 PDE9A POLR2C POLR2D POLR1E POLR3D	112 115 171568 30834 4830 5152 5432 5433 64425 661
Paclitaxel rep2	FDA approved	Pyrimidine metabolism	path:00240_99	7	6.791825	0.011049724	NME7 ZNRD1 POLR2D POLR2I POLR1E POLR3D POLR1C	29922 30834 5433 5438 64425 661 9533
Paclitaxel rep2	FDA approved	Ras signaling pathway	path:04014_58	6	6.173856	0.039779006	AKT3 PIK3R5 PIK3CA PIK3R1 RAC3 RRAS	10000 23533 5290 5295 5881 6237
Paclitaxel rep2	FDA approved	Rap1 signaling pathway	path:04015_76	8	6.401018	0.027624309	AKT3 PIK3R5 AFDN PIK3CA PIK3R1 RALGDS RAP1B RAP1GAP	10000 23533 4301 5290 5295 5900 5908 5909
Paclitaxel rep2	FDA approved	Chemokine signaling pathway	path:04062_74	8	7.419308	0.001104972	AKT3 PLCB1 PIK3R5 GNB1 GNG11 PIK3R1 PLCB4 PRKCZ	10000 23236 23533 2782 2791 5295 5332 5590
Paclitaxel rep2	FDA approved	HIF-1 signaling pathway	path:04066_24	8	6.731801	0.013259669	ENO1 EP300 HIF1A NPPA PDK1 PFKFB3 PFKL HKDC1	2023 2033 3091 4878 5163 5209 5211 80201
Paclitaxel rep2	FDA approved	FoxO signaling pathway	path:04068_94	13	7.896433	0	AKT3 CDKN1A PLK2 GADD45A GABARAPL1 IL7R FOXO4 PRKAG2 PRKAA2 RAG2 CCND1 STAT3 CCNB2	10000 1026 10769 1647 23710 3575 4303 51422 5563 5897 595 6774 9133
Paclitaxel rep2	FDA approved	Sphingolipid signaling pathway	path:04071_24	9	6.104104	0.040883978	AKT3 PLCB1 PIK3R5 GNAI1 PDPK1 PIK3R1 PLCB4 RAC3 BDKRB2	10000 23236 23533 2770 5170 5295 5332 5881 624
Paclitaxel rep2	FDA approved	AMPK signaling pathway	path:04152_36	5	6.738752	0.013259669	ADRA1A MTOR PRKAG2 PFKFB3 PRKAA2	148 2475 51422 5209 5563
Paclitaxel rep2	FDA approved	Axon guidance	path:04360_6	4	6.232147	0.035359116	EPHA2 RAC3 RASA1 CDC42	1969 5881 5921 998
Paclitaxel rep2	FDA approved	Hippo signaling pathway	path:04390_45	3	6.288473	0.030939227	ITGB2 PPP2R2A YWHAZ	3689 5520 7534
Paclitaxel rep2	FDA approved	Focal adhesion	path:04510_106	6	6.947636	0.008839779	FLNA FLNB ITGA2B ITGB1 ITGB3 PXN	2316 2317 3674 3688 3690 5829
Paclitaxel rep2	FDA approved	Jak-STAT signaling pathway	path:04630_88	4	6.877822	0.009944751	EP300 CCND1 STAT3 STAT5A	2033 595 6774 6776
Paclitaxel rep2	FDA approved	Serotonergic synapse	path:04726_30	6	6.129025	0.039779006	PLCB1 GNB1 GNG11 HTR1D HTR6 PLCB4	23236 2782 2791 3352 3362 5332
Paclitaxel rep2	FDA approved	GABAergic synapse	path:04727_27	7	6.106097	0.040883978	ADCY6 ADCY9 GABARAPL1 GABBR1 GABRD GNB1 GNG11	112 115 23710 2550 2563 2782 2791
Paclitaxel rep2	FDA approved	Insulin signaling pathway	path:04910_23	6	6.937276	0.008839779	AKT3 EIF4EBP1 PIK3R5 MTOR PRKCZ HKDC1	10000 1978 23533 2475 5590 80201
Paclitaxel rep2	FDA approved	Pathways in cancer	path:05200_43	8	5.977743	0.043093923	AKT3 CDKN1A EGFR FLT3 PIK3CB PIK3R1 CYCS CASP9	10000 1026 1956 2322 5291 5295 54205 842
Paclitaxel rep2	FDA approved	Pancreatic cancer	path:05212_15	7	6.781039	0.011049724	AKT3 EGFR PIK3R5 PIK3CA PIK3R1 STAT3 TGFA	10000 1956 23533 5290 5295 6774 7039
Paclitaxel rep2	FDA approved	Chronic myeloid leukemia	path:05220_13	8	6.834547	0.011049724	AKT3 CDKN2A CRK PIK3R5 MDM2 PIK3R1 BAD BCL2L1	10000 1029 1398 23533 4193 5295 572 598
Palbociclib	FDA approved	Ras signaling pathway	path:04014_59	7	6.139691	0.019911504	MRAS GNB1 GNG5 GNG11 GNG12 RASGRF1 GNB4	22808 2782 2787 2791 55970 5923 59345
Palbociclib	FDA approved	Calcium signaling pathway	path:04020_60	10	5.763737	0.036504425	PTK2B GRIN2A ATP2A1 ATP2A3 P2RX5 PLCG2 PRKCB TNNC2 VDAC3 CALM3	2185 2903 487 489 5026 5336 5579 7125 7419 808
Palbociclib	FDA approved	cAMP signaling pathway	path:04024_36	11	7.174638	0.002212389	ADRB1 GABBR1 GNAI3 HTR1B HTR1E HTR4 OXTR SSTR2 SSTR5 VIPR2 GABBR2	153 2550 2773 3351 3354 3360 5021 6752 6755 7434 9568
Palbociclib	FDA approved	Phagosome	path:04145_1	3	6.354941	0.01659292	DYNC1H1 DYNC1LI2 DYNC1LI1	1778 1783 51143
Palbociclib	FDA approved	Focal adhesion	path:04510_107	3	7.200221	0.002212389	ITGAV PRKCB THBS1	3685 5579 7057
Palbociclib	FDA approved	Tight junction	path:04530_15	3	6.988871	0.003318584	CTNNB1 PRKCB ACTB	1499 5579 60
Palbociclib	FDA approved	Gap junction	path:04540_5	6	6.789587	0.006637168	ADCY5 ADCY9 GNAI3 HRAS PRKACA PRKACB	111 115 2773 3265 5566 5567
Palbociclib	FDA approved	Jak-STAT signaling pathway	path:04630_89	10	7.071672	0.003318584	IFNAR1 IFNG IFNGR2 IL2 IL5RA IL6ST IL12RB2 IL23A SOCS3 OSMR	3454 3458 3460 3558 3568 3572 3595 51561 9021 9180
Palbociclib	FDA approved	Natural killer cell mediated cytotoxicity	path:04650_9	6	6.362241	0.015486726	LAT PIK3CA PLCG2 PRKCB SHC1 SYK	27040 5290 5336 5579 6464 6850
Palbociclib	FDA approved	Circadian entrainment	path:04713_44	13	6.223889	0.019911504	ADCY1 ADCY5 ADCY8 ADCY9 GNAI3 GNB1 GNG5 GNG11 GNG13 PRKACB MAPK1 GNG12 GNB4	107 111 114 115 2773 2782 2787 2791 51764 5567 5594 55970 59345
Palbociclib	FDA approved	Retrograde endocannabinoid signaling	path:04723_34	14	5.839726	0.033185841	ADCY1 ADCY5 ADCY8 ADCY9 GNAI3 GNB1 GNG5 GNG11 PRKACA PRKACB MAPK1 GNG12 MAPK13 GNB4	107 111 114 115 2773 2782 2787 2791 5566 5567 5594 55970 5603 59345
Palbociclib	FDA approved	Glutamatergic synapse	path:04724_35	6	6.365278	0.015486726	ADCY8 GNB1 GNG5 GRM7 GNG12 GNB4	114 2782 2787 2917 55970 59345
Palbociclib	FDA approved	Cholinergic synapse	path:04725_52	9	5.951383	0.026548673	ADCY5 ADCY8 GNAI3 GNB1 GNG5 GNG11 PRKACA GNG12 GNB4	111 114 2773 2782 2787 2791 5566 55970 59345
Palbociclib	FDA approved	Serotonergic synapse	path:04726_31	9	6.829499	0.004424779	GNAI3 GNB1 GNG5 GNG11 HTR1E HTR4 HTR5A GNG12 GNB4	2773 2782 2787 2791 3354 3360 3361 55970 59345
Palbociclib	FDA approved	GABAergic synapse	path:04727_28	6	7.562879	0.002212389	GABRA1 GABRA4 GABRA6 GABRB2 GABRG2 GABBR2	2554 2557 2559 2561 2566 9568
Palbociclib	FDA approved	Morphine addiction	path:05032_35	6	7.693061	0.002212389	GNAI3 GNB1 GNG5 PRKACB GNG12 GABBR2	2773 2782 2787 5567 55970 9568
Panobinostat	FDA approved	Purine metabolism	path:00230_145	7	7.67816	0.002207506	ADCY9 AK5 ZNRD1 NT5E PDE3B POLR2D POLR3E	115 26289 30834 4907 5140 5433 55718
Panobinostat	FDA approved	Pyrimidine metabolism	path:00240_100	7	6.521517	0.023178808	NME6 CTPS1 NT5E CMPK1 POLR2D POLR2H POLR3E	10201 1503 4907 51727 5433 5437 55718
Panobinostat	FDA approved	Glycerophospholipid metabolism	path:00564_20	9	5.915298	0.047461369	PEMT LYPLA1 MBOAT2 PLA2G15 PLA2G2D PNPLA7 PLA2G3 PLA2G2A PLA2G2F	10400 10434 129642 23659 26279 375775 50487 5320 64600
Panobinostat	FDA approved	Nicotinate and nicotinamide metabolism	path:00760_6	6	6.14522	0.033112583	NAMPT AOX1 NNMT NT5E ENPP1 NMNAT1	10135 316 4837 4907 5167 64802
Panobinostat	FDA approved	Chemokine signaling pathway	path:04062_75	6	6.12529	0.034216336	AKT3 FOXO3 GNAI3 GNGT1 PIK3CD PIK3CG	10000 2309 2773 2792 5293 5294
Panobinostat	FDA approved	PI3K-Akt signaling pathway	path:04151_82	3	6.481905	0.024282561	ITGB1 PTK2 THBS1	3688 5747 7057
Panobinostat	FDA approved	Hippo signaling pathway	path:04390_46	3	6.642003	0.020971302	ITGB2 SERPINE1 YWHAG	3689 5054 7532
Panobinostat	FDA approved	Focal adhesion	path:04510_108	5	7.022175	0.011037528	FLNC ITGAV ITGB1 THBS1 TLN2	2318 3685 3688 7057 83660
Panobinostat	FDA approved	Circadian entrainment	path:04713_45	7	5.998709	0.04415011	ADCY9 GNAI3 GNB1 GNB3 GNG11 GNGT1 GNG12	115 2773 2782 2784 2791 2792 55970
Panobinostat	FDA approved	Retrograde endocannabinoid signaling	path:04723_35	9	6.055695	0.038631347	ADCY9 CNR1 GNAI3 GNB1 GNB3 GNG11 GNGT1 GNG12 MAPK8	115 1268 2773 2782 2784 2791 2792 55970 5599
Panobinostat	FDA approved	Cholinergic synapse	path:04725_53	11	6.974647	0.013245033	AKT3 ADCY9 AKT1 GNAI3 GNB1 GNB3 GNG11 GNGT1 PIK3CG GNG12 PIK3R3	10000 115 207 2773 2782 2784 2791 2792 5294 55970 8503
Panobinostat	FDA approved	Serotonergic synapse	path:04726_32	9	6.393189	0.027593819	GNAI3 GNB1 GNB3 GNG11 GNGT1 HTR1B HTR1D HTR1E GNG12	2773 2782 2784 2791 2792 3351 3352 3354 55970
Panobinostat	FDA approved	GABAergic synapse	path:04727_29	8	7.541108	0.003311258	ADCY9 GABRG2 GNAI3 GNB1 GNG11 GNGT1 GNG12 GABBR2	115 2566 2773 2782 2791 2792 55970 9568
Panobinostat	FDA approved	Morphine addiction	path:05032_36	8	6.939743	0.014348786	ADCY9 GNAI3 GNB3 GNG11 GNGT1 PRKCA GNG12 GABBR2	115 2773 2784 2791 2792 5578 55970 9568
Pazopanib rep1	FDA approved	Purine metabolism	path:00230_146	15	8.764481	0	ADCY6 ADSL DCK AK9 NME7 GUCY2D NPR2 RRM2B PDE2A PDE1B POLR2A POLR2B POLR2C POLR2K PDE8B	112 158 1633 221264 29922 3000 4882 50484 5138 5153 5430 5431 5432 5440 8622
Pazopanib rep1	FDA approved	Pyrimidine metabolism	path:00240_101	8	6.681725	0.019650655	AK9 RRM2B POLR2A POLR2B POLR2C POLR2K POLE4 RRM2	221264 50484 5430 5431 5432 5440 56655 6241
Pazopanib rep1	FDA approved	Inositol phosphate metabolism	path:00562_23	9	7.173906	0.004366812	IMPA1 INPP1 INPP5K PIK3CB PIP4K2A PLCB4 IMPAD1 MIOX MINPP1	3612 3628 51763 5291 5305 5332 54928 55586 9562
Pazopanib rep1	FDA approved	Rap1 signaling pathway	path:04015_77	6	6.018972	0.046943231	RAPGEF3 RASGRP3 PIK3CB PLCB4 RAP1B TIAM1	10411 25780 5291 5332 5908 7074
Pazopanib rep1	FDA approved	Chemokine signaling pathway	path:04062_76	10	6.008296	0.049126638	CX3CR1 GRK2 GNAI3 CXCL1 CXCL2 CXCR1 CXCL10 ARRB2 PF4 CCL5	1524 156 2773 2919 2920 3577 3627 409 5196 6352
Pazopanib rep1	FDA approved	Phosphatidylinositol signaling system	path:04070_68	10	7.095327	0.005458515	IMPA1 INPP1 INPP5K PIK3C2B PIK3CB PIP4K2A PLCB4 IMPAD1 PI4K2B DGKI	3612 3628 51763 5287 5291 5305 5332 54928 55300 9162
Pazopanib rep1	FDA approved	Focal adhesion	path:04510_109	6	6.121347	0.038209607	FLNC ITGA5 ITGB1 ITGB3 PTK2 TLN1	2318 3678 3688 3690 5747 7094
Pazopanib rep1	FDA approved	Regulation of actin cytoskeleton	path:04810_42	3	6.550742	0.020742358	CRK ITGA5 ITGB3	1398 3678 3690
Pazopanib rep2	FDA approved	Purine metabolism	path:00230_147	7	6.278639	0.026519337	NME1 NPR2 POLR2A POLR2B POLR2G POLR2K PDE5A	4830 4882 5430 5431 5436 5440 8654
Pazopanib rep2	FDA approved	Inositol phosphate metabolism	path:00562_24	6	6.840148	0.011049724	INPPL1 PIK3C2B PIP4K2A PLCB4 PI4K2B PTEN	3636 5287 5305 5332 55300 5728
Pazopanib rep2	FDA approved	MAPK signaling pathway	path:04010_33	11	6.03334	0.036464088	DUSP10 DDIT3 DUSP1 DUSP4 DUSP6 HSPB1 MAPK11 MAPK10 MAPK13 MAPKAPK3 MAPKAPK2	11221 1649 1843 1846 1848 3315 5600 5602 5603 7867 9261
Pazopanib rep2	FDA approved	Ras signaling pathway	path:04014_60	8	5.847864	0.044198895	MRAS ABL1 ABL2 KRAS RASGRF1 RRAS PIK3R3 RIN1	22808 25 27 3845 5923 6237 8503 9610
Pazopanib rep2	FDA approved	Rap1 signaling pathway	path:04015_78	15	6.409322	0.02320442	CSF1 FGF2 FGF3 FGF5 FGF9 FGFR1 ANGPT1 INSR KDR NGFR PDGFA PLCB4 PDGFC VEGFB VEGFC	1435 2247 2248 2250 2254 2260 284 3643 3791 4804 5154 5332 56034 7423 7424
Pazopanib rep2	FDA approved	Cell cycle	path:04110_16	9	6.966043	0.009944751	CDKN1C CDKN2A CDKN2B CDKN2C E2F2 PCNA CCND1 CCNA2 CCNE2	1028 1029 1030 1031 1870 5111 595 890 9134
Pazopanib rep2	FDA approved	p53 signaling pathway	path:04115_24	11	6.120275	0.032044199	GADD45A RCHY1 FAS RRM2B SERPINE1 SERPINB5 STEAP3 PTEN TP53 TP73 SESN2	1647 25898 355 50484 5054 5268 55240 5728 7157 7161 83667
Pazopanib rep2	FDA approved	PI3K-Akt signaling pathway	path:04151_83	3	7.134101	0.006629834	ITGA5 ITGB1 ITGB3	3678 3688 3690
Pazopanib rep2	FDA approved	Hedgehog signaling pathway	path:04340_6	3	5.749521	0.048618785	GLI3 PRKX BMP2	2737 5613 650
Pazopanib rep2	FDA approved	Focal adhesion	path:04510_110	8	8.401348	0	ITGA5 ITGB1 ITGB3 PTK2 TLN1 CAV1 CAV2 CAV3	3678 3688 3690 5747 7094 857 858 859
Pazopanib rep2	FDA approved	Jak-STAT signaling pathway	path:04630_90	6	6.974664	0.009944751	IFNLR1 IFNG IL6ST IL7 IL15 OSMR	163702 3458 3572 3574 3600 9180
Pazopanib rep2	FDA approved	Circadian entrainment	path:04713_46	8	5.774355	0.047513812	ADCY5 ADCY8 GNAI3 GNB3 GNG11 PLCB4 GNG12 PRKX	111 114 2773 2784 2791 5332 55970 5613
