Detail

Chr	NA
start	NA
end	NA
lncRNA name	91H
entrez id	NA
hgnc id	NA
ensg id	NA
refseq id	NA
methods	qPCR, RNAi, ChIP, Cell proliferation assay etc.
regulated	up-regulated
function description	Here, we observed that 91H, H19 and IGF2 are overexpressed in breast tumors. By using 91H-knockdown breast cancer cells, we demonstrated that 91H exerts oncogenic properties by promoting cell growth, migration and invasion as well as tumor growth in xenografted immunodeficient mouse model. Moreover, 91H-knockdown reduces the expression of H19 and IGF2 in breast cancer cells. By chromatin-immunoprecipitation and methylation studies, we found that 91H expression prevents histone and DNA methylation on the maternal allele at the H19/IGF2 locus.
pubmed id	27780718
year	2017
title	The long non-coding RNA 91H increases aggressive phenotype of breast cancer cells and up-regulates H19/IGF2 expression through epigenetic modifications.
drug	X
circulating	X
survival	X