Pazopanib rep2	FDA approved	Retrograde endocannabinoid signaling	path:04723_36	10	6.344169	0.025414365	ADCY5 ADCY8 GNAI3 GNB3 GNG11 GNG12 MAPK11 MAPK10 MAPK13 PRKX	111 114 2773 2784 2791 55970 5600 5602 5603 5613
Pazopanib rep2	FDA approved	GABAergic synapse	path:04727_30	5	5.768372	0.047513812	GABRA5 GABRG1 GABRP GABRR1 GABBR2	2558 2565 2568 2569 9568
Pemetrexed	FDA approved	Purine metabolism	path:00230_148	18	7.837794	0.001103753	POLR3F POLR3A AK1 HPRT1 ENTPD8 NME3 PDE8A POLR2A POLR2D POLR2E POLR2I POLR2J POLR3B POLR3E GMPS ENTPD6 ENTPD3 ENTPD5	10621 11128 203 3251 377841 4832 5151 5430 5433 5434 5438 5439 55703 55718 8833 955 956 957
Pemetrexed	FDA approved	Pyrimidine metabolism	path:00240_102	14	7.100096	0.013245033	POLR3F POLR3C POLR2J2 NME4 POLR2A POLR2D POLR2E POLR2H POLR2I POLR2J POLR2K POLR3B CTPS2 POLR3D	10621 10623 246721 4833 5430 5433 5434 5437 5438 5439 5440 55703 56474 661
Pemetrexed	FDA approved	Jak-STAT signaling pathway	path:04630_91	9	6.061941	0.045253863	CTF1 IFNG IL2RG IL4R IL13RA1 LEPR MPL IL21R SOCS1	1489 3458 3561 3566 3597 3953 4352 50615 8651
Pentostatin	FDA approved	Purine metabolism	path:00230_149	7	7.949666	0.001118568	NUDT16 DGUOK NT5E PDE6G PKM GMPS ENTPD6	131870 1716 4907 5148 5315 8833 955
Pentostatin	FDA approved	MAPK signaling pathway	path:04010_34	8	6.208609	0.036912752	DUSP4 DUSP5 DUSP8 MECOM MAPK8 MAPK9 PTPN7 MAPK12	1846 1847 1850 2122 5599 5601 5778 6300
Pentostatin	FDA approved	Ras signaling pathway	path:04014_61	7	6.540119	0.025727069	RALBP1 AKT1 HRAS PIK3CA PIK3CB PIK3CG RAC3	10928 207 3265 5290 5291 5294 5881
Pentostatin	FDA approved	cGMP-PKG signaling pathway	path:04022_31	11	6.338585	0.032438479	KCNMB2 ATF2 KCNMB3 ATP1B3 PPP1CB PRKCE PRKG1 RGS2 SLC8A3 CREB3L3 CREB5	10242 1386 27094 483 5500 5581 5592 5997 6547 84699 9586
Pentostatin	FDA approved	Chemokine signaling pathway	path:04062_77	10	6.507835	0.026845638	CHUK AKT1 GNG4 GSK3B HRAS PIK3CA PIK3CB GNG12 GNB4 SRC	1147 207 2786 2932 3265 5290 5291 55970 59345 6714
Pentostatin	FDA approved	Sphingolipid signaling pathway	path:04071_25	7	6.474744	0.029082774	GNAI1 PIK3CA PLD1 PRKCE RAC3 PIK3R3 SPHK1	2770 5290 5337 5581 5881 8503 8877
Pentostatin	FDA approved	p53 signaling pathway	path:04115_25	9	7.839765	0.001118568	MDM4 SHISA5 ATR PIDD1 ZMAT3 TP53 CASP8 PPM1D TNFRSF10B	4194 51246 545 55367 64393 7157 841 8493 8795
Pentostatin	FDA approved	PI3K-Akt signaling pathway	path:04151_84	6	6.022822	0.044742729	AKT1 HRAS JAK2 PIK3CA PIK3CB PRL	207 3265 3717 5290 5291 5617
Pentostatin	FDA approved	Adrenergic signaling in cardiomyocytes	path:04261_29	6	6.156842	0.039149888	CACNG5 PPP1CB PPP2R2A PPP2R3A PRKACA CACNB3	27091 5500 5520 5523 5566 784
Pentostatin	FDA approved	Focal adhesion	path:04510_111	7	8.262026	0	FLNB ILK ITGB5 PRKCB PXN SRC TLN2	2317 3611 3693 5579 5829 6714 83660
Pentostatin	FDA approved	Insulin signaling pathway	path:04910_24	6	6.284482	0.033557047	AKT1 GSK3B PPP1CB PYGB SLC2A4 CALML3	207 2932 5500 5834 6517 810
Pentostatin	FDA approved	GnRH signaling pathway	path:04912_5	6	6.345191	0.032438479	HRAS MAP3K3 PLD1 PRKCB MAP2K3 SRC	3265 4215 5337 5579 5606 6714
Pentostatin	FDA approved	Thyroid hormone signaling pathway	path:04919_26	10	6.181447	0.039149888	AKT1 GSK3B HIF1A ATP1B3 PFKFB2 PFKP PIK3CA PIK3CB SLC2A1 SRC	207 2932 3091 483 5208 5214 5290 5291 6513 6714
Pentostatin	FDA approved	Pathways in cancer	path:05200_44	7	6.24408	0.035794183	ABL1 GRB2 HRAS PIK3CA PIK3CB PRKCB CBLB	25 2885 3265 5290 5291 5579 868
Pentostatin	FDA approved	Choline metabolism in cancer	path:05231_13	6	5.966996	0.049217002	GRB2 HRAS PIK3CA PIK3CB PLD1 SOS1	2885 3265 5290 5291 5337 6654
Pipobroman	FDA approved	Purine metabolism	path:00230_150	26	6.244842	0.036263736	ADA ADCY3 POLR3A NT5C3B ADSSL1 NUDT16 DCK ADCY4 POLR2J2 AMPD1 GMPR GUCY1A2 GUCY2D NUDT2 NME4 PDE4B PDE6A PDE6D POLR2A POLR2C POLR2K POLR3B POLR1E POLR3GL PDE5A ENTPD3	100 109 11128 115024 122622 131870 1633 196883 246721 270 2766 2977 3000 318 4833 5142 5145 5147 5430 5432 5440 55703 64425 84265 8654 956
Pipobroman	FDA approved	Glycerolipid metabolism	path:00561_8	7	6.020765	0.046153846	MBOAT2 DGKG LPIN1 LIPC PNPLA2 DGKD LIPG	129642 1608 23175 3990 57104 8527 9388
Pipobroman	FDA approved	Focal adhesion	path:04510_112	4	7.014751	0.00989011	FLNB ITGA2 ITGA5 THBS1	2317 3673 3678 7057
Pipobroman	FDA approved	Leukocyte transendothelial migration	path:04670_9	8	6.156338	0.037362637	RAPGEF3 CYBA PIK3R5 NOX1 GNAI3 MAPK13 ACTG1 VCAM1	10411 1535 23533 27035 2773 5603 71 7412
Pipobroman	FDA approved	Small cell lung cancer	path:05222_17	4	6.031921	0.045054945	AKT3 PIK3R5 ITGA2 PTK2	10000 23533 3673 5747
Ponatinib	FDA approved	Purine metabolism	path:00230_151	6	6.874723	0.012304251	ADSSL1 AMPD1 AMPD3 ENTPD8 NT5E PDE1A	122622 270 272 377841 4907 5136
Ponatinib	FDA approved	Pyrimidine metabolism	path:00240_103	6	6.789387	0.015659955	DCK DCTD ENTPD8 NT5E UCK1 ENTPD5	1633 1635 377841 4907 83549 957
Ponatinib	FDA approved	Rap1 signaling pathway	path:04015_79	6	6.456239	0.024608501	EFNA1 EFNA3 EFNA4 FGF12 MET VEGFB	1942 1944 1945 2257 4233 7423
Ponatinib	FDA approved	Protein processing in endoplasmic reticulum	path:04141_1	5	6.570429	0.020134228	DDIT3 EIF2S1 PPP1R15A EIF2AK1 NFE2L2	1649 1965 23645 27102 4780
Ponatinib	FDA approved	Focal adhesion	path:04510_113	4	7.58028	0.003355705	FLNC ITGA5 ITGAV ITGB1	2318 3678 3685 3688
Pralatrexate	FDA approved	Purine metabolism	path:00230_152	7	6.504959	0.010917031	POLR3F ADCY5 ADCY8 ZNRD1 NME1 POLR2F POLR2K	10621 111 114 30834 4830 5435 5440
Pralatrexate	FDA approved	Focal adhesion	path:04510_114	5	5.735694	0.048034934	ITGAV ITGB3 ITGB5 PRKCA SRC	3685 3690 3693 5578 6714
Pralatrexate	FDA approved	Insulin signaling pathway	path:04910_25	6	5.8849	0.041484716	GSK3B GYS2 PPP1CB PPP1CC PYGB CALM1	2932 2998 5500 5501 5834 801
Pralatrexate	FDA approved	GnRH signaling pathway	path:04912_6	8	5.997097	0.031659389	PLCB1 MAP3K3 MAP3K4 PRKCA MAPK7 MAPK11 MAP2K6 MAPK12	23236 4215 4216 5578 5598 5600 5608 6300
Pralatrexate	FDA approved	Oxytocin signaling pathway	path:04921_31	8	5.874177	0.042576419	ADCY5 PLCB1 GNAI3 GNAO1 GNAS PRKCA CALM1 PIK3R3	111 23236 2773 2775 2778 5578 801 8503
Procarbazine	FDA approved	Purine metabolism	path:00230_153	23	6.608699	0.013114754	POLR3C PDE10A ADCY3 ADCY8 ADCY9 NT5C3B NUDT16 AK5 IMPDH1 ITPA ATIC NME4 NPR2 POLR1D PDE4B PDE4D PDE9A POLR2A POLR2B RRM1 RRM2 POLR1E PDE8B	10623 10846 109 114 115 115024 131870 26289 3614 3704 471 4833 4882 51082 5142 5144 5152 5430 5431 6240 6241 64425 8622
Procarbazine	FDA approved	Glycerophospholipid metabolism	path:00564_21	6	6.419993	0.019672131	LPCAT3 LPIN1 LCLAT1 PLD2 AGPAT4 PTDSS2	10162 23175 253558 5338 56895 81490
Procarbazine	FDA approved	Ras signaling pathway	path:04014_62	10	5.664965	0.046994536	RRAS2 MRAS RASGRP3 HRAS PIK3R1 RRAS SOS1 PIK3R3 RASAL2 RIN1	22800 22808 25780 3265 5295 6237 6654 8503 9462 9610
Procarbazine	FDA approved	cGMP-PKG signaling pathway	path:04022_32	12	6.535144	0.01420765	KCNMA1 ATF4 ATP1B2 ATP1B3 FXYD2 NPR2 ATP2B1 PLCB4 PRKG2 TRPC6 VASP CREB5	3778 468 482 483 486 4882 490 5332 5593 7225 7408 9586
Procarbazine	FDA approved	cAMP signaling pathway	path:04024_37	4	5.634869	0.048087432	ATP2B1 PDE4D PRKX CREB5	490 5144 5613 9586
Procarbazine	FDA approved	Chemokine signaling pathway	path:04062_78	6	5.712487	0.042622951	CCR3 GNAI1 CXCR1 ARRB2 CXCR5 CXCL14	1232 2770 3577 409 643 9547
Procarbazine	FDA approved	FoxO signaling pathway	path:04068_95	15	7.071096	0.006557377	KLF2 PLK2 GABARAP GADD45A FOXO4 PLK1 PRKAG3 PRKAA2 MAPK11 MAPK9 MAPK10 RAG1 MAPK12 BNIP3 ATG12	10365 10769 11337 1647 4303 5347 53632 5563 5600 5601 5602 5896 6300 664 9140
Procarbazine	FDA approved	PI3K-Akt signaling pathway	path:04151_85	4	8.586807	0	ITGA2 ITGA5 ITGAV ITGB3	3673 3678 3685 3690
Procarbazine	FDA approved	AMPK signaling pathway	path:04152_37	6	6.255157	0.021857923	GYS1 GYS2 HMGCR LIPE PRKAG3 PRKAA2	2997 2998 3156 3991 53632 5563
Procarbazine	FDA approved	Focal adhesion	path:04510_115	3	8.840343	0	ITGA2 ITGAV ITGB3	3673 3685 3690
Procarbazine	FDA approved	Jak-STAT signaling pathway	path:04630_92	7	6.345013	0.020765027	CSF2 CBLC IL6ST LEPR LIFR MPL CBL	1437 23624 3572 3953 3977 4352 867
Procarbazine	FDA approved	Cholinergic synapse	path:04725_54	11	5.657232	0.046994536	ADCY3 CHRM4 ADCY8 ADCY9 GNG11 HRAS PIK3R1 PRKACA GNG12 PRKX PIK3R3	109 1132 114 115 2791 3265 5295 5566 55970 5613 8503
Procarbazine	FDA approved	Glucagon signaling pathway	path:04922_10	7	5.683064	0.044808743	CPT1C GYS2 ATF4 PRKAG3 PRKAA2 PRKX CREB5	126129 2998 468 53632 5563 5613 9586
Procarbazine	FDA approved	Type II diabetes mellitus	path:04930_4	7	5.656993	0.046994536	PIK3R1 PRKCZ MAPK9 MAPK10 SLC2A4 IRS4 PIK3R3	5295 5590 5601 5602 6517 8471 8503
Procarbazine	FDA approved	Choline metabolism in cancer	path:05231_14	8	6.151075	0.02295082	EGFR HRAS PDGFB PIK3R1 PLD2 PDGFC SOS1 PIK3R3	1956 3265 5155 5295 5338 56034 6654 8503
Raltitrexed	FDA approved	Purine metabolism	path:00230_154	10	6.896371	0.018888889	POLR3F POLD3 ADCY6 AK1 NME1 NME3 POLR2D POLR2H POLR3B ENTPD2	10621 10714 112 203 4830 4832 5433 5437 55703 954
Raltitrexed	FDA approved	Pyrimidine metabolism	path:00240_104	26	7.103967	0.014444444	POLR3F POLD3 NT5C3B CANT1 CTPS1 DUT AK9 ZNRD1 ENTPD8 NME1 NME3 NME4 POLE3 POLR2C POLR2D POLR2H POLR2K PRIM1 POLR3B POLD4 RRM2 POLR1E TYMS UCK2 ENTPD3 ENTPD5	10621 10714 115024 124583 1503 1854 221264 30834 377841 4830 4832 4833 54107 5432 5433 5437 5440 5557 55703 57804 6241 64425 7298 7371 956 957
Raltitrexed	FDA approved	Chemokine signaling pathway	path:04062_79	8	6.322038	0.035555556	PIK3R5 GNAI2 GNGT2 PIK3CG PLCB2 PRKCZ PREX1 GNB4	23533 2771 2793 5294 5330 5590 57580 59345
Raltitrexed	FDA approved	FoxO signaling pathway	path:04068_96	15	6.472929	0.031111111	CDKN2B GABARAP S1PR1 FOXO1 PCK1 NLK RAG1 RAG2 RBL2 CCND1 BCL6 MAPK12 BNIP3 STK4 CCNG2	1030 11337 1901 2308 5105 51701 5896 5897 5934 595 604 6300 664 6789 901
Raltitrexed	FDA approved	Phosphatidylinositol signaling system	path:04070_69	8	6.303251	0.035555556	IMPA2 INPP4A OCRL PIK3C2A PIK3C2B PIK3CG PLCB2 PIP4K2C	3613 3631 4952 5286 5287 5294 5330 79837
Raltitrexed	FDA approved	PI3K-Akt signaling pathway	path:04151_86	7	6.534829	0.028888889	GNGT2 PDPK1 PIK3CA PIK3CG PTK2 GNB4 LPAR2	2793 5170 5290 5294 5747 59345 9170
Raltitrexed	FDA approved	Focal adhesion	path:04510_116	4	7.942062	0.003333333	ITGA2B ITGA5 ITGB1 PTK2	3674 3678 3688 5747
Raltitrexed	FDA approved	Adherens junction	path:04520_10	6	7.502273	0.007777778	CSNK2A2 CTNNB1 CTNND1 ERBB2 RAC2 CDH1	1459 1499 1500 2064 5880 999
Raltitrexed	FDA approved	Jak-STAT signaling pathway	path:04630_93	9	6.172934	0.037777778	CBLC IL2RB IL2RG IL4 IL10RB OSM STAT5B SOCS1 CBL	23624 3560 3561 3565 3588 5008 6777 8651 867
Sonidegib	FDA approved	Purine metabolism	path:00230_155	32	8.429531	0	ADCY1 ADCY2 POLR3A ADCY7 ADCY8 CANT1 ADK AK2 AK9 GUCY2C GUK1 ITPA HDDC3 ATIC RRM2B PDE1C PDE2A PDE3A PDE3B PDE6D PDE6G PDE8A PDE1B POLD2 POLR2C POLR2D POLD4 RRM1 POLR1E NME5 NTPCR ENTPD6	107 108 11128 113 114 124583 132 204 221264 2984 2987 3704 374659 471 50484 5137 5138 5139 5140 5147 5148 5151 5153 5425 5432 5433 57804 6240 64425 8382 84284 955
Sonidegib	FDA approved	Pyrimidine metabolism	path:00240_105	6	6.06488	0.027442371	CANT1 DUT ITPA NME1 TK1 ENTPD6	124583 1854 3704 4830 7083 955
Sonidegib	FDA approved	Sphingolipid metabolism	path:00600_12	12	5.531215	0.047200878	DEGS2 SGPP2 CERS3 GBA CERS2 ENPP7 SMPD4 SPHK2 CERK CERS4 DEGS1 SPHK1	123099 130367 204219 2629 29956 339221 55627 56848 64781 79603 8560 8877
Sonidegib	FDA approved	Ras signaling pathway	path:04014_63	17	6.154265	0.025246981	CSF1 EGFR FGF2 FGF7 FGF14 FGFR1 FGFR3 FLT1 FGF22 GRB2 IGF1R KIT SHC4 MET NGFR ANGPT4 PDGFC	1435 1956 2247 2252 2259 2260 2261 2321 27006 2885 3480 3815 399694 4233 4804 51378 56034
Sonidegib	FDA approved	cAMP signaling pathway	path:04024_38	8	5.601539	0.043907794	ADCY1 ADCY2 ADCY7 CNGB1 GNAI1 PDE3A PRKACA CAMK4	107 108 113 1258 2770 5139 5566 814
Sonidegib	FDA approved	Chemokine signaling pathway	path:04062_80	6	6.775003	0.010976948	GNB5 PLCB1 GNAI1 GNG4 GNG11 PREX1	10681 23236 2770 2786 2791 57580
Sonidegib	FDA approved	FoxO signaling pathway	path:04068_97	9	5.747251	0.035126235	CDKN1A CDKN2D PLK2 FOXO1 IL7R PRKAG2 PRKAA1 PRKAA2 BNIP3	1026 1032 10769 2308 3575 51422 5562 5563 664
Sonidegib	FDA approved	Phosphatidylinositol signaling system	path:04070_70	23	5.819022	0.032930845	DGKH DGKQ PIKFYVE PLCB1 INPP5J INPP1 INPP5D INPPL1 ITPKA ITPKB ITPR2 ITPR3 PIK3R1 PLCB2 PLCB4 PLCD1 PLCG1 PLCG2 IMPAD1 PTEN DGKE DGKD DGKI	160851 1609 200576 23236 27124 3628 3635 3636 3706 3707 3709 3710 5295 5330 5332 5333 5335 5336 54928 5728 8526 8527 9162
Sonidegib	FDA approved	PI3K-Akt signaling pathway	path:04151_87	16	6.011828	0.027442371	CSF1 EGFR FGF2 FGF7 FGF14 FGFR1 FGFR3 FLT1 FGF22 GRB2 IGF1R KIT MET NGFR ANGPT4 PDGFC	1435 1956 2247 2252 2259 2260 2261 2321 27006 2885 3480 3815 4233 4804 51378 56034
Sonidegib	FDA approved	Gap junction	path:04540_6	5	5.696178	0.040614709	ADCY1 ADCY2 ADCY7 GNAI1 PRKACA	107 108 113 2770 5566
Sonidegib	FDA approved	Jak-STAT signaling pathway	path:04630_94	11	6.783587	0.010976948	CTF1 EPOR IL19 IL2RB IL7R IL10 LIFR IL20 PRLR SOCS3 OSMR	1489 2057 29949 3560 3575 3586 3977 50604 5618 9021 9180
Sonidegib	FDA approved	Circadian entrainment	path:04713_47	12	6.528394	0.017563117	GNB5 ADCY1 ADCY2 ADCY8 PLCB1 GNAI1 GNG4 GNG11 PLCB2 PLCB4 PRKACA ADCY10	10681 107 108 114 23236 2770 2786 2791 5330 5332 5566 55811
Sonidegib	FDA approved	Retrograde endocannabinoid signaling	path:04723_37	11	6.09943	0.025246981	GNB5 ADCY1 ADCY2 ADCY7 ADCY8 GNAI1 GNAO1 GNG4 GNG11 PRKACA MAPK10	10681 107 108 113 114 2770 2775 2786 2791 5566 5602
Sonidegib	FDA approved	Glutamatergic synapse	path:04724_36	9	6.242702	0.025246981	GNB5 ADCY1 ADCY2 ADCY8 GNAI1 GNAO1 GNG4 GNG11 GRM6	10681 107 108 114 2770 2775 2786 2791 2916
Sonidegib	FDA approved	Cholinergic synapse	path:04725_55	8	5.998973	0.027442371	GNB5 ADCY1 ADCY8 GNAI1 GNAO1 GNG4 GNG11 PRKACA	10681 107 114 2770 2775 2786 2791 5566
Sonidegib	FDA approved	Serotonergic synapse	path:04726_33	9	6.024502	0.027442371	GNB5 PLCB1 GNAI1 GNG4 GNG11 HTR5A ITPR2 ITPR3 PLCB2	10681 23236 2770 2786 2791 3361 3709 3710 5330
Sonidegib	FDA approved	Dopaminergic synapse	path:04728_46	5	5.658261	0.043907794	PLCB1 GNAI1 GNG11 PLCB2 PRKCA	23236 2770 2791 5330 5578
Sonidegib	FDA approved	Morphine addiction	path:05032_37	7	6.870444	0.008781559	GNB5 ADCY1 ADCY8 GNAI1 GNG4 GNG11 GABBR2	10681 107 114 2770 2786 2791 9568
Streptozocin	FDA approved	Purine metabolism	path:00230_156	7	7.269258	0.007726269	CANT1 IMPDH1 NT5E RRM2B GMPR2 NME5 ENTPD5	124583 3614 4907 50484 51292 8382 957
Streptozocin	FDA approved	Pyrimidine metabolism	path:00240_106	9	6.218912	0.029801325	POLD3 CTPS1 POLR2J2 RRM2B POLR2K POLR2L PRIM2 NME5 ENTPD5	10714 1503 246721 50484 5440 5441 5558 8382 957
Streptozocin	FDA approved	Inositol phosphate metabolism	path:00562_25	7	5.956519	0.037527594	INPP1 INPP5A INPP5B PIP4K2C ITPKC PIP5K1A PLCZ1	3628 3632 3633 79837 80271 8394 89869
Streptozocin	FDA approved	Ras signaling pathway	path:04014_64	13	6.50971	0.01986755	EFNA1 EFNA3 EFNA4 EFNA5 EPHA2 FGF12 FGFR3 INS MET PGF TEK PDGFD FGF18	1942 1944 1945 1946 1969 2257 2261 3630 4233 5228 7010 80310 8817
Streptozocin	FDA approved	Rap1 signaling pathway	path:04015_80	13	6.50971	0.01986755	EFNA1 EFNA3 EFNA4 EFNA5 EPHA2 FGF12 FGFR3 INS MET PGF TEK PDGFD FGF18	1942 1944 1945 1946 1969 2257 2261 3630 4233 5228 7010 80310 8817
Streptozocin	FDA approved	Phosphatidylinositol signaling system	path:04070_71	11	6.575649	0.017660044	DGKA DGKH INPP1 INPP5A INPP5B ITPR2 PIK3C3 PIP4K2C ITPKC PIP5K1A PLCZ1	1606 160851 3628 3632 3633 3709 5289 79837 80271 8394 89869
Streptozocin	FDA approved	TGF-beta signaling pathway	path:04350_5	5	6.212456	0.030905077	ID1 IFNG SMAD3 SMAD6 ACVR1	3397 3458 4088 4091 90
Streptozocin	FDA approved	Axon guidance	path:04360_7	7	5.816257	0.045253863	PAK4 EFNA1 EFNA3 EFNA4 EFNA5 EPHA2 RAC1	10298 1942 1944 1945 1946 1969 5879
Streptozocin	FDA approved	Focal adhesion	path:04510_117	4	7.146686	0.007726269	PTK2 PXN CAPN2 TLN2	5747 5829 824 83660
Sunitinib	FDA approved	Purine metabolism	path:00230_157	10	7.110616	0.005580357	ADCY1 ADCY2 AK7 AMPD3 GUCY1A2 POLR1D PDE1C PDE4D PDE6A POLR2L	107 108 122481 272 2977 51082 5137 5144 5145 5441
Sunitinib	FDA approved	Ras signaling pathway	path:04014_65	20	6.862064	0.0078125	EFNA4 EFNA5 EGF FGF6 FGF7 FGF9 FGF12 FGF13 FGF14 FLT1 FLT4 IGF1R INS KDR NGF PGF SHC1 PDGFD FGF18 FGF19	1945 1946 1950 2251 2252 2254 2257 2258 2259 2321 2324 3480 3630 3791 4803 5228 6464 80310 8817 9965
Sunitinib	FDA approved	Rap1 signaling pathway	path:04015_81	21	7.416715	0.005580357	CRK EFNA4 EFNA5 EGF FGF6 FGF7 FGF9 FGF12 FGF13 FGF14 FLT1 PLCB1 FLT4 IGF1R INS KDR NGF PGF PDGFD FGF18 FGF19	1398 1945 1946 1950 2251 2252 2254 2257 2258 2259 2321 23236 2324 3480 3630 3791 4803 5228 80310 8817 9965
Sunitinib	FDA approved	cAMP signaling pathway	path:04024_39	11	6.245864	0.020089286	ADRB1 ADRB2 DRD1 GNAI3 HTR1D HTR1E HTR1F HTR4 OXTR PTGER2 SSTR5	153 154 1812 2773 3352 3354 3355 3360 5021 5732 6755
Sunitinib	FDA approved	FoxO signaling pathway	path:04068_98	17	6.274977	0.017857143	SGK2 PLK2 AKT1 FOXO1 IKBKB IL7R GADD45B ATM PRKAA1 PRKAA2 MAPK8 MAPK9 G6PC2 CCND1 MAPK12 CCNB1 G6PC3	10110 10769 207 2308 3551 3575 4616 472 5562 5563 5599 5601 57818 595 6300 891 92579
Sunitinib	FDA approved	PI3K-Akt signaling pathway	path:04151_88	8	6.38866	0.013392857	ATF2 AKT1 HSP90AA1 PPP2R1A PPP2R2B PPP2R5C PPP2R5E RAF1	1386 207 3320 5518 5521 5527 5529 5894
Sunitinib	FDA approved	Tight junction	path:04530_16	3	6.256825	0.020089286	PPP2R1A PRKCB ACTB	5518 5579 60
Sunitinib	FDA approved	Jak-STAT signaling pathway	path:04630_95	9	6.239466	0.020089286	IFNLR1 IL4 IL5 IL6ST IL7R LIFR OSM IL20RA OSMR	163702 3565 3567 3572 3575 3977 5008 53832 9180
Sunitinib	FDA approved	Glutamatergic synapse	path:04724_37	16	6.253759	0.020089286	ADCY1 ADCY2 ADCY8 GRIN3A GNAO1 GRIA1 GRIA4 GRIK2 GRIK4 GRIN2D GRM1 GRM6 GRM7 GRM8 PRKACA GNB4	107 108 114 116443 2775 2890 2893 2898 2900 2906 2911 2916 2917 2918 5566 59345
Sunitinib	FDA approved	Oxytocin signaling pathway	path:04921_32	8	5.797095	0.035714286	ADCY1 ADCY2 PLCB1 GNAO1 OXTR PRKCB RAF1 CALM1	107 108 23236 2775 5021 5579 5894 801
Sunitinib	FDA approved	Choline metabolism in cancer	path:05231_15	6	6.027305	0.026785714	CHKB HIF1A HRAS RAC2 RAF1 SOS2	1120 3091 3265 5880 5894 6655
Tegafur	FDA approved	Pyrimidine metabolism	path:00240_107	15	7.832984	0.004366812	POLR3G ITPA NME1 NME4 NT5E POLD1 POLR2D POLR2H PRIM1 RRM2 TYMS POLR1B PNPT1 POLR1C ENTPD3	10622 3704 4830 4833 4907 5424 5433 5437 5557 6241 7298 84172 87178 9533 956
Tegafur	FDA approved	Valine, leucine and isoleucine degradation	path:00280_4	6	6.264634	0.030567686	DBT HADHA ACADM ACADS AUH MCCC2	1629 3030 34 35 549 64087
Tegafur	FDA approved	Focal adhesion	path:04510_118	7	6.674948	0.019650655	FLNA FLNB ITGAV ITGB1 THBS1 TLN1 TLN2	2316 2317 3685 3688 7057 7094 83660
Temsirolimus	FDA approved	Tryptophan metabolism	path:00380_1	9	6.294719	0.031938326	INMT AFMID CYP1A1 IDO2 AOC1 AADAT TPH1 KMO KYAT1	11185 125061 1543 169355 26 51166 7166 8564 883
Temsirolimus	FDA approved	MAPK signaling pathway	path:04010_35	8	6.355799	0.029735683	DUSP4 DUSP6 HSPB1 MAPK11 PTPN7 PTPRR PTPN5 MAPKAPK2	1846 1848 3315 5600 5778 5801 84867 9261
Temsirolimus	FDA approved	Ras signaling pathway	path:04014_66	14	6.994548	0.005506608	EFNA4 FGF2 FGF5 FGF11 FGF14 FGFR1 FGFR2 ANGPT1 IGF1 INS INSR KDR SHC4 VEGFC	1945 2247 2250 2256 2259 2260 2263 284 3479 3630 3643 3791 399694 7424
Temsirolimus	FDA approved	Rap1 signaling pathway	path:04015_82	27	6.931422	0.00660793	EFNA4 FGF2 FGF5 FGF8 FGF11 FGF12 FGF13 FGF14 FGFR1 FGFR2 FLT1 PLCB1 FGF20 ANGPT1 HGF IGF1 INS INSR KDR KIT MET NGFR PDGFRB PLCB3 PLCB4 PDGFC VEGFC	1945 2247 2250 2253 2256 2257 2258 2259 2260 2263 2321 23236 26281 284 3082 3479 3630 3643 3791 3815 4233 4804 5159 5331 5332 56034 7424
Temsirolimus	FDA approved	PI3K-Akt signaling pathway	path:04151_89	20	7.026929	0.005506608	FGF2 FGF5 FGF8 FGF11 FGF12 FGF14 FGFR1 FGFR2 FLT1 FGF20 ANGPT1 GRB2 IGF1 INS INSR KDR NGFR PDGFRB SOS1 VEGFC	2247 2250 2253 2256 2257 2259 2260 2263 2321 26281 284 2885 3479 3630 3643 3791 4804 5159 6654 7424
Temsirolimus	FDA approved	Focal adhesion	path:04510_119	5	9.239865	0	FYN ITGAV THBS1 TLN2 CAV2	2534 3685 7057 83660 858
Temsirolimus	FDA approved	Insulin signaling pathway	path:04910_26	7	6.331996	0.030837004	GRB2 INSR PIK3CB PIK3CG PRKCZ SOS1 IRS2	2885 3643 5291 5294 5590 6654 8660
Temsirolimus	FDA approved	Type II diabetes mellitus	path:04930_5	8	5.914502	0.049559471	INSR PIK3CB PIK3CG PRKCE PRKCZ PIK3R3 IRS2 SOCS3	3643 5291 5294 5581 5590 8503 8660 9021
Teniposide rep1	FDA approved	Purine metabolism	path:00230_158	15	7.072973	0.002181025	ADCY5 ADCY6 AK1 AK5 AMPD3 NME7 IMPDH1 NME1 NPR1 NT5E PDE4D PDE6C PDE9A PDE1B POLR3GL	111 112 203 26289 272 29922 3614 4830 4881 4907 5144 5146 5152 5153 84265
Teniposide rep1	FDA approved	Inositol phosphate metabolism	path:00562_26	10	5.76294	0.034896401	ITPK1 PIK3CB PIK3CG PLCB2 PLCB3 PLCG2 PTEN PIP4K2B SYNJ2 MINPP1	3705 5291 5294 5330 5331 5336 5728 8396 8871 9562
Teniposide rep1	FDA approved	Ras signaling pathway	path:04014_67	9	6.139336	0.019629226	RRAS2 AFDN NF1 PLCE1 PIK3CG RAC2 STK4 RASSF5 RIN1	22800 4301 4763 51196 5294 5880 6789 83593 9610
Teniposide rep1	FDA approved	Chemokine signaling pathway	path:04062_81	7	6.139288	0.019629226	GNB5 GNAI2 HCK PIK3CG PLCB2 PRKCZ GNG12	10681 2771 3055 5294 5330 5590 55970
Teniposide rep1	FDA approved	Phosphatidylinositol signaling system	path:04070_72	16	6.785537	0.00436205	INPP1 INPPL1 PLCE1 PIK3C2A PIK3C2B PIK3CG PI4KA PLCB2 PLCB3 PI4K2A PTEN PIP5K1A PIP4K2B DGKZ DGKE SYNJ2	3628 3636 51196 5286 5287 5294 5297 5330 5331 55361 5728 8394 8396 8525 8526 8871
Teniposide rep1	FDA approved	Endocytosis	path:04144_20	6	5.651882	0.046892039	WWP1 ERBB3 CBLC SH3GLB1 ITCH CBLB	11059 2065 23624 51100 83737 868
Teniposide rep1	FDA approved	PI3K-Akt signaling pathway	path:04151_90	5	8.92322	0	ITGA2B ITGA5 ITGB3 ITGB5 PTK2	3674 3678 3690 3693 5747
Teniposide rep1	FDA approved	Focal adhesion	path:04510_120	5	9.100148	0	ITGA2B ITGA5 ITGB3 ITGB5 PTK2	3674 3678 3690 3693 5747
Teniposide rep1	FDA approved	ECM-receptor interaction	path:04512_19	4	7.404294	0.002181025	ITGA2 ITGA2B ITGAV ITGB3	3673 3674 3685 3690
Teniposide rep1	FDA approved	Jak-STAT signaling pathway	path:04630_96	7	5.924539	0.030534351	IL2RG IL10RA IL12RB2 LEPR MPL IL23A CBLB	3561 3587 3595 3953 4352 51561 868
Teniposide rep1	FDA approved	Dopaminergic synapse	path:04728_47	7	5.680061	0.045801527	GNB5 ADCY5 DRD3 DRD4 GNG5 PLCB3 GNG12	10681 111 1814 1815 2787 5331 55970
Teniposide rep1	FDA approved	Regulation of actin cytoskeleton	path:04810_43	5	6.825992	0.003271538	VAV3 RRAS2 PIK3CB PTK2 RAC2	10451 22800 5291 5747 5880
Teniposide rep1	FDA approved	Insulin signaling pathway	path:04910_27	7	6.385861	0.015267176	MTOR GRB2 INPPL1 PIK3CG PRKCZ RPS6KB1 IRS4	2475 2885 3636 5294 5590 6198 8471
Teniposide rep1	FDA approved	Chronic myeloid leukemia	path:05220_14	8	5.838454	0.033805889	CRK CRKL CBLC GRB2 PIK3CB PIK3CG CBLB GAB2	1398 1399 23624 2885 5291 5294 868 9846
Teniposide rep1	FDA approved	Small cell lung cancer	path:05222_18	3	6.288593	0.015267176	ITGA2B ITGAV PTK2	3674 3685 5747
Teniposide rep2	FDA approved	PPAR signaling pathway	path:03320_17	6	5.721359	0.048034934	CPT1C ACSL1 MMP1 OLR1 PPARG RXRA	126129 2180 4312 4973 5468 6256
Teniposide rep2	FDA approved	ErbB signaling pathway	path:04012_20	8	5.677291	0.049126638	EGFR ERBB2 ERBB3 CBLC PIK3R1 SHC3 TGFA CBL	1956 2064 2065 23624 5295 53358 7039 867
Teniposide rep2	FDA approved	Calcium signaling pathway	path:04020_61	9	5.896614	0.043668122	ITPR1 PLCE1 RYR1 TNNC1 CACNA1A CACNA1C CALM1 ITPKC P2RX6	3708 51196 6261 7134 773 775 801 80271 9127
Teniposide rep2	FDA approved	cGMP-PKG signaling pathway	path:04022_33	10	5.735965	0.048034934	GNA13 EDNRA GNA11 ITPR1 RHOA MEF2D NFATC1 PLCB2 PLCB3 TRPC6	10672 1909 2767 3708 387 4209 4772 5330 5331 7225
Teniposide rep2	FDA approved	cAMP signaling pathway	path:04024_40	6	5.692027	0.049126638	ADCY6 DRD2 EDNRA GNAI1 GNAI2 GABBR2	112 1813 1909 2770 2771 9568
Teniposide rep2	FDA approved	FoxO signaling pathway	path:04068_99	11	6.644678	0.017467249	AKT3 SGK2 FOXO1 FOXO3 SGK3 ATM MAPK13 RBL2 CCND1 STAT3 CCNG2	10000 10110 2308 2309 23678 472 5603 5934 595 6774 901
Teniposide rep2	FDA approved	p53 signaling pathway	path:04115_26	11	5.822392	0.044759825	CHEK1 SESN3 SFN MDM4 ATM SERPINB5 PERP THBS1 TP53 PPM1D CCNG2	1111 143686 2810 4194 472 5268 64065 7057 7157 8493 901
Teniposide rep2	FDA approved	Endocytosis	path:04144_21	9	6.06325	0.036026201	WWP1 ERBB3 CBLC NTRK1 EPN3 SH3GLB2 SMURF2 ITCH CBL	11059 2065 23624 4914 55040 56904 64750 83737 867
Teniposide rep2	FDA approved	Vascular smooth muscle contraction	path:04270_4	7	6.184097	0.027292576	EDNRA GNA11 ITPR1 PLCB2 PLCB3 PLA2G12A PLA2G4C	1909 2767 3708 5330 5331 81579 8605
Teniposide rep2	FDA approved	Hippo signaling pathway	path:04390_47	7	7.060926	0.009825328	YWHAQ CSNK1E GSK3B BIRC2 PPP2R1A CCND1 YWHAZ	10971 1454 2932 329 5518 595 7534
Teniposide rep2	FDA approved	Focal adhesion	path:04510_121	9	6.029865	0.036026201	AKT3 ERBB2 HGF ITGB1 PDGFB PIK3R1 PTK2 VEGFC PDGFD	10000 2064 3082 3688 5155 5295 5747 7424 80310
Teniposide rep2	FDA approved	Tight junction	path:04530_17	4	6.533297	0.020742358	RRAS2 AFDN PRKCD MAGI1	22800 4301 5580 9223
Teniposide rep2	FDA approved	Platelet activation	path:04611_16	8	5.913751	0.040393013	AKT3 ADCY6 GNAI2 GNAS ITGA2 ITPR1 PIK3CG PIK3R1	10000 112 2771 2778 3673 3708 5294 5295
Teniposide rep2	FDA approved	Jak-STAT signaling pathway	path:04630_97	11	6.886037	0.013100437	IL24 IFNLR1 CBLC IFNL1 IFNG JAK2 MPL OSM IL21 CBL CBLB	11009 163702 23624 282618 3458 3717 4352 5008 59067 867 868
Teniposide rep2	FDA approved	Thyroid hormone signaling pathway	path:04919_27	7	6.920505	0.012008734	AKT3 EP300 PIK3R5 PIK3R1 CCND1 RXRA THRB	10000 2033 23533 5295 595 6256 7068
Teniposide rep2	FDA approved	Pancreatic cancer	path:05212_16	7	5.89788	0.043668122	AKT3 ERBB2 PIK3R5 NFKB1 PIK3CG PIK3R1 BCL2L1	10000 2064 23533 4790 5294 5295 598
Teniposide rep3	FDA approved	Purine metabolism	path:00230_159	8	6.487144	0.020134228	ADCY6 NT5C3B NUDT16 ADSL AK1 NME1 PDE6C ENTPD6	112 115024 131870 158 203 4830 5146 955
Teniposide rep3	FDA approved	FoxO signaling pathway	path:04068_100	17	7.343416	0.004474273	CDK2 GABARAPL2 CHUK CSNK1E S1PR1 FOXO1 SGK3 FASLG ATM NLK PRKAB1 MAPK1 RBL2 CCND1 STAT3 CCNG2 G6PC3	1017 11345 1147 1454 1901 2308 23678 356 472 51701 5564 5594 5934 595 6774 901 92579
Teniposide rep3	FDA approved	PI3K-Akt signaling pathway	path:04151_91	4	8.506333	0.001118568	ITGA2B ITGA5 ITGB3 PTK2	3674 3678 3690 5747
Teniposide rep3	FDA approved	AMPK signaling pathway	path:04152_38	5	6.629701	0.015659955	FASN GYS1 HMGCR PFKFB2 PRKAB1	2194 2997 3156 5208 5564
Teniposide rep3	FDA approved	Focal adhesion	path:04510_122	4	8.889907	0	ITGA2B ITGA5 ITGB3 PTK2	3674 3678 3690 5747
Teniposide rep3	FDA approved	Jak-STAT signaling pathway	path:04630_98	9	6.403546	0.022371365	IFNAR1 IFNG IL10RB LEPR MPL IL23A IL20RB IL26 CBLB	3454 3458 3588 3953 4352 51561 53833 55801 868
Teniposide rep3	FDA approved	Prolactin signaling pathway	path:04917_8	5	5.896278	0.042505593	GSK3B CCND1 STAT3 STAT5B SOCS3	2932 595 6774 6777 9021
Teniposide rep3	FDA approved	Thyroid hormone signaling pathway	path:04919_28	6	5.864812	0.044742729	CTNNB1 AKT2 FOXO1 GSK3B MDM2 THRA	1499 208 2308 2932 4193 7067
Teniposide rep3	FDA approved	Pathways in cancer	path:05200_45	6	6.451172	0.020134228	CRK ERBB2 ITGA2B PIK3CG PTK2 CBLB	1398 2064 3674 5294 5747 868
Testolactone	FDA approved	Purine metabolism	path:00230_160	9	8.299563	0.001101322	ADCY6 GUK1 NT5E RRM2B PDE8A PKM POLR2K POLR1E POLR3D	112 2987 4907 50484 5151 5315 5440 64425 661
Testolactone	FDA approved	Pyrimidine metabolism	path:00240_108	8	6.59112	0.026431718	CANT1 POLR2J2 RRM2B POLR2K POLR2L PRIM2 POLR3D NME5	124583 246721 50484 5440 5441 5558 661 8382
Testolactone	FDA approved	Rap1 signaling pathway	path:04015_83	12	6.845847	0.018722467	CRK EFNA1 EFNA2 EFNA5 EPHA2 FLT4 FGF22 ANGPT1 IGF1R MET VEGFB BCAR1	1398 1942 1943 1946 1969 2324 27006 284 3480 4233 7423 9564
Testolactone	FDA approved	FoxO signaling pathway	path:04068_101	17	6.749507	0.024229075	CDKN2D KLF2 PLK2 GADD45A FOXO1 PRKAG3 PRKAB2 MAPK1 MAPK11 MAPK9 MAPK10 RBL2 CCND1 BCL6 CCNG2 CCNB2 ATG12	1032 10365 10769 1647 2308 53632 5565 5594 5600 5601 5602 5934 595 604 901 9133 9140
Testolactone	FDA approved	Cell cycle	path:04110_17	3	6.145266	0.04845815	YWHAG YWHAZ CDC25C	7532 7534 995
Testolactone	FDA approved	TGF-beta signaling pathway	path:04350_6	6	6.530394	0.026431718	SMAD3 SMAD4 SMAD6 SMURF2 SKP1 ZFYVE9	4088 4089 4091 64750 6500 9372
Testolactone	FDA approved	Focal adhesion	path:04510_123	3	8.196423	0.001101322	FLNB PTK2 CAV2	2317 5747 858
Testolactone	FDA approved	Jak-STAT signaling pathway	path:04630_99	15	6.829413	0.018722467	CSF2 IFNLR1 IFNAR1 IFNAR2 IFNGR2 IL5RA IL6ST IL9 IL10RB IL13RA1 JAK2 LIF MPL OSM CBLB	1437 163702 3454 3455 3460 3568 3572 3578 3588 3597 3717 3976 4352 5008 868
Testolactone	FDA approved	Regulation of actin cytoskeleton	path:04810_44	7	6.302258	0.040748899	CRK ITGA2 ITGAL ITGB2 PTK2 RAC3 BCAR1	1398 3673 3683 3689 5747 5881 9564
Thiotepa	FDA approved	Pyrimidine metabolism	path:00240_109	11	6.042608	0.032858708	POLD3 ENTPD8 NME1 NME4 CMPK1 POLE POLR2A POLR2C POLR2G PRIM1 ENTPD6	10714 377841 4830 4833 51727 5426 5430 5432 5436 5557 955
Thiotepa	FDA approved	Calcium signaling pathway	path:04020_62	23	5.892847	0.04381161	CHRNA7 GRIN2D SLC25A4 ITPR1 ATP2A3 ATP2B3 P2RX1 P2RX3 P2RX4 P2RX5 PLCE1 PLCB3 PRKCA PRKCG SLC8A2 TNNC1 CACNA1A CACNA1C CACNA1F CACNA1S ITPKC CACNA1H CACNA1G	1139 2906 291 3708 489 492 5023 5024 5025 5026 51196 5331 5578 5582 6543 7134 773 775 778 779 80271 8912 8913
Thiotepa	FDA approved	Chemokine signaling pathway	path:04062_82	6	6.052866	0.032858708	CX3CR1 GNAI2 GNB3 GNG5 GNG12 SRC	1524 2771 2784 2787 55970 6714
Thiotepa	FDA approved	FoxO signaling pathway	path:04068_102	25	6.491882	0.016429354	AKT3 BCL2L11 SGK2 CDK2 CDKN2B GABARAP GABARAPL2 CHUK GADD45A S1PR1 FOXO1 FOXO3 IL7R PCK1 NLK PRKAB1 PRKAG1 MAPK10 MAPK13 RAG1 RAG2 RBL2 CCND1 BNIP3 STAT3	10000 10018 10110 1017 1030 11337 11345 1147 1647 1901 2308 2309 3575 5105 51701 5564 5571 5602 5603 5896 5897 5934 595 664 6774
Thiotepa	FDA approved	Endocytosis	path:04144_22	15	6.385794	0.023001095	RNF41 EPS15 ERBB3 FGFR3 FGFR2 CBLC MDM2 NEDD4 SH3GLB1 EPN3 SH3GLB2 SMURF2 TRAF6 ITCH CBL	10193 2060 2065 2261 2263 23624 4193 4734 51100 55040 56904 64750 7189 83737 867
Thiotepa	FDA approved	Focal adhesion	path:04510_124	4	7.91529	0.00109529	ITGA2B ITGA5 PRKCA PRKCG	3674 3678 5578 5582
Thiotepa	FDA approved	Circadian entrainment	path:04713_48	9	5.806188	0.048192771	ADCY6 ADCYAP1R1 GNAS GNB3 GNG5 GNGT2 PLCB3 GNG12 GNB4	112 117 2778 2784 2787 2793 5331 55970 59345
Thiotepa	FDA approved	Glutamatergic synapse	path:04724_38	7	7.55186	0.004381161	ADCY6 GNB3 GNG5 GRM4 PRKACB GNB4 CACNA1A	112 2784 2787 2914 5567 59345 773
Thiotepa	FDA approved	Cholinergic synapse	path:04725_56	10	5.984648	0.040525739	AKT3 ADCY6 PIK3R5 GNB3 GNG5 GNGT2 KRAS GNB4 CACNA1A PIK3R3	10000 112 23533 2784 2787 2793 3845 59345 773 8503
Thiotepa	FDA approved	GABAergic synapse	path:04727_31	8	5.86283	0.0449069	ADCY6 GABBR1 GNB3 GNG5 GNGT2 PRKACB GNB4 CACNA1C	112 2550 2784 2787 2793 5567 59345 775
Thiotepa	FDA approved	Regulation of actin cytoskeleton	path:04810_45	5	6.909263	0.012048193	PAK4 MYL9 PPP1R12A PAK6 MYLK3	10298 10398 4659 56924 91807
Thiotepa	FDA approved	Morphine addiction	path:05032_38	5	5.972626	0.040525739	GNB3 GNG5 PRKACB PRKCA GNB4	2784 2787 5567 5578 59345
Topotecan rep1	FDA approved	Inositol phosphate metabolism	path:00562_27	10	6.446562	0.03674833	INPP5J INPP1 ITPK1 INPP5K PLCG1 PLCG2 IPPK ITPKC PIP5K1A MINPP1	27124 3628 3705 51763 5335 5336 64768 80271 8394 9562
Topotecan rep1	FDA approved	FoxO signaling pathway	path:04068_103	20	7.604137	0.006681514	AKT3 BCL2L11 CDKN2B GADD45G S1PR1 FOXO3 SGK3 IL7R PCK2 NLK PLK1 PRKAB1 MAPK11 MAPK13 RBL2 CCND1 BNIP3 STAT3 CCNB1 CCNG2	10000 10018 1030 10912 1901 2309 23678 3575 5106 51701 5347 5564 5600 5603 5934 595 664 6774 891 901
Topotecan rep1	FDA approved	Phosphatidylinositol signaling system	path:04070_73	10	6.903759	0.020044543	INPP5J INPP1 ITPR1 ITPR2 INPP5K PLCG1 PLCG2 ITPKC PIP5K1A DGKZ	27124 3628 3708 3709 51763 5335 5336 80271 8394 8525
Topotecan rep1	FDA approved	p53 signaling pathway	path:04115_27	10	6.514229	0.033407572	GADD45G SFN MDM2 MDM4 SERPINB5 BAX PERP TP53 PPM1D CCNG2	10912 2810 4193 4194 5268 581 64065 7157 8493 901
Topotecan rep1	FDA approved	Hippo signaling pathway	path:04390_48	3	7.090407	0.018930958	CCND1 TGFBR2 YWHAE	595 7048 7531
Topotecan rep1	FDA approved	Jak-STAT signaling pathway	path:04630_100	9	7.287322	0.014476615	IFNLR1 CBLC IFNGR1 IL7R LEPR MPL IL20RA IL21 CBL	163702 23624 3459 3575 3953 4352 53832 59067 867
Topotecan rep1	FDA approved	Regulation of actin cytoskeleton	path:04810_46	3	6.536551	0.031180401	PAK4 GNA13 PAK6	10298 10672 56924
Topotecan rep1	FDA approved	Pathways in cancer	path:05200_46	3	6.74459	0.022271715	GLI1 GLI3 PTCH1	2735 2737 5727
Topotecan rep1	FDA approved	Basal cell carcinoma	path:05217_4	3	6.74459	0.022271715	GLI1 GLI3 PTCH1	2735 2737 5727
Topotecan rep2	FDA approved	Purine metabolism	path:00230_161	10	6.994542	0.002222222	POLR3A NT5C3B GUCY2D NME1 PDE6C POLR2A POLR2F POLR3B RRM1 ENTPD6	11128 115024 3000 4830 5146 5430 5435 55703 6240 955
Topotecan rep2	FDA approved	Pyrimidine metabolism	path:00240_110	15	7.046204	0.002222222	POLR3A NT5C3B POLR3H NME7 ZNRD1 NME1 CMPK1 POLE3 POLE POLR2A POLR2F PRIM1 POLR3B RRM1 ENTPD6	11128 115024 171568 29922 30834 4830 51727 54107 5426 5430 5435 5557 55703 6240 955
Topotecan rep2	FDA approved	Glycosphingolipid biosynthesis - lacto and neolacto series	path:00601_4	9	5.924151	0.031111111	B3GNT3 FUT1 FUT2 FUT3 FUT4 B3GNT4 B3GNT5 B4GALT4 B4GALT3	10331 2523 2524 2525 2526 79369 84002 8702 8703
Topotecan rep2	FDA approved	MAPK signaling pathway	path:04010_36	9	5.751828	0.04	DUSP10 DUSP3 DUSP6 ELK4 MAPK1 MAPK11 MAPK10 MAPK13 PTPRR	11221 1845 1848 2005 5594 5600 5602 5603 5801
Topotecan rep2	FDA approved	Calcium signaling pathway	path:04020_63	13	5.785014	0.038888889	PPIF GRIN2D SLC25A4 ITPR1 ATP2A2 PLCG2 PRKCA PRKCG SLC8A1 TNNC1 VDAC1 CACNA1D ITPKC	10105 2906 291 3708 488 5336 5578 5582 6546 7134 7416 776 80271
Topotecan rep2	FDA approved	FoxO signaling pathway	path:04068_104	24	6.662898	0.006666667	AKT3 BCL2L11 CDK2 CDKN2B GABARAP CHUK S1PR1 AKT1 FOXO1 SGK3 IL7R PCK2 NLK PRKAB1 MAPK1 MAPK11 MAPK10 MAPK13 RBL2 CCND1 BNIP3 STAT3 CAT G6PC3	10000 10018 1017 1030 11337 1147 1901 207 2308 23678 3575 5106 51701 5564 5594 5600 5602 5603 5934 595 664 6774 847 92579
Topotecan rep2	FDA approved	p53 signaling pathway	path:04115_28	10	5.919757	0.031111111	CHEK2 BBC3 SFN MDM2 MDM4 SERPINB5 BAX PERP TP53 PPM1D	11200 27113 2810 4193 4194 5268 581 64065 7157 8493
Topotecan rep2	FDA approved	Vascular smooth muscle contraction	path:04270_5	7	6.005862	0.025555556	KCNU1 KCNMB4 ITPR1 KCNMA1 PRKACB PRKX MYLK3	157855 27345 3708 3778 5567 5613 91807
Topotecan rep2	FDA approved	Focal adhesion	path:04510_125	6	7.045179	0.002222222	ITGA2B ITGA5 PRKCA PRKCG PXN VASP	3674 3678 5578 5582 5829 7408
Topotecan rep2	FDA approved	Jak-STAT signaling pathway	path:04630_101	8	6.748354	0.004444444	IFNLR1 CBLC IL7R LEPR MPL OSM IL22 IL21	163702 23624 3575 3953 4352 5008 50616 59067
Topotecan rep2	FDA approved	Glutamatergic synapse	path:04724_39	12	5.657947	0.045555556	GNB5 GNAI2 GNB3 GNG5 GNG7 GNGT2 GRIA1 GRIK4 GRIN2D GRM2 GRM4 GNB4	10681 2771 2784 2787 2788 2793 2890 2900 2906 2912 2914 59345
Topotecan rep2	FDA approved	Regulation of actin cytoskeleton	path:04810_47	6	5.833921	0.034444444	GNA13 RRAS2 MRAS HRAS PAK6 MYLK3	10672 22800 22808 3265 56924 91807
Topotecan rep2	FDA approved	Choline metabolism in cancer	path:05231_16	8	5.863163	0.032222222	CHKA MTOR HRAS KRAS PIK3R2 PLD1 RAF1 PIP5K1A	1119 2475 3265 3845 5296 5337 5894 8394
Trametinib	FDA approved	Fatty acid degradation	path:00071_1	6	5.891451	0.033842795	EHHADH ACAA1 HADHA HADHB ACADS ACAT2	1962 30 3030 3032 35 39
Trametinib	FDA approved	Purine metabolism	path:00230_162	10	7.202381	0.003275109	POLR3G PDE10A ADCY3 AK1 GUCY1A2 PDE4B PDE4D PDE8A POLR2L ENTPD6	10622 10846 109 203 2977 5142 5144 5151 5441 955
Trametinib	FDA approved	Valine, leucine and isoleucine degradation	path:00280_5	10	6.097229	0.026200873	EHHADH HIBCH ACAA1 HADHA HADHB AOX1 ACADS IVD ACAT2 MCCC2	1962 26275 30 3030 3032 316 35 3712 39 64087
Trametinib	FDA approved	Glycerolipid metabolism	path:00561_9	7	5.781705	0.042576419	AGPAT2 DGKA DGKG LCLAT1 AGPAT4 PNPLA3 DGKE	10555 1606 1608 253558 56895 80339 8526
Trametinib	FDA approved	Glycerophospholipid metabolism	path:00564_22	6	6.028951	0.031659389	LPCAT3 LYPLA1 LYPLA2 DGKG PLA2G2D CHPT1	10162 10434 11313 1608 26279 56994
Trametinib	FDA approved	cGMP-PKG signaling pathway	path:04022_34	13	6.798478	0.009825328	KCNMB2 CREB1 KCNU1 GUCY1A2 KCNMA1 PPP1R12A ATP1B3 PLCB2 PPP1CC PRKCE PRKG2 BAD RAF1	10242 1385 157855 2977 3778 4659 483 5330 5501 5581 5593 572 5894
Trametinib	FDA approved	cAMP signaling pathway	path:04024_41	9	5.709267	0.043668122	CREB1 GRIA4 RHOA ATP2B2 PDE4B PDE4D PRKACA BAD RELA	1385 2893 387 491 5142 5144 5566 572 5970
Trametinib	FDA approved	Vascular smooth muscle contraction	path:04270_6	6	6.82507	0.009825328	ITPR3 PLCB2 PRKACA PRKCD PRKCE RAF1	3710 5330 5566 5580 5581 5894
Trametinib	FDA approved	Focal adhesion	path:04510_126	3	6.882972	0.009825328	ITGAV ITGB3 THBS1	3685 3690 7057
Trametinib	FDA approved	Adherens junction	path:04520_11	7	5.805347	0.042576419	CSNK2B CTNNB1 CTNND1 FYN IGF1R ACP1 SRC	1460 1499 1500 2534 3480 52 6714
Uracil mustard	FDA approved	Purine metabolism	path:00230_163	14	7.597128	0.005518764	POLR3A ADCY6 AK1 ZNRD1 NME1 NME4 PDE1B PKM POLE3 POLE PRIM1 POLR3B POLR3GL ENTPD6	11128 112 203 30834 4830 4833 5153 5315 54107 5426 5557 55703 84265 955
Uracil mustard	FDA approved	Pyrimidine metabolism	path:00240_111	11	6.787846	0.014348786	ZNRD1 NME1 NME4 POLE3 POLE POLR2A POLR2D PRIM1 POLR3B POLR3GL ENTPD6	30834 4830 4833 54107 5426 5430 5433 5557 55703 84265 955
Uracil mustard	FDA approved	Calcium signaling pathway	path:04020_64	9	5.800144	0.049668874	GRIN2D ITPR1 ITPR2 ATP2A2 PLCG1 SLC8A2 TNNC1 ITPKC CACNA1H	2906 3708 3709 488 5335 6543 7134 80271 8912
Uracil mustard	FDA approved	Chemokine signaling pathway	path:04062_83	8	6.096025	0.03200883	AKT1 GNAI2 GNB3 GNG5 GNGT2 PIK3CG PRKCZ GNB4	207 2771 2784 2787 2793 5294 5590 59345
Uracil mustard	FDA approved	FoxO signaling pathway	path:04068_105	16	6.364595	0.023178808	CDK2 CDKN2B S1PR1 AKT1 FOXO1 IKBKB NLK PRKAB1 PRKAG1 MAPK1 MAPK13 RBL2 CCND1 BNIP3 STAT3 CCNG2	1017 1030 1901 207 2308 3551 51701 5564 5571 5594 5603 5934 595 664 6774 901
Uracil mustard	FDA approved	p53 signaling pathway	path:04115_29	10	6.169439	0.028697572	BBC3 SFN MDM2 MDM4 SERPINB5 BAX PERP TP53 PPM1D CCNG2	27113 2810 4193 4194 5268 581 64065 7157 8493 901
Uracil mustard	FDA approved	Vascular smooth muscle contraction	path:04270_7	8	6.598622	0.018763797	ADCY6 GNAS ITPR1 ITPR2 ITPR3 PRKACB PTGIR MYLK3	112 2778 3708 3709 3710 5567 5739 91807
Uracil mustard	FDA approved	Focal adhesion	path:04510_127	6	8.600766	0	ITGA2 ITGA2B ITGA5 PRKCA PXN VASP	3673 3674 3678 5578 5829 7408
Uracil mustard	FDA approved	Platelet activation	path:04611_17	8	5.895281	0.04415011	ADCY6 ITPR1 ITPR3 PLCB3 PRKACB PRKCZ ACTG1 VASP	112 3708 3710 5331 5567 5590 71 7408
Uracil mustard	FDA approved	Jak-STAT signaling pathway	path:04630_102	7	6.850283	0.01214128	CBLC IL19 IFNGR1 IL10 MPL IL20RA CBL	23624 29949 3459 3586 4352 53832 867
Uracil mustard	FDA approved	Circadian entrainment	path:04713_49	9	6.011899	0.035320088	ADCY6 GNAI2 GNAS GNB3 GNG5 GNGT2 MTNR1A PRKACB GNB4	112 2771 2778 2784 2787 2793 4543 5567 59345
Uracil mustard	FDA approved	Retrograde endocannabinoid signaling	path:04723_38	8	5.821174	0.048565121	ADCY6 GNAI2 GNB3 GNG5 GNGT2 PRKACB MAPK13 GNB4	112 2771 2784 2787 2793 5567 5603 59345
Uracil mustard	FDA approved	Glutamatergic synapse	path:04724_40	12	6.452663	0.022075055	ADCY6 GNAI2 GNB3 GNG5 GNGT2 GRIK4 GRIN2D GRM2 GRM4 GRM7 GNG13 GNB4	112 2771 2784 2787 2793 2900 2906 2912 2914 2917 51764 59345
Uracil mustard	FDA approved	Cholinergic synapse	path:04725_57	10	5.997458	0.035320088	ADCY6 AKT1 GNAI2 GNB3 GNG5 GNGT2 PIK3CG PRKACB GNB4 BCL2	112 207 2771 2784 2787 2793 5294 5567 59345 596
Uracil mustard	FDA approved	Regulation of actin cytoskeleton	path:04810_48	6	6.79738	0.014348786	PAK4 GNA13 RRAS2 PAK6 RAC2 MYLK3	10298 10672 22800 56924 5880 91807
Uracil mustard	FDA approved	Morphine addiction	path:05032_39	10	6.375587	0.022075055	ADCY6 GABBR1 GABRE GNAI2 GNB3 GNG5 GNGT2 PRKACB PRKCA GNB4	112 2550 2564 2771 2784 2787 2793 5567 5578 59345
Valrubicin	FDA approved	Purine metabolism	path:00230_164	11	7.371636	0.008898776	POLR3A ADCY6 AK1 AMPD2 IMPDH2 NME1 PDE1B POLR2C POLR2K POLR3B ENTPD6	11128 112 203 271 3615 4830 5153 5432 5440 55703 955
Valrubicin	FDA approved	Pyrimidine metabolism	path:00240_112	6	5.985072	0.045606229	UPRT DUT NME1 NT5E TYMS ENTPD6	139596 1854 4830 4907 7298 955
Valrubicin	FDA approved	Inositol phosphate metabolism	path:00562_28	9	5.984121	0.045606229	INPPL1 PIK3CB PIK3CG PI4KA PLCB2 PIP4K2C PIP5K1A PIP4K2B SYNJ2	3636 5291 5294 5297 5330 79837 8394 8396 8871
Valrubicin	FDA approved	Glycerophospholipid metabolism	path:00564_23	8	6.012773	0.045606229	CEPT1 CDS1 DGKA DGKG PLD3 LCAT PCYT1A DGKZ	10390 1040 1606 1608 23646 3931 5130 8525
Valrubicin	FDA approved	ErbB signaling pathway	path:04012_21	5	6.183114	0.036707453	ERBB2 ERBB3 GRB2 PIK3CG SHC3	2064 2065 2885 5294 53358
Valrubicin	FDA approved	Phosphatidylinositol signaling system	path:04070_74	6	6.697999	0.022246941	INPPL1 PIK3CB PIK3CG PLCB2 PIP4K2C PIP4K2B	3636 5291 5294 5330 79837 8396
Valrubicin	FDA approved	Endocytosis	path:04144_23	5	6.129881	0.040044494	WWP1 ERBB3 CBLC SH3GLB1 SMURF2	11059 2065 23624 51100 64750
Valrubicin	FDA approved	mTOR signaling pathway	path:04150_9	4	6.056253	0.042269188	EIF4B MTOR RPS6KB1 ULK1	1975 2475 6198 8408
Valrubicin	FDA approved	AMPK signaling pathway	path:04152_39	6	6.892463	0.014460512	MTOR GYS1 PFKFB2 PRKAB1 RPS6KB1 ULK1	2475 2997 5208 5564 6198 8408
Valrubicin	FDA approved	Focal adhesion	path:04510_128	5	7.678196	0.004449388	ERBB2 GRB2 HGF SHC3 PTK2	2064 2885 3082 53358 5747
Valrubicin	FDA approved	Adherens junction	path:04520_12	6	6.789448	0.0189099	CSNK2A2 CTNNB1 ERBB2 ACP1 MAPK1 CDH1	1459 1499 2064 52 5594 999
Valrubicin	FDA approved	Jak-STAT signaling pathway	path:04630_103	7	5.96441	0.045606229	CSF3 CBLC IFNGR1 IL2RG IL13RA1 OSM IL23A	1440 23624 3459 3561 3597 5008 51561
Valrubicin	FDA approved	Circadian entrainment	path:04713_50	10	6.951167	0.014460512	ADCY6 GNAI2 GNAO1 GNG5 GNGT2 PLCB2 PRKACB MAPK1 GNB4 RPS6KA5	112 2771 2775 2787 2793 5330 5567 5594 59345 9252
Valrubicin	FDA approved	Retrograde endocannabinoid signaling	path:04723_39	9	6.980733	0.013348165	ADCY6 GNAI2 GNAO1 GNG5 GNGT2 PRKACB MAPK1 GNB4 MAPK12	112 2771 2775 2787 2793 5567 5594 59345 6300
Valrubicin	FDA approved	Glutamatergic synapse	path:04724_41	7	6.460892	0.028921023	ADCY6 GNAI2 GNAO1 GNG5 GNGT2 PRKACB GNB4	112 2771 2775 2787 2793 5567 59345
Valrubicin	FDA approved	Cholinergic synapse	path:04725_58	10	6.865085	0.015572859	ADCY6 GNAI2 GNAI3 GNAO1 GNG4 GNG5 GNGT2 PIK3CG GNG12 GNB4	112 2771 2773 2775 2786 2787 2793 5294 55970 59345
Valrubicin	FDA approved	GABAergic synapse	path:04727_32	7	6.460892	0.028921023	ADCY6 GNAI2 GNAO1 GNG5 GNGT2 PRKACB GNB4	112 2771 2775 2787 2793 5567 59345
Valrubicin	FDA approved	Morphine addiction	path:05032_40	7	6.460892	0.028921023	ADCY6 GNAI2 GNAO1 GNG5 GNGT2 PRKACB GNB4	112 2771 2775 2787 2793 5567 59345
Vandetanib	FDA approved	Purine metabolism	path:00230_165	9	5.910772	0.046119235	POLR3G ADCY7 ADCY9 POLR3H NPR1 POLR1D POLR2A POLR1E PDE8B	10622 113 115 171568 4881 51082 5430 64425 8622
Vandetanib	FDA approved	Ras signaling pathway	path:04014_68	11	6.228196	0.029246344	RASSF1 MRAS HRAS PLCE1 RAF1 RALGDS RASA1 RRAS SYNGAP1 RASAL2 RIN1	11186 22808 3265 51196 5894 5900 5921 6237 8831 9462 9610
Vandetanib	FDA approved	Hippo signaling pathway	path:04390_49	5	6.440752	0.01912261	SMAD2 SMAD4 SMAD7 BMPR2 YWHAE	4087 4089 4092 659 7531
Vandetanib	FDA approved	Focal adhesion	path:04510_129	5	6.240223	0.029246344	FLNC ITGAV ITGB1 ITGB3 CAV3	2318 3685 3688 3690 859
Vandetanib	FDA approved	Pathways in cancer	path:05200_47	9	5.921182	0.046119235	CREBBP EGFR HIF1A ARNT PDGFB TGFA TGFB2 VEGFB VHL	1387 1956 3091 405 5155 7039 7042 7423 7428
Vemurafenib	FDA approved	Purine metabolism	path:00230_166	8	6.224032	0.020948181	AK7 ADK POLR2C POLR2F POLR2G PDE8B PNPT1 ENTPD1	122481 132 5432 5435 5436 8622 87178 953
Vemurafenib	FDA approved	PPAR signaling pathway	path:03320_18	6	5.690963	0.045203969	CYP8B1 ACSL3 APOC3 PPARA ACSBG2 FADS2	1582 2181 345 5465 81616 9415
Vemurafenib	FDA approved	Rap1 signaling pathway	path:04015_84	11	6.907823	0.007717751	CSF1R FGFR3 FGFR4 FLT4 FGF21 MET PDGFB PLCB3 PDGFC FGF18 FGF17	1436 2261 2264 2324 26291 4233 5155 5331 56034 8817 8822
Vemurafenib	FDA approved	Adrenergic signaling in cardiomyocytes	path:04261_30	9	5.832941	0.037486218	PPP1CA PPP2CA PPP2R1B PPP2R2C PPP2R5B PPP2R5C PPP2R5E CACNA1S CAMK2A	5499 5515 5519 5522 5526 5527 5529 779 815
Vemurafenib	FDA approved	Focal adhesion	path:04510_130	3	6.295677	0.017640573	FLNB FLNC ITGB5	2317 2318 3693
Vemurafenib	FDA approved	Neurotrophin signaling pathway	path:04722_6	12	5.848725	0.034178611	KRAS ATF4 CALML5 PLCG1 PRKCD MAP2K2 RAF1 RPS6KA3 BRAF CALML3 CAMK2A CAMK2G	3845 468 51806 5335 5580 5605 5894 6197 673 810 815 818
Vemurafenib	FDA approved	Regulation of actin cytoskeleton	path:04810_49	4	5.643531	0.048511577	PAK1 PPP1CA MYLK2 MYLK3	5058 5499 85366 91807
Vemurafenib	FDA approved	Insulin signaling pathway	path:04910_28	9	5.796268	0.040793826	AKT1 GYS1 CALML5 PHKB PPP1CA PYGB PYGM CALM1 CALML3	207 2997 51806 5257 5499 5834 5837 801 810
Vinblastine rep1	FDA approved	Purine metabolism	path:00230_167	11	6.903728	0.010976948	ADCY5 ADSL ADSS AK5 AMPD1 GUK1 NT5E PDE6A PDE9A GMPS ENTPD6	111 158 159 26289 270 2987 4907 5145 5152 8833 955
Vinblastine rep1	FDA approved	Inositol phosphate metabolism	path:00562_29	4	5.8196	0.047200878	PLCB1 INPPL1 PIK3CB PLCB4	23236 3636 5291 5332
Vinblastine rep1	FDA approved	Rap1 signaling pathway	path:04015_85	9	8.462728	0.001097695	CSF1 EFNA3 EPHA2 FGFR1 FGFR2 PLCB1 ANGPT1 NGF PLCB4	1435 1944 1969 2260 2263 23236 284 4803 5332
Vinblastine rep1	FDA approved	Chemokine signaling pathway	path:04062_84	9	8.275202	0.001097695	AKT3 PLCB1 PIK3R5 GNAI1 GNG11 NRAS PIK3CB PLCB4 GNG12	10000 23236 23533 2770 2791 4893 5291 5332 55970
Vinblastine rep1	FDA approved	HIF-1 signaling pathway	path:04066_25	8	6.137724	0.032930845	ENO2 ANGPT1 HIF1A HK2 PFKFB3 PFKL EGLN1 HKDC1	2026 284 3091 3099 5209 5211 54583 80201
Vinblastine rep1	FDA approved	FoxO signaling pathway	path:04068_106	12	7.783395	0.00219539	AKT3 CDKN1B PLK2 GABARAPL2 MAPK14 GADD45A S1PR1 GABARAPL1 IL7R FOXO4 PRKAA2 CCND1	10000 1027 10769 11345 1432 1647 1901 23710 3575 4303 5563 595
Vinblastine rep1	FDA approved	Phosphatidylinositol signaling system	path:04070_75	6	6.231174	0.026344676	PLCB1 PIK3R5 INPPL1 PIK3CB PLCB4 DGKZ	23236 23533 3636 5291 5332 8525
Vinblastine rep1	FDA approved	Sphingolipid signaling pathway	path:04071_26	8	6.893627	0.010976948	S1PR1 PLCB1 PIK3R5 GNAI1 NRAS PIK3CB PLCB4 RAC1	1901 23236 23533 2770 4893 5291 5332 5879
Vinblastine rep1	FDA approved	p53 signaling pathway	path:04115_30	10	5.770359	0.048298573	CDKN1A CHEK1 CHEK2 GADD45A RCHY1 FAS ATR THBS1 TP53 EI24	1026 1111 11200 1647 25898 355 545 7057 7157 9538
Vinblastine rep1	FDA approved	Wnt signaling pathway	path:04310_21	3	6.949199	0.010976948	PLCB1 PLCB4 PPP3R1	23236 5332 5534
Vinblastine rep1	FDA approved	Hippo signaling pathway	path:04390_50	3	6.334194	0.021953897	PPP2R2D ACTB STK3	55844 60 6788
Vinblastine rep1	FDA approved	Focal adhesion	path:04510_131	3	7.4629	0.005488474	PIK3R5 ILK VAV1	23533 3611 7409
Vinblastine rep1	FDA approved	ECM-receptor interaction	path:04512_20	5	6.527695	0.017563117	ITGAV ITGB1 ITGB3 THBS1 CD36	3685 3688 3690 7057 948
Vinblastine rep1	FDA approved	Platelet activation	path:04611_18	6	6.162924	0.03183315	ADCY5 ADCY9 PLCB1 GNAI1 ITPR1 PLCB4	111 115 23236 2770 3708 5332
Vinblastine rep1	FDA approved	Jak-STAT signaling pathway	path:04630_104	14	7.587646	0.004390779	CTF1 IFNL1 IFNAR1 IFNAR2 IFNG IFNGR2 IL2RA IL6ST IL7R IL9 IL10RA IL12RB2 MPL IL21	1489 282618 3454 3455 3458 3460 3559 3572 3575 3578 3587 3595 4352 59067
Vinblastine rep1	FDA approved	Leukocyte transendothelial migration	path:04670_10	7	6.091863	0.03622393	MAPK14 CYBA PIK3R5 GNAI1 PIK3CB RAC1 VCAM1	1432 1535 23533 2770 5291 5879 7412
Vinblastine rep1	FDA approved	Circadian entrainment	path:04713_51	8	7.090055	0.009879254	ADCY5 ADCY9 PLCB1 GNAI1 GNG4 GNG11 PLCB4 GNG12	111 115 23236 2770 2786 2791 5332 55970
Vinblastine rep1	FDA approved	Cholinergic synapse	path:04725_59	8	6.403986	0.020856202	ADCY5 ADCY6 ADCY9 PIK3R5 GNAI1 GNG4 GNG11 GNG12	111 112 115 23533 2770 2786 2791 55970
Vinblastine rep1	FDA approved	Serotonergic synapse	path:04726_34	7	6.943475	0.010976948	ADCY5 PLCB1 GNAI1 GNG4 GNG11 PLCB4 GNG12	111 23236 2770 2786 2791 5332 55970
Vinblastine rep1	FDA approved	Dopaminergic synapse	path:04728_48	7	6.943475	0.010976948	ADCY5 PLCB1 GNAI1 GNG4 GNG11 PLCB4 GNG12	111 23236 2770 2786 2791 5332 55970
Vinblastine rep1	FDA approved	Melanogenesis	path:04916_9	4	5.975939	0.038419319	PLCB1 GNAI1 PLCB4 CALML3	23236 2770 5332 810
Vinblastine rep1	FDA approved	Thyroid hormone synthesis	path:04918_3	6	6.377281	0.020856202	CREB3 ADCY5 ADCY8 ADCY9 PRKCA PRKX	10488 111 114 115 5578 5613
Vinblastine rep1	FDA approved	Oxytocin signaling pathway	path:04921_33	8	6.99539	0.010976948	ADCY5 ADCY9 PLCB1 PIK3R5 GNAI1 OXTR PIK3CB PLCB4	111 115 23236 23533 2770 5021 5291 5332
Vinblastine rep1	FDA approved	Gastric acid secretion	path:04971_3	5	6.159342	0.03183315	PLCB1 PLCB4 PRKCA PRKX ACTB	23236 5332 5578 5613 60
Vinblastine rep2	FDA approved	Purine metabolism	path:00230_168	13	7.567554	0.003293085	ADCY6 ADCY9 AK2 ZNRD1 NME3 PDE4D PDE6B POLR2C POLR2D POLR3E ADCY10 RRM2 PNPT1	112 115 204 30834 4832 5144 5158 5432 5433 55718 55811 6241 87178
Vinblastine rep2	FDA approved	Calcium signaling pathway	path:04020_65	9	6.447901	0.021953897	PPIF ATP2B2 ATP2B4 CALML5 PRKCG RYR2 TNNC1 CACNA1G ORAI3	10105 491 493 51806 5582 6262 7134 8913 93129
Vinblastine rep2	FDA approved	HIF-1 signaling pathway	path:04066_26	9	5.975081	0.040614709	CREBBP HIF1A HK3 LTBR PFKFB3 TFRC TIMP1 HKDC1 CAMK2A	1387 3091 3101 4055 5209 7037 7076 80201 815
Vinblastine rep2	FDA approved	FoxO signaling pathway	path:04068_107	7	6.557301	0.018660812	CDKN1A PLK2 MAPK14 FOXO1 FASLG PRKAA1 CCNB2	1026 10769 1432 2308 356 5562 9133
Vinblastine rep2	FDA approved	PI3K-Akt signaling pathway	path:04151_92	4	6.370846	0.025246981	ITGAV ITGB1 ITGB3 THBS1	3685 3688 3690 7057
Vinblastine rep2	FDA approved	Focal adhesion	path:04510_132	7	7.200568	0.009879254	FLNA ITGAV ITGB1 ITGB3 PRKCG THBS1 TLN2	2316 3685 3688 3690 5582 7057 83660
Vinblastine rep2	FDA approved	Circadian entrainment	path:04713_52	9	7.288698	0.007683864	ADCY6 ADCY9 GNAI1 GNB1 GNG4 GNG11 GNGT1 PLCB4 ADCY10	112 115 2770 2782 2786 2791 2792 5332 55811
Vinblastine rep2	FDA approved	Retrograde endocannabinoid signaling	path:04723_40	9	6.003439	0.038419319	ADCY6 ADCY9 MAPK14 GNAI1 GNB1 GNG4 GNG11 GNGT1 MAPK10	112 115 1432 2770 2782 2786 2791 2792 5602
Vinblastine rep2	FDA approved	Serotonergic synapse	path:04726_35	5	6.071317	0.037321625	GNAI1 GNB1 GNG4 GNG11 PLCB4	2770 2782 2786 2791 5332
Vinblastine rep2	FDA approved	Dopaminergic synapse	path:04728_49	7	5.895579	0.043907794	ADCY5 GNAI1 GNB1 GNG4 GNG11 GNGT1 PLCB4	111 2770 2782 2786 2791 2792 5332
Vinblastine rep2	FDA approved	Thyroid hormone synthesis	path:04918_4	3	6.187889	0.03402854	PLCB4 PRKCG CREB5	5332 5582 9586
Vinblastine rep2	FDA approved	Morphine addiction	path:05032_41	8	5.847707	0.045005488	ADCY6 ADCY9 GNAI1 GNB1 GNG4 GNG11 GNGT1 PRKCG	112 115 2770 2782 2786 2791 2792 5582
Vinblastine rep3	FDA approved	Purine metabolism	path:00230_169	17	7.880204	0.001118568	POLR3G ADCY3 ADCY7 ADK POLR3H NME7 NUDT2 POLR1D PDE4B POLR2C POLR2D POLR2F ADCY10 RRM2 POLR1B PNPT1 POLR1C	10622 109 113 132 171568 29922 318 51082 5142 5432 5433 5435 55811 6241 84172 87178 9533
Vinblastine rep3	FDA approved	Pyrimidine metabolism	path:00240_113	13	7.214048	0.004474273	POLR3G POLR3H NME7 POLR1D POLR2C POLR2D POLR2E POLR2F POLR2I RRM2 POLR1B PNPT1 POLR1C	10622 171568 29922 51082 5432 5433 5434 5435 5438 6241 84172 87178 9533
Vinblastine rep3	FDA approved	Calcium signaling pathway	path:04020_66	10	6.254974	0.024608501	PPIF ITPKB MYLK P2RX7 CALML5 PPP3R1 PRKCA TNNC2 CACNA1S CALML3	10105 3707 4638 5027 51806 5534 5578 7125 779 810
Vinblastine rep3	FDA approved	cAMP signaling pathway	path:04024_42	9	5.975706	0.041387025	ADCYAP1R1 ADORA1 ADORA2A ADRB2 FSHR HTR1D HTR4 HTR6 OXTR	117 134 135 154 2492 3352 3360 3362 5021
Vinblastine rep3	FDA approved	Chemokine signaling pathway	path:04062_85	9	6.998728	0.005592841	AKT3 AKT2 GNG11 GNGT1 GSK3B PIK3CB PIK3R1 PLCB4 PRKCZ	10000 208 2791 2792 2932 5291 5295 5332 5590
Vinblastine rep3	FDA approved	HIF-1 signaling pathway	path:04066_27	9	6.346954	0.020134228	EP300 HIF1A HK2 HK3 NPPA SERPINE1 PFKL HKDC1 RBX1	2033 3091 3099 3101 4878 5054 5211 80201 9978
Vinblastine rep3	FDA approved	p53 signaling pathway	path:04115_31	9	6.090378	0.034675615	CHEK2 SESN3 SFN SERPINE1 RRM2 SIAH1 THBS1 TP53 TP73	11200 143686 2810 5054 6241 6477 7057 7157 7161
Vinblastine rep3	FDA approved	PI3K-Akt signaling pathway	path:04151_93	4	6.355478	0.020134228	ITGAV ITGB1 PTK2 THBS1	3685 3688 5747 7057
Vinblastine rep3	FDA approved	Focal adhesion	path:04510_133	3	7.585158	0.001118568	FLNB ITGB1 THBS1	2317 3688 7057
Vinblastine rep3	FDA approved	ECM-receptor interaction	path:04512_21	3	6.415378	0.016778523	ITGAV ITGB1 THBS1	3685 3688 7057
Vinblastine rep3	FDA approved	Jak-STAT signaling pathway	path:04630_105	16	6.2331	0.024608501	CTF1 IFNLR1 IFNG IL2RA IL6ST IL12B IL15 IL15RA LEPR LIF MPL OSM IL22 IL22RA1 CBLB OSMR	1489 163702 3458 3559 3572 3593 3600 3601 3953 3976 4352 5008 50616 58985 868 9180
Vinblastine rep3	FDA approved	Circadian entrainment	path:04713_53	8	6.58701	0.013422819	ADCY7 GNB1 GNG11 GNGT1 MTNR1B PLCB4 ADCY10 MAPK1	113 2782 2791 2792 4544 5332 55811 5594
Vinblastine rep3	FDA approved	Insulin signaling pathway	path:04910_29	5	6.580699	0.013422819	AKT3 MTOR CALML5 PHKB CALML3	10000 2475 51806 5257 810
Vincristine rep1	FDA approved	Purine metabolism	path:00230_170	13	7.533491	0.003318584	ADCY6 AK5 ITPA NT5E POLR1D PDE4B POLR2C POLR2H POLR2I POLR2K POLR3GL PNPT1 ENTPD6	112 26289 3704 4907 51082 5142 5432 5437 5438 5440 84265 87178 955
Vincristine rep1	FDA approved	Nicotinate and nicotinamide metabolism	path:00760_7	5	6.58292	0.01880531	AOX1 NNMT PNP NT5E BST1	316 4837 4860 4907 683
Vincristine rep1	FDA approved	Rap1 signaling pathway	path:04015_86	6	7.237788	0.003318584	FGFR3 FGFR2 PLCB1 KIT ANGPT4 PLCB4	2261 2263 23236 3815 51378 5332
Vincristine rep1	FDA approved	cGMP-PKG signaling pathway	path:04022_35	7	6.043488	0.033185841	KCNU1 KCNMA1 KCNMB1 PRKG1 CACNA1D CACNA1F CACNA1S	157855 3778 3779 5592 776 778 779
Vincristine rep1	FDA approved	Chemokine signaling pathway	path:04062_86	4	8.132474	0	PLCB1 GNG11 PLCB4 GNG12	23236 2791 5332 55970
Vincristine rep1	FDA approved	FoxO signaling pathway	path:04068_108	12	7.486054	0.003318584	AKT3 PLK2 PLK3 GADD45A SGK3 FOXO4 PRKAA1 PRKAA2 CCND1 S1PR4 CCNB1 CCNB2	10000 10769 1263 1647 23678 4303 5562 5563 595 8698 891 9133
Vincristine rep1	FDA approved	Phosphatidylinositol signaling system	path:04070_76	4	6.908235	0.009955752	DGKQ PLCB1 PLCB4 CDS2	1609 23236 5332 8760
Vincristine rep1	FDA approved	Cell cycle	path:04110_18	9	7.500836	0.003318584	GADD45A ANAPC4 PCNA ANAPC5 CDC16 CCNB1 CCNB2 BUB3 CDC20	1647 29945 5111 51433 8881 891 9133 9184 991
Vincristine rep1	FDA approved	Vascular smooth muscle contraction	path:04270_8	6	6.369162	0.023230088	ADCY6 ADCY9 PLCB1 ITPR2 PLCB4 PRKX	112 115 23236 3709 5332 5613
Vincristine rep1	FDA approved	Focal adhesion	path:04510_134	7	7.298345	0.003318584	FLNA ITGA2 ITGB1 ITGB3 TLN1 TLN2 CAV2	2316 3673 3688 3690 7094 83660 858
Vincristine rep1	FDA approved	ECM-receptor interaction	path:04512_22	4	6.147875	0.029867257	ITGA2 ITGAV ITGB1 ITGB3	3673 3685 3688 3690
Vincristine rep1	FDA approved	Signaling pathways regulating pluripotency of stem cells	path:04550_6	7	6.014564	0.034292035	AKT3 FGFR3 FGFR2 PIK3R5 GRB2 IL6ST PIK3CD	10000 2261 2263 23533 2885 3572 5293
Vincristine rep1	FDA approved	Jak-STAT signaling pathway	path:04630_106	9	7.005432	0.005530973	CSF2RB CSF3 IFNGR2 IL4 IL6ST IL12RB2 IL13RA1 IL15 IL23A	1439 1440 3460 3565 3572 3595 3597 3600 51561
Vincristine rep1	FDA approved	Circadian entrainment	path:04713_54	9	8.875752	0	ADCY6 ADCY9 PLCB1 GNAI1 GNG11 PLCB4 GNG12 PRKX RPS6KA5	112 115 23236 2770 2791 5332 55970 5613 9252
Vincristine rep1	FDA approved	Retrograde endocannabinoid signaling	path:04723_41	8	6.745513	0.014380531	ADCY2 ADCY6 ADCY9 GNAI1 GNG11 GNGT1 GNG12 PRKX	108 112 115 2770 2791 2792 55970 5613
Vincristine rep1	FDA approved	Glutamatergic synapse	path:04724_42	9	7.18552	0.004424779	ADCY2 ADCY6 ADCY9 GNAI1 GNG11 GNGT1 GRM6 GNG12 PRKX	108 112 115 2770 2791 2792 2916 55970 5613
Vincristine rep1	FDA approved	Cholinergic synapse	path:04725_60	9	6.875902	0.009955752	ADCY2 ADCY6 ADCY9 PIK3R5 GNAI1 GNG11 GNGT1 GNG12 PRKX	108 112 115 23533 2770 2791 2792 55970 5613
Vincristine rep1	FDA approved	Serotonergic synapse	path:04726_36	4	8.132474	0	PLCB1 GNG11 PLCB4 GNG12	23236 2791 5332 55970
Vincristine rep1	FDA approved	GABAergic synapse	path:04727_33	10	6.985574	0.006637168	ADCY2 ADCY6 ADCY9 GNAI1 GNG11 GNGT1 GNG12 PRKX CACNA1D CACNA1F	108 112 115 2770 2791 2792 55970 5613 776 778
Vincristine rep1	FDA approved	Dopaminergic synapse	path:04728_50	6	8.664129	0	DRD1 DRD4 PLCB1 GNG11 PLCB4 GNG12	1812 1815 23236 2791 5332 55970
Vincristine rep1	FDA approved	Regulation of actin cytoskeleton	path:04810_50	5	6.029051	0.033185841	PAK4 PAK3 GNG12 RAC2 BCAR1	10298 5063 55970 5880 9564
Vincristine rep1	FDA approved	Melanogenesis	path:04916_10	3	5.990912	0.037610619	PLCB1 PLCB4 CALM1	23236 5332 801
Vincristine rep1	FDA approved	Thyroid hormone signaling pathway	path:04919_29	3	6.63588	0.01880531	PLCB1 ITGB3 PLCB4	23236 3690 5332
Vincristine rep1	FDA approved	Oxytocin signaling pathway	path:04921_34	8	7.694594	0.001106195	ADCY2 ADCY6 ADCY9 PLCB1 GNAI1 OXTR PLCB4 PRKX	108 112 115 23236 2770 5021 5332 5613
Vincristine rep1	FDA approved	Morphine addiction	path:05032_42	8	6.745513	0.014380531	ADCY2 ADCY6 ADCY9 GNAI1 GNG11 GNGT1 GNG12 PRKX	108 112 115 2770 2791 2792 55970 5613
Vincristine rep2	FDA approved	Fructose and mannose metabolism	path:00051_4	5	5.981021	0.037321625	PFKFB1 PFKFB3 PFKL PFKP HKDC1	5207 5209 5211 5214 80201
Vincristine rep2	FDA approved	Purine metabolism	path:00230_171	10	5.764376	0.045005488	POLR3G ADCY5 ADCY7 ADCY8 ADCY9 ADCY4 NME3 POLR2F POLR2J POLR1E	10622 111 113 114 115 196883 4832 5435 5439 64425
Vincristine rep2	FDA approved	MAPK signaling pathway	path:04010_37	4	5.950026	0.039517014	MAPK14 DUSP1 DUSP5 ELK1	1432 1843 1847 2002
Vincristine rep2	FDA approved	Chemokine signaling pathway	path:04062_87	9	6.199827	0.020856202	AKT3 AKT1 FGR GNAI3 GNB1 GNG3 PIK3CB PIK3R1 SRC	10000 207 2268 2773 2782 2785 5291 5295 6714
Vincristine rep2	FDA approved	NF-kappa B signaling pathway	path:04064_10	8	6.66012	0.012074643	CSNK2B CXCL2 XIAP NFKBIA BCL2A1 RELA BCL2L1 TRAF2	1460 2920 331 4792 597 5970 598 7186
Vincristine rep2	FDA approved	HIF-1 signaling pathway	path:04066_28	6	6.732209	0.012074643	EGLN2 MTOR HIF1A EGLN1 PRKCA PRKCG	112398 2475 3091 54583 5578 5582
Vincristine rep2	FDA approved	FoxO signaling pathway	path:04068_109	6	6.095898	0.026344676	AKT3 AKT1 AKT2 IKBKB FOXO4 PTEN	10000 207 208 3551 4303 5728
Vincristine rep2	FDA approved	Phosphatidylinositol signaling system	path:04070_77	12	6.650429	0.013172338	INPP5A ITPKB MTM1 PLCE1 PIK3CB PIK3R1 PI4KA PLCB4 PLCG1 PTEN DGKZ PLCZ1	3632 3707 4534 51196 5291 5295 5297 5332 5335 5728 8525 89869
Vincristine rep2	FDA approved	VEGF signaling pathway	path:04370_3	7	6.762561	0.012074643	AKT3 AKT1 KDR PIK3CG PIK3R1 SRC CASP9	10000 207 3791 5294 5295 6714 842
Vincristine rep2	FDA approved	Focal adhesion	path:04510_135	4	5.946432	0.039517014	FLNA FLNB ITGAV ITGB1	2316 2317 3685 3688
Vincristine rep2	FDA approved	Tight junction	path:04530_18	3	5.782294	0.042810099	PRKCA PRKCG PRKCQ	5578 5582 5588
Vincristine rep2	FDA approved	Platelet activation	path:04611_19	8	6.357092	0.017563117	AKT3 AKT1 AKT2 GNAI3 ITGB1 PIK3CB PIK3R1 BTK	10000 207 208 2773 3688 5291 5295 695
Vincristine rep2	FDA approved	Circadian entrainment	path:04713_55	12	6.417102	0.016465423	ADCY7 ADCY8 ADCY9 GNB1 GNB3 GNG4 GNGT1 MTNR1A MTNR1B PLCB4 PRKACA ADCY10	113 114 115 2782 2784 2786 2792 4543 4544 5332 5566 55811
Vincristine rep2	FDA approved	Retrograde endocannabinoid signaling	path:04723_42	5	5.891267	0.040614709	ADCY7 ADCY9 MAPK14 GNB1 GNG4	113 115 1432 2782 2786
Vincristine rep2	FDA approved	Cholinergic synapse	path:04725_61	8	6.881581	0.009879254	ADCY7 ADCY9 GNB1 GNB3 GNG4 GNGT1 PIK3R1 PRKACA	113 115 2782 2784 2786 2792 5295 5566
Vincristine rep2	FDA approved	Thyroid hormone signaling pathway	path:04919_30	9	7.377595	0.003293085	AKT2 ATP1A1 ATP1B1 PIK3CB PIK3CD PIK3CG PIK3R1 SRC THRB	208 476 481 5291 5293 5294 5295 6714 7068
Vincristine rep2	FDA approved	Oxytocin signaling pathway	path:04921_35	7	6.317967	0.017563117	EGFR GNAI1 PIK3CB PIK3R1 PLCB4 PRKCA SRC	1956 2770 5291 5295 5332 5578 6714
Vincristine rep2	FDA approved	Salmonella infection	path:05132_4	3	6.23602	0.018660812	MAPK14 WAS CDC42	1432 7454 998
Vincristine rep2	FDA approved	Pathways in cancer	path:05200_48	7	6.258924	0.017563117	AKT3 AKT1 AKT2 IKBKB NFKBIA PIK3R1 CASP9	10000 207 208 3551 4792 5295 842
Vincristine rep2	FDA approved	Prostate cancer	path:05215_11	14	6.304008	0.017563117	AKT3 CDKN1A EGFR AKT1 AKT2 PIK3R5 MTOR IKBKB PIK3CA PIK3CB PIK3CD PIK3R1 PTEN CASP9	10000 1026 1956 207 208 23533 2475 3551 5290 5291 5293 5295 5728 842
Vincristine rep2	FDA approved	Non-small cell lung cancer	path:05223_3	8	5.733456	0.048298573	AKT3 EGFR AKT1 AKT2 PIK3CB PIK3R1 PLCG1 CASP9	10000 1956 207 208 5291 5295 5335 842
Vinorelbine rep1	FDA approved	Glycolysis / Gluconeogenesis	path:00010_3	9	7.172082	0.006615215	FBP1 ALDOB ALDOC GAPDH GPI PFKL PFKP TPI1 FBP2	2203 229 230 2597 2821 5211 5214 7167 8789
Vinorelbine rep1	FDA approved	Pentose phosphate pathway	path:00030_2	6	6.394522	0.015435502	FBP1 ALDOB GPI PFKL PFKP FBP2	2203 229 2821 5211 5214 8789
Vinorelbine rep1	FDA approved	Fructose and mannose metabolism	path:00051_5	8	6.949559	0.007717751	FBP1 ALDOB HK3 PFKL PFKP TPI1 HKDC1 FBP2	2203 229 3101 5211 5214 7167 80201 8789
Vinorelbine rep1	FDA approved	Purine metabolism	path:00230_172	7	6.25504	0.017640573	PDE10A ADCY5 IMPDH2 NT5E PDE9A GMPS ENTPD4	10846 111 3615 4907 5152 8833 9583
Vinorelbine rep1	FDA approved	PPAR signaling pathway	path:03320_19	6	5.88336	0.035281147	CPT1A FABP3 PDPK1 PPARD RXRA ACOX3	1374 2170 5170 5467 6256 8310
Vinorelbine rep1	FDA approved	MAPK signaling pathway	path:04010_38	9	6.075158	0.023153252	MAPK14 DUSP1 DUSP3 ELK1 MAPK8 MAPK9 MAP2K3 MAP2K4 SRF	1432 1843 1845 2002 5599 5601 5606 6416 6722
Vinorelbine rep1	FDA approved	Rap1 signaling pathway	path:04015_87	16	6.363649	0.016538037	CRK CRKL CSF1 EFNA5 EGFR EPHA2 FGF6 FGFR4 PLCB1 RASGRP3 FGF20 ANGPT2 NGF PLCB4 PDGFC VEGFA	1398 1399 1435 1946 1956 1969 2251 2264 23236 25780 26281 285 4803 5332 56034 7422
Vinorelbine rep1	FDA approved	Chemokine signaling pathway	path:04062_88	14	6.880464	0.007717751	AKT3 AKT2 PLCB1 PIK3R5 GNB3 GNG4 GNG11 GNGT1 PIK3CA PIK3CB PIK3CG PIK3R1 PLCB4 GNG12	10000 208 23236 23533 2784 2786 2791 2792 5290 5291 5294 5295 5332 55970
Vinorelbine rep1	FDA approved	FoxO signaling pathway	path:04068_110	11	7.564831	0.003307607	AKT3 KLF2 PLK2 GABARAPL2 MAPK14 AKT2 GABARAPL1 FOXO4 PRKAA2 RAG2 CCND1	10000 10365 10769 11345 1432 208 23710 4303 5563 5897 595
Vinorelbine rep1	FDA approved	Phosphatidylinositol signaling system	path:04070_78	11	6.326216	0.016538037	PLCB1 PIK3R5 MTM1 PIK3CA PIK3CB PIK3CG PIK3R1 PLCB4 DGKZ CDS2 DGKI	23236 23533 4534 5290 5291 5294 5295 5332 8525 8760 9162
Vinorelbine rep1	FDA approved	Sphingolipid signaling pathway	path:04071_27	6	5.653876	0.049614112	AKT3 MAPK14 PDPK1 PPP2R2A PPP2R5C BAX	10000 1432 5170 5520 5527 581
Vinorelbine rep1	FDA approved	PI3K-Akt signaling pathway	path:04151_94	6	5.726182	0.042998897	AKT3 PIK3CG PIK3R1 PPP2R2A IKBKG CREB5	10000 5294 5295 5520 8517 9586
Vinorelbine rep1	FDA approved	Wnt signaling pathway	path:04310_22	3	6.739908	0.009922822	PLCB1 PLCB4 CAMK2A	23236 5332 815
Vinorelbine rep1	FDA approved	Focal adhesion	path:04510_136	3	7.274225	0.005512679	FLNA FLNB ITGB1	2316 2317 3688
Vinorelbine rep1	FDA approved	ECM-receptor interaction	path:04512_23	3	6.347042	0.016538037	ITGAV ITGB1 THBS1	3685 3688 7057
Vinorelbine rep1	FDA approved	Platelet activation	path:04611_20	7	5.781975	0.03969129	AKT3 ITGB1 LCP2 PIK3CA PIK3CB PLCG2 BTK	10000 3688 3937 5290 5291 5336 695
Vinorelbine rep1	FDA approved	Jak-STAT signaling pathway	path:04630_107	17	6.767089	0.008820287	IL24 CBLC IFNAR1 IFNAR2 IFNGR2 IL2RG IL6 IL6ST IL10RA IL10RB IL12B IL12RB2 IL15 LIF MPL IL20RA OSMR	11009 23624 3454 3455 3460 3561 3569 3572 3587 3588 3593 3595 3600 3976 4352 53832 9180
Vinorelbine rep1	FDA approved	Circadian entrainment	path:04713_56	10	5.763318	0.040793826	ADCY5 ADCY7 PLCB1 GNB3 GNG4 GNG11 GNGT1 PLCB4 ADCY10 GNG12	111 113 23236 2784 2786 2791 2792 5332 55811 55970
Vinorelbine rep1	FDA approved	Cholinergic synapse	path:04725_62	16	6.239326	0.018743109	AKT3 ADCY5 ADCY7 AKT2 PIK3R5 GNB3 GNG4 GNG11 GNGT1 PIK3CA PIK3CB PIK3CG PIK3R1 PRKACA GNG12 CAMK2A	10000 111 113 208 23533 2784 2786 2791 2792 5290 5291 5294 5295 5566 55970 815
Vinorelbine rep1	FDA approved	Serotonergic synapse	path:04726_37	9	5.733925	0.042998897	ADCY5 PLCB1 GNB3 GNG4 GNG11 GNGT1 HTR1D PLCB4 GNG12	111 23236 2784 2786 2791 2792 3352 5332 55970
Vinorelbine rep1	FDA approved	Regulation of actin cytoskeleton	path:04810_51	8	6.067262	0.023153252	ARAF MYLK PAK3 PIK3CA GNG12 BDKRB1 RRAS BDKRB2	369 4638 5063 5290 55970 623 6237 624
Vinorelbine rep1	FDA approved	Insulin signaling pathway	path:04910_30	6	5.67769	0.046306505	AKT3 AKT2 PDPK1 PHKA2 PHKG2 PYGL	10000 208 5170 5256 5261 5836
Vinorelbine rep1	FDA approved	Melanogenesis	path:04916_11	3	6.111878	0.022050717	PLCB1 GNAO1 PLCB4	23236 2775 5332
Vinorelbine rep1	FDA approved	Thyroid hormone signaling pathway	path:04919_31	6	5.661289	0.048511577	AKT3 HIF1A ATP1B1 PIK3CG PIK3R1 THRA	10000 3091 481 5294 5295 7067
Vinorelbine rep1	FDA approved	Pathways in cancer	path:05200_49	10	6.337633	0.016538037	AKT3 CDKN1A CRKL EGFR AKT2 CBLC PIK3CA PIK3CB PIK3CG PIK3R1	10000 1026 1399 1956 208 23624 5290 5291 5294 5295
Vinorelbine rep1	FDA approved	Pancreatic cancer	path:05212_17	9	6.058707	0.023153252	AKT3 EGFR AKT2 PIK3R5 PIK3CA PIK3CB PIK3CG PIK3R1 BCL2L1	10000 1956 208 23533 5290 5291 5294 5295 598
Vinorelbine rep1	FDA approved	Prostate cancer	path:05215_12	10	5.648825	0.049614112	AKT3 CDKN1A EGFR AKT2 PIK3R5 PDPK1 PIK3CA PIK3CB PIK3CG PIK3R1	10000 1026 1956 208 23533 5170 5290 5291 5294 5295
Vinorelbine rep1	FDA approved	Small cell lung cancer	path:05222_19	3	5.997899	0.02646086	ITGAV ITGB1 PTK2	3685 3688 5747
Vinorelbine rep2	FDA approved	Glycolysis / Gluconeogenesis	path:00010_4	9	6.396967	0.012263099	ALDOA ALDOC GAPDHS GPI HK1 HK2 HK3 PFKL PFKP	226 230 26330 2821 3098 3099 3101 5211 5214
Vinorelbine rep2	FDA approved	Citrate cycle (TCA cycle)	path:00020_4	8	5.616873	0.040133779	DLD FH MDH2 ACLY PC PCK2 PDHA1 PDHB	1738 2271 4191 47 5091 5106 5160 5162
Vinorelbine rep2	FDA approved	Pentose phosphate pathway	path:00030_3	8	5.514503	0.045707915	ALDOA ALDOC G6PD GPI PFKL PFKP TALDO1 TKTL1	226 230 2539 2821 5211 5214 6888 8277
Vinorelbine rep2	FDA approved	Fructose and mannose metabolism	path:00051_6	8	6.111412	0.02006689	ALDOA ALDOC HK2 HK3 PFKFB3 PFKL PFKP SORD	226 230 3099 3101 5209 5211 5214 6652
Vinorelbine rep2	FDA approved	Purine metabolism	path:00230_173	6	5.620501	0.039018952	NT5C2 AMPD2 NT5C NT5E GMPR2 PDE6C	22978 271 30833 4907 51292 5146
Vinorelbine rep2	FDA approved	Inositol phosphate metabolism	path:00562_30	11	5.664891	0.036789298	PLCB1 INPP5J ITPKB OCRL PLCE1 PIK3CG PIP4K2A PLCB2 PLCB4 PLCG1 PIP4K2C	23236 27124 3707 4952 51196 5294 5305 5330 5332 5335 79837
Vinorelbine rep2	FDA approved	Sphingolipid metabolism	path:00600_13	7	6.438574	0.012263099	ASAH1 SPHK2 GBA2 CERK SMPD2 UGCG CERS5	427 56848 57704 64781 6610 7357 91012
Vinorelbine rep2	FDA approved	Ras signaling pathway	path:04014_69	12	5.898146	0.028985507	CSF1 EPHA2 FGF2 FGF9 FGF13 FGFR4 FLT4 FGF20 IGF1 PDGFB PDGFC FGF17	1435 1969 2247 2254 2258 2264 2324 26281 3479 5155 56034 8822
Vinorelbine rep2	FDA approved	Rap1 signaling pathway	path:04015_88	14	7.017552	0.004459309	CRKL EPHA2 FGF2 FGF9 FGF13 FGFR4 PLCB1 FLT4 FGF20 IGF1 PDGFB PLCB4 PDGFC FGF17	1399 1969 2247 2254 2258 2264 23236 2324 26281 3479 5155 5332 56034 8822
Vinorelbine rep2	FDA approved	Calcium signaling pathway	path:04020_67	9	6.281718	0.015607581	PTK2B SLC25A5 ITPKB ITPR1 ATP2B3 CALML5 PLCB4 RYR1 CACNA1G	2185 292 3707 3708 492 51806 5332 6261 8913
Vinorelbine rep2	FDA approved	FoxO signaling pathway	path:04068_111	16	5.912883	0.02787068	AKT3 CDKN2D PLK2 S1PR1 AKT1 AKT2 FOXO1 FOXO4 GADD45B ATM MAPK1 MAPK8 MAP2K2 CCND1 S1PR4 CCNB2	10000 1032 10769 1901 207 208 2308 4303 4616 472 5594 5599 5605 595 8698 9133
Vinorelbine rep2	FDA approved	Phosphatidylinositol signaling system	path:04070_79	14	7.381736	0	PLCB1 INPP5J INPP4A INPP5A ITPKB MTM1 OCRL PLCE1 PIK3CG PIK3R2 PI4KA PLCB4 PI4K2A CALML3	23236 27124 3631 3632 3707 4534 4952 51196 5294 5296 5297 5332 55361 810
Vinorelbine rep2	FDA approved	Wnt signaling pathway	path:04310_23	7	6.38141	0.012263099	PLCB1 PLCB4 PPP3CC PPP3R1 PRKCA CAMK2A CAMK2D	23236 5332 5533 5534 5578 815 817
Vinorelbine rep2	FDA approved	Hippo signaling pathway	path:04390_51	6	5.834685	0.031215162	SERPINE1 PPP1CC PPP2R1A PPP2R2A CCND1 BTRC	5054 5501 5518 5520 595 8945
Vinorelbine rep2	FDA approved	Focal adhesion	path:04510_137	5	6.030058	0.021181717	FLNA ITGA2B ITGB1 PTK2 PXN	2316 3674 3688 5747 5829
Vinorelbine rep2	FDA approved	Jak-STAT signaling pathway	path:04630_108	10	6.054738	0.021181717	CSF2RB CSF3 CBLC IFNG IL2RA IL10RA IL12A LIF IL23A OSMR	1439 1440 23624 3458 3559 3587 3592 3976 51561 9180
Vinorelbine rep2	FDA approved	Circadian entrainment	path:04713_57	9	5.890917	0.028985507	ADCY7 ADCYAP1R1 PLCB1 GNAI3 GNB3 GNG13 PLCB4 PRKACA MAPK1	113 117 23236 2773 2784 51764 5332 5566 5594
Vinorelbine rep2	FDA approved	Long-term potentiation	path:04720_4	9	5.774435	0.032329989	GRIA1 GRIN2D CALML5 PPP1CC PPP3CC PRKACA MAPK1 CALML3 CAMK2A	2890 2906 51806 5501 5533 5566 5594 810 815
Vinorelbine rep2	FDA approved	Neurotrophin signaling pathway	path:04722_7	6	5.644098	0.037904125	AKT3 NFKBIA NFKBIB NGFR PIK3CG PTPN11	10000 4792 4793 4804 5294 5781
Vinorelbine rep2	FDA approved	Dopaminergic synapse	path:04728_51	8	5.826671	0.031215162	CREB1 PLCB1 GNG13 CALML5 PLCB4 PRKACA PRKCA CREB3L3	1385 23236 51764 51806 5332 5566 5578 84699
Vinorelbine rep2	FDA approved	GnRH signaling pathway	path:04912_7	8	5.650741	0.037904125	PLCB1 GNA11 ITPR1 CALML5 PLCB4 PRKCA CALML3 CAMK2A	23236 2767 3708 51806 5332 5578 810 815
Vismodegib	FDA approved	Glycolysis / Gluconeogenesis	path:00010_5	7	6.103754	0.025386313	GALM ALDOC GAPDHS GPI HK1 PFKM PGK1	130589 230 26330 2821 3098 5213 5230
Vismodegib	FDA approved	Fructose and mannose metabolism	path:00051_7	4	5.772793	0.036423841	ALDOC HK1 PFKFB1 PFKM	230 3098 5207 5213
Vismodegib	FDA approved	Purine metabolism	path:00230_174	22	7.263528	0.001103753	POLR3F POLR3G PDE10A POLR3A ADCY6 ADSL PDE7B GUCY2C GUK1 NME1 POLR1D PDE2A PDE4A PDE4D PDE6D PDE8A POLR2I POLR2L RRM1 RRM2 POLR1B PNPT1	10621 10622 10846 11128 112 158 27115 2984 2987 4830 51082 5138 5141 5144 5147 5151 5438 5441 6240 6241 84172 87178
Vismodegib	FDA approved	Pyrimidine metabolism	path:00240_114	12	6.404878	0.016556291	POLR3F POLR3G POLR3A AK9 POLR1D POLR2C POLR2L POLR3B CTPS2 POLR1B PNPT1 ENTPD6	10621 10622 11128 221264 51082 5432 5441 55703 56474 84172 87178 955
Vismodegib	FDA approved	Arginine and proline metabolism	path:00330_1	9	5.57143	0.048565121	ALDH1B1 AMD1 MAOA ODC1 OTC CNDP2 SAT1 SMS SRM	219 262 4128 4953 5009 55748 6303 6611 6723
Vismodegib	FDA approved	Inositol phosphate metabolism	path:00562_31	6	6.125138	0.024282561	INPP5B MTM1 PIK3C2A PIK3CG PLCB4 PI4K2B	3633 4534 5286 5294 5332 55300
Vismodegib	FDA approved	Pyruvate metabolism	path:00620_2	8	5.757303	0.036423841	DLAT ALDH1B1 ALDH3A2 ACAT1 ACAT2 ACSS2 ACSS1 ACYP2	1737 219 224 38 39 55902 84532 98
Vismodegib	FDA approved	Rap1 signaling pathway	path:04015_89	10	6.128688	0.024282561	EGFR EPHA2 FGF1 FGF6 FGF13 FGFR1 IGF1 INS NGF PLCB4	1956 1969 2246 2251 2258 2260 3479 3630 4803 5332
Vismodegib	FDA approved	FoxO signaling pathway	path:04068_112	11	6.966353	0.003311258	AKT3 PLK2 FOXO4 GADD45B PRKAG3 RAG1 RAG2 CCND1 MAPK12 CCNB3 S1PR4	10000 10769 4303 4616 53632 5896 5897 595 6300 85417 8698
Vismodegib	FDA approved	Phosphatidylinositol signaling system	path:04070_80	3	6.839709	0.005518764	MTM1 PIK3C2A PLCB4	4534 5286 5332
Vismodegib	FDA approved	PI3K-Akt signaling pathway	path:04151_95	4	6.701744	0.007726269	ITGA2 ITGAV ITGB1 PTK2	3673 3685 3688 5747
Vismodegib	FDA approved	Adrenergic signaling in cardiomyocytes	path:04261_31	6	5.748985	0.037527594	CACNG2 PPP1CC PPP2R3A PRKX CACNA1D CACNA1F	10369 5501 5523 5613 776 778
Vismodegib	FDA approved	Vascular smooth muscle contraction	path:04270_9	7	6.180571	0.022075055	PLCB1 GNAQ ARAF ITPR1 PLA2G3 PLCB4 PRKCA	23236 2776 369 3708 50487 5332 5578
Vismodegib	FDA approved	Focal adhesion	path:04510_138	5	6.567502	0.01214128	ITGA2 ITGAV ITGB1 PRKCA CAV2	3673 3685 3688 5578 858
Vismodegib	FDA approved	ECM-receptor interaction	path:04512_24	3	5.65789	0.04415011	ITGA2 ITGAV ITGB1	3673 3685 3688
Vismodegib	FDA approved	Jak-STAT signaling pathway	path:04630_109	15	7.10135	0.002207506	IL24 EPOR IFNL1 IL19 IL2RG IL10 IL10RA JAK3 OSM IL20 IL21R IL22 PIK3CG IL20RA SOCS1	11009 2057 282618 29949 3561 3586 3587 3718 5008 50604 50615 50616 5294 53832 8651
Vismodegib	FDA approved	Serotonergic synapse	path:04726_38	9	5.676564	0.043046358	GNAQ GNB3 GNGT1 HTR1D HTR2A HTR2C PLCB4 CACNA1D CACNA1F	2776 2784 2792 3352 3356 3358 5332 776 778
Vismodegib	FDA approved	Regulation of actin cytoskeleton	path:04810_52	5	6.977242	0.003311258	RRAS2 MRAS ARAF KRAS PIK3CG	22800 22808 369 3845 5294
Vismodegib	FDA approved	Insulin signaling pathway	path:04910_31	9	5.870774	0.03200883	AKT3 GYS2 PDE3B PHKA1 PHKA2 PPP1CB PRKX PYGB PYGL	10000 2998 5140 5255 5256 5500 5613 5834 5836
Vismodegib	FDA approved	Glucagon signaling pathway	path:04922_11	9	6.119275	0.024282561	GYS2 ATF4 PFKFB1 PHKA1 PHKA2 PRKAG3 PRKX PYGB PYGL	2998 468 5207 5255 5256 53632 5613 5834 5836
Vismodegib	FDA approved	Pathways in cancer	path:05200_50	9	5.812874	0.034216336	AKT3 EGFR FLT3 HRAS ARAF KRAS PIK3CG RALGDS RET	10000 1956 2322 3265 369 3845 5294 5900 5979
Vismodegib	FDA approved	Colorectal cancer	path:05210_3	7	5.66409	0.04415011	AKT3 ARAF KRAS RHOA PIK3CG RAC2 RALGDS	10000 369 3845 387 5294 5880 5900
Vismodegib	FDA approved	Pancreatic cancer	path:05212_18	6	6.531359	0.013245033	AKT3 ARAF KRAS PIK3CG RALGDS BCL2L1	10000 369 3845 5294 5900 598
Vismodegib	FDA approved	Small cell lung cancer	path:05222_20	4	5.609707	0.046357616	ITGA2 ITGAV ITGB1 PTK2	3673 3685 3688 5747
Vorinostat rep1	FDA approved	Purine metabolism	path:00230_175	10	6.678428	0.015625	ADCY1 ADCY9 AK1 NME7 ZNRD1 NME4 POLR3K POLE POLR2D POLR1B	107 115 203 29922 30834 4833 51728 5426 5433 84172
Vorinostat rep1	FDA approved	Ras signaling pathway	path:04014_70	9	6.073016	0.035714286	RASGRP2 PIK3R5 PLCE1 RAC1 RALGDS RRAS BRAP RASAL1 SYNGAP1	10235 23533 51196 5879 5900 6237 8315 8437 8831
Vorinostat rep1	FDA approved	Rap1 signaling pathway	path:04015_90	15	6.578647	0.021205357	CRK CSF1 EFNA3 EFNA5 EGFR EPHA2 FGF1 FGF13 FGF20 MET NGF PLCB2 PDGFC VEGFA VEGFC	1398 1435 1944 1946 1956 1969 2246 2258 26281 4233 4803 5330 56034 7422 7424
Vorinostat rep1	FDA approved	Calcium signaling pathway	path:04020_68	13	6.550683	0.022321429	CHRNA7 PTK2B GRIN2A ITPKB ATP2A3 P2RX4 P2RX7 PLCE1 PLCB2 PLCG2 PRKCA PRKCB SLC8A1	1139 2185 2903 3707 489 5025 5027 51196 5330 5336 5578 5579 6546
Vorinostat rep1	FDA approved	cAMP signaling pathway	path:04024_43	10	6.737184	0.015625	CREB3 EP300 GLI3 GRIN2A GRIN2C NFATC1 PDE3B PRKACA PRKACB SOX9	10488 2033 2737 2903 2905 4772 5140 5566 5567 6662
Vorinostat rep1	FDA approved	Chemokine signaling pathway	path:04062_89	12	6.566809	0.022321429	CCL26 GRK2 CXCR3 GRK6 CXCL2 CCL3 CCL14 CCL15 CCL18 CCL23 CXCR4 CXCL14	10344 156 2833 2870 2920 6348 6358 6359 6362 6368 7852 9547
Vorinostat rep1	FDA approved	p53 signaling pathway	path:04115_32	13	6.360905	0.025669643	SESN3 DDB2 GADD45A IGFBP3 GADD45B SERPINE1 SHISA5 RPRM THBS1 TP53 TSC2 PPM1D TNFRSF10B	143686 1643 1647 3486 4616 5054 51246 56475 7057 7157 7249 8493 8795
Vorinostat rep1	FDA approved	Vascular smooth muscle contraction	path:04270_10	9	5.960436	0.043526786	ADCY1 ADCY2 ADCY9 GNAS ITPR1 MYLK PLCB2 PRKACA PRKACB	107 108 115 2778 3708 4638 5330 5566 5567
Vorinostat rep1	FDA approved	Gap junction	path:04540_7	6	6.13348	0.034598214	ADCY1 ADCY2 ADCY9 GNAI3 HRAS PRKACB	107 108 115 2773 3265 5567
Vorinostat rep1	FDA approved	Jak-STAT signaling pathway	path:04630_110	15	6.64779	0.015625	IL2RG IL5RA IL6R IL6ST IL7R IL10RA IL11 IL13RA1 LIF LIFR IL23A STAT5A SOCS1 SOCS3 OSMR	3561 3568 3570 3572 3575 3587 3589 3597 3976 3977 51561 6776 8651 9021 9180
Vorinostat rep1	FDA approved	Circadian entrainment	path:04713_58	12	6.859097	0.013392857	ADCY1 ADCY2 ADCY9 GNAS GNB3 GNG5 GNG7 GNG13 PLCB2 PRKACA PRKACB GNG12	107 108 115 2778 2784 2787 2788 51764 5330 5566 5567 55970
Vorinostat rep1	FDA approved	Retrograde endocannabinoid signaling	path:04723_43	11	6.188959	0.034598214	ADCY1 ADCY2 ADCY9 GNB3 GNG5 GNG7 GNG13 PRKACA PRKACB GNG12 MAPK9	107 108 115 2784 2787 2788 51764 5566 5567 55970 5601
Vorinostat rep1	FDA approved	Glutamatergic synapse	path:04724_43	11	6.370042	0.024553571	ADCY1 ADCY2 ADCY9 GNAS GNB3 GNG7 GRM8 GNG13 PRKACA PRKACB GNG12	107 108 115 2778 2784 2788 2918 51764 5566 5567 55970
Vorinostat rep1	FDA approved	Cholinergic synapse	path:04725_63	13	6.706142	0.015625	ADCY1 ADCY2 ADCY9 PIK3R5 GNB3 GNG5 GNG7 NRAS GNG13 PIK3CG PRKACA PRKACB GNG12	107 108 115 23533 2784 2787 2788 4893 51764 5294 5566 5567 55970
Vorinostat rep1	FDA approved	GABAergic synapse	path:04727_34	7	6.541678	0.022321429	ADCY1 ADCY2 ADCY9 GNG5 GNG13 PRKACA GABBR2	107 108 115 2787 51764 5566 9568
Vorinostat rep1	FDA approved	Dopaminergic synapse	path:04728_52	8	6.288914	0.029017857	CREB3 ATF2 GRIN2A PLCB2 PRKACA PRKACB PRKCA MAPK9	10488 1386 2903 5330 5566 5567 5578 5601
Vorinostat rep1	FDA approved	Insulin secretion	path:04911_2	8	6.43253	0.024553571	CREB3 ADCY1 ADCY2 ADCY9 ATF2 GNAS PRKACA PRKACB	10488 107 108 115 1386 2778 5566 5567
Vorinostat rep1	FDA approved	Estrogen signaling pathway	path:04915_6	8	6.43253	0.024553571	CREB3 ADCY1 ADCY2 ADCY9 ATF2 GNAS PRKACA PRKACB	10488 107 108 115 1386 2778 5566 5567
Vorinostat rep1	FDA approved	Glucagon signaling pathway	path:04922_12	12	6.599202	0.020089286	CREB3 ADCY2 ATF2 ITPR1 PCK1 PDE3B PHKG2 PKM PRKAA1 PRKAB1 PRKACA PRKACB	10488 108 1386 3708 5105 5140 5261 5315 5562 5564 5566 5567
Vorinostat rep1	FDA approved	Gastric acid secretion	path:04971_4	7	6.272583	0.029017857	ADCY1 ADCY2 ADCY9 GNAS HRH2 PRKACA PRKACB	107 108 115 2778 3274 5566 5567
Vorinostat rep1	FDA approved	Morphine addiction	path:05032_43	15	6.266492	0.029017857	ADCY1 ADCY2 ADCY9 GNAS GNB2 GNG5 GNG7 GNG11 GNGT2 GNG13 PRKACA PRKCA PRKCB GNG12 GABBR2	107 108 115 2778 2783 2787 2788 2791 2793 51764 5566 5578 5579 55970 9568
Vorinostat rep1	FDA approved	Pathways in cancer	path:05200_51	3	6.290037	0.029017857	PIK3R5 ITGB1 PTK2	23533 3688 5747
Vorinostat rep2	FDA approved	Purine metabolism	path:00230_176	7	6.802345	0.011173184	ADCY2 ADCY8 ADCY9 POLR3H ITPA POLR2D POLR1B	108 114 115 171568 3704 5433 84172
Vorinostat rep2	FDA approved	ErbB signaling pathway	path:04012_22	6	5.986625	0.039106145	EGFR NCK1 PAK3 MAPK8 PAK6 MAP2K4	1956 4690 5063 5599 56924 6416
Vorinostat rep2	FDA approved	Ras signaling pathway	path:04014_71	8	5.987847	0.039106145	RRAS2 PIK3R5 AFDN PLCE1 PRKCA RALGDS RRAS SYNGAP1	22800 23533 4301 51196 5578 5900 6237 8831
Vorinostat rep2	FDA approved	Calcium signaling pathway	path:04020_69	8	5.8707	0.049162011	ADRA1B GNA11 GNA15 HRH1 PLCB2 LTB4R2 PTGER1 TACR1	147 2767 2769 3269 5330 56413 5731 6869
Vorinostat rep2	FDA approved	Chemokine signaling pathway	path:04062_90	8	7.131018	0.003351955	ADCY1 ADCY2 ADCY9 CCR6 GNAI2 GNGT2 PLCB2 PRKCB	107 108 115 1235 2771 2793 5330 5579
Vorinostat rep2	FDA approved	Phosphatidylinositol signaling system	path:04070_81	13	6.730354	0.011173184	DGKH DGKQ PIK3R5 INPP5A ITPKB ITPR1 OCRL PIP4K2A PLCB2 PLCG1 PIP4K2B DGKZ CDS2	160851 1609 23533 3632 3707 3708 4952 5305 5330 5335 8396 8525 8760
Vorinostat rep2	FDA approved	AMPK signaling pathway	path:04152_40	6	6.192028	0.030167598	AKT2 PRKAG3 PRKAA1 TSC2 SCD5 CD36	208 53632 5562 7249 79966 948
Vorinostat rep2	FDA approved	Jak-STAT signaling pathway	path:04630_111	8	5.933381	0.044692737	EPOR PIK3R5 IL2RB IL6R IL12RB2 OSM STAT5A SOCS3	2057 23533 3560 3570 3595 5008 6776 9021
Vorinostat rep2	FDA approved	Thyroid hormone synthesis	path:04918_5	7	6.765238	0.011173184	CREB3 ATF2 ITPR1 PLCB2 PLCB3 PRKACA PRKCA	10488 1386 3708 5330 5331 5566 5578
Vorinostat rep2	FDA approved	Oxytocin signaling pathway	path:04921_36	9	6.370998	0.020111732	EGFR GNAO1 ITPR1 MYLK CALML5 PLCB2 PRKCA PRKCB CALML3	1956 2775 3708 4638 51806 5330 5578 5579 